ZFIN ID: ZDB-GENE-000125-4
Gene Name: deltaC
Gene Symbol: dlc
Previous Names: bea, beamter
Location: Chr: 15   Details
GENE EXPRESSION
All Expression Data: 115 figures from 73 publications
Directly Submitted Expression Data: 6 figures (26 images) from Thisse et al., 2005 [eu289]
  6 figures (20 images) from Thisse et al., 2008 [cssl:d401]
  6 figures (18 images) from Thisse et al., 2005 [eu238]
Wild-type Stages, Structures: Blastula:30%-epiboly (4.66h-5.25h) to Adult (90d-730d, breeding adult)
  alar plate midbrain region, artery, brain, cardiovascular system (all 59) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 21 Genotypes
Knockdown reagents: MO1-dlc (1), MO2-dlc (1), MO3-dlc (1), MO4-dlc (1), MO5-dlc (1) (all 9) expand

Allele Type Mutagen Suppliers
b663 Unknown
dlc_unspecified Unspecified
la012690Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • thf102 Small Deletion
    tit446 Point Mutation
  • Zebrafish International Resource Center (ZIRC) (order this)
  •    expand Show all 10 alleles
    PHENOTYPE
    Data: 17 figures from 8 publications
    Observed in: blood, blood vessel morphogenesis, determination of left/right asymmetry in lateral mesoderm, ectoderm development (all 18) expand

    Phenotype of Human Orthologue OMIM Phenotype ID
    Spondylocostal dysostosis 1, autosomal recessive 277300
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal aorta development (more)
    Cellular Component cytoplasm (more)
    Molecular Function PDZ domain binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000152 (1)
  • InterPro:IPR000742 (1)
  • InterPro:IPR001774 (1)
  • InterPro:IPR001881 (1)
  • InterPro:IPR009030 (1)
  • InterPro:IPR011651 (1)
  • InterPro:IPR013032 (1)
  • InterPro:IPR018097 (1)
  • PROSITE:PS00010 (1)
  • PROSITE:PS00022 (1)
  • PROSITE:PS01186 (1)
  • PROSITE:PS01187 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS51051 (1)
  • Pfam:PF00008 (1)
  • Pfam:PF01414 (1)
  • Pfam:PF07657 (1)
  • Pfam:PF12661 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA dlc-001 (1) 3567
    ncRNA dlc-002 (1) 728
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dlc
    Tg(hsp70l:dlc), Tg(mitfa:dlc), Tg(UAS:dlc)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    dlc Contained in: [BAC] DKEY-46I14 (1) (order this)
    dlc Encodes: [EST] eu238 (1), eu289 (1)
    [cDNA] cssl:d401 (1) (order this), MGC:193544 (1) (order this), MGC:193551 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130944 (1) 3610 bp
    Genomic GenBank:CR626887 (1) 198090 bp
    Select Tool
    Polypeptide UniProtKB:A4JYS0 (1) 664 aa
    Sequence Clusters UniGene:81314 (1)
    Sequence Information (all 26)
    OTHER dlc GENE PAGES
  • Gene:30120 (1)
  • VEGA:OTTDARG00000020683 (1)
  • Ensembl(Zv9):ENSDARG00000002336 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish dlc 15  
    Human DLL3 19 (19q13)
  • OMIM:602768
  • Gene:10683
  • Orthology Details
    CITATIONS (179)