Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-000125-4
Gene Name: deltaC
Gene Symbol: dlc
Previous Names: bea, beamter
Location: Chr: 15   Details
GENE EXPRESSION
All Expression Data: 106 figures from 64 publications
Directly Submitted Expression Data: 6 figures (26 images) from Thisse et al., 2005 [eu289]
  6 figures (20 images) from Thisse et al., 2008 [cssl:d401]
  6 figures (18 images) from Thisse et al., 2005 [eu238]
Wild-type Stages, Structures: Blastula:30%-epiboly (4.66h-5.25h) to Adult (90d-730d, breeding adult)
  alar plate midbrain region, brain, cardiovascular system, central nervous system (all 52) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 19 genotypes
Alleles: b663, dlc_unspecified, la012690Tg, thf102, tit446 (all 10) expand
Knockdown reagents: MO1-dlc (1), MO2-dlc (1), MO3-dlc (1), MO4-dlc (1), MO5-dlc (1) (all 9) expand
PHENOTYPE
Data: 17 figures from 8 publications
Observed in: blood, blood vessel morphogenesis, determination of left/right asymmetry in lateral mesoderm, ectoderm development (all 18) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Spondylocostal dysostosis 1, autosomal recessive 277300
GENE ONTOLOGY
Ontology GO Term
Biological Process hematopoietic stem cell differentiation (more)
Cellular Component cytoplasm (more)
Molecular Function PDZ domain binding (more)
GO Terms (all 17)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000152 (1)
  • InterPro:IPR000742 (1)
  • InterPro:IPR001774 (1)
  • InterPro:IPR001881 (1)
  • InterPro:IPR009030 (1)
  • InterPro:IPR011651 (1)
  • InterPro:IPR013032 (1)
  • InterPro:IPR018097 (1)
  • PROSITE:PS00010 (1)
  • PROSITE:PS00022 (1)
  • PROSITE:PS01186 (1)
  • PROSITE:PS01187 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS51051 (1)
  • Pfam:PF00008 (1)
  • Pfam:PF01414 (1)
  • Pfam:PF07657 (1)
  • Pfam:PF12661 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA dlc-001 (1) 3567
    ncRNA dlc-002 (1) 728
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM dlc
    Tg(mitfa:dlc), Tg(UAS:dlc)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    dlc Contained in: [BAC] DKEY-46I14 (1)
    dlc Encodes: [EST] eu238 (1), eu289 (1)
    [cDNA] cssl:d401 (1) (order this), MGC:193544 (1) (order this), MGC:193551 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130944 (1) 3610 bp
    Genomic GenBank:CR626887 (1) 198090 bp
    Select Tool
    Polypeptide UniProtKB:A4JYS0 (1) 664 aa
    Sequence Clusters UniGene:81314 (1)
    Sequence Information (all 26)
    OTHER dlc GENE PAGES
  • Gene:30120 (1)
  • VEGA:OTTDARG00000020683 (1)
  • Ensembl(Zv9):ENSDARG00000002336 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish dlc 15  
    Human DLL3 19 (19q13)
  • OMIM:602768
  • Gene:10683
  • Orthology Details
    CITATIONS (164)