Gene
dlc
- ID
- ZDB-GENE-000125-4
- Name
- deltaC
- Symbol
- dlc Nomenclature History
- Previous Names
-
- bea
- beamter
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Enables PDZ domain binding activity and identical protein binding activity. Acts upstream of or within several processes, including blood vessel development; neuron differentiation; and somite development. Located in perinuclear region of cytoplasm and plasma membrane. Is expressed in several structures, including immature eye; integument; mesoderm; nervous system; and trunk. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis 1. Orthologous to human DLL3 (delta like canonical Notch ligand 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 177 figures from 110 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d401 (20 images)
- eu289 (26 images)
- eu238 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 9 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b663 | unknown | Unknown | Unknown | not specified | |
| dlc_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| ion32h | Allele with one delins | Exon 4 | Unknown | CRISPR | |
| la012690Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa35867 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42530 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| thf102 | Allele with one deletion | Unknown | Unknown | not specified | |
| tit446 | Allele with one point mutation | Unknown | Unknown | not specified | |
| tm98 | Allele with one point mutation | Unknown | Unknown | ENU | |
| to202 | Allele with one point mutation | Unknown | Unknown | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dlc | Jin et al., 2022 | |
| CRISPR2-dlc | Jin et al., 2022 | |
| CRISPR3-dlc | Jin et al., 2022 | |
| CRISPR4-dlc | Jin et al., 2022 | |
| MO1-dlc | N/A | (5) |
| MO2-dlc | N/A | (7) |
| MO3-dlc | N/A | Oates et al., 2005 |
| MO4-dlc | N/A | Oates et al., 2005 |
| MO5-dlc | N/A | (2) |
| MO6-dlc | N/A | Shaw et al., 2006 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondylocostal dysostosis 1 | Alliance | Spondylocostal dysostosis 1, autosomal recessive | 277300 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001774 | Delta/Serrate/lag-2 (DSL) protein |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR011651 | Notch ligand, N-terminal domain |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Additional Resources | Length | Delta/Serrate/lag-2 (DSL) protein | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | Notch ligand, N-terminal domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A4JYS0 | InterPro | 664 | ||||||||
| UniProtKB:Q9IAT6 | InterPro | 664 |
Interactions and Pathways
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg2(dlc:mCherry) |
|
| 1 | Chen et al., 2019 | |
| Tg3(dlc:mCherry) |
|
| 1 | Chen et al., 2019 | |
| TgBAC(dlc:EGFP) |
|
| 1 | (2) | |
| TgBAC(dlc:mCherry-NTR) |
|
| 1 | Sun et al., 2022 | |
| Tg(dlc:mCherry) |
|
| 1 | Chen et al., 2019 | |
| Tg(hsp70l:dlc) |
|
| 1 | (3) | |
| Tg(hsp70l:Venus-dlc-UTR) |
| 3 | Tietz et al., 2020 | ||
| Tg(mitfa:dlc) |
|
| 1 | (3) | |
| Tg(UAS:dlc) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-46I14 | ZFIN Curated Data | |
| Encodes | EST | eu238 | Thisse et al., 2005 | |
| Encodes | EST | eu289 | Thisse et al., 2005 | |
| Encodes | cDNA | cssl:d401 | Bushell et al., 2007 | |
| Encodes | cDNA | MGC:193544 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193551 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130944 (1) | 3610 nt | ||
| Genomic | GenBank:CR626887 (2) | 198090 nt | ||
| Polypeptide | UniProtKB:A4JYS0 (1) | 664 aa |
- Ding, S., Aziz, T., Meng, A., Jia, S. (2024) Aagab is required for zebrafish larval development by regulating neural activity. Journal of genetics and genomics = Yi chuan xue bao. 51(6):630-641
- Wang, X., Zhao, J., Xu, J., Li, B., Liu, X., Xie, G., Duan, X., Liu, D. (2024) Noncaloric monosaccharides induce excessive sprouting angiogenesis in zebrafish via foxo1a-marcksl1a signal. eLIFE. 13:
- Zhou, W., Ghersi, J.J., Ristori, E., Semanchik, N., Prendergast, A., Zhang, R., Carneiro, P., Baldissera, G., Sessa, W.C., Nicoli, S. (2024) Akt is a mediator of artery specification during zebrafish development. Development (Cambridge, England). 151(17):
- Li, H., Luo, Q., Cai, S., Tie, R., Meng, Y., Shan, W., Xu, Y., Zeng, X., Qian, P., Huang, H. (2023) Glia maturation factor-γ is required for initiation and maintenance of hematopoietic stem and progenitor cells. Stem Cell Research & Therapy. 14:117117
- Liao, T., Xu, X., Wu, J., Xie, Y., Yan, J. (2023) Increased expression levels of DLX5 inhibit the development of the nervous system. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 83(8):728-739
- Song, K., Lin, Z., Cao, L., Lu, B., Chen, Y., Zhang, S., Lu, J., Xu, H. (2023) Sox11b regulates the migration and fate determination of Müller glia-derived progenitors during retina regeneration in zebrafish. Neural regeneration research. 18:445-450
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) FGF8 rescues motor deficits in zebrafish model of limb-girdle muscular dystrophy R18. Biochemical and Biophysical Research Communications. 652:768376-83
- Wesselman, H.M., Flores-Mireles, A.L., Bauer, A., Pei, L., Wingert, R.A. (2023) Esrrγa regulates nephron and ciliary development by controlling prostaglandin synthesis. Development (Cambridge, England). 150(10):
- Wu, J., Li, J., Chen, K., Liu, G., Zhou, Y., Chen, W., Zhu, X., Ni, T.T., Zhang, B., Jin, D., Li, D., Kang, L., Wu, Y., Zhu, P., Xie, P., Zhong, T.P. (2023) Atf7ip and Setdb1 interaction orchestrates the hematopoietic stem and progenitor cell state with diverse lineage differentiation. Proceedings of the National Academy of Sciences of the United States of America. 120:e2209062120e2209062120
- Jin, M., Zhang, H., Xu, B., Li, Y., Qin, H., Yu, S., He, J. (2022) Jag2b-Notch3/1b-mediated neuron-to-glia crosstalk controls retinal gliogenesis. EMBO reports. 23(10):e54922
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