ZFIN ID: ZDB-GENE-000125-4
Gene Name: deltaC
Gene Symbol: dlc
Previous Names: bea, beamter
Location: Chr: 15 Mapping Details/Browsers
GENE EXPRESSION
All Expression Data: 129 figures from 81 publications
Directly Submitted Expression Data: 6 figures (26 images) from Thisse et al., 2005 [eu289]
  6 figures (20 images) from Thisse et al., 2008 [cssl:d401]
  6 figures (18 images) from Thisse et al., 2005 [eu238]
Wild-type Stages, Structures: Blastula:30%-epiboly (4.66h-5.25h) to Adult (90d-730d, breeding adult)
  alar plate midbrain region, artery, brain, cardiovascular system (all 63) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b663 Unknown Unknown Unknown
dlc_unspecified Unspecified Unknown Unknown
la012690Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35867 Point Mutation Unknown Unknown ENU
    sa42530 Point Mutation Unknown Unknown ENU
    thf102 Small Deletion Unknown Unknown
    tit446 Point Mutation Unknown Unknown
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tm98 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • to202 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tw212b Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • y56 Point Mutation Unknown Unknown ENU
    y70 Unknown Unknown Unknown ENU
    Targeting reagents: MO1-dlc (1), MO2-dlc (1), MO3-dlc (1), MO4-dlc (1), MO5-dlc (1) (all 9) expand
    PHENOTYPE
    Data: 18 figures from 9 publications
    Observed in: blood, blood vessel morphogenesis, determination of left/right asymmetry in lateral mesoderm, ectoderm development (all 20) expand
    DISEASE ASSOCIATED WITH dlc HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    spondylocostal dysostosis Spondylocostal dysostosis 1, autosomal recessive 277300
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal aorta development (more)
    Cellular Component cytoplasm (more)
    Molecular Function PDZ domain binding (more)
    GO Terms (all 22)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000152 (1)
  • InterPro:IPR000742 (1)
  • InterPro:IPR001774 (1)
  • InterPro:IPR001881 (1)
  • InterPro:IPR009030 (1)
  • InterPro:IPR013032 (1)
  • InterPro:IPR018097 (1)
  • PROSITE:PS00010 (1)
  • PROSITE:PS00022 (1)
  • PROSITE:PS01186 (1)
  • PROSITE:PS01187 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS51051 (1)
  • Pfam:PF00008 (1)
  • Pfam:PF01414 (1)
  • Pfam:PF12661 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA dlc-001 (1) 3567
    ncRNA dlc-002 (1) 728
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM dlc
    Tg(hsp70l:dlc), Tg(mitfa:dlc), Tg(UAS:dlc)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    dlcContained in: [BAC] DKEY-46I14 (1) (order this)
    dlcEncodes: [EST] eu238 (1), eu289 (1)
    [cDNA] cssl:d401 (1) (order this), MGC:193544 (1) (order this), MGC:193551 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130944 (1) 3610bp
    Genomic GenBank:CR626887 (1) 198090bp
    Select Tool
    Polypeptide UniProtKB:A4JYS0 (1) 664aa
    Sequence Clusters UniGene:81314 (1)
    Sequence Information (all 26)
    OTHER dlc GENE PAGES
  • Gene:30120 (1)
  • VEGA:OTTDARG00000020683 (1)
  • Ensembl(GRCz10):ENSDARG00000002336 (1)
  • ORTHOLOGY for dlc (Chr: 15)
    Species Symbol Chromosome Accession # Evidence
    Human DLL3 19
  • Gene:10683
  • OMIM:602768
  • HGNC:2909
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (196)