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General Information
ZIRC
ZFIN ID: ZDB-GENE-010131-2
Gene Name: cyclin-dependent kinase 5
Gene Symbol: cdk5
GO Details
Ontology Qualifier Term Evidence Inferred From Annotation Extension Reference(s)
Molecular Function ATP binding IEA InterPro:IPR000719 ZFIN Electronic Annotation
ATP binding IEA InterPro:IPR017441 ZFIN Electronic Annotation
ATP binding IEA UniProtKB-KW:KW-0067 ZFIN Electronic Annotation
cyclin-dependent protein serine/threonine kinase activity IBA dictyBase:DDB_G0272813, MGI:MGI:104772, SGD:S000005963, SGD:S000001622, RGD:70514, FB:FBgn0263237, FB:FBgn0004106, TAIR:locus:2011761, UniProtKB:Q00534, PomBase:SPAC2F3.15, RGD:2319, MGI:MGI:88351, FB:FBgn0019949, FB:FBgn0013762, PomBase:SPAC23H4.17c, WB:WBGene00000405, MGI:MGI:88357, UniProtKB:O94921, SGD:S000000364, SGD:S000005952, UniProtKB:P50750, UniProtKB:P11802, UniProtKB:Q8IJQ1, UniProtKB:P61075, SGD:S000006365, PomBase:SPBC11B10.09, RGD:621120, FB:FBgn0005640, RGD:70486, PomBase:SPBC32H8.10, UniProtKB:P06493, PomBase:SPBC19F8.07, UniProtKB:C9K505, dictyBase:DDB_G0288677, UniProtKB:P24941, PANTHER:PTN000623091, RGD:621124 Gaudet et al., 2010
cyclin-dependent protein serine/threonine kinase activity IMP MO2-cdk5 Kanungo et al., 2009
histone kinase activity IDA Kanungo et al., 2006
histone kinase activity IMP Kanungo et al., 2007
kinase activity IEA UniProtKB-KW:KW-0418 ZFIN Electronic Annotation
nucleotide binding IEA UniProtKB-KW:KW-0547 ZFIN Electronic Annotation
protein kinase activity IEA InterPro:IPR000719 ZFIN Electronic Annotation
protein kinase activity IEA InterPro:IPR008271 ZFIN Electronic Annotation
protein serine/threonine kinase activity IEA UniProtKB-KW:KW-0723 ZFIN Electronic Annotation
transferase activity IEA UniProtKB-KW:KW-0808 ZFIN Electronic Annotation
Cellular Component cytoplasm IBA UniProtKB:Q00536, MGI:MGI:101765, RGD:70514, dictyBase:DDB_G0288677, MGI:MGI:894318, PANTHER:PTN002373304 Gaudet et al., 2010
nucleus IBA TAIR:locus:2008595, UniProtKB:P49336, RGD:70514, MGI:MGI:101765, TAIR:locus:2194045, UniProtKB:Q92772, UniProtKB:Q8W4P1, UniProtKB:P21127, MGI:MGI:88353, MGI:MGI:88357, UniProtKB:O94921, RGD:1359638, SGD:S000005952, UniProtKB:O76039, UniProtKB:Q8IJQ1, UniProtKB:P61075, TAIR:locus:2033349, SGD:S000006365, TAIR:locus:2080290, RGD:621120, RGD:70486, FB:FBgn0015618, UniProtKB:P79432, TAIR:locus:2158554, dictyBase:DDB_G0288677, RGD:621124, MGI:MGI:104772, UniProtKB:Q9UQ88, SGD:S000001622, FB:FBgn0263237, TAIR:locus:2084086, UniProtKB:Q9NYV4, RGD:619874, UniProtKB:Q00535, MGI:MGI:102956, UniProtKB:Q00534, PomBase:SPAC2F3.15, TAIR:locus:2027819, RGD:2319, UniProtKB:Q8RWN3, FB:FBgn0019949, dictyBase:DDB_G0267442, WB:WBGene00000405, RGD:1305435, SGD:S000000364, UniProtKB:P11802, SGD:S000002266, UniProtKB:P50613, PomBase:SPBC11B10.09, PomBase:SPBC32H8.10, UniProtKB:P06493, MGI:MGI:1328368, UniProtKB:Q8IDW1, TAIR:locus:2099478, MGI:MGI:894318, UniProtKB:P24941, PANTHER:PTN000623091, TAIR:locus:2119961 Gaudet et al., 2010
Biological Process axonogenesis IBA MGI:MGI:101765, FB:FBgn0013762, PANTHER:PTN000623852 Gaudet et al., 2010
central nervous system neuron development IMP MO2-cdk5 Kanungo et al., 2009
embryonic retina morphogenesis in camera-type eye IMP MO1-cdk5 Leung et al., 2008
negative regulation of neuron apoptotic process IDA Kanungo et al., 2006
negative regulation of neuron apoptotic process IMP Kanungo et al., 2006
neuron apoptotic process IBA MGI:MGI:101765, RGD:70514, PANTHER:PTN000623852 Gaudet et al., 2010
neuron differentiation IMP MO1-cdk5 Leung et al., 2008
optic nerve formation IMP MO1-cdk5 Leung et al., 2008
peripheral nervous system neuron development IMP Kanungo et al., 2007
phosphorylation IEA UniProtKB-KW:KW-0418 ZFIN Electronic Annotation
protein phosphorylation IBA dictyBase:DDB_G0272813, MGI:MGI:104772, UniProtKB:Q9UQ88, SGD:S000005963, SGD:S000001865, SGD:S000001622, RGD:70514, FB:FBgn0263237, SGD:S000005488, FB:FBgn0004106, UniProtKB:Q00534, MGI:MGI:101765, UniProtKB:P21127, MGI:MGI:88351, dictyBase:DDB_G0267442, FB:FBgn0013762, WB:WBGene00000407, MGI:MGI:88357, WB:WBGene00000405, SGD:S000005952, UniProtKB:P50750, UniProtKB:P11802, SGD:S000006365, FB:FBgn0005640, FB:FBgn0015618, UniProtKB:P06493, WB:WBGene00019362, dictyBase:DDB_G0288677, UniProtKB:P24941, PANTHER:PTN000623091, RGD:621124, TAIR:locus:2119961, FB:FBgn0013435 Gaudet et al., 2010
protein phosphorylation IEA InterPro:IPR000719 ZFIN Electronic Annotation
protein phosphorylation IEA InterPro:IPR008271 ZFIN Electronic Annotation
retina layer formation IMP MO1-cdk5 Leung et al., 2008
synaptic vesicle transport IBA WB:WBGene00000407, PANTHER:PTN000623852 Gaudet et al., 2010
type B pancreatic cell differentiation IMP cdk5ki110/ki110 Liu et al., 2017