Gene

cdk5

ID

ZDB-GENE-010131-2

Name

cyclin-dependent kinase 5

Symbol

cdk5 Nomenclature History

Previous Names

zgc:101604

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Exhibits cyclin-dependent protein serine/threonine kinase activity and histone kinase activity. Involved in several processes, including nervous system development; retina morphogenesis in camera-type eye; and type B pancreatic cell differentiation. Predicted to localize to cytoplasm and nucleus. Is expressed in blastomere; central nervous system; immature eye; musculature system; and neural plate. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly. Orthologous to human CDK5 (cyclin dependent kinase 5).

Genome Resources

Note

None

Expression

All Expression Data

7 figures from 7 publications

Cross-Species Comparison

High Throughput Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cdk5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Lissencephaly 7 with cerebellar hypoplasia	616342

Associated With cdk5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily