Gene

cdk5

ID
ZDB-GENE-010131-2
Name
cyclin-dependent kinase 5
Symbol
cdk5 Nomenclature History
Previous Names
  • zgc:101604
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Exhibits cyclin-dependent protein serine/threonine kinase activity and histone kinase activity. Involved in several processes, including nervous system development; retina morphogenesis in camera-type eye; and type B pancreatic cell differentiation. Predicted to localize to cytoplasm and nucleus. Is expressed in blastomere; central nervous system; immature eye; musculature system; and neural plate. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly. Orthologous to human CDK5 (cyclin dependent kinase 5).
Genome Resources
Note
None
Expression
All Expression Data
7 figures from 7 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cdk5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Lissencephaly 7 with cerebellar hypoplasia 616342
Associated With cdk5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q5U3V4 292
UniProtKB:Q9DE44 292
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cdk5 polyclonal IgG Rabbit
  • WB
Santa Cruz Biotechnology, Inc.
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations