Gene
cdk5
- ID
- ZDB-GENE-010131-2
- Name
- cyclin-dependent kinase 5
- Symbol
- cdk5 Nomenclature History
- Previous Names
-
- zgc:101604
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Exhibits cyclin-dependent protein serine/threonine kinase activity and histone kinase activity. Involved in several processes, including nervous system development; retina morphogenesis in camera-type eye; and type B pancreatic cell differentiation. Predicted to localize to cytoplasm and nucleus. Is expressed in blastomere; central nervous system; immature eye; musculature system; and neural plate. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly. Orthologous to human CDK5 (cyclin dependent kinase 5).
- Genome Resources
- Note
- None
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
?Lissencephaly 7 with cerebellar hypoplasia | 616342 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
---|---|---|---|---|---|
UniProtKB:Q5U3V4
|
292 | ||||
UniProtKB:Q9DE44
|
292 |
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-cdk5 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
3 |
Plasmids
No data available