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ZIRC
ZFIN ID: ZDB-GENE-010131-2
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Gene Name: cyclin-dependent kinase 5
Gene Symbol: cdk5    Nomenclature History

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Previous Name: zgc:101604

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Exhibits cyclin-dependent protein serine/threonine kinase activity and histone kinase activity. Involved in several processes, including nervous system development; retina morphogenesis in camera-type eye; and type B pancreatic cell differentiation. Predicted to localize to the cytosol and nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly. Is expressed in blastomere; central nervous system; immature eye; musculature system; and neural plate. Orthologous to human CDK5 (cyclin dependent kinase 5).
Genome Resources: Alliance (1),  Gene:65234 (1),  Ensembl(GRCz11):ENSDARG00000056683 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 7 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:101604]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ki110 Small Deletion Unknown Frameshift, Premature Stop CRISPR
la014588Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la023006Tg Transgenic Insertion Unknown Unknown DNA
    la023007Tg Transgenic Insertion Unknown Unknown DNA
    la023008Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cdk5 1
    MO1-cdk5 N/A 3
    MO2-cdk5 N/A 1
    MO3-cdk5 N/A 2
    PHENOTYPE
    Data: 8 figures from 4 publications
    Observed in:
    DISEASE ASSOCIATED WITH cdk5 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Lissencephaly 7 with cerebellar hypoplasia 616342
    DISEASE ASSOCIATED WITH cdk5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of neuron apoptotic process (more)
    Cellular Component cytoplasm (more)
    Molecular Function histone kinase activity (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR008271 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR017441 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00108 (1)
  • PROSITE:PS50011 (1)
  • Pfam:PF00069 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cdk5-201 (1)    Ensembl 1899
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-cdk5 polyclonal IgG Rabbit WB Santa Cruz Biotechnology, Inc.
    		3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cdk5 No data available
    MARKER RELATIONSHIPS
    cdk5 Contained in: [BAC] DKEYP-87A6 (1)
    cdk5 Encodes: [cDNA] MGC:101604 (1) (order this), MGC:191976 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131719 (1) 2881 bp
    Select Tool
    Genomic GenBank:CU019563 (1) 194521 bp
    Select Tool
    Polypeptide UniProtKB:Q5U3V4 (1) 292 aa
    Select Tool
    Sequence Clusters UniGene:105878 (1)
    Sequence Information (all 17)
    ORTHOLOGY for cdk5 ( Chr: 24 )
    CITATIONS (38)