ZFIN Gene: cdk5

ZFIN ID: ZDB-GENE-010131-2

ZFIN ID: ZDB-GENE-010131-2

Gene Name:

cyclin-dependent kinase 5

Gene Symbol:

cdk5 Nomenclature History

Previous Name:

zgc:101604

Gene Type:

protein_coding_gene

Location:

Chr: 24 Mapping Details/Browsers

Description:

Exhibits cyclin-dependent protein serine/threonine kinase activity and histone kinase activity. Involved in several processes, including nervous system development; retina morphogenesis in camera-type eye; and type B pancreatic cell differentiation. Predicted to localize to cytoplasm and nucleus. Is expressed in blastomere; central nervous system; immature eye; musculature system; and neural plate. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly. Orthologous to human CDK5 (cyclin dependent kinase 5).

Genome Resources:

Alliance (1), Gene:65234 (1), Ensembl(GRCz11):ENSDARG00000056683 (2)

GENE EXPRESSION
All Expression Data:	7 figures from 7 publications
Directly Submitted Expression Data:	1 figure (1 image) from Thisse et al., 2004 [MGC:101604]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
	blastomere brain central nervous system immature eye musculature system neural plate spinal cord medial-lateral axis spinal cord whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
ki110	Small Deletion	Unknown	Frameshift, Premature Stop	CRISPR
la014588Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la023006Tg	Transgenic Insertion	Unknown	Unknown	DNA
la023007Tg	Transgenic Insertion	Unknown	Unknown	DNA
la023008Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-cdk5	ki110	1
MO1-cdk5	N/A	3
MO2-cdk5	N/A	1
MO3-cdk5	N/A	2

PHENOTYPE

Data:

8 figures from 4 publications

Observed in:

DISEASE ASSOCIATED WITH cdk5 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Lissencephaly 7 with cerebellar hypoplasia	616342

DISEASE ASSOCIATED WITH cdk5 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	negative regulation of neuron apoptotic process (more)
Cellular Component	cytoplasm (more)
Molecular Function	histone kinase activity (more)

GO Terms (all 24)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	cdk5-201 (1)	1899	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES

Name	Type	Isotype	Host Organism	Assay	Source	Publications
Ab1-cdk5	polyclonal	IgG	Rabbit	WB	Santa Cruz Biotechnology, Inc.	3

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM cdk5 No data available

MARKER RELATIONSHIPS

cdk5 Contained in:	[BAC] DKEYP-87A6 (1)
cdk5 Encodes:	[cDNA] MGC:101604 (1), MGC:191976 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_131719 (1)	2881 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU019563 (1)	194521 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q5U3V4 (1)	292 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 16)

ORTHOLOGY for cdk5 ( Chr: 24 )

CITATIONS (40)

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