Kayman Kürekçi, G., Kaur Bajwa, G., Zhang, S., Leclerc, S., de Chantal, E., Belke, D., Andelfinger, G., Deniset, J.F., Marín-Juez, R. (2026) Attenuation of epicardial activation and myofibroblast abundance via the Fbln2-Nupr1b axis stimulates cardiac regeneration in zebrafish. Nature cardiovascular research. 5:218-233
|
Rouf, M.A., Kürekçi, G.K., Zhang, S., Vanier, S.L., Kamel, S.M., Lee, A.N., Yang, R.B., Lai, S.L., Marín-Juez, R. (2026) Developmental single-cell atlas of coronary growth and cardiomyocyte interaction in zebrafish. Development (Cambridge, England). 153:dev205065
|
Gupta, S., Bajwa, G.K., El-Sammak, H., Mattonet, K., Günther, S., Looso, M., Stainier, D.Y.R., Marín-Juez, R. (2025) The transmembrane glycoprotein Gpnmb is required for the immune and fibrotic responses during zebrafish heart regeneration. Developmental Biology. 521:153-162
|
Ravishankar, S., Tuohey, S.M., Ramos, N.O., Uchiyama, S., Hayes, M.I., Kang, K., Nizet, V., Madigan, C.A. (2025) Group B Streptococci lyse endothelial cells to infect the brain in a zebrafish meningitis model. PLoS Biology. 23:e3003236
|
Duca, S., Xia, Y., Elmagid, L.A., Bakis, I., Qiu, M., Cao, Y., Guo, Y., Eichenbaum, J.V., McCain, M.L., Kang, J., Harrison, M.R.M., Cao, J. (2024) Differential vegfc expression dictates lymphatic response during zebrafish heart development and regeneration. Development (Cambridge, England). 151(22):
|
Goumenaki, P., Günther, S., Kikhi, K., Looso, M., Marín-Juez, R., Stainier, D.Y.R. (2024) The innate immune regulator MyD88 dampens fibrosis during zebrafish heart regeneration. Nature cardiovascular research. 3:115811761158-1176
|
Miladinovic, O., Canto, P.Y., Pouget, C., Piau, O., Radic, N., Freschu, P., Megherbi, A., Prats, C.B., Jacques, S., Hirsinger, E., Geeverding, A., Dufour, S., Petit, L., Souyri, M., North, T., Isambert, H., Traver, D., Jaffredo, T., Charbord, P., Durand, C. (2024) A multistep computational approach reveals a neuro-mesenchymal cell population in the embryonic hematopoietic stem cell niche. Development (Cambridge, England). 151(7):
|
|
|
Wang, Z.Y., Mehra, A., Wang, Q.C., Gupta, S., Ribeiro da Silva, A., Juan, T., Günther, S., Looso, M., Detleffsen, J., Stainier, D.Y.R., Marín-Juez, R. (2024) flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response. Development (Cambridge, England). 151(23):
|
Hußmann, M., Schulte, D., Weischer, S., Carlantoni, C., Nakajima, H., Mochizuki, N., Stainier, D.Y.R., Zobel, T., Koch, M., Schulte-Merker, S. (2023) Svep1 is a binding ligand of Tie1 and affects specific aspects of facial lymphatic development in a Vegfc-independent manner. eLIFE. 12:
|
Lelièvre, E., Bureau, C., Bordat, Y., Frétaud, M., Langevin, C., Jopling, C., Kissa, K. (2023) Deficiency in hereditary hemorrhagic telangiectasia-associated Endoglin elicits hypoxia-driven heart failure in zebrafish. Disease models & mechanisms. 16(5):
|
|
|
|
|
Coxam, B., Collins, R.T., Hußmann, M., Huisman, Y., Meier, K., Jung, S., Bartels-Klein, E., Szymborska, A., Finotto, L., Helker, C.S.M., Stainier, D.Y.R., Schulte-Merker, S., Gerhardt, H. (2022) Svep1 stabilizes developmental vascular anastomosis in reduced flow conditions. Development (Cambridge, England). 149(6):
|
El-Sammak, H., Yang, B., Guenther, S., Chen, W., Marín-Juez, R., Stainier, D.Y.R. (2022) A Vegfc-Emilin2a-Cxcl8a Signaling Axis Required for Zebrafish Cardiac Regeneration. Circulation research. 130(7):1014-1029
|
Hu, B., Lelek, S., Spanjaard, B., El-Sammak, H., Simões, M.G., Mintcheva, J., Aliee, H., Schäfer, R., Meyer, A.M., Theis, F., Stainier, D.Y.R., Panáková, D., Junker, J.P. (2022) Origin and function of activated fibroblast states during zebrafish heart regeneration. Nature Genetics. 54(8):1227-1237
|
Leonard, E.V., Figueroa, R.J., Bussmann, J., Lawson, N.D., Amigo, J.D., Siekmann, A.F. (2022) Regenerating vascular mural cells in zebrafish fin blood vessels are not derived from pre-existing ones and differentially require pdgfrb signalling for their development. Development (Cambridge, England). 149(7)
|
Mitra, S., Devi, S., Lee, M.S., Jui, J., Sahu, A., Goldman, D. (2022) Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2211690119
|
Arias-Alpizar, G., Koch, B., Hamelmann, N.M., Neustrup, M.A., Paulusse, J.M.J., Jiskoot, W., Kros, A., Bussmann, J. (2021) Stabilin-1 is required for the endothelial clearance of small anionic nanoparticles. Nanomedicine : nanotechnology, biology, and medicine. 34:102395
|
Gioacchino, E., Koyunlar, C., Zink, J., de Looper, H., de Jong, M., Dobrzycki, T., Mahony, C.B., Hoogenboezem, R., Bosch, D., van Strien, P.M.H., van Royen, M.E., French, P.J., Bindels, E., Gussinklo, K.J., Monteiro, R., Touw, I.P., de Pater, E. (2021) Essential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish. Blood advances. 5:2687-2700
|
Huisman, Y., Uphoff, K., Berger, M., Dobrindt, U., Schelhaas, M., Zobel, T., Bussmann, J., van Impel, A., Schulte-Merker, S. (2021) Meningeal lymphatic endothelial cells fulfill scavenger endothelial cell function and cooperate with microglia in waste removal from the brain. Glia. 70(1):35-49
|
Maglitto, A., Mariani, S.A., de Pater, E., Rodriguez-Seoane, C., Vink, C.S., Piao, X., Lukke, M.L., Dzierzak, E. (2021) Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation. Blood advances. 5:829-842
|
|
|
Soto, R.A., Najia, M.A.T., Hachimi, M., Frame, J.M., Yette, G.A., Lummertz da Rocha, E., Stankunas, K., Daley, G.Q., North, T.E. (2021) Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2. Stem Cell Reports. 16(7):1718-1734
|
Beisaw, A., Kuenne, C., Günther, S., Dallmann, J., Wu, C.C., Bentsen, M., Looso, M., Stainier, D. (2020) AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion during Zebrafish Heart Regeneration. Circulation research. 126(12):1760-1778
|
Klems, A., van Rijssel, J., Ramms, A.S., Wild, R., Hammer, J., Merkel, M., Derenbach, L., Préau, L., Hinkel, R., Suarez-Martinez, I., Schulte-Merker, S., Vidal, R., Sauer, S., Kivelä, R., Alitalo, K., Kupatt, C., van Buul, J.D., le Noble, F. (2020) The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models. Nature communications. 11:5319
|
Kotini, M.P., Bachmann, F., Spickermann, J., McSheehy, P.M., Affolter, M. (2020) Probing the Effects of the FGFR-Inhibitor Derazantinib on Vascular Development in Zebrafish Embryos. Pharmaceuticals (Basel, Switzerland). 14(1):
|
Wang, G., Muhl, L., Padberg, Y., Dupont, L., Peterson-Maduro, J., Stehling, M., le Noble, F., Colige, A., Betsholtz, C., Schulte-Merker, S., van Impel, A. (2020) Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis. Nature communications. 11:2724
|
Capasso, T.L., Li, B., Volek, H.J., Khalid, W., Rochon, E.R., Anbalagan, A., Herdman, C., Yost, H.J., Villanueva, F.S., Kim, K., Roman, B.L. (2019) BMP10-mediated ALK1 signaling is continuously required for vascular development and maintenance. Angiogenesis. 23(2):203-220
|
Eng, T.C., Chen, W., Okuda, K.S., Misa, J.P., Padberg, Y., Crosier, K.E., Crosier, P.S., Hall, C.J., Schulte-Merker, S., Hogan, B.M., Astin, J.W. (2019) Zebrafish facial lymphatics develop through sequential addition of venous and non-venous progenitors. EMBO reports. 20(5):
|
Geudens, I., Coxam, B., Alt, S., Gebala, V., Vion, A.C., Meier, K., Rosa, A., Gerhardt, H. (2019) Artery-vein specification in the zebrafish trunk is pre-patterned by heterogeneous Notch activity and balanced by flow-mediated fine tuning. Development (Cambridge, England). 146(16):
|
Harrison, M.R., Feng, X., Mo, G., Aguayo, A., Villafuerte, J., Yoshida, T., Pearson, C.A., Schulte-Merker, S., Lien, C.L. (2019) Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration. eLIFE. 8:
|
Marín-Juez, R., El-Sammak, H., Helker, C.S.M., Kamezaki, A., Mullapuli, S.T., Bibli, S.I., Foglia, M.J., Fleming, I., Poss, K.D., Stainier, D.Y.R. (2019) Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation. Developmental Cell. 51:503-515.e4
|
Mullapudi, S.T., Boezio, G.L.M., Rossi, A., Marass, M., Matsuoka, R.L., Matsuda, H., Helker, C.S.M., Yang, Y.H.C., Stainier, D.Y.R. (2019) Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function. Development (Cambridge, England). 146(21):
|
Savage, A.M., Kurusamy, S., Chen, Y., Jiang, Z., Chhabria, K., MacDonald, R.B., Kim, H.R., Wilson, H.L., van Eeden, F.J.M., Armesilla, A.L., Chico, T.J.A., Wilkinson, R.N. (2019) tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis. Nature communications. 10:732
|
Stanic, K., Reig, G., Wichmann, I.A., Opazo, J.C., Owen, G.I., Corvalán, A.H., Concha, M.L., Amigo, J.D. (2019) The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish. Scientific Reports. 9:7131
|
Yip, J.K., Harrison, M., Villafuerte, J., Fernandez, G.E., Petersen, A.P., Lien, C.L., McCain, M.L. (2019) Extended culture and imaging of normal and regenerating adult zebrafish hearts in a fluidic device. Lab on a Chip. 20(2):274-284
|
Campbell, F., Bos, F.L., Sieber, S., Arias-Alpizar, G., Koch, B.E., Huwyler, J., Kros, A., Bussmann, J. (2018) Directing Nanoparticle Biodistribution Through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake. ACS nano. 12(3):2138-2150
|
Nadarajah, N., Schulte, D., McConnell, V., Martin-Almedina, S., Karapouliou, C., Mortimer, P.S., Jeffery, S., Schulte-Merker, S., Gordon, K., Mansour, S., Ostergaard, P. (2018) A Novel Splice-Site Mutation in VEGFC Is Associated with Congenital Primary Lymphoedema of Gordon.. International Journal of Molecular Sciences. 19(8)
|
|
|
Weijts, B., Gutierrez, E., Saikin, S.K., Ablooglu, A.J., Traver, D., Groisman, A., Tkachenko, E. (2018) Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos. Nature communications. 9:5314
|
Hasan, S.S., Tsaryk, R., Lange, M., Wisniewski, L., Moore, J.C., Lawson, N.D., Wojciechowska, K., Schnittler, H., Siekmann, A.F. (2017) Endothelial Notch signalling limits angiogenesis via control of artery formation. Nature cell biology. 19(8):928-940
|
Kärpanen, T., Padberg, Y., van de Pavert, S.A., Dierkes, C., Morooka, N., Peterson-Maduro, J., van de Hoek, G., Adrian, M., Mochizuki, N., Sekiguchi, K., Kiefer, F., Schulte, D., Schulte-Merker, S. (2017) An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation. Circulation research. 120(8):1263-1275
|
|
|
Sugden, W.W., Meissner, R., Aegerter-Wilmsen, T., Tsaryk, R., Leonard, E.V., Bussmann, J., Hamm, M.J., Herzog, W., Jin, Y., Jakobsson, L., Denz, C., Siekmann, A.F. (2017) Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Nature cell biology. 19(6):653-665
|
van Lessen, M., Shibata-Germanos, S., van Impel, A., Hawkins, T.A., Rihel, J., Schulte-Merker, S. (2017) Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development. eLIFE. 6
|
Wild, R., Klems, A., Takamiya, M., Hayashi, Y., Strähle, U., Ando, K., Mochizuki, N., van Impel, A., Schulte-Merker, S., Krueger, J., Preau, L., le Noble, F. (2017) Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization. Nature communications. 8:13991
|
Kwon, H.B., Wang, S., Helker, C.S., Rasouli, S.J., Maischein, H.M., Offermanns, S., Herzog, W., Stainier, D.Y. (2016) In vivo modulation of endothelial polarization by Apelin receptor signalling. Nature communications. 7:11805
|
Marín-Juez, R., Marass, M., Gauvrit, S., Rossi, A., Lai, S.L., Materna, S.C., Black, B.L., Stainier, D.Y. (2016) Fast revascularization of the injured area is essential to support zebrafish heart regeneration. Proceedings of the National Academy of Sciences of the United States of America. 113(40):11237-11242
|
Matsuoka, R.L., Marass, M., Avdesh, A., Helker, C.S., Maischein, H.M., Grosse, A.S., Kaur, H., Lawson, N.D., Herzog, W., Stainier, D.Y. (2016) Radial glia regulate vascular patterning around the developing spinal cord. eLIFE. 5
|
Coxam, B., Neyt, C., Grassini, D.R., Le Guen, L., Smith, K.A., Schulte-Merker, S., Hogan, B.M. (2015) carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (cad) regulates Notch signaling and vascular development in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(1):1-9
|
Harrison, M.R., Bussmann, J., Huang, Y., Zhao, L., Osorio, A., Burns, C.G., Burns, C.E., Sucov, H.M., Siekmann, A.F., Lien, C.L. (2015) Chemokine-guided angiogenesis directs coronary vasculature formation in zebrafish. Developmental Cell. 33:442-54
|
Kashiwada, T., Fukuhara, S., Terai, K., Tanaka, T., Wakayama, Y., Ando, K., Nakajima, H., Fukui, H., Yuge, S., Saito, Y., Gemma, A., Mochizuki, N. (2015) β-catenin-dependent transcription is central to Bmp-mediated formation of venous vessels. Development (Cambridge, England). 142(3):497-509
|
Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108
|
Coxam, B., Sabine, A., Bower, N.I., Smith, K.A., Pichol-Thievend, C., Skoczylas, R., Astin, J.W., Frampton, E., Jaquet, M., Crosier, P.S., Parton, R.G., Harvey, N.L., Petrova, T.V., Schulte-Merker, S., Francois, M., Hogan, B.M. (2014) Pkd1 Regulates Lymphatic Vascular Morphogenesis during Development. Cell Reports. 7:623-33
|
Guiu, J., Bergen, D.J., De Pater, E., Islam, A.B., Ayllón, V., Gama-Norton, L., Ruiz-Herguido, C., González, J., López-Bigas, N., Menendez, P., Dzierzak, E., Espinosa, L., Bigas, A. (2014) Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence. The Journal of experimental medicine. 211(12):2411-23
|
Kartopawiro, J., Bower, N.I., Karnezis, T., Kazenwadel, J., Betterman, K.L., Lesieur, E., Koltowska, K., Astin, J., Crosier, P., Vermeren, S., Achen, M.G., Stacker, S.A., Smith, K.A., Harvey, N.L., François, M., and Hogan, B.M. (2014) Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Human molecular genetics. 23(5):1286-97
|
Le Guen, L., Karpanen, T., Schulte, D., Harris, N.C., Koltowska, K., Roukens, G., Bower, N.I., van Impel, A., Stacker, S.A., Achen, M.G., Schulte-Merker, S., and Hogan, B.M. (2014) Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis. Development (Cambridge, England). 141(6):1239-1249
|
van Impel, A., Zhao, Z., Hermkens, D.M., Roukens, M.G., Fischer, J.C., Peterson-Maduro, J., Duckers, H., Ober, E.A., Ingham, P.W., and Schulte-Merker, S. (2014) Divergence of zebrafish and mouse lymphatic cell fate specification pathways. Development (Cambridge, England). 141(6):1228-1238
|
Xu, C., Hasan, S.S., Schmidt, I., Rocha, S.F., Pitulescu, M.E., Bussmann, J., Meyen, D., Raz, E., Adams, R.H., Siekmann, A.F. (2014) Arteries are formed by vein-derived endothelial tip cells. Nature communications. 5:5758
|
Anton, H., Harlepp, S., Ramspacher, C., Wu, D., Monduc, F., Bhat, S., Liebling, M., Paoletti, C., Charvin, G., Freund, J.B., and Vermot, J. (2013) Pulse propagation by a capacitive mechanism drives embryonic blood flow. Development (Cambridge, England). 140(21):4426-34
|
Cermenati, S., Moleri, S., Neyt, C., Bresciani, E., Carra, S., Grassini, D.R., Omini, A., Goi, M., Cotelli, F., François, M., Hogan, B.M., and Beltrame, M. (2013) Sox18 Genetically Interacts With VegfC to Regulate Lymphangiogenesis in Zebrafish. Arterioscler. Thromb. Vasc. Biol.. 33(6):1238-47
|
Gordon, K., Schulte, D., Brice, G., Simpson, M.A., Roukens, M.G., van Impel, A.W., Connell, F., Kalidas, K., Jeffery, S., Mortimer, P.S., Mansour, S., Schulte-Merker, S., and Ostergaard, P. (2013) Mutation in Vascular Endothelial Growth Factor-C, a Ligand for Vascular Endothelial Growth Factor Receptor-3, Is Associated With Autosomal Dominant Milroy-Like Primary Lymphedema. Circulation research. 112(6):956-60
|
|
|
Bussmann, J., Bos, F.L., Urasaki, A., Kawakami, K., Duckers, H.J., and Schulte-Merker, S. (2010) Arteries provide essential guidance cues for lymphatic endothelial cells in the zebrafish trunk. Development (Cambridge, England). 137(16):2653-2657
|