ZFIN

ZFIN ID: ZDB-TGCONSTRCT-110504-1

ZFIN ID: ZDB-TGCONSTRCT-110504-1

CITATIONS (55 total)

Transgenic Construct Name:	Tg(-0.8flt1:RFP)
Transgenic Construct Symbol:	Tg(-0.8flt1:RFP)

Lelièvre, E., Bureau, C., Bordat, Y., Frétaud, M., Langevin, C., Jopling, C., Kissa, K. (2023) Deficiency in hereditary hemorrhagic telangiectasia-associated Endoglin elicits hypoxia-driven heart failure in zebrafish. Disease models & mechanisms. 16(5):

Coxam, B., Collins, R.T., Hußmann, M., Huisman, Y., Meier, K., Jung, S., Bartels-Klein, E., Szymborska, A., Finotto, L., Helker, C.S.M., Stainier, D.Y.R., Schulte-Merker, S., Gerhardt, H. (2022) Svep1 stabilizes developmental vascular anastomosis in reduced flow conditions. Development (Cambridge, England). 149(6):

El-Sammak, H., Yang, B., Guenther, S., Chen, W., Marín-Juez, R., Stainier, D.Y.R. (2022) A Vegfc-Emilin2a-Cxcl8a Signaling Axis Required for Zebrafish Cardiac Regeneration. Circulation research. 130(7):1014-1029

Hu, B., Lelek, S., Spanjaard, B., El-Sammak, H., Simões, M.G., Mintcheva, J., Aliee, H., Schäfer, R., Meyer, A.M., Theis, F., Stainier, D.Y.R., Panáková, D., Junker, J.P. (2022) Origin and function of activated fibroblast states during zebrafish heart regeneration. Nature Genetics. 54(8):1227-1237

Leonard, E.V., Figueroa, R.J., Bussmann, J., Lawson, N.D., Amigo, J.D., Siekmann, A.F. (2022) Regenerating vascular mural cells in zebrafish fin blood vessels are not derived from pre-existing ones and differentially require pdgfrb signalling for their development. Development (Cambridge, England). 149(7)

Mitra, S., Devi, S., Lee, M.S., Jui, J., Sahu, A., Goldman, D. (2022) Vegf signaling between Müller glia and vascular endothelial cells is regulated by immune cells and stimulates retina regeneration. Proceedings of the National Academy of Sciences of the United States of America. 119:e2211690119e2211690119

Arias-Alpizar, G., Koch, B., Hamelmann, N.M., Neustrup, M.A., Paulusse, J.M.J., Jiskoot, W., Kros, A., Bussmann, J. (2021) Stabilin-1 is required for the endothelial clearance of small anionic nanoparticles. Nanomedicine : nanotechnology, biology, and medicine. 34:102395

Gioacchino, E., Koyunlar, C., Zink, J., de Looper, H., de Jong, M., Dobrzycki, T., Mahony, C.B., Hoogenboezem, R., Bosch, D., van Strien, P.M.H., van Royen, M.E., French, P.J., Bindels, E., Gussinklo, K.J., Monteiro, R., Touw, I.P., de Pater, E. (2021) Essential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish. Blood advances. 5:2687-2700

Huisman, Y., Uphoff, K., Berger, M., Dobrindt, U., Schelhaas, M., Zobel, T., Bussmann, J., van Impel, A., Schulte-Merker, S. (2021) Meningeal lymphatic endothelial cells fulfill scavenger endothelial cell function and cooperate with microglia in waste removal from the brain. Glia. 70(1):35-49

Maglitto, A., Mariani, S.A., de Pater, E., Rodriguez-Seoane, C., Vink, C.S., Piao, X., Lukke, M.L., Dzierzak, E. (2021) Unexpected redundancy of Gpr56 and Gpr97 during hematopoietic cell development and differentiation. Blood advances. 5:829-842

Mauri, C., van Impel, A., Mackay, E.W., Schulte-Merker, S. (2021) The adaptor protein Grb2b is an essential modulator for lympho-venous sprout formation in the zebrafish trunk. Angiogenesis. 24(2):345-362

Soto, R.A., Najia, M.A.T., Hachimi, M., Frame, J.M., Yette, G.A., Lummertz da Rocha, E., Stankunas, K., Daley, G.Q., North, T.E. (2021) Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2. Stem Cell Reports. 16(7):1718-1734

Beisaw, A., Kuenne, C., Günther, S., Dallmann, J., Wu, C.C., Bentsen, M., Looso, M., Stainier, D. (2020) AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion during Zebrafish Heart Regeneration. Circulation research. 126(12):1760-1778

Klems, A., van Rijssel, J., Ramms, A.S., Wild, R., Hammer, J., Merkel, M., Derenbach, L., Préau, L., Hinkel, R., Suarez-Martinez, I., Schulte-Merker, S., Vidal, R., Sauer, S., Kivelä, R., Alitalo, K., Kupatt, C., van Buul, J.D., le Noble, F. (2020) The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models. Nature communications. 11:5319

Kotini, M.P., Bachmann, F., Spickermann, J., McSheehy, P.M., Affolter, M. (2020) Probing the Effects of the FGFR-Inhibitor Derazantinib on Vascular Development in Zebrafish Embryos. Pharmaceuticals (Basel, Switzerland). 14(1):

Wang, G., Muhl, L., Padberg, Y., Dupont, L., Peterson-Maduro, J., Stehling, M., le Noble, F., Colige, A., Betsholtz, C., Schulte-Merker, S., van Impel, A. (2020) Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis. Nature communications. 11:2724

Capasso, T.L., Li, B., Volek, H.J., Khalid, W., Rochon, E.R., Anbalagan, A., Herdman, C., Yost, H.J., Villanueva, F.S., Kim, K., Roman, B.L. (2019) BMP10-mediated ALK1 signaling is continuously required for vascular development and maintenance. Angiogenesis. 23(2):203-220

Eng, T.C., Chen, W., Okuda, K.S., Misa, J.P., Padberg, Y., Crosier, K.E., Crosier, P.S., Hall, C.J., Schulte-Merker, S., Hogan, B.M., Astin, J.W. (2019) Zebrafish facial lymphatics develop through sequential addition of venous and non-venous progenitors. EMBO reports. 20(5):

Geudens, I., Coxam, B., Alt, S., Gebala, V., Vion, A.C., Meier, K., Rosa, A., Gerhardt, H. (2019) Artery-vein specification in the zebrafish trunk is pre-patterned by heterogeneous Notch activity and balanced by flow-mediated fine tuning. Development (Cambridge, England). 146(16):

Harrison, M.R., Feng, X., Mo, G., Aguayo, A., Villafuerte, J., Yoshida, T., Pearson, C.A., Schulte-Merker, S., Lien, C.L. (2019) Late developing cardiac lymphatic vasculature supports adult zebrafish heart function and regeneration. eLIFE. 8:

Marín-Juez, R., El-Sammak, H., Helker, C.S.M., Kamezaki, A., Mullapuli, S.T., Bibli, S.I., Foglia, M.J., Fleming, I., Poss, K.D., Stainier, D.Y.R. (2019) Coronary Revascularization During Heart Regeneration Is Regulated by Epicardial and Endocardial Cues and Forms a Scaffold for Cardiomyocyte Repopulation. Developmental Cell. 51:503-515.e4

Mullapudi, S.T., Boezio, G.L.M., Rossi, A., Marass, M., Matsuoka, R.L., Matsuda, H., Helker, C.S.M., Yang, Y.H.C., Stainier, D.Y.R. (2019) Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function. Development (Cambridge, England). 146(21):

Savage, A.M., Kurusamy, S., Chen, Y., Jiang, Z., Chhabria, K., MacDonald, R.B., Kim, H.R., Wilson, H.L., van Eeden, F.J.M., Armesilla, A.L., Chico, T.J.A., Wilkinson, R.N. (2019) tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis. Nature communications. 10:732

Stanic, K., Reig, G., Wichmann, I.A., Opazo, J.C., Owen, G.I., Corvalán, A.H., Concha, M.L., Amigo, J.D. (2019) The Reprimo gene family member, reprimo-like (rprml), is required for blood development in embryonic zebrafish. Scientific Reports. 9:7131

Yip, J.K., Harrison, M., Villafuerte, J., Fernandez, G.E., Petersen, A.P., Lien, C.L., McCain, M.L. (2019) Extended culture and imaging of normal and regenerating adult zebrafish hearts in a fluidic device. Lab on a Chip. 20(2):274-284

Campbell, F., Bos, F.L., Sieber, S., Arias-Alpizar, G., Koch, B.E., Huwyler, J., Kros, A., Bussmann, J. (2018) Directing Nanoparticle Biodistribution Through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake. ACS nano. 12(3):2138-2150

Nadarajah, N., Schulte, D., McConnell, V., Martin-Almedina, S., Karapouliou, C., Mortimer, P.S., Jeffery, S., Schulte-Merker, S., Gordon, K., Mansour, S., Ostergaard, P. (2018) A Novel Splice-Site Mutation in VEGFC Is Associated with Congenital Primary Lymphoedema of Gordon.. International Journal of Molecular Sciences. 19(8)

Rasmussen, J.P., Vo, N.T., Sagasti, A. (2018) Fish Scales Dictate the Pattern of Adult Skin Innervation and Vascularization. Developmental Cell. 46(3):344-359.e4

Weijts, B., Gutierrez, E., Saikin, S.K., Ablooglu, A.J., Traver, D., Groisman, A., Tkachenko, E. (2018) Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos. Nature communications. 9:5314

Hasan, S.S., Tsaryk, R., Lange, M., Wisniewski, L., Moore, J.C., Lawson, N.D., Wojciechowska, K., Schnittler, H., Siekmann, A.F. (2017) Endothelial Notch signalling limits angiogenesis via control of artery formation. Nature cell biology. 19(8):928-940

Kärpanen, T., Padberg, Y., van de Pavert, S.A., Dierkes, C., Morooka, N., Peterson-Maduro, J., van de Hoek, G., Adrian, M., Mochizuki, N., Sekiguchi, K., Kiefer, F., Schulte, D., Schulte-Merker, S. (2017) An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation. Circulation research. 120(8):1263-1275

Matsuoka, R.L., Rossi, A., Stone, O.A., Stainier, D.Y.R. (2017) CNS-resident progenitors direct the vascularization of neighboring tissues. Proceedings of the National Academy of Sciences of the United States of America. 114(38):10137-10142

Sugden, W.W., Meissner, R., Aegerter-Wilmsen, T., Tsaryk, R., Leonard, E.V., Bussmann, J., Hamm, M.J., Herzog, W., Jin, Y., Jakobsson, L., Denz, C., Siekmann, A.F. (2017) Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Nature cell biology. 19(6):653-665

van Lessen, M., Shibata-Germanos, S., van Impel, A., Hawkins, T.A., Rihel, J., Schulte-Merker, S. (2017) Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development. eLIFE. 6

Wild, R., Klems, A., Takamiya, M., Hayashi, Y., Strähle, U., Ando, K., Mochizuki, N., van Impel, A., Schulte-Merker, S., Krueger, J., Preau, L., le Noble, F. (2017) Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization. Nature communications. 8:13991

Kwon, H.B., Wang, S., Helker, C.S., Rasouli, S.J., Maischein, H.M., Offermanns, S., Herzog, W., Stainier, D.Y. (2016) In vivo modulation of endothelial polarization by Apelin receptor signalling. Nature communications. 7:11805

Marín-Juez, R., Marass, M., Gauvrit, S., Rossi, A., Lai, S.L., Materna, S.C., Black, B.L., Stainier, D.Y. (2016) Fast revascularization of the injured area is essential to support zebrafish heart regeneration. Proceedings of the National Academy of Sciences of the United States of America. 113(40):11237-11242

Matsuoka, R.L., Marass, M., Avdesh, A., Helker, C.S., Maischein, H.M., Grosse, A.S., Kaur, H., Lawson, N.D., Herzog, W., Stainier, D.Y. (2016) Radial glia regulate vascular patterning around the developing spinal cord. eLIFE. 5

Coxam, B., Neyt, C., Grassini, D.R., Le Guen, L., Smith, K.A., Schulte-Merker, S., Hogan, B.M. (2015) carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (cad) regulates Notch signaling and vascular development in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(1):1-9

Harrison, M.R., Bussmann, J., Huang, Y., Zhao, L., Osorio, A., Burns, C.G., Burns, C.E., Sucov, H.M., Siekmann, A.F., Lien, C.L. (2015) Chemokine-guided angiogenesis directs coronary vasculature formation in zebrafish. Developmental Cell. 33:442-54

Kashiwada, T., Fukuhara, S., Terai, K., Tanaka, T., Wakayama, Y., Ando, K., Nakajima, H., Fukui, H., Yuge, S., Saito, Y., Gemma, A., Mochizuki, N. (2015) β-catenin-dependent transcription is central to Bmp-mediated formation of venous vessels. Development (Cambridge, England). 142(3):497-509

Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108

Coxam, B., Sabine, A., Bower, N.I., Smith, K.A., Pichol-Thievend, C., Skoczylas, R., Astin, J.W., Frampton, E., Jaquet, M., Crosier, P.S., Parton, R.G., Harvey, N.L., Petrova, T.V., Schulte-Merker, S., Francois, M., Hogan, B.M. (2014) Pkd1 Regulates Lymphatic Vascular Morphogenesis during Development. Cell Reports. 7:623-33

Guiu, J., Bergen, D.J., De Pater, E., Islam, A.B., Ayllón, V., Gama-Norton, L., Ruiz-Herguido, C., González, J., López-Bigas, N., Menendez, P., Dzierzak, E., Espinosa, L., Bigas, A. (2014) Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence. The Journal of experimental medicine. 211(12):2411-23

Kartopawiro, J., Bower, N.I., Karnezis, T., Kazenwadel, J., Betterman, K.L., Lesieur, E., Koltowska, K., Astin, J., Crosier, P., Vermeren, S., Achen, M.G., Stacker, S.A., Smith, K.A., Harvey, N.L., François, M., and Hogan, B.M. (2014) Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Human molecular genetics. 23(5):1286-97

Le Guen, L., Karpanen, T., Schulte, D., Harris, N.C., Koltowska, K., Roukens, G., Bower, N.I., van Impel, A., Stacker, S.A., Achen, M.G., Schulte-Merker, S., and Hogan, B.M. (2014) Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis. Development (Cambridge, England). 141(6):1239-1249

van Impel, A., Zhao, Z., Hermkens, D.M., Roukens, M.G., Fischer, J.C., Peterson-Maduro, J., Duckers, H., Ober, E.A., Ingham, P.W., and Schulte-Merker, S. (2014) Divergence of zebrafish and mouse lymphatic cell fate specification pathways. Development (Cambridge, England). 141(6):1228-1238

Xu, C., Hasan, S.S., Schmidt, I., Rocha, S.F., Pitulescu, M.E., Bussmann, J., Meyen, D., Raz, E., Adams, R.H., Siekmann, A.F. (2014) Arteries are formed by vein-derived endothelial tip cells. Nature communications. 5:5758

Anton, H., Harlepp, S., Ramspacher, C., Wu, D., Monduc, F., Bhat, S., Liebling, M., Paoletti, C., Charvin, G., Freund, J.B., and Vermot, J. (2013) Pulse propagation by a capacitive mechanism drives embryonic blood flow. Development (Cambridge, England). 140(21):4426-34

Cermenati, S., Moleri, S., Neyt, C., Bresciani, E., Carra, S., Grassini, D.R., Omini, A., Goi, M., Cotelli, F., François, M., Hogan, B.M., and Beltrame, M. (2013) Sox18 Genetically Interacts With VegfC to Regulate Lymphangiogenesis in Zebrafish. Arterioscler. Thromb. Vasc. Biol.. 33(6):1238-47

Gordon, K., Schulte, D., Brice, G., Simpson, M.A., Roukens, M.G., van Impel, A.W., Connell, F., Kalidas, K., Jeffery, S., Mortimer, P.S., Mansour, S., Schulte-Merker, S., and Ostergaard, P. (2013) Mutation in Vascular Endothelial Growth Factor-C, a Ligand for Vascular Endothelial Growth Factor Receptor-3, Is Associated With Autosomal Dominant Milroy-Like Primary Lymphedema. Circulation research. 112(6):956-60

Weijts, B.G., van Impel, A., Schulte-Merker, S., and de Bruin, A. (2013) Atypical E2fs Control Lymphangiogenesis through Transcriptional Regulation of Ccbe1 and Flt4. PLoS One. 8(9):e73693

Bussmann, J., Bos, F.L., Urasaki, A., Kawakami, K., Duckers, H.J., and Schulte-Merker, S. (2010) Arteries provide essential guidance cues for lymphatic endothelial cells in the zebrafish trunk. Development (Cambridge, England). 137(16):2653-2657

Additional Citations (2):

ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.

ZFIN Staff (2002) Scientific Curation. Manually curated data.