Phenotype Summary

Phenotypes

Publication	Data		Phenotype
Thakur et al., 2014	Fig. 1		intestinal epithelial cell detached from intestinal epithelium, abnormal intestinal epithelial cell disorganized, abnormal intestinal epithelial cell shape, abnormal intestinal villus damage, abnormal intestine decreased size, abnormal intestine decreased volume, abnormal whole organism dead, abnormal
	Fig. 2		goblet cell condensed nuclear chromosome increased amount, abnormal goblet cell detached from intestinal epithelium, abnormal goblet cell disorganized, abnormal goblet cell mislocalised, abnormal intestinal epithelial cell brush border atrophied, abnormal intestinal epithelial cell brush border morphology, abnormal intestinal epithelial cell cortical actin cytoskeleton decreased thickness, abnormal intestinal epithelial cell cytoplasm immature, abnormal intestinal epithelial cell detached from intestinal epithelium, abnormal intestinal epithelial cell disorganized, abnormal intestinal epithelial cell shape, abnormal intestinal epithelial cell vesicle increased size, abnormal intestinal villus damage, abnormal intestine mucus layer decreased thickness, abnormal response to bacterium disrupted, abnormal
	Fig. 3		intestinal epithelial cell apoptotic, abnormal intestinal epithelial cell cell population proliferation decreased process quality, abnormal intestinal epithelium decreased thickness, abnormal
	Fig. 4		enteroendocrine cell autophagosome increased amount, abnormal goblet cell increased amount, abnormal intestinal epithelial cell autophagosome increased amount, abnormal intestinal epithelial cell autophagy of mitochondrion increased process quality, abnormal intestinal epithelial cell endoplasmic reticulum distended, abnormal intestinal epithelial cell Golgi apparatus distended, abnormal intestinal epithelial cell mitochondrion decreased amount, abnormal intestinal epithelial cell mitochondrion morphology, abnormal intestinal epithelial cell vesicle increased size, abnormal
	Fig. 6		goblet cell increased amount, abnormal intestinal epithelial cell apoptotic, abnormal intestinal epithelial cell autophagosome increased amount, abnormal intestinal epithelial cell autophagy increased occurrence, abnormal intestine decreased size, abnormal intestine decreased volume, abnormal intestine leukocyte increased amount, abnormal intestine leukocyte normal amount, normal
	Fig. 7		goblet cell normal amount, normal intestinal epithelial cell apoptotic, abnormal intestinal villus damage, abnormal intestine decreased size, abnormal intestine decreased volume, abnormal intestine leukocyte increased amount, abnormal
	Fig. S1		intestine decreased size, abnormal intestine decreased volume, abnormal
	Fig. S2		goblet cell cytoskeleton disorganized, abnormal goblet cell exocytic vesicle morphology, abnormal intestinal epithelial cell apoptotic, abnormal intestinal epithelial cell brush border decreased thickness, abnormal intestinal epithelial cell detached from intestinal epithelium, abnormal intestinal epithelial cell vesicle increased amount, abnormal intestinal epithelial cell vesicle increased size, abnormal intestine mucus layer decreased thickness, abnormal mid intestine goblet cell decreased amount, abnormal mid intestine goblet cell normal amount, normal
	Fig. S5		intestinal epithelial cell autophagosome increased amount, abnormal intestinal epithelial cell autophagy increased occurrence, abnormal intestinal epithelial cell autophagy of mitochondrion increased process quality, abnormal intestinal epithelial cell endoplasmic reticulum lumen distended, abnormal intestinal epithelial cell endoplasmic reticulum lumen vacuolated, abnormal intestinal epithelial cell positive regulation of autophagy in response to ER overload increased process quality, abnormal pancreatic acinar cell endoplasmic reticulum lumen distended, abnormal
Blaker-Lee et al., 2012	Fig. S2		forebrain decreased width, abnormal ventricular system decreased size, abnormal
Murphy et al., 2011	Fig. 1		lens cell disorganized, abnormal lens decreased size, abnormal lens degenerate, abnormal lens epithelium columnar/cuboidal epithelial cell disorganized, abnormal retina layer formation disrupted, abnormal retinal photoreceptor layer aplastic, abnormal
	Fig. 2		eye photoreceptor cell chromatin condensed, abnormal lens epithelium epithelial cell organized, normal lens morphology, normal retinal photoreceptor layer retinal cone cell disorganized, abnormal retinal photoreceptor layer retinal rod cell disorganized, abnormal
	Fig. 3		eye decreased size, abnormal lens cell poorly differentiated, abnormal lens epithelium columnar/cuboidal epithelial cell disorganized, abnormal lens epithelium columnar/cuboidal epithelial cell shape, abnormal retinal photoreceptor layer lacks all parts of type retinal cone cell, abnormal retinal photoreceptor layer lacks all parts of type retinal rod cell, abnormal
	Fig. 4		lens cell disorganized, abnormal retinal photoreceptor layer has fewer parts of type retinal rod cell, abnormal retinal photoreceptor layer lacks parts or has fewer parts of type retinal cone cell, abnormal
	Fig. 5		apoptotic process increased occurrence, abnormal apoptotic process occurrence, normal lens cell apoptotic, abnormal retinal photoreceptor layer eye photoreceptor cell apoptotic, abnormal