Gene

pde6c

ID
ZDB-GENE-040426-1664
Name
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
Symbol
pde6c Nomenclature History
Previous Names
  • eclipse (1)
  • pde6 alpha prime (1)
  • zgc:73085
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to enable 3',5'-cyclic-nucleotide phosphodiesterase activity. Acts upstream of or within embryonic retina morphogenesis in camera-type eye; photoreceptor cell maintenance; and visual perception. Is expressed in head and visual system. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in cone-rod dystrophy. Orthologous to human PDE6C (phosphodiesterase 6C).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
28 figures from 10 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pde6c Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cone dystrophy 4 613093
Associated With pde6c Via Experimental Models
Human Disease Fish Conditions Citations
retinal degeneration pde6cw59/w59 standard conditions (3)
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
Domain IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Domain IPR003018 GAF domain
Domain IPR003607 HD/PDEase domain
Family IPR023088 3'5'-cyclic nucleotide phosphodiesterase
Homologous_superfamily IPR029016 GAF-like domain superfamily
Homologous_superfamily IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
Domain Details Per Protein
Protein Length 3'5'-cyclic nucleotide phosphodiesterase 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily 3'5'-cyclic nucleotide phosphodiesterase, conserved site GAF domain GAF-like domain superfamily HD/PDEase domain
UniProtKB:Q6P4P8 852
UniProtKB:A0A0R4IUY2 852
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pde6c polyclonal IgG Rabbit
  • WB
Abcam plc
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations