Gene

pde6c

ID
ZDB-GENE-040426-1664
Name
phosphodiesterase 6C, cGMP-specific, cone, alpha prime
Symbol
pde6c Nomenclature History
Previous Names
  • eclipse (1)
  • pde6 alpha prime (1)
  • zgc:73085
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have 3',5'-cyclic-nucleotide phosphodiesterase activity and metal ion binding activity. Involved in embryonic retina morphogenesis in camera-type eye; photoreceptor cell maintenance; and visual perception. Used to study retinal degeneration. Human ortholog(s) of this gene implicated in cone-rod dystrophy. Is expressed in head and visual system. Orthologous to human PDE6C (phosphodiesterase 6C).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
17 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
28 figures from 10 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pde6c Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cone dystrophy 4 613093
Associated With pde6c Via Experimental Models
Human Disease Fish Conditions Citations
retinal degeneration pde6cw59/w59 standard conditions (3)
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
Domain IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Domain IPR003018 GAF domain
Domain IPR003607 HD/PDEase domain
Family IPR023088 3'5'-cyclic nucleotide phosphodiesterase
Homologous_superfamily IPR029016 GAF-like domain superfamily
Homologous_superfamily IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
Domain Details Per Protein
Protein Length 3'5'-cyclic nucleotide phosphodiesterase 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily 3'5'-cyclic nucleotide phosphodiesterase, conserved site GAF domain GAF-like domain superfamily HD/PDEase domain
UniProtKB:Q6P4P8 852
UniProtKB:A0A0R4IUY2 852
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pde6c polyclonal IgG Rabbit
  • WB
Abcam plc
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations