ZFIN Fish: pde6c^w59/w59

ZFIN ID: ZDB-FISH-150901-15741

ZFIN ID: ZDB-FISH-150901-15741

Fish name:	pde6c^w59/w59
Genotype:	pde6c^w59/w59
Targeting Reagent:	none

HUMAN DISEASE MODELED by pde6c^w59/w59

Human Disease	Conditions	Citations
retinal degeneration	standard conditions	(3)

GENE EXPRESSION
Gene expression in pde6c^w59/w59

RNA expression

Expressed Gene	Structure	Conditions	Figures
cahz	Muller cell	standard conditions	Fig. 1 from Morris et al., 2008
gnat1	eye	standard conditions	Fig. 4 from Zhang et al., 2017
gnat2	eye	standard conditions	Fig. 4 from Zhang et al., 2017
nr2e3	retinal rod cell	chemical treatment: 5-bromo-2'-deoxyuridine	Fig. 3 from Morris et al., 2008
opn1lw2	eye	standard conditions	Fig. 4 from Zhang et al., 2017
opn1mw1	eye	standard conditions	Fig. 4 from Zhang et al., 2017
opn1sw1	eye	standard conditions	Fig. 4 from Zhang et al., 2017
opn1sw2	eye	standard conditions	Fig. 4 from Zhang et al., 2017
rho	eye	standard conditions	Fig. 4 from Zhang et al., 2017

Protein expression

Antibody	Structure	Conditions	Figures
Ab-4C12	green sensitive photoreceptor cell red sensitive photoreceptor cell retinal cone cell	chemical treatment: (+)-schisandrin B	Fig. 4 from Zhang et al., 2016
zpr-1	green sensitive photoreceptor cell red sensitive photoreceptor cell retinal cone cell	standard conditions	Fig. 4 from Zhang et al., 2016 Fig. 3 , Fig. 4 , Fig. 6 from Viringipurampeer et al., 2014
Ab-4C12	retinal rod cell	control	Fig. 4 from Zhang et al., 2016

Reporter gene expression No data available

PHENOTYPE
Phenotype in pde6c^w59/w59

Phenotype	Conditions	Figures
cell population proliferation increased occurrence, abnormal	standard conditions	Fig. 1 from Morris et al., 2008
detection of light stimulus involved in visual perception process quality, abnormal	standard conditions	Fig. 2 from Jia et al., 2014
eye size, normal	standard conditions	Fig. 1 from Stearns et al., 2007
Muller cell morphology, abnormal	standard conditions	Fig. 1 from Morris et al., 2008
positive phototaxis movement behavioral quality, normal	standard conditions	Fig. 7 from Saade et al., 2013
response to light stimulus decreased process quality, abnormal	standard conditions	Fig. 7 from Viringipurampeer et al., 2014
retina has fewer parts of type retinal cone cell, abnormal	standard conditions	Fig. 1 from Morris et al., 2008
retinal bipolar neuron axon displaced, abnormal	standard conditions	Fig. 4 from Stearns et al., 2007
retinal bipolar neuron nucleus displaced, abnormal	standard conditions	Fig. 4 from Stearns et al., 2007
retinal cone cell decreased amount, abnormal	chemical treatment: (+)-schisandrin B	Fig. 4 from Zhang et al., 2016
retinal cone cell degenerate, abnormal	standard conditions	Fig. 6 , Fig. 8 from Viringipurampeer et al., 2014 Fig. 1, Fig. S2 from Morris et al., 2008 Fig. 1 from Stearns et al., 2007
retinal cone cell cell death increased process quality, abnormal	standard conditions	Fig. 6 , Fig. 8 from Viringipurampeer et al., 2014
retinal outer plexiform layer has fewer parts of type neuron synapse, abnormal	standard conditions	Fig. 5 from Stearns et al., 2007
retinal rod cell degenerate, abnormal	standard conditions	Fig. 4 from Stearns et al., 2007
retinal rod cell increased volume, abnormal	control	Fig. 4 from Zhang et al., 2016
retinal rod cell increased volume, ameliorated	chemical treatment: (+)-schisandrin B	Fig. 4 from Zhang et al., 2016
swim bladder morphology, normal	standard conditions	Fig. 1 from Stearns et al., 2007
visual behavior decreased occurrence, abnormal	control	Fig. 2, Fig. 3, Fig. 4 from Zhang et al., 2016
visual behavior decreased occurrence, ameliorated	chemical treatment: (+)-schisandrin B	Fig. 3 from Zhang et al., 2016
visual perception arrested, abnormal	standard conditions	Fig. 1 from Stearns et al., 2007

CITATIONS (11)