PUBLICATION
Imaging Approaches to Investigate Pathophysiological Mechanisms of Brain Disease in Zebrafish
- Authors
- Turrini, L., Roschi, L., de Vito, G., Pavone, F.S., Vanzi, F.
- ID
- ZDB-PUB-230628-60
- Date
- 2023
- Source
- International Journal of Molecular Sciences 24(12): (Review)
- Registered Authors
- Turrini, Lapo, Vanzi, Francesco
- Keywords
- Alzheimer’s, Parkinson’s, autism spectrum disorders, behavior, brain disease models, epilepsy, functional imaging, myelination, neurological disorders, zebrafish
- MeSH Terms
-
- Animals
- Brain/diagnostic imaging
- Brain/physiology
- Brain Diseases*/diagnostic imaging
- Disease Models, Animal
- Humans
- Nervous System Diseases*/diagnostic imaging
- Zebrafish/genetics
- PubMed
- 37372981 Full text @ Int. J. Mol. Sci.
Citation
Turrini, L., Roschi, L., de Vito, G., Pavone, F.S., Vanzi, F. (2023) Imaging Approaches to Investigate Pathophysiological Mechanisms of Brain Disease in Zebrafish. International Journal of Molecular Sciences. 24(12):.
Abstract
Zebrafish has become an essential model organism in modern biomedical research. Owing to its distinctive features and high grade of genomic homology with humans, it is increasingly employed to model diverse neurological disorders, both through genetic and pharmacological intervention. The use of this vertebrate model has recently enhanced research efforts, both in the optical technology and in the bioengineering fields, aiming at developing novel tools for high spatiotemporal resolution imaging. Indeed, the ever-increasing use of imaging methods, often combined with fluorescent reporters or tags, enable a unique chance for translational neuroscience research at different levels, ranging from behavior (whole-organism) to functional aspects (whole-brain) and down to structural features (cellular and subcellular). In this work, we present a review of the imaging approaches employed to investigate pathophysiological mechanisms underlying functional, structural, and behavioral alterations of human neurological diseases modeled in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping