PUBLICATION
A conserved transcriptional fingerprint of multi-neurotransmitter neurons necessary for social behavior
- Authors
- Ncube, D., Tallafuss, A., Serafin, J., Bruckner, J., Farnsworth, D.R., Miller, A.C., Eisen, J.S., Washbourne, P.
- ID
- ZDB-PUB-221001-1
- Date
- 2022
- Source
- BMC Genomics 23: 675 (Journal)
- Registered Authors
- Eisen, Judith S., Farnsworth, Dylan, Miller, Adam, Tallafuss, Alexandra, Washbourne, Philip
- Keywords
- Neuronal identity, Neurotransmitter, Social behavior, Transcription factors
- MeSH Terms
-
- Acetylcholine*
- Animals
- Cholinergic Agents
- Cholinergic Neurons
- Neurotransmitter Agents
- Social Behavior
- Transcription Factors
- Zebrafish*/genetics
- gamma-Aminobutyric Acid
- PubMed
- 36175871 Full text @ BMC Genomics
Citation
Ncube, D., Tallafuss, A., Serafin, J., Bruckner, J., Farnsworth, D.R., Miller, A.C., Eisen, J.S., Washbourne, P. (2022) A conserved transcriptional fingerprint of multi-neurotransmitter neurons necessary for social behavior. BMC Genomics. 23:675.
Abstract
Background An essential determinant of a neuron's functionality is its neurotransmitter phenotype. We previously identified a defined subpopulation of cholinergic neurons required for social orienting behavior in zebrafish.
Results We transcriptionally profiled these neurons and discovered that they are capable of synthesizing both acetylcholine and GABA. We also established a constellation of transcription factors and neurotransmitter markers that can be used as a "transcriptomic fingerprint" to recognize a homologous neuronal population in another vertebrate.
Conclusion Our results suggest that this transcriptomic fingerprint and the cholinergic-GABAergic neuronal subtype that it defines are evolutionarily conserved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping