ZFIN ID: ZDB-PERS-091202-7
Miller, Adam
Email: acmiller@uoregon.edu
URL: https://www.adammillerlab.com/
Affiliation: Adam C Miller Lab
Address: Institute of Neuroscience 1425 E 13th Ave Huestis 214 Eugene, OR 97403-1254
Country: United States
Phone: 541.346.4523
Fax:
ORCID ID: 0000-0001-7519-3677


BIOGRAPHY AND RESEARCH INTERESTS
The human brain is estimated to contain more connections between neurons than the Milky Way has stars! In the Miller lab we are interested in understanding the molecular and activity-based logic of how neural circuits wire together and produce behavior. We study genes, synapses, neural circuits, and behavior, and how they all come together in the zebrafish. We use zebrafish as a model, first because its obviously the best, and also because to solve the big problems of how circuits of a brain are created zebrafish offers the forward and reverse genetic techniques, the cellular and neural activity imaging, and the behavioral accessibility needed to construct a systematic understanding of the complex wiring steps required to make a functional brain.


PUBLICATIONS
Michel, J.C., Grivette, M.M.B., Harshfield, A.T., Huynh, L., Komons, A.P., Loomis, B., McKinnis, K., Miller, B.T., Nguyen, E.Q., Huang, T.W., Lauf, S., Michel, E.S., Michel, M.E., Kissinger, J.S., Marsh, A.J., Crow, W.E., Kaye, L.E., Lasseigne, A.M., Lukowicz-Bedford, R.M., Farnsworth, D.R., Martin, E.A., Miller, A.C. (2023) Electrical synapse structure requires distinct isoforms of a postsynaptic scaffold. PLoS Genetics. 19:e1011045e1011045
Martin, E.A., Michel, J.C., Kissinger, J.S., Echeverry, F.A., Lin, Y.P., O'Brien, J., Pereda, A.E., Miller, A.C. (2023) Neurobeachin controls the asymmetric subcellular distribution of electrical synapse proteins. Current biology : CB. 33(10):2063-2074.e4
Quint, W.H., Tadema, K.C.D., Kokke, N.C.C.J., Meester-Smoor, M.A., Miller, A.C., Willemsen, R., Klaver, C.C.W., Iglesias, A.I. (2023) Post-GWAS screening of candidate genes for refractive error in mutant zebrafish models. Scientific Reports. 13:20172017
Ncube, D., Tallafuss, A., Serafin, J., Bruckner, J., Farnsworth, D.R., Miller, A.C., Eisen, J.S., Washbourne, P. (2022) A conserved transcriptional fingerprint of multi-neurotransmitter neurons necessary for social behavior. BMC Genomics. 23:675
Michel, J.C., Lasseigne, A.M., Marsh, A.J., Miller, A.C. (2022) The disconnect2 mutation disrupts the tjp1b gene that is required for electrical synapse formation. microPublication. Biology. 2022:
Bearce, E.A., Irons, Z.H., Craig, S.B., Kuhns, C.J., Sabazali, C., Farnsworth, D.R., Miller, A.C., Grimes, D.T. (2022) Daw1 regulates the timely onset of cilia motility during development. Development (Cambridge, England). 149(12)
Pallucchi, I., Bertuzzi, M., Michel, J.C., Miller, A.C., El Manira, A. (2022) Transformation of an early-established motor circuit during maturation in zebrafish. Cell Reports. 39:110654
Lukowicz-Bedford, R.M., Farnsworth, D.R., Miller, A.C. (2022) Connexinplexity: The spatial and temporal expression of connexin genes during vertebrate organogenesis. G3 (Bethesda). 12(5):
Quint, W.H., Tadema, K.C.D., de Vrieze, E., Lukowicz, R.M., Broekman, S., Winkelman, B.H.J., Hoevenaars, M., de Gruiter, H.M., van Wijk, E., Schaeffel, F., Meester-Smoor, M., Miller, A.C., Willemsen, R., Klaver, C.C.W., Iglesias, A.I. (2021) Loss of Gap Junction Delta-2 (GJD2) gene orthologs leads to refractive error in zebrafish. Communications biology. 4:676
Lasseigne, A.M., Echeverry, F.A., Ijaz, S., Michel, J.C., Martin, E.A., Marsh, A.J., Trujillo, E., Marsden, K.C., Pereda, A.E., Miller, A.C. (2021) Electrical synaptic transmission requires a postsynaptic scaffolding protein. eLIFE. 10:
Yan, Y.L., Titus, T., Desvignes, T., BreMiller, R., Batzel, P., Sydes, J., Farnsworth, D., Dillon, D., Wegner, J., Phillips, J.B., Peirce, J., Dowd, J., Undiagnosed Diseases Network, Buck, C.L., Miller, A., Westerfield, M., Postlethwait, J.H. (2021) Erratum to: A fish with no sex: gonadal and adrenal functions partition between zebrafish NR5A1 co-orthologs. Genetics. 218(1)
Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
Farnsworth, D., Posner, M., Miller, A. (2021) Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development. Experimental Eye Research. 206:108535
Loes, A.N., Hinman, M.N., Farnsworth, D.R., Miller, A.C., Guillemin, K., Harms, M.J. (2021) Identification and Characterization of Zebrafish Tlr4 Coreceptor Md-2. Journal of immunology (Baltimore, Md. : 1950). 206(5):1046-1057
Postlethwait, J.H., Farnsworth, D.R., Miller, A.C. (2020) An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. ZFIN Direct Data Submission.
Farnsworth, D.R., Saunders, L.M., Miller, A.C. (2020) A single-cell transcriptome atlas for zebrafish development. Developmental Biology. 459(2):100-108
Bremer, J., Marsden, K.C., Miller, A., Granato, M. (2019) The ubiquitin ligase PHR promotes directional regrowth of spinal zebrafish axons. Communications biology. 2:195
Marsh, A.J., Michel, J.C., Adke, A.P., Heckman, E.L., Miller, A.C. (2017) Asymmetry of an Intracellular Scaffold at Vertebrate Electrical Synapses. Current biology : CB. 27:3561-3567.e4
Miller, A.C., Whitebirch, A.C., Shah, A.N., Marsden, K.C., Granato, M., O'Brien, J., Moens, C.B. (2017) A genetic basis for molecular asymmetry at vertebrate electrical synapses. eLIFE. 6:e25364
Shah, A.N., Davey, C.F., Whitebirch, A.C., Miller, A.C., Moens, C.B. (2016) Rapid Reverse Genetic Screening Using CRISPR in Zebrafish. Zebrafish. 13:152-3
Shah, A.N., Moens, C.B., Miller, A.C. (2016) Targeted candidate gene screens using CRISPR/Cas9 technology. Methods in cell biology. 135:89-106
Shah, A.N., Davey, C.F., Whitebirch, A.C., Miller, A.C., Moens, C.B. (2015) Rapid reverse genetic screening using CRISPR in zebrafish. Nature Methods. 12(6):535-40
Miller, A.C., Voelker, L.H., Shah, A.N., Moens, C.B. (2015) Neurobeachin Is Required Postsynaptically for Electrical and Chemical Synapse Formation. Current biology : CB. 25(1):16-28
Miller, A.C., Obholzer, N.D., Shah, A.N., Megason, S.G., and Moens, C.B. (2013) RNA-seq based mapping and candidate identification of mutations from forward genetic screens. Genome research. 23(4):679-686

NON-ZEBRAFISH PUBLICATIONS
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