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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-020717-17
Patton, E. Elizabeth
Email: e.patton@igmm.ed.ac.uk
URL:
Affiliation: E. Elizabeth Patton Lab
Address: Edinburgh Cancer Research Centre The University of Edinburgh Cancer Research UK Building Crewe Road South Edinburgh, Scotland, EH4 2XR United Kingdom
Country: United Kingdom
Phone: +44 (0) 131 777 3573
Fax: +44 (0) 131 777 3583
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Patton, E.E., Tobin, D.M. (2019) Spotlight on zebrafish: the next wave of translational research. Disease models & mechanisms. 12(3)
Camargo-Sosa, K., Colanesi, S., Müller, J., Schulte-Merker, S., Stemple, D., Patton, E.E., Kelsh, R.N. (2019) Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependent pigment progenitors in zebrafish. PLoS Genetics. 15:e1007941
Zeng, Z., Lopez-Baez, J.C., Lleras-Forero, L., Brunsdon, H., Wyatt, C., Rybski, W., Hastie, N.D., Schulte-Merker, S., Patton, E.E. (2018) Notochord Injury Assays that Stimulate Transcriptional Responses in Zebrafish Larvae. Bio-protocol. 8:e3100
Brunsdon, H., Patton, E.E. (2018) Fishing for ancestry. eLIFE. 7
Al-Olabi, L., Polubothu, S., Dowsett, K., Andrews, K.A., Stadnik, P., Joseph, A.P., Knox, R., Pittman, A., Clark, G., Baird, W., Bulstrode, N., Glover, M., Gordon, K., Hargrave, D., Huson, S.M., Jacques, T.S., James, G., Kondolf, H., Kangesu, L., Keppler-Noreuil, K.M., Khan, A., Lindhurst, M.J., Lipson, M., Mansour, S., O'Hara, J., Mahon, C., Mosica, A., Moss, C., Murthy, A., Ong, J., Parker, V.E., Rivière, J.B., Sapp, J.C., Sebire, N.J., Shah, R., Sivakumar, B., Thomas, A., Virasami, A., Waelchli, R., Zeng, Z., Biesecker, L.G., Barnacle, A., Topf, M., Semple, R.K., Patton, E.E., Kinsler, V.A. (2018) Mosaic RAS/MAPK variants cause sporadic vascular malformations which respond to targeted therapy. The Journal of Clinical Investigation. 128(4):1496-1508
Lopez-Baez, J.C., Simpson, D.J., LLeras Forero, L., Zeng, Z., Brunsdon, H., Salzano, A., Brombin, A., Wyatt, C., Rybski, W., Huitema, L.F.A., Dale, R.M., Kawakami, K., Englert, C., Chandra, T., Schulte-Merker, S., Hastie, N.D., Patton, E.E. (2018) Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair.. eLIFE. 7
Scahill, C.M., Digby, Z., Sealy, I.M., Wojciechowska, S., White, R.J., Collins, J.E., Stemple, D.L., Bartke, T., Mathers, M.E., Patton, E.E., Busch-Nentwich, E.M. (2017) Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish. PLoS Genetics. 13:e1006959
Fraser, C., Dawson, J.C., Dowling, R., Houston, D.R., Weiss, J.T., Munro, A.F., Muir, M., Harrington, L., Webster, S.P., Frame, M.C., Brunton, V.G., Patton, E.E., Carragher, N.O., Unciti-Broceta, A. (2016) Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines that Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase. Journal of medicinal chemistry. 59(10):4697-4710
Thomas, A.C., Zeng, Z., Rivière, J.B., O'Shaughnessy, R., Al-Olabi, L., St-Onge, J., Atherton, D.J., Aubert, H., Bagazgoitia, L., Barbarot, S., Bourrat, E., Chiaverini, C., Chong, W.K., Duffourd, Y., Glover, M., Groesser, L., Hadj-Rabia, S., Hamm, H., Happle, R., Mushtaq, I., Lacour, J.P., Waelchli, R., Wobser, M., Vabres, P., Patton, E.E., Kinsler, V.A. (2016) Mosaic activating mutations in GNA11 and GNAQ are associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis. The Journal of investigative dermatology. 136(4):770-8
Macdonald, N.P., Zhu, F., Hall, C.J., Reboud, J., Crosier, P.S., Patton, E.E., Wlodkowic, D., Cooper, J.M. (2016) Assessment of biocompatibility of 3D printed photopolymers using zebrafish embryo toxicity assays. Lab on a Chip. 16(2):291-7
van der Weyden, L., Patton, E.E., Wood, G.A., Foote, A., Brenn, T., Arends, M.J., Adams, D.J. (2016) Cross-species models of human melanoma. The Journal of pathology. 238(2):152-65
Wojciechowska, S., Zeng, Z., Lister, J.A., Ceol, C.J., Patton, E.E. (2016) Melanoma Regression and Recurrence in Zebrafish. Methods in molecular biology (Clifton, N.J.). 1451:143-53
Wojciechowska, S., van Rooijen, E., Ceol, C., Patton, E.E., White, R.M. (2016) Generation and analysis of zebrafish melanoma models. Methods in cell biology. 134:531-49
Lundegaard, P.R., Anastasaki, C., Grant, N.J., Sillito, R.R., Zich, J., Zeng, Z., Paranthaman, K., Larsen, A.P., Armstrong, J.D., Porteous, D.J., Patton, E.E. (2015) MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish. Chemistry & Biology. 22(10):1335-46
Zeng, Z., Johnson, S.L., Lister, J.A., Patton, E.E. (2015) Temperature-sensitive splicing of mitfa by an intron mutation in zebrafish. Pigment cell & melanoma research. 28(2):229-32
Mort, R.L., Jackson, I.J., Patton, E.E. (2015) The melanocyte lineage in development and disease. Development (Cambridge, England). 142:620-632
Patton, E.E., Dhillon, P., Amatruda, J.F., Ramakrishnan, L. (2014) Spotlight on Zebrafish: Translational Impact. Disease models & mechanisms. 7:731-733
Weiss, J.T., Dawson, J.C., Fraser, C., Rybski, W., Torres-Sanchez, C., Bradley, M., Patton, E.E., Carragher, N.O., Unciti-Broceta, A. (2014) Development and Bioorthogonal Activation of Palladium-Labile Prodrugs of Gemcitabine. Journal of medicinal chemistry. 57(12):5395-404
Weiss, J.T., Dawson, J.C., Macleod, K.G., Rybski, W., Fraser, C., Torres-Sánchez, C., Patton, E.E., Bradley, M., Carragher, N.O., and Unciti-Broceta, A. (2014) Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach. Nature communications. 5:3277
Lister, J.A., Capper, A., Zeng, Z., Mathers, M.E., Richardson, J., Paranthaman, K., Jackson, I.J., and Patton, E.E. (2014) A Conditional Zebrafish MITF Mutation Reveals MITF Levels Are Critical for Melanoma Promotion vs. Regression In Vivo. The Journal of investigative dermatology. 134(1):133-40
Longman, D., Hug, N., Keith, M., Anastasaki, C., Patton, E.E., Grimes, G., and Cáceres, J.F. (2013) DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Nucleic acids research. 41(17):8319-31
Reimer, M.M., Norris, A., Ohnmacht, J., Patani, R., Zhong, Z., Dias, T.B., Kuscha, V., Scott, A.L., Chen, Y.C., Rozov, S., Frazer, S.L., Wyatt, C., Higashijima, S., Patton, E.E., Panula, P., Chandran, S., Becker, T., and Becker, C.G. (2013) Dopamine from the Brain Promotes Spinal Motor Neuron Generation during Development and Adult Regeneration. Developmental Cell. 25(5):478-491
Yen, J., White, R.M., Wedge, D.C., Van Loo, P., de Ridder, J., Capper, A., Richardson, J., Jones, D., Raine, K., Watson, I.R., Wu, C.J., Cheng, J., Martincorena, I., Nik-Zainal, S., Mudie, L., Moreau, Y., Marshall, J., Ramakrishna, M., Tarpey, P., Shlien, A., Whitmore, I., Gamble, S., Latimer, C., Langdon, E., Kaufman, C., Dovey, M., Taylor, A., Menzies, A., McLaren, S., O Meara, S., Butler, A., Teague, J., Lister, J., Chin, L., Campbell, P., Adams, D.J., Zon, L.I., Patton, E.E., Stemple, D.L., and Futreal, P.A. (2013) The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models. Genome biology. 14(10):R113
Patton, E.E. (2012) Live imaging in zebrafish reveals neu(trophil) insight into the metastatic niche. The Journal of pathology. 227(4):381-384
Zhou, L., Ishizaki, H., Spitzer, M., Taylor, K.L., Temperley, N.D., Johnson, S.L., Brear, P., Gautier, P., Zeng, Z., Mitchell, A., Narayan, V., McNeil, E.M., Melton, D.W., Smith, T.K., Tyers, M., Westwood, N.J., and Patton, E.E. (2012) ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species. Chemistry & Biology. 19(7):883-892
Anastasaki, C., Rauen, K.A., and Patton, E.E. (2012) Continual and partial MEK inhibition ameliorates cardio-facio-cutaneous phenotypes in zebrafish. Disease models & mechanisms. 5(4):546-552
Colanesi, S., Taylor, K.L., Temperley, N.D., Lundegaard, P.R., Liu, D., North, T.E., Ishizaki, H., Kelsh, R.N., and Patton, E.E. (2012) Small molecule screening identifies targetable zebrafish pigmentation pathways. Pigment cell & melanoma research. 25(2):131-143
Taylor, K.L., Lister, J.A., Zeng, Z., Ishizaki, H., Anderson, C., Kelsh, R.N., Jackson, I.J., and Patton, E.E. (2011) Differentiated melanocyte cell division occurs in vivo and is promoted by mutations in Mitf. Development (Cambridge, England). 138(16):3579-89
Shu, X., Zeng, Z., Gautier, P., Lennon, A., Gakovic, M., Cheetham, M.E., Patton, E.E., and Wright, A.F. (2011) Knock-down of the Zebrafish Orthologue of the Retinitis Pigmentosa 2 (RP2) Gene Results in Retinal Degeneration. Investigative ophthalmology & visual science. 52(6):2960-6
Anastasaki, C., Longman, D., Capper, A., Patton, E.E., and Cáceres, J.F. (2011) Dhx34 and Nbas function in the NMD pathway and are required for embryonic development in zebrafish. Nucleic acids research. 39(9):3686-3694
Donaldson, L.R., Wallace, S., Haigh, D., Patton, E.E., and Hulme, A.N. (2011) Rapid synthesis and zebrafish evaluation of a phenanthridine-based small molecule library. Organic & biomolecular chemistry. 9(7):2233-9
Richardson, J., Zeng, Z., Ceol, C., Mione, M., Jackson, I.J., and Patton, E.E. (2011) A zebrafish model for nevus regeneration. Pigment cell & melanoma research. 24(2):378-381
Patton, E.E., Mathers, M.E., and Schartl, M. (2011) Generating and analyzing fish models of melanoma. Methods in cell biology. 105:339-366
Ishizaki, H., Spitzer, M., Wildenhain, J., Anastasaki, C., Zeng, Z., Dolma, S., Shaw, M., Madsen, E., Gitlin, J., Marais, R., Tyers, M., and Patton, E.E. (2010) Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that modulate melanocyte pigmentation. Disease models & mechanisms. 3(9-10):639-651
Taylor, K.L., Grant, N.J., Temperley, N.D., and Patton, E.E. (2010) Small molecule screening in zebrafish: an in vivo approach to identifying new chemical tools and drug leads. Cell communication and signaling : CCS. 8:11
Patton, E.E., Mitchell, D.L., and Nairn, R.S. (2010) Genetic and Environmental Melanoma Models in Fish. Pigment cell & melanoma research. 23(3):314-337
Grabher, C., Patton, E.E., and Strähle, U. (2010) Sharing Chemical Libraries Within the European Zebrafish Community. Zebrafish. 7(1):83
Shu, X., Zeng, Z., Gautier, P., Lennon, A., Gakovic, M., Patton, E., and Wright, A. (2010) Zebrafish Rpgr is required for normal retinal development and plays a role in dynein-based retrograde transport processes. Human molecular genetics. 19(4):657-670
Poulton, L.D., Nolan, K.F., Anastasaki, C., Waldmann, H., and Patton, E.E. (2010) A novel role for Glucocorticoid-Induced TNF Receptor Ligand (Gitrl) in early embryonic zebrafish development. The International journal of developmental biology. 54(5):815-825
Zeng, Z., Richardson, J., Verduzco, D., Mitchell, D.L., and Patton, E.E. (2009) Zebrafish have a competent p53-dependent nucleotide excision repair pathway to resolve ultraviolet B-induced DNA damage in the skin. Zebrafish. 6(4):405-415
Anastasaki, C., Estep, A.L., Marais, R., Rauen, K.A., and Patton, E.E. (2009) Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors. Human molecular genetics. 18(14):2543-2554
Dovey, M., Patton, E.E., Bowman, T., North, T., Goessling, W., Zhou, Y., and Zon, L.I. (2009) Topoisomerase II alpha is required for embryonic development and liver regeneration in zebrafish. Molecular and cellular biology. 29(13):3746-3753
Richardson, J., Lundegaard, P.R., Reynolds, N.L., Dorin, J.R., Porteous, D.J., Jackson, I.J., and Patton, E.E. (2008) mc1r Pathway regulation of zebrafish melanosome dispersion. Zebrafish. 5(4):289-295
Amatruda, J.F., and Patton, E.E. (2008) Chapter 1 genetic models of cancer in zebrafish. International review of cell and molecular biology. 271:1-34
Grzmil, M., Whiting, D., Maule, J., Anastasaki, C., Amatruda, J.F., Kelsh, R.N., Norbury, C.J., and Patton, E.E. (2007) The INT6 Cancer Gene and MEK Signaling Pathways Converge during Zebrafish Development. PLoS One. 2(9):e959
Patton, E.E., Widlund, H.R., Kutok, J.L., Kopani, K.R., Amatruda, J.F., Murphey, R.D., Berghmans, S., Mayhall, E.A., Traver, D., Fletcher, C.D., Aster, J.C., Granter, S.R., Look, A.T., Lee, C., Fisher, D.E., and Zon, L.I. (2005) BRAF Mutations Are Sufficient to Promote Nevi Formation and Cooperate with p53 in the Genesis of Melanoma. Current biology : CB. 15(3):249-254
Patton, E.E. and Zon, L.I. (2005) Taking Human Cancer Genes to the Fish: A Transgenic Model of Melanoma in Zebrafish. Zebrafish. 1(4):363-368
Traver, D., Herbomel, P., Patton, E.E., Murphey, R.D., Yoder, J.A., Litman, G.W., Catic, A., Amemiya, C.T., Zon, L.I., and Trede, N.S. (2003) The zebrafish as a model organism to study development of the immune system. Advances in immunology. 81:253-330
Patton, E.E. and Zon, L.I. (2001) The art and design of genetic screens: zebrafish. Nature reviews. Genetics. 2(12):956-966

NON-ZEBRAFISH PUBLICATIONS