ZFIN ID: ZDB-PERS-040810-5
Lam, Siew Hong
Email:
URL:
Affiliation: Zhiyuan Gong Lab
Address: Department of Biological Sciences The National University of Singapore 10 Kent Ridge Crescent Singapore, 119260 Singapore
Country: Singapore
Phone:
Fax:
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Lee, Y.M., Li, C., Lam, S.H., Gong, Z., Lin, Q. (2018) Proteomic Analysis of Zebrafish (Danio rerio) After Chemical Exposure. Methods in molecular biology (Clifton, N.J.). 1797:443-459
Li, C., Chen, Q., Zhang, X., Snyder, S.A., Gong, Z., Lam, S.H. (2017) An integrated approach with the zebrafish model for biomonitoring of municipal wastewater effluent and receiving waters. Water research. 131:33-44
Chen, Q., Li, C., Gong, Z., Chan, E.C., Snyder, S.A., Lam, S.H. (2017) Common deregulated gene expression profiles and morphological changes in developing zebrafish larvae exposed to environmental-relevant high to low concentrations of glucocorticoids. Chemosphere. 172:429-439
Lui, E.Y., Li, C., Li, Z.H., Gong, Z., Lam, S.H. (2016) Molecular insights of organochlorine biocide-induced toxicity in zebrafish: Whole-adult-organism toxicogenomics, targeted gene expression and histological analyses. Journal of genetics and genomics = Yi chuan xue bao. 43(8):525-8
Li, C., Li, P., Tan, Y.M., Lam, S.H., Chan, E.C., Gong, Z. (2016) Metabolomic Characterizations of Liver Injury Caused by Acute Arsenic Toxicity in Zebrafish. PLoS One. 11:e0151225
Chen, Q., Jia, A., Snyder, S.A., Gong, Z., Lam, S.H. (2016) Glucocorticoid activity detected by in vivo zebrafish assay and in vitro glucocorticoid receptor bioassay at environmental relevant concentrations. Chemosphere. 144:1162-1169
Liu, C., Xu, H., Lam, S.H., and Gong, Z. (2013) Selection of Reliable Biomarkers from PCR Array Analyses Using Relative Distance Computational Model: Methodology and Proof-of-Concept Study. PLoS One. 8(12):e83954
Li, Z.H., Xu, H., Zheng, W., Lam, S.H., and Gong, Z. (2013) RNA-Sequencing Analysis of TCDD-Induced Responses in Zebrafish Liver Reveals High Relatedness to In Vivo Mammalian Models and Conserved Biological Pathways. PLoS One. 8(10):e77292
Lam, S.H., Ung, C.Y., Hlaing, M.M., Hu, J., Li, Z.H., Mathavan, S., and Gong, Z. (2013) Molecular insights into 4-nitrophenol-induced hepatotoxicity in zebrafish: Transcriptomic, histological and targeted gene expression analyses. Biochimica et biophysica acta. General subjects. 1830(10):4778-4789
Xu, H., Lam, S.H., Shen, Y., and Gong, Z. (2013) Genome-wide identification of molecular pathways and biomarkers in response to arsenic exposure in zebrafish liver. PLoS One. 8(7):e68737
Gabor, K.A., Stevens, C.R., Pietraszewski, M.J., Gould, T.J., Shim, J., Yoder, J.A., Lam, S.H., Gong, Z., Hess, S.T., and Kim, C.H. (2013) Super Resolution Microscopy Reveals that Caveolin-1 Is Required for Spatial Organization of CRFB1 and Subsequent Antiviral Signaling in Zebrafish. PLoS One. 8(7):e68759
Huang, S.M., Xu, F., Lam, S.H., Gong, Z., and Ong, C.N. (2013) Metabolomics of developing zebrafish embryos using gas chromatography- and liquid chromatography-mass spectrometry. Molecular Biosystems. 9(6):1372-80
Zheng, W., Xu, H., Lam, S.H., Luo, H., Karuturi, R.K., and Gong, Z. (2013) Transcriptomic analyses of sexual dimorphism of the zebrafish liver and the effect of sex hormones. PLoS One. 8(1):e53562
Ung, C.Y., Lam, S.H., Zhang, X., Li, H., Zhang, L., Li, B., and Gong, Z. (2013) Inverted expression profiles of sex-biased genes in response to toxicant perturbations and diseases. PLoS One. 8(2):e56668
Chng, H.T., Ho, H.K., Yap, C.W., Lam, S.H., and Chan, E.C. (2012) An Investigation of the Bioactivation Potential and Metabolism Profile of Zebrafish versus Human. Journal of Biomolecular Screening. 17(7):974-986
Sukardi, H., Zhang, X., Lui, E.Y., Ung, C.Y., Mathavan, S., Gong, Z., and Lam, S.H. (2012) Liver X receptor agonist T0901317 induced liver perturbation in zebrafish: Histological, gene set enrichment and expression analyses. Biochimica et biophysica acta. General subjects. 1820(1):33-43
Zhang, X., Ung, C.Y., Lam, S.H., Ma, J., Chen, Y.Z., Zhang, L., Gong, Z., and Li, B. (2012) Toxicogenomic analysis suggests chemical-induced sexual dimorphism in the expression of metabolic genes in zebrafish liver. PLoS One. 7(12):e51971
Nguyen, A.T., Emelyanov, A., Koh, C.H., Spitsbergen, J.M., Lam, S.H., Mathavan, S., Parinov, S., and Gong, Z. (2011) A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish. Disease models & mechanisms. 4(6):801-13
Lam, S.H., Lee, S.G., Lin, C.Y., Thomsen, J.S., Fu, P.Y., Murthy, K.R., Li, H., Govindarajan, K.R., Nick, L.C., Bourque, G., Gong, Z., Lufkin, T., Liu, E.T., and Mathavan, S. (2011) Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines. BMC Medical Genomics. 4(1):41
Sukardi, H., Chng, H.T., Chan, E.C., Gong, Z., and Lam, S.H. (2011) Zebrafish for drug toxicity screening: bridging the in vitro cell-based models and in vivo mammalian models. Expert opinion on drug metabolism & toxicology. 7(5):579-589
Lam, S.H., Hlaing, M.M., Zhang, X., Yan, C., Duan, Z., Zhu, L., Ung, C.Y., Mathavan, S., Ong, C.N., and Gong, Z. (2011) Toxicogenomic and phenotypic analyses of bisphenol-a early-life exposure toxicity in zebrafish. PLoS One. 6(12):e28273
Ung, C.Y., Lam, S.H., Zhang, X., Li, H., Ma, J., Zhang, L., Li, B., and Gong, Z. (2011) Existence of inverted profile in chemically responsive molecular pathways in the zebrafish liver. PLoS One. 6(11):e27819
Wang, Z., Du, J., Lam, S.H., Mathavan, S., Matsudaira, P., and Gong, Z. (2010) Morphological and molecular evidence for functional organization along the rostrocaudal axis of the adult zebrafish intestine. BMC Genomics. 11:392
Ung, C.Y., Lam, S.H., Hlaing, M.M., Winata, C.L., Korzh, S., Mathavan, S., and Gong, Z. (2010) Mercury-induced hepatotoxicity in zebrafish: in vivo mechanistic insights from transcriptome analysis, phenotype anchoring and targeted gene expression validation. BMC Genomics. 11:212
Sukardi, H., Ung, C.Y., Gong, Z., and Lam, S.H. (2010) Incorporating Zebrafish Omics into Chemical Biology and Toxicology. Zebrafish. 7(1):41-52
Ung, C.Y., Lam, S.H., and Gong, Z. (2009) Comparative Transcriptome Analyses Revealed Conserved Biological and Transcription Factor Target Modules Between the Zebrafish and Human Tumors. Zebrafish. 6(4):425-431
Lam, S.H., Mathavan, S., and Gong, Z. (2009) Zebrafish spotted-microarray for genome-wide expression profiling experiments. Part I: array printing and hybridization. Methods in molecular biology (Clifton, N.J.). 546:175-195
Lam, S.H., Krishna Murthy Karuturi, R., and Gong, Z. (2009) Zebrafish spotted-microarray for genome-wide expression profiling experiments: data acquisition and analysis. Methods in molecular biology (Clifton, N.J.). 546:197-226
Lam, S.H., Mathavan, S., Tong, Y., Li, H., Karuturi, R.K., Wu, Y., Vega, V.B., Liu, E.T., and Gong, Z. (2008) Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology. PLoS Genetics. 4(7):e1000121
Lam, S.H., Winata, C.L., Tong, Y., Korzh, S., Lim, W.S., Korzh, V., Spitsbergen, J., Mathavan, S., Miller, L.D., Liu, E.T., and Gong, Z. (2006) Transcriptome Kinetics of Arsenic-induced Adaptive Response in Zebrafish Liver. Physiological Genomics. 27(3):351-361
Lam, S.H., and Gong, Z. (2006) Modeling liver cancer using zebrafish: a comparative oncogenomics approach. Cell cycle (Georgetown, Tex.). 5(6):573-577
Lam, S.H., Wu, Y.L., Vega, V.B., Miller, L.D., Spitsbergen, J., Tong, Y., Zhan, H., Govindarajan, K.R., Lee, S., Mathavan, S., Krishna Murthy, K.R., Buhler, D.R., Liu, E.T., and Gong, Z. (2006) Conservation of gene expression signatures between zebrafish and human liver tumors and tumor progression. Nat. Biotechnol.. 24(1):73-75
Mathavan, S., Lee, S.G., Mak, A., Miller, L.D., Murthy, K.R., Govindarajan, K.R., Tong, Y., Wu, Y.L., Lam, S.H., Yang, H., Ruan, Y., Korzh, V., Gong, Z., Liu, E.T., and Lufkin, T. (2005) Transcriptome analysis of zebrafish embryogenesis using microarrays. PLoS Genetics. 1(2):e29
Lam, S.H., Sin, Y.M., Gong, Z., and Lam, T.J. (2005) Effects of thyroid hormone on the development of immune system in zebrafish. General and comparative endocrinology. 142(3):325-335

NON-ZEBRAFISH PUBLICATIONS
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.