ZFIN ID: ZDB-PUB-110524-22
Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2
Verhoeven, M.C., Haase, C., Christoffels, V.M., Weidinger, G., and Bakkers, J.
Date: 2011
Source: Birth defects research. Part A, Clinical and molecular teratology   91(6): 435-40 (Journal)
Registered Authors: Bakkers, Jeroen, Haase, Christa, Weidinger, Gilbert
Keywords: wnt, β-catenin, BMP4, BMP2, tbx2, atrioventricular canal (AVC), zebrafish, alk2, alk8, conduction
MeSH Terms:
  • Activin Receptors, Type I
  • Animals
  • Bone Morphogenetic Protein 4/genetics
  • Bone Morphogenetic Protein 4/metabolism*
  • Bone Morphogenetic Protein Receptors/genetics
  • Cell Differentiation/genetics
  • Gene Expression Regulation, Developmental
  • Heart Atria/embryology
  • Heart Valves/embryology
  • Heart Ventricles/embryology*
  • Heart Ventricles/metabolism*
  • Mutation
  • T-Box Domain Proteins/genetics*
  • Wnt Proteins/genetics
  • Wnt Proteins/metabolism
  • Wnt Signaling Pathway*
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish/metabolism*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
  • beta Catenin/genetics
  • beta Catenin/metabolism
PubMed: 21567896 Full text @ Birth Defects Res. Part A Clin. Mol. Teratol.
In the developing heart, the atrioventricular canal (AVC) is essential for separation and alignment of the cardiac chambers, for valve formation, and serves to delay the electrical impulse from the atria to the ventricles. Defects in various aspects of its formation are the most common form of congenital heart defects. Using mutant and transgenic approaches in zebrafish, this study demonstrates that Wnt/β-catenin signaling is both sufficient and required for the induction of BMP4 and Tbx2b expression in the AVC and consequently the proper patterning of the myocardium. Furthermore, genetic analysis shows that Wnt/β-catenin signaling is upstream and in a linear pathway with BMP and Tbx2 during AVC specification. Birth Defects Research(Part A), 2011.