ZFIN Person: Weidinger, Gilbert

ZFIN ID: ZDB-PERS-980505-6

ZFIN ID: ZDB-PERS-980505-6

Weidinger, Gilbert

Email:	gilbert.weidinger@uni-ulm.de
URL:	http://www.uni-ulm.de/weidinger
Affiliation:	Weidinger Lab
Address:	Institute for Biochemistry and Molecular Biology Ulm University Albert-Einstein-Allee 11 89081 Ulm Germany
Country:	Germany
Phone:	0049 731 500 23290
Fax:	0049 731 500 23277
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

* Born the 8th of December, 1970 in Salzburg, Austria.
* Studied genetics in Salzburg, Austria.
* Diploma thesis on neural induction in Xenopus.
* Graduate student in the lab of Erez Raz in Freiburg, Germany working on germ cell migration in zebrafish (September 1998 - November 2000).
* In November 2000, the whole lab moved to the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany.
* Ph.D received in September 2001.
* Postdoc in the lab of Erez Raz wotking on germ cell specification (October 2001 - December 2001).
* Postdoc in the lab of Randy Moon, Seattle, working on Wnt signaling (February 2002 - September 2006).
* Group leader at the Biotechnology Center at the University of Dresden, Germany (October 2006 - December 2011).
* Professor for Biochemistry and Molecular Biology at Ulm University, Germany (since January 2012).

PUBLICATIONS

Sehring, I.M., Mohammadi, H.F., Haffner-Luntzer, M., Ignatius, A., Huber-Lang, M., Weidinger, G. (2022) Zebrafish fin regeneration involves generic and regeneration-specific osteoblast injury responses. eLIFE. 11:

Barthold, L., Heber, S., Schmidt, C.Q., Gradl, M., Weidinger, G., Barth, H., Fischer, S. (2022) Human α-Defensin-6 Neutralizes Clostridioides difficile Toxins TcdA and TcdB by Direct Binding. International Journal of Molecular Sciences. 23(9):

Bertozzi, A., Wu, C.C., Hans, S., Brand, M., Weidinger, G. (2021) Wnt/β-catenin signaling acts cell-autonomously to promote cardiomyocyte regeneration in the zebrafish heart. Developmental Biology. 481:226-237

Bühler, A., Gahr, B.M., Park, D.D., Bertozzi, A., Boos, A., Dalvoy, M., Pott, A., Oswald, F., Kovall, R.A., Kühn, B., Weidinger, G., Rottbauer, W., Just, S. (2021) Histone deacetylase 1 controls cardiomyocyte proliferation during embryonic heart development and cardiac regeneration in zebrafish. PLoS Genetics. 17:e1009890

Harms, M., Habib, M.M.W., Nemska, S., Nicolò, A., Gilg, A., Preising, N., Sokkar, P., Carmignani, S., Raasholm, M., Weidinger, G., Kizilsavas, G., Wagner, M., Ständker, L., Abadi, A.H., Jumaa, H., Kirchhoff, F., Frossard, N., Sanchez-Garcia, E., Münch, J. (2021) An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation. Acta pharmaceutica Sinica. B. 11:2694-2708

Noschka, R., Wondany, F., Kizilsavas, G., Weil, T., Weidinger, G., Walther, P., Michaelis, J., Stenger, S. (2021) Gran1: A Granulysin-Derived Peptide with Potent Activity against Intracellular Mycobacterium tuberculosis. International Journal of Molecular Sciences. 22(16):

Noschka, R., Gerbl, F., Löffler, F., Kubis, J., Rodríguez, A.A., Mayer, D., Grieshober, M., Holch, A., Raasholm, M., Forssmann, W.G., Spellerberg, B., Wiese, S., Weidinger, G., Ständker, L., Stenger, S. (2021) Unbiased Identification of Angiogenin as an Endogenous Antimicrobial Protein With Activity Against Virulent Mycobacterium tuberculosis. Frontiers in microbiology. 11:618278

Bertozzi, A., Wu, C.C., Nguyen, P.D., Vasudevarao, M.D., Mulaw, M.A., Koopman, C.D., de Boer, T.P., Bakkers, J., Weidinger, G. (2020) Is zebrafish heart regeneration "complete"? Lineage-restricted cardiomyocytes proliferate to pre-injury numbers but some fail to differentiate in fibrotic hearts. Developmental Biology. 471:106-118

Honkoop, H., de Bakker, D.E., Aharonov, A., Kruse, F., Shakked, A., Nguyen, P.D., de Heus, C., Garric, L., Muraro, M.J., Shoffner, A., Tessadori, F., Peterson, J.C., Noort, W., Bertozzi, A., Weidinger, G., Posthuma, G., Grun, D., van der Laarse, W.J., Klumperman, J., Jaspers, R.T., Poss, K.D., van Oudenaarden, A., Tzahor, E., Bakkers, J. (2019) Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart. eLIFE. 8:

Mishra, R., Sehring, I., Cederlund, M., Mulaw, M., Weidinger, G. (2019) NF-κB Signaling Negatively Regulates Osteoblast Dedifferentiation during Zebrafish Bone Regeneration. Developmental Cell. 52(2):167-182.e7

Sehring, I.M., Weidinger, G. (2019) Recent advancements in understanding fin regeneration in zebrafish. Wiley interdisciplinary reviews. Developmental biology. 9(1):e367

Reisser, M., Palmer, A., Popp, A.P., Jahn, C., Weidinger, G., Gebhardt, J.C.M. (2018) Single-molecule imaging correlates decreasing nuclear volume with increasing TF-chromatin associations during zebrafish development. Nature communications. 9:5218

Owlarn, S., Klenner, F., Schmidt, D., Rabert, F., Tomasso, A., Reuter, H., Mulaw, M.A., Moritz, S., Gentile, L., Weidinger, G., Bartscherer, K. (2017) Generic wound signals initiate regeneration in missing-tissue contexts. Nature communications. 8:2282

Jahn, C., Weidinger, G. (2017) Regulatory T Cells Know What Is Needed to Regenerate. Developmental Cell. 43:651-652

Magadum, A., Ding, Y., He, L., Kim, T., Vasudevarao, M.D., Long, Q., Yang, K., Wickramasinghe, N., Renikunta, H.V., Dubois, N., Weidinger, G., Yang, Q., Engel, F.B. (2017) Live cell screening platform identifies PPARδ as a regulator of cardiomyocyte proliferation and cardiac repair. Cell Research. 27(8):1002-1019

Sezgin, E., Azbazdar, Y., Ng, X.W., Teh, C., Simons, K., Weidinger, G., Wohland, T., Eggeling, C., Ozhan, G. (2017) Binding of canonical Wnt ligands to their receptor complexes occurs in ordered plasma membrane environments. The FEBS journal. 284:2513-2526

Wehner, D., Tsarouchas, T.M., Michael, A., Haase, C., Weidinger, G., Reimer, M.M., Becker, T., Becker, C.G. (2017) Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish. Nature communications. 8:126

Sehring, I.M., Jahn, C., Weidinger, G. (2016) Zebrafish fin and heart: what's special about regeneration?. Current opinion in genetics & development. 40:48-56

Masselink, W., Cole, N.J., Fenyes, F., Berger, S., Sonntag, C., Wood, A., Nguyen, P.D., Cohen, N., Knopf, F., Weidinger, G., Hall, T.E., Currie, P.D. (2016) A somitic contribution to the apical ectodermal ridge is essential for fin formation. Nature. 535(7613):542-6

Wu, C.C., Kruse, F., Vasudevarao, M.D., Junker, J.P., Zebrowski, D.C., Fischer, K., Noël, E.S., Grün, D., Berezikov, E., Engel, F.B., van Oudenaarden, A., Weidinger, G., Bakkers, J. (2016) Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration. Developmental Cell. 36(1):36-49

Zebrowski, D.C., Vergarajauregui, S., Wu, C.C., Piatkowski, T., Becker, R., Leone, M., Hirth, S., Ricciardi, F., Falk, N., Giessl, A., Just, S., Braun, T., Weidinger, G., Engel, F.B. (2015) Developmental alterations in centrosome integrity contribute to the post-mitotic state of mammalian cardiomyocytes. eLIFE. 4

Özhan, G., Weidinger, G. (2015) Wnt/β-catenin signaling in heart regeneration. Cell regeneration (London, England). 4:3

Wehner, D., Jahn, C., Weidinger, G. (2015) Use of the TetON System to Study Molecular Mechanisms of Zebrafish Regeneration. Journal of visualized experiments : JoVE. (100):e52756

Wehner, D., Weidinger, G. (2015) Signaling networks organizing regenerative growth of the zebrafish fin. Trends in genetics : TIG. 31(6):336-343

Stangenberg, R., Wu, Y., Hedrich, J., Kurzbach, D., Wehner, D., Weidinger, G., Kuan, S.L., Jansen, M.I., Jelezko, F., Luhmann, H.J., Hinderberger, D., Weil, T., Müllen, K. (2015) A Polyphenylene Dendrimer Drug Transporter with Precisely Positioned Amphiphilic Surface Patches. Advanced Healthcare Materials. 4(3):377-84

Walker, M.P., Stopford, C.M., Cederlund, M., Fang, F., Jahn, C., Rabinowitz, A.D., Goldfarb, D., Graham, D.M., Yan, F., Deal, A.M., Fedoriw, Y., Richards, K.L., Davis, I.J., Weidinger, G., Damania, B., Major, M.B. (2015) FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma. Science signaling. 8(362):ra12

Reuter, H., März, M., Vogg, M.C., Eccles, D., Grífol-Boldú, L., Wehner, D., Owlarn, S., Adell, T., Weidinger, G., Bartscherer, K. (2015) β-Catenin-Dependent Control of Positional Information along the AP Body Axis in Planarians Involves a Teashirt Family Member. Cell Reports. 10(2):253-65

Kizil, C., Küchler, B., Yan, J.J., Özhan, G., Moro, E., Argenton, F., Brand, M., Weidinger, G., Antos, C.L. (2014) Simplet/Fam53b is required for Wnt signal transduction by regulating β-catenin nuclear localization. Development (Cambridge, England). 141:3529-39

Geurtzen, K., Knopf, F., Wehner, D., Huitema, L.F., Schulte-Merker, S., Weidinger, G. (2014) Mature osteoblasts dedifferentiate in response to traumatic bone injury in the zebrafish fin and skull. Development (Cambridge, England). 141(11):2225-34

Wehner, D., Cizelsky, W., Vasudevaro, M.D., Özhan, G., Haase, C., Kagermeier-Schenk, B., Röder, A., Dorsky, R.I., Moro, E., Argenton, F., Kühl, M., and Weidinger, G. (2014) Wnt/β-Catenin Signaling Defines Organizing Centers that Orchestrate Growth and Differentiation of the Regenerating Zebrafish Caudal Fin. Cell Reports. 6(3):467-481

Luz, M., Spannl-Müller, S., Özhan, G., Kagermeier-Schenk, B., Rhinn, M., Weidinger, G., and Brand, M. (2014) Dynamic Association with Donor Cell Filopodia and Lipid-Modification Are Essential Features of Wnt8a during Patterning of the Zebrafish Neuroectoderm. PLoS One. 9(1):e84922

Özhan, G., Sezgin, E., Wehner, D., Pfister, A.S., Kühl, S.J., Kagermeier-Schenk, B., Kühl, M., Schwille, P., and Weidinger, G. (2013) Lypd6 Enhances Wnt/beta-Catenin Signaling by Promoting Lrp6 Phosphorylation in Raft Plasma Membrane Domains. Developmental Cell. 26(4):331-345

Grotek, B., Wehner, D., and Weidinger, G. (2013) Notch signaling coordinates cellular proliferation with differentiation during zebrafish fin regeneration. Development (Cambridge, England). 140(7):1412-1423

Thieme, S., Gyárfás, T., Richter, C., Özhan, G., Fu, J., Alexopulou, D., Muders, M.H., Michalk, I., Jakob, C., Dahl, A., Klink, B., Bandola, J., Bachmann, M., Schröck, E., Buchholz, F., Stewart, A.F., Weidinger, G., Anastassiadis, K., and Brenner, S. (2013) The histone demethylase UTX regulates stem cell migration and hematopoiesis. Blood. 121(13):2462-2473

Moro, E., Özhan, G., Mongera, A., Beis, D., Wierzbicki, C., Young, R.M., Bournele, D., Domenichini, A., Valdivia, L.E., Lum, L., Chen, C., Amatruda, J.F., Tiso, N., Weidinger, G., and Argenton, F. (2012) In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains. Developmental Biology. 366(2):327-340

Shin, D., Weidinger, G., Moon, R.T., and Stainier, D.Y. (2012) Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver. Mechanisms of Development. 128(11-12):525-535

Kagermeier-Schenk, B., Wehner, D., Ozhan-Kizil, G., Yamamoto, H., Li, J., Kirchner, K., Hoffmann, C., Stern, P., Kikuchi, A., Schambony, A., and Weidinger, G. (2011) Waif1/5T4 Inhibits Wnt/β-Catenin Signaling and Activates Noncanonical Wnt Pathways by Modifying LRP6 Subcellular Localization. Developmental Cell. 21(6):1129-43

Verhoeven, M.C., Haase, C., Christoffels, V.M., Weidinger, G., and Bakkers, J. (2011) Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2. Birth defects research. Part A, Clinical and molecular teratology. 91(6):435-40

Knopf, F., Hammond, C., Chekuru, A., Kurth, T., Hans, S., Weber, C.W., Mahatma, G., Fisher, S., Brand, M., Schulte-Merker, S., and Weidinger, G. (2011) Bone Regenerates via Dedifferentiation of Osteoblasts in the Zebrafish Fin. Developmental Cell. 20(5):713-724

Schnabel, K., Wu, C.C., Kurth, T., and Weidinger, G. (2011) Regeneration of cryoinjury induced necrotic heart lesions in zebrafish is associated with epicardial activation and cardiomyocyte proliferation. PLoS One. 6(4):e18503

Azevedo, A.S., Grotek, B., Jacinto, A., Weidinger, G., and Saúde, L. (2011) The regenerative capacity of the zebrafish caudal fin is not affected by repeated amputations. PLoS One. 6(7):e22820

Knopf, F., Schnabel, K., Haase, C., Pfeifer, K., Anastassiadis, K., and Weidinger, G. (2010) Dually inducible TetON systems for tissue-specific conditional gene expression in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 107(46):19933-19938

Nemtsas, P., Wettwer, E., Christ, T., Weidinger, G., and Ravens, U. (2010) Adult zebrafish heart as a model for human heart? An electrophysiological study. Journal of Molecular and Cellular Cardiology. 48(1):161-171

Lee, Y., Hami, D., De Val, S., Kagermeier-Schenk, B., Wills, A.A., Black, B.L., Weidinger, G., and Poss, K.D. (2009) Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins. Developmental Biology. 331(2):270-280

Goessling, W., North, T.E., Loewer, S., Lord, A.M., Lee, S., Stoick-Cooper, C.L., Weidinger, G., Puder, M., Daley, G.Q., Moon, R.T., and Zon, L.I. (2009) Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 136(6):1136-1147

Slanchev, K., Stebler, J., Goudarzi, M., Cojocaru, V., Weidinger, G., and Raz, E. (2009) Control of Dead end localization and activity – Implications for the function of the protein in antagonizing miRNA function. Mechanisms of Development. 126(3-4):270-277

Lyons, J.P., Miller, R.K., Zhou, X., Weidinger, G., Deroo, T., Denayer, T., Park, J.I., Ji, H., Hong, J.Y., Li, A., Moon, R.T., Jones, E.A., Vleminckx, K., Vize, P.D., and McCrea, P.D. (2009) Requirement of Wnt/beta-catenin signaling in pronephric kidney development. Mechanisms of Development. 126(3-4):142-159

Goessling, W., North, T.E., Lord, A.M., Ceol, C., Lee, S., Weidinger, G., Bourque, C., Strijbosch, R., Haramis, A.P., Puder, M., Clevers, H., Moon, R.T., and Zon, L.I. (2008) APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Developmental Biology. 320(1):161-174

McFarland, K.A., Topczewska, J.M., Weidinger, G., Dorsky, R.I., and Appel, B. (2008) Hh and Wnt signaling regulate formation of olig2(+) neurons in the zebrafish cerebellum. Developmental Biology. 318(1):162-171

Bonner, J., Gribble, S.L., Veien, E.S., Nikolaus, O.B., Weidinger, G., and Dorsky, R.I. (2008) Proliferation and patterning are mediated independently in the dorsal spinal cord downstream of canonical Wnt signaling. Developmental Biology. 313(1):398-407

Nakamura, Y., Weidinger, G., Liang, J.O., Aquilina-Beck, A., Tamai, K., Moon, R.T., and Warman, M.L. (2007) The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling. J. Clin. Invest.. 117(10):3075-3086

Stoick-Cooper, C.L., Moon, R.T., and Weidinger, G. (2007) Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine. Genes & Development. 21(11):1292-1315

Ueno, S., Weidinger, G., Osugi, T., Kohn, A.D., Golob, J.L., Pabon, L., Reinecke, H., Moon, R.T., and Murry, C.E. (2007) Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 104(23):9685-9690

Stoick-Cooper, C.L., Weidinger, G., Riehle, K.J., Hubbert, C., Major, M.B., Fausto N., and Moon, R.T. (2007) Distinct Wnt signaling pathways have opposing roles in appendage regeneration. Development (Cambridge, England). 134(3):479-489

Thorpe, C.J., Weidinger, G., and Moon, R.T. (2005) Wnt/β-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish. Development (Cambridge, England). 132(8):1763-1772

Weidinger, G., Thorpe, C.J., Wuennenberg-Stapleton, K., Ngai, J., and Moon, R.T. (2005) The Sp1-Related Transcription Factors sp5 and sp5-like Act Downstream of Wnt/beta-Catenin Signaling in Mesoderm and Neuroectoderm Patterning. Current biology : CB. 15(6):489-500

Weidinger, G. and Moon, R.T. (2003) When Wnts antagonize Wnts. The Journal of cell biology. 162(5):753-756

Weidinger, G., Stebler, J., Slanchev, K., Dumstrei, K., Wise, C., Lovell-Badge, R., Thisse, C., Thisse, B., and Raz, E. (2003) dead end, a novel vertebrate germ plasm component, is required for zebrafish primordial germ cell migration and survival. Current biology : CB. 13(16):1429-1434

Ciruna, B., Weidinger, G., Knaut, H., Thisse, B., Thisse, C., Raz, E., and Schier, A.F. (2002) Production of maternal-zygotic mutant zebrafish by germ-line replacement. Proceedings of the National Academy of Sciences of the United States of America. 99(23):14919-14924

Wolke, U., Weidinger, G., Köprunner, M., and Raz, E. (2002) Multiple levels of post-transcriptional control lead to germ line specific gene expression in the zebrafish. Current biology : CB. 12(4):289-294

Weidinger, G., Wolke, U., Köprunner, M., Thisse, C., Thisse, B. and Raz, E. (2002) Regulation of zebrafish primordial germ cell migration by attraction towards an intermediate target. Development (Cambridge, England). 129:25-36

Weidinger, G., Koprunner, M., Wolke, U., Thisse, C., Thisse, B., and Raz, E. (2001) Attraction, active migration, and clustering of zebrafish primordial germ cells. Developmental Biology. 235(1):175 (#18)

Weidinger, G., Wolke, U., Köprunner, M., Klinger, M., and Raz, E. (1999) Identification of tissues and patterning events required for distinct steps in early migration of zebrafish primordial germ cells. Development (Cambridge, England). 126(23):5295-5307

NON-ZEBRAFISH PUBLICATIONS
Fritz Aberger, Gilbert Weidinger, Klaus Richter (1997). A member of the Met/HGF-receptor family is expressed in a BMP-4-like pattern in the ectoderm of Xenopus gastrulae. Biochem Biophys Res Commun. 231, 191-195.

Fritz Aberger, Gilbert Weidinger, Horst Grunz, Klaus Richter (1998). Anterior specification of embryonic ectoderm: the role of the Xenopus cement gland-specific gene XAG-2. Mech Dev. 72, 115-130.