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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-980519-6
Bakkers, Jeroen
Email: j.bakkers@hubrecht.eu
URL: http://www.hubrecht.eu/research-groups/bakkers-group/
Affiliation: Bakkers Lab
Address: Hubrecht Laboratory Netherlands Institute for Developmental Biology Uppsalalaan 8 Utrecht, 3584 CT Netherlands
Country: Netherlands
Phone: 31-30-2121892
Fax: 31-30-2121801
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Monroe, G.R., van Eerde, A.M., Tessadori, F., Duran, K.J., Savelberg, S.M.C., van Alfen, J.C., Terhal, P.A., van der Crabben, S.N., Lichtenbelt, K.D., Fuchs, S.A., Gerrits, J., van Roosmalen, M.J., van Gassen, K.L., van Aalderen, M., Koot, B.G., Oostendorp, M., Duran, M., Visser, G., de Koning, T.J., Calì, F., Bosco, P., Geleijns, K., de Sain-van der Velden, M.G.M., Knoers, N.V., Bakkers, J., Verhoeven-Duif, N.M., van Haaften, G., Jans, J.J. (2019) Identification of human D lactate dehydrogenase deficiency. Nature communications. 10:1477
Chrispijn, N.D., Elurbe, D.M., Mickoleit, M., Aben, M., de Bakker, D.E.M., Andralojc, K.M., Huisken, J., Bakkers, J., Kamminga, L.M. (2019) Loss of the Polycomb group protein Rnf2 results in derepression of tbx-transcription factors and defects in embryonic and cardiac development. Scientific Reports. 9:4327
Tessadori, F., Roessler, H.I., Savelberg, S.M.C., Chocron, S., Kamel, S.M., Duran, K.J., van Haelst, M.M., van Haaften, G., Bakkers, J. (2018) Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders. Disease models & mechanisms. 11(10):
van Opbergen, C.J.M., Koopman, C.D., Kok, B.J.M., Knöpfel, T., Renninger, S.L., Orger, M.B., Vos, M.A., van Veen, T.A.B., Bakkers, J., de Boer, T.P. (2018) Optogenetic sensors in the zebrafish heart: a novel in vivo electrophysiological tool to study cardiac arrhythmogenesis. Theranostics. 8:4750-4764
Burkhard, S.B., Bakkers, J. (2018) Spatially resolved RNA-sequencing of the embryonic heart identifies a role for Wnt/β-catenin signaling in autonomic control of heart rate. eLIFE. 7
Kievit, A., Tessadori, F., Douben, H., Jordens, I., Maurice, M., Hoogeboom, J., Hennekam, R., Nampoothiri, S., Kayserili, H., Castori, M., Whiteford, M., Motter, C., Melver, C., Cunningham, M., Hing, A., Kokitsu-Nakata, N.M., Vendramini-Pittoli, S., Richieri-Costa, A., Baas, A.F., Breugem, C.C., Duran, K., Massink, M., Derksen, P.W.B., van IJcken, W.F.J., van Unen, L., Santos-Simarro, F., Lapunzina, P., Gil-da Silva Lopes, V.L., Lustosa-Mendes, E., Krall, M., Slavotinek, A., Martinez-Glez, V., Bakkers, J., van Gassen, K.L.I., de Klein, A., van den Boogaard, M.H., van Haaften, G. (2018) Variants in members of the cadherin-catenin complex, CDH1 and CTNND1, cause blepharocheilodontic syndrome. European journal of human genetics : EJHG. 26(2):210-219
Sala, L., van Meer, B.J., Tertoolen, L.T., Bakkers, J., Bellin, M., Davis, R.P., Denning, C.N., Dieben, M.A., Eschenhagen, T., Giacomelli, E., Grandela, C., Hansen, A., Holman, E., Jongbloed, M.R., Kamel, S.M., Koopman, C.D., Lachaud, Q., Mannhardt, I., Mol, M.P., Mosqueira, D., Orlova, V.V., Passier, R., Ribeiro, M.C., Saleem, U., Smith, G., Burton, F.L.L., Mummery, C.L. (2017) MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo. Circulation research. 122(3):e5-e16
Tessadori, F., Giltay, J.C., Hurst, J.A., Massink, M.P., Duran, K., Vos, H.R., van Es, R.M., Scott, R.H., van Gassen, K.L.I., Bakkers, J., van Haaften, G. (2017) Germline mutations affecting the histone H4 core cause a developmental syndrome by altering DNA damage response and cell cycle control. Nature Genetics. 49(11):1642-1646
Burkhard, S., van Eif, V., Garric, L., Christoffels, V.M., Bakkers, J. (2017) On the Evolution of the Cardiac Pacemaker. Journal of cardiovascular development and disease. 4(2)
De Angelis, J.E., Lagendijk, A.K., Chen, H., Tromp, A., Bower, N.I., Tunny, K.A., Brooks, A.J., Bakkers, J., Francois, M., Yap, A.S., Simons, C., Wicking, C., Hogan, B.M., Smith, K.A. (2017) Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover. Developmental Cell. 40:123-136
Paulussen, A.D., Steyls, A., Vanoevelen, J., van Tienen, F.H., Krapels, I.P., Claes, G.R., Chocron, S., Velter, C., Tan-Sindhunata, G.M., Lundin, C., Valenzuela, I., Nagy, B., Bache, I., Maroun, L.L., Avela, K., Brunner, H.G., Smeets, H.J., Bakkers, J., van den Wijngaard, A. (2016) Rare novel variants in the ZIC3 gene cause X-linked heterotaxy. European journal of human genetics : EJHG. 24(12):1783-1791
Han, M.K., Hoijman, E., Nöel, E., Garric, L., Bakkers, J., de Rooij, J. (2016) αE-catenin-dependent mechanotransduction is essential for proper convergent extension in zebrafish. Biology Open. 5(10):1461-1472
Lodder, E.M., De Nittis, P., Koopman, C.D., Wiszniewski, W., Moura de Souza, C.F., Lahrouchi, N., Guex, N., Napolioni, V., Tessadori, F., Beekman, L., Nannenberg, E.A., Boualla, L., Blom, N.A., de Graaff, W., Kamermans, M., Cocciadiferro, D., Malerba, N., Mandriani, B., Akdemir, Z.H., Fish, R.J., Eldomery, M.K., Ratbi, I., Wilde, A.A., de Boer, T., Simonds, W.F., Neerman-Arbez, M., Sutton, V.R., Kok, F., Lupski, J.R., Reymond, A., Bezzina, C.R., Bakkers, J., Merla, G. (2016) GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability. American journal of human genetics. 99(3):704-10
Josifova, D.J., Monroe, G.R., Tessadori, F., de Graaff, E., van der Zwaag, B., Mehta, S.G., Harakalova, M., Duran, K.J., Savelberg, S.M., Nijman, I.J., Jungbluth, H., Hoogenraad, C.C., Bakkers, J., Knoers, N.V., Firth, H.V., Beales, P.L., van Haaften, G., van Haelst, M.M. (2016) Heterozygous KIDINS220/ARMS nonsense variants cause spastic paraplegia, intellectual disability, nystagmus, and obesity. Human molecular genetics. 25(11):2158-2167
San, B., Chrispijn, N.D., Wittkopp, N., van Heeringen, S.J., Lagendijk, A.K., Aben, M., Bakkers, J., Ketting, R.F., Kamminga, L.M. (2016) Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2. Scientific Reports. 6:24658
Noël, E.S., Momenah, T.S., Al-Dagriri, K., Al-Suwaid, A., Al-Shahrani, S., Jiang, H., Willekers, S., Oostveen, Y.Y., Chocron, S., Postma, A.V., Bhuiyan, Z.A., Bakkers, J. (2016) A zebrafish Loss-of-Function Model for Human CFAP53 Mutations Reveals its Specific Role in Laterality Organ Function. Human Mutation. 37(2):194-200
Wu, C.C., Kruse, F., Vasudevarao, M.D., Junker, J.P., Zebrowski, D.C., Fischer, K., Noël, E.S., Grün, D., Berezikov, E., Engel, F.B., van Oudenaarden, A., Weidinger, G., Bakkers, J. (2016) Spatially Resolved Genome-wide Transcriptional Profiling Identifies BMP Signaling as Essential Regulator of Zebrafish Cardiomyocyte Regeneration. Developmental Cell. 36(1):36-49
Kruse, F., Junker, J.P., van Oudenaarden, A., Bakkers, J. (2016) Tomo-seq: A method to obtain genome-wide expression data with spatial resolution. Methods in cell biology. 135:299-307
Marchegiani, S., Davis, T., Tessadori, F., van Haaften, G., Brancati, F., Hoischen, A., Huang, H., Valkanas, E., Pusey, B., Schanze, D., Venselaar, H., Vulto-van Silfhout, A.T., Wolfe, L.A., Tifft, C.J., Zerfas, P.M., Zambruno, G., Kariminejad, A., Sabbagh-Kermani, F., Lee, J., Tsokos, M.G., Lee, C.R., Ferraz, V., da Silva, E.M., Stevens, C.A., Roche, N., Bartsch, O., Farndon, P., Bermejo-Sanchez, E., Brooks, B.P., Maduro, V., Dallapiccola, B., Ramos, F.J., Chung, H.B., Le Caignec, C., Martins, F., Jacyk, W.K., Mazzanti, L., Brunner, H.G., Bakkers, J., Lin, S., Malicdan, M.C., Boerkoel, C.F., Gahl, W.A., de Vries, B.B., van Haelst, M.M., Zenker, M., Markello, T.C. (2015) Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes. American journal of human genetics. 97(1):99-110
Ramspacher, C., Steed, E., Boselli, F., Ferreira, R., Faggianelli, N., Roth, S., Spiegelhalter, C., Messaddeq, N., Trinh, L., Liebling, M., Chacko, N., Tessadori, F., Bakkers, J., Laporte, J., Hnia, K., Vermot, J. (2015) Developmental Alterations in Heart Biomechanics and Skeletal Muscle Function in Desmin Mutants Suggest an Early Pathological Root for Desminopathies. Cell Reports. 11:1564-76
Strate, I., Tessadori, F., Bakkers, J. (2015) Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling. Development (Cambridge, England). 142:1767-76
Duncker, D.J., Bakkers, J., Brundel, B.J., Robbins, J., Tardiff, J.C., Carrier, L. (2015) Animal- and In Silico Models for the study of Sarcomeric Cardiomyopathies. Cardiovascular research. 105(4):439-448
Tessadori, F., Noël, E.S., Rens, E.G., Magliozzi, R., Evers-van Gogh, I.J., Guardavaccaro, D., Merks, R.M., Bakkers, J. (2015) Nodal Signaling Range Is Regulated by Proprotein Convertase-Mediated Maturation. Developmental Cell. 32(5):631-9
Jiménez-Amilburu, V., Jong-Raadsen, S., Bakkers, J., Spaink, H.P., Marín-Juez, R. (2015) GLUT12 deficiency during early development results in heart failure and a diabetic phenotype. The Journal of endocrinology. 224(1):1-15
Chetaille, P., Preuss, C., Burkhard, S., Côté, J.M., Houde, C., Castilloux, J., Piché, J., Gosset, N., Leclerc, S., Wünnemann, F., Thibeault, M., Gagnon, C., Galli, A., Tuck, E., Hickson, G.R., Amine, N.E., Boufaied, I., Lemyre, E., de Santa Barbara, P., Faure, S., Jonzon, A., Cameron, M., Dietz, H.C., Gallo-McFarlane, E., Benson, D.W., Moreau, C., Labuda, D., FORGE Canada Consortium, Zhan, S.H., Shen, Y., Jomphe, M., Jones, S.J., Bakkers, J., Andelfinger, G. (2014) Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm. Nature Genetics. 46(11):1245-9
Junker, J.P., Noël, E.S., Guryev, V., Peterson, K.A., Shah, G., Huisken, J., McMahon, A.P., Berezikov, E., Bakkers, J., van Oudenaarden, A. (2014) Genome-wide RNA Tomography in the Zebrafish Embryo. Cell. 159:662-75
Bonetti, M., Paardekooper Overman, J., Tessadori, F., Noël, E., Bakkers, J., den Hertog, J. (2014) Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish. Development (Cambridge, England). 141:1961-70
Goudarzi, M., Strate, I., Paksa, A., Lagendijk, A.K., Bakkers, J., and Raz, E. (2013) On the robustness of germ cell migration and microRNA-mediated regulation of chemokine signaling. Nature Genetics. 45(11):1264-1265
Mugoni, V., Postel, R., Catanzaro, V., De Luca, E., Turco, E., Digilio, G., Silengo, L., Murphy, M.P., Medana, C., Stainier, D.Y., Bakkers, J., and Santoro, M.M. (2013) Ubiad1 Is an Antioxidant Enzyme that Regulates eNOS Activity by CoQ10 Synthesis. Cell. 152(3):504-518
Noël, E.S., Verhoeven, M., Lagendijk, A.K., Tessadori, F., Smith, K., Choorapoikayil, S., den Hertog, J., and Bakkers, J. (2013) A Nodal-independent and tissue-intrinsic mechanism controls heart-looping chirality. Nature communications. 4:2754
Hyde, A.S., Farmer, E., Easley, K.E., van Lammeren, K., Christoffels, V.M., Barycki, J.J., Bakkers, J., and Simpson, M.A. (2012) UDP-Glucose Dehydrogenase polymorphisms from patients with congenital heart valve defects disrupt enzyme stability and quaternary assembly. The Journal of biological chemistry. 287(39):32708-32716
Goudarzi, M., Banisch, T.U., Mobin, M.B., Maghelli, N., Tarbashevich, K., Strate, I., van den Berg, J., Blaser, H., Bandemer, S., Paluch, E., Bakkers, J., Toli-Nørrelykke, I.M., and Raz, E. (2012) Identification and Regulation of a Molecular Module for Bleb-Based Cell Motility. Developmental Cell. 23(1):210-218
Lagendijk, A.K., Moulton, J.D., and Bakkers, J. (2012) Revealing details: whole mount microRNA in situ hybridization protocol for zebrafish embryos and adult tissues. Biology Open. 1(6):566-569
de Pater, E., Ciampricotti, M., Priller, F., Veerkamp, J., Strate, I., Smith, K., Lagendijk, A.K., Schilling, T.F., Herzog, W., Abdelilah-Seyfried, S., Hammerschmidt, M., and Bakkers, J. (2012) Bmp Signaling Exerts Opposite Effects on Cardiac Differentiation. Circulation research. 110(4):578-587
Tessadori, F., van Weerd, J.H., Burkhard, S.B., Verkerk, A.O., de Pater, E., Boukens, B.J., Vink, A., Christoffels, V.M., and Bakkers, J. (2012) Identification and functional characterization of cardiac pacemaker cells in zebrafish. PLoS One. 7(10):e47644
Smith, K.A., Lagendijk, A.K., Courtney, A.D., Chen, H., Paterson, S., Hogan, B.M., Wicking, C., and Bakkers, J. (2011) Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development. Development (Cambridge, England). 138(19):4193-4198
Lagendijk, A.K., Goumans, M.J., Burkhard, S.B., and Bakkers, J. (2011) MicroRNA-23 Restricts Cardiac Valve Formation by Inhibiting Has2 and Extracellular Hyaluronic Acid Production. Circulation research. 109(6):649-57
Smith, K.A., Noël, E., Thurlings, I., Rehmann, H., Chocron, S., and Bakkers, J. (2011) Bmp and Nodal Independently Regulate lefty1 Expression to Maintain Unilateral Nodal Activity during Left-Right Axis Specification in Zebrafish. PLoS Genetics. 7(9):e1002289
Ghani, S., Riemke, P., Schönheit, J., Lenze, D., Stumm, J., Hoogenkamp, M., Lagendijk, A., Heinz, S., Bonifer, C., Bakkers, J., Abdelilah-Seyfried, S., Hummel, M., and Rosenbauer, F. (2011) Macrophage development from hematopoietic stem cells requires PU.1 coordinated microRNA expression. Blood. 118(8):2275-84
Bakkers, J. (2011) Zebrafish as a model to study cardiac development and human cardiac disease. Cardiovascular research. 91(2):279-88
Verhoeven, M.C., Haase, C., Christoffels, V.M., Weidinger, G., and Bakkers, J. (2011) Wnt signaling regulates atrioventricular canal formation upstream of BMP and Tbx2. Birth defects research. Part A, Clinical and molecular teratology. 91(6):435-40
Joziasse, I.C., Smith, K.A., Chocron, S., van Dinther, M., Guryev, V., van de Smagt, J.J., Cuppen, E., Ten Dijke, P., Mulder, B.J., Maslen, C.L., Reshey, B., Doevendans, P.A., and Bakkers, J. (2011) ALK2 mutation in a patient with Down's syndrome and a congenital heart defect. European journal of human genetics : EJHG. 19(4):389-93
Beqqali, A., Monshouwer-Kloots, J., Monteiro, R., Welling, M., Bakkers, J., Ehler, E., Verkleij, A., Mummery, C., and Passier, R. (2010) CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. Journal of Cell Science. 123(Pt 7):1141-1150
Smith, K.A., Joziasse, I.C., Chocron, S., van Dinther, M., Guryev, V., Verhoeven, M.C., Rehmann, H., van der Smagt, J.J., Doevendans, P.A., Cuppen, E., Mulder, B.J., Ten Dijke, P., and Bakkers, J. (2009) Dominant-Negative ALK2 Allele Associates With Congenital Heart Defects. Circulation. 119(24):3062-3069
Bakkers, J., Verhoeven, M.C., and Abdelilah-Seyfried, S. (2009) Shaping the zebrafish heart: from left-right axis specification to epithelial tissue morphogenesis. Developmental Biology. 330(2):213-220
de Pater, E., Clijsters, L., Marques, S.R., Lin, Y.F., Garavito-Aguilar, Z.V., Yelon, D., and Bakkers, J. (2009) Distinct phases of cardiomyocyte differentiation regulate growth of the zebrafish heart. Development (Cambridge, England). 136(10):1633-1641
Marques, I.J., Weiss, F.U., Vlecken, D.H., Nitsche, C., Bakkers, J., Lagendijk, A., Partecke, L.I., Heidecke, C.D., Lerch, M.M., and Bagowski, C.P. (2009) Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model. BMC cancer. 9:128
Krens, S.F., He, S., Lamers, G.E., Meijer, A.H., Bakkers, J., Schmidt, T., Spaink, H.P., and Snaar-Jagalska, B.E. (2008) Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation. Developmental Biology. 319(2):370-383
Postel, R., Vakeel, P., Topczewski, J., Knöll, R., and Bakkers, J. (2008) Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex. Developmental Biology. 318(1):92-101
Monteiro, R., van Dinther, M., Bakkers, J., Wilkinson, R., Patient, R., Ten Dijke, P., and Mummery, C. (2008) Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish. Developmental Biology. 315(1):55-71
Smith, K.A., Chocron, S., von der Hardt, S., de Pater, E., Soufan, A., Bussmann, J., Schulte-Merker, S., Hammerschmidt, M., and Bakkers, J. (2008) Rotation and asymmetric development of the zebrafish heart requires directed migration of cardiac progenitor cells. Developmental Cell. 14(2):287-297
Bussmann, J., Bakkers, J., and Schulte-Merker, S. (2007) Early Endocardial Morphogenesis Requires Scl/Tal1. PLoS Genetics. 3(8):e140
Knöll, R., Postel, R., Wang, J., Krätzner, R., Hennecke, G., Vacaru, A.M., Vakeel, P., Schubert, C., Murthy, K., Rana, B.K., Kube, D., Knöll, G., Schäfer, K., Hayashi, T., Holm, T., Kimura, A., Schork, N., Toliat, M.R., Nürnberg, P., Schultheiss, H.P., Schaper, W., Schaper, J., Bos, E., den Hertog, J., van Eeden, F.J., Peters, P.J., Hasenfuss, G., Chien, K.R., and Bakkers, J. (2007) Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. Circulation. 116(5):515-525
Chocron, S., Verhoeven, M.C., Rentzsch, F., Hammerschmidt, M., and Bakkers, J. (2007) Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points. Developmental Biology. 305(2):577-588
von der Hardt, S., Bakkers, J., Inbal, A., Carvalho, L., Solnica-Krezel, L., Heisenberg, C.P., and Hammerschmidt, M. (2007) The Bmp Gradient of the Zebrafish Gastrula Guides Migrating Lateral Cells by Regulating Cell-Cell Adhesion. Current biology : CB. 17(6):475-487
van der Meer, D.L., Marques, I.J., Leito, J.T., Besser, J., Bakkers, J., Schoonheere, E., and Bagowski, C.P. (2006) Zebrafish cypher is important for somite formation and heart development. Developmental Biology. 299(2):356-372
Thijssen, V.L., Postel, R., Brandwijk, R.J., Dings, R.P., Nesmelova, I., Satijn, S., Verhofstad, N., Nakabeppu, Y., Baum, L.G., Bakkers, J., Mayo, K.H.,Poirier, F., and Griffioen, A.W. (2006) Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. Proceedings of the National Academy of Sciences of the United States of America. 103(43):15975-15980
Bakkers, J., Camacho-Carvajal, M., Nowak, M., Kramer, C., Danger, B., and Hammerschmidt, M. (2005) Destabilization of DeltaNp63alpha by Nedd4-Mediated Ubiquitination and Ubc9-Mediated Sumoylation, and Its Implications on Dorsoventral Patterning of the Zebrafish Embryo. Cell cycle (Georgetown, Tex.). 4(6):790-800
Rentzsch, F., Bakkers, J., Kramer, C., and Hammerschmidt, M. (2004) Fgf signaling induces posterior neuroectoderm independently of Bmp signaling inhibition. Developmental dynamics : an official publication of the American Association of Anatomists. 231(4):750-757
Brembeck, F.H., Schwarz-Romond, T., Bakkers, J., Wilhelm, S., Hammerschmidt, M., and Birchmeier, W. (2004) Essential role of BCL9-2 in the switch between β-catenin's adhesive and transcriptional functions. Genes & Development. 18(18):2225-2230
Bakkers, J., Kramer, C., Pothof, J., Quaedvlieg, N.E., Spaink, H.P., and Hammerschmidt, M. (2004) Has2 is required upstream of Rac1 to govern dorsal migration of lateral cells during zebrafish gastrulation. Development (Cambridge, England). 131(3):525-537
Schwarz-Romond, T., Asbrand, C., Bakkers, J., Kühl, M., Schaeffer, H.J., Huelsken, J., Behrens, J., Hammerschmidt, M. and Birchmeier, W. (2002) The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the betacatenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes & Development. 16(16):2073-2084
Bakkers, J., Hild, M., Kramer, C., Furutani-Seiki, M., and Hammerschmidt, M. (2002) Zebrafish Delta Np63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm. Developmental Cell. 2(5):617-627
Lele, Z., Bakkers, J., and Hammerschmidt, M. (2001) Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutations. Genesis (New York, N.Y. : 2000). 30(3):190-194
Bakkers, J.P.W.M. (2000) Chitin oligosaccharides in zebrafish development : investigations at the molecular and cellular level. Ph.D. Thesis. :149p
Kamst, E., Bakkers, J., Quaedvlieg, N.E., Pilling, J., Kijne, J.W., Lugtenberg, B.J., and Spaink, H.P. (1999) Chitin oligosaccharide synthesis by rhizobia and zebrafish embryos starts by glycosyl transfer to O4 of the reducing-terminal residue. Biochemistry. 13:4045-4052
Bakkers, J., Kijne, J.W. and Spaink, H.P. (1999) Function of chitin oligosaccharides in plant and animal development. In Chitin and chitinases, R.A.A. Muzzarelli and P. Jollès, eds. Basel/Switzerland: Birkhäuser Verlag. :69-81
Semino, C.E., Allende, M.L., Bakkers, J., Sapink, H.P., and Robbins, P.P. (1998) Expression of Rhizobium Chitin Oligosaccharide Fucosyltransferase in zebrafish embryos disrupts normal development. Annals of the New York Academy of Sciences. 842:49-54
Bakkers, J., Semino, C.E., Stroband, H., Kijne, J.W., Robbins, P.W., and Spaink, H.P. (1997) An important developmental role for oligosaccharides during early embryogenesis of cyprinid fish. Proceedings of the National Academy of Sciences of the United States of America. 94(15):7982-7986

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