ZFIN ID: ZDB-PUB-101018-15
The habenula is crucial for experience-dependent modification of fear responses in zebrafish
Agetsuma, M., Aizawa, H., Aoki, T., Nakayama, R., Takahoko, M., Goto, M., Sassa, T., Amo, R., Shiraki, T., Kawakami, K., Hosoya, T., Higashijima, S.I., and Okamoto, H.
Date: 2010
Source: Nature Neuroscience   13(11): 1354-1356 (Journal)
Registered Authors: Agetsuma, Masakazu, Aizawa, Hidenori, Aoki, Tazu, Goto, Midori, Higashijima, Shin-ichi, Kawakami, Koichi, Nakayama, Ryoko, Okamoto, Hitoshi, Shiraki, Toshiyuki, Takahoko, Mikako
Keywords: none
MeSH Terms:
  • Adaptation, Physiological/physiology
  • Amino Acids/metabolism
  • Analysis of Variance
  • Animals
  • Animals, Genetically Modified
  • Behavior, Animal
  • Carbocyanines/metabolism
  • Conditioning, Classical/physiology
  • DNA-Binding Proteins/genetics
  • DNA-Binding Proteins/metabolism
  • Electroshock/adverse effects
  • Fear/physiology*
  • Gene Expression Regulation/physiology*
  • Green Fluorescent Proteins/genetics
  • HSP72 Heat-Shock Proteins/genetics
  • Habenula/cytology
  • Habenula/metabolism
  • Habenula/physiology*
  • In Situ Nick-End Labeling
  • Larva
  • Locomotion/physiology
  • Neural Pathways/physiology
  • Neurons/metabolism
  • RNA, Messenger/metabolism
  • Time Factors
  • Transcription Factor Brn-3A/genetics
  • Tryptophan Hydroxylase/genetics
  • Tryptophan Hydroxylase/metabolism
  • Zebrafish/physiology*
  • Zebrafish Proteins/genetics
  • Zebrafish Proteins/metabolism*
PubMed: 20935642 Full text @ Nat. Neurosci.
The zebrafish dorsal habenula (dHb) shows conspicuous asymmetry in its connection with the interpeduncular nucleus (IPN) and is equivalent to the mammalian medial habenula. Genetic inactivation of the lateral subnucleus of dHb (dHbL) biased fish towards freezing rather than the normal flight response to a conditioned fear stimulus, suggesting that the dHbL-IPN pathway is important for controlling experience-dependent modification of fear responses.