PUBLICATION

Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity

Authors
Hill, A.J., Teraoka, H., Heideman, W., and Peterson, R.E.
ID
ZDB-PUB-050211-1
Date
2005
Source
Toxicological sciences : an official journal of the Society of Toxicology   86(1): 6-19 (Review)
Registered Authors
Heideman, Warren, Hill, Adrian, Peterson, Richard E., Teraoka, Hiroki
Keywords
none
MeSH Terms
  • Animals
  • Cells, Cultured
  • Models, Animal*
  • Oligonucleotide Array Sequence Analysis
  • Toxicity Tests*
  • Zebrafish/embryology
  • Zebrafish/genetics
PubMed
15703261 Full text @ Toxicol. Sci.
Abstract
Zebrafish (Danio rerio ) has been a prominent model vertebrate in a variety of biological disciplines. Substantial information gathered from developmental and genetic research, together with near-completion of the zebrafish genome project, has placed zebrafish in an attractive position for use as a toxicological model. Although still in its infancy, there is a clear potential for zebrafish to provide valuable new insights into chemical toxicity, drug discovery, and human disease using recent advances in forward and reverse genetic techniques coupled with large-scale, high-throughput screening. Here we present an overview of the rapidly increasing use of zebrafish in toxicology. Advantages of the zebrafish both in identifying endpoints of toxicity and elucidating mechanisms of toxicity are highlighted.
Genes / Markers
Figures
Show all Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes