ZFIN ID: ZDB-PERS-981030-17
Teraoka, Hiroki
Email: hteraoka@rakuno.ac.jp
Address: Department of Toxicology School of Veterinary Medicine Rakuno Gakuen University Ebetsu, 069-8501 Japan
Phone: +81-11-388-4791
Fax: +81-11-387-5890


Tanaka, K., Adachi, H., Akasaka, H., Tamaoki, J., Fuse, Y., Kobayashi, M., Kitazawa, T., Teraoka, H. (2021) Oxidative stress inducers potentiate 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated pre-cardiac edema in larval zebrafish. The Journal of veterinary medical science. 83(7):1050-1058
Nawaji, T., Yamashita, N., Umeda, H., Zhang, S., Mizoguchi, N., Seki, M., Kitazawa, T., Teraoka, H. (2020) Cytochrome P450 Expression and Chemical Metabolic Activity before Full Liver Development in Zebrafish. Pharmaceuticals (Basel, Switzerland). 13(12):
Nijoukubo, D., Adachi, H., Kitazawa, T., Teraoka, H. (2020) Blood vessels are primary targets for 2,3,7,8-tetrachlorodibenzo-p-dioxin in pre-cardiac edema formation in larval zebrafish. Chemosphere. 254:126808
Watanabe, R., Nakanishi, Y., Nijoukubo, D., Teraoka, H., Ogasawara, H., Mori, K. (2019) Usefulness of zebrafish in evaluating drug-induced teratogenicity in cardiovascular system. Drug and chemical toxicology. 42(6):649-656
Xu, J., Li, Y., Lv, Y., Bian, C., You, X., Endoh, D., Teraoka, H., Shi, Q. (2019) Molecular Evolution of Tryptophan Hydroxylases in Vertebrates: A Comparative Genomic Survey. Genes. 10(3):
Kubota, A., Kawai, Y.K., Yamashita, N., Lee, J.S., Kondoh, D., Zhang, S., Nishi, Y., Suzuki, K., Kitazawa, T., Teraoka, H. (2019) Transcriptional profiling of cytochrome P450 genes in the liver of adult zebrafish, Danio rerio. The Journal of Toxicological Sciences. 44:347-356
Chen, X., Fang, M., Chernick, M., Wang, F., JingfengYang, ., Yu, Y., Zheng, N., Teraoka, H., Nanba, S., Hiraga, T., Hinton, D.E., Dong, W. (2018) The case for thyroid disruption in early life stage exposures to thiram in zebrafish (Danio rerio). General and comparative endocrinology. 271:73-81
Tanaka, Y., Fujiwara, M., Shindo, A., Yin, G., Kitazawa, T., Teraoka, H. (2018) Aroclor 1254 and BDE-47 inhibit dopaminergic function manifesting as changes in locomotion behaviors in zebrafish embryos. Chemosphere. 193:1207-1215
Nawaji, T., Mizoguchi, N., Ono, M., Matuura, T., Seki, M., Teraoka, H. (2018) Comparing time-series of chemical concentrations in zebrafish (Danio rerio) embryos/larvae exposed to teratogens with different hydrophobicity; caffeine, sodium valproate, and diethylstilbestrol. The Journal of Toxicological Sciences. 43:267-273
Kitazawa, T., Yoshida, M., Teraoka, H., Kaiya, H. (2017) Does motilin peptide regulate gastrointestinal motility of zebrafish? An in vitro study using isolated intestinal strips. General and comparative endocrinology. 249:15-23
Yin, G., Cao, L., Du, J., Jia, R., Kitazawa, T., Kubota, A., Teraoka, H. (2017) Dexamethasone-induced hepatomegaly and steatosis in larval zebrafish. The Journal of Toxicological Sciences. 42:455-459
Nijoukubo, D., Tanaka, Y., Okuno, Y., Yin, G., Kitazawa, T., Peterson, R.E., Kubota, A., Teraoka, H. (2016) Protective effect of prostacyclin against pre-cardiac edema caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin and a thromboxane receptor agonist in developing zebrafish. Chemosphere. 156:111-117
Teraoka, H., Okuno, Y., Nijoukubo, D., Yamakoshi, A., Peterson, R.E., Stegeman, J.J., Kitazawa, T., Hiraga, T., Kubota, A. (2014) Involvement of COX2-thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 154C:19-26
Kim, K.H., Park, H.J., Kim, J.H., Kim, S., Williams, D.R., Kim, M.K., Jung, Y.D., Teraoka, H., Park, H.C., Choy, H.E., Shin, B.A., and Choi, S.Y. (2013) Cyp1a reporter zebrafish reveals target tissues for dioxin. Aquatic toxicology (Amsterdam, Netherlands). 134-135:57-65
Kubota, A., Stegeman, J.J., Woodin, B.R., Iwanaga, T., Harano, R., Peterson, R.E., Hiraga, T., and Teraoka, H. (2011) Role of zebrafish cytochrome P450 CYP1C genes in the reduced mesencephalic vein blood flow caused by activation of AHR2. Toxicology and applied pharmacology. 253(3):244-52
Teraoka, H., Ogawa, A., Kubota, A., Stegeman, J.J., Peterson, R.E., and Hiraga, T. (2010) Malformation of certain brain blood vessels caused by TCDD activation of Ahr2/Arnt1 signaling in developing zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 99(2):241-247
Teraoka, H., Kubota, A., Dong, W., Kawai, Y., Yamazaki, K., Mori, C., Harada, Y., Peterson, R.E., and Hiraga, T. (2009) Role of the cyclooxygenase 2-thromboxane pathway in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced decrease in mesencephalic vein blood flow in the zebrafish embryo. Toxicology and applied pharmacology. 234(1):33-40
Teraoka, H., Dong, W., Okuhara, Y., Iwasa, H., Shindo, A., Hill, A.J., Kawakami, A., and Hiraga, T. (2006) Impairment of lower jaw growth in developing zebrafish exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and reduced hedgehog expression. Aquatic toxicology (Amsterdam, Netherlands). 78(2):103-113
Dong, W., Muramoto, W., Nagai, Y., Takehana, K., Stegeman, J.J., Teraoka, H., and Hiraga, T. (2006) Retinal Neuronal Cell is a Toxicological Target of Tributyltin in Developing Zebrafish. The Journal of veterinary medical science. 68(6):573-579
Teraoka, H., Urakawa, S., Nanba, S., Nagai, Y., Dong, W., Imagawa, T., Tanguay, R.L., Svoboda, K., Handley-Goldstone, H.M., Stegeman, J.J., and Hiraga, T. (2006) Muscular contractions in the zebrafish embryo are necessary to reveal thiuram-induced notochord distortions. Toxicology and applied pharmacology. 212(1):24-34
Incardona, J.P., Carls, M.G., Teraoka, H., Sloan, C.A., Collier, T.K., and Scholz, N.L. (2005) Aryl Hydrocarbon Receptor-Independent Toxicity of Weathered Crude Oil during Fish Development. Environmental health perspectives. 113(12):1755-1762
Hill, A.J., Teraoka, H., Heideman, W., and Peterson, R.E. (2005) Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity. Toxicological sciences : an official journal of the Society of Toxicology. 86(1):6-19
Norton, W.H., Mangoli, M., Lele, Z., Pogoda, H.M., Diamond, B., Mercurio, S., Russell, C., Teraoka, H., Stickney, H.L., Rauch, G.J., Heisenberg, C.P., Houart, C., Schilling, T.F., Frohnhoefer, H.G., Rastegar, S., Neumann, C.J., Gardiner, R.M., Strähle, U., Geisler, R., Rees, M., Talbot, W.S., and Wilson, S.W. (2005) Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphe neurones and cranial motoneurones. Development (Cambridge, England). 132(4):645-658
Teraoka, H., Russell, C., Regan, J., Chandrasekhar, A., Concha, M.L., Yokoyama, R., Higashi, K., Take-Uchi, M., Dong, W., Hiraga, T., Holder, N., and Wilson, S.W. (2004) Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos. Journal of neurobiology. 60(3):275-288
Dong, W., Teraoka, H., Tsujimoto, Y., Stegeman, J.J., and Hiraga, T. (2004) Role of aryl hydrocarbon receptor in mesencephalic circulation failure and apoptosis in zebrafish embryos exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological sciences : an official journal of the Society of Toxicology. 77(1):109-116
Prasch, A.L., Teraoka, H., Carney, S.A., Dong, W., Hiraga, T., Stegeman, J.J., Heideman, W., and Peterson, R.E. (2003) Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 76(1):138-150
Teraoka, H., Dong, W., and Hiraga, T. (2003) Zebrafish as a novel experimental model for developmental toxicology. Congenital anomalies. 43(2):123-132
Teraoka, H., Dong, W., Tsujimoto, Y., Iwasa, H., Endoh, D., Ueno, N., Stegeman, J.J., Peterson, R.E., and Hiraga, T. (2003) Induction of cytochrome P450 1A is required for circulation failure and edema by 2,3,7,8-tetrachlorodibenzo-p-dioxin in zebrafish. Biochemical and Biophysical Research Communications. 304(2):223-228
Dong, W., Teraoka, H., Yamazaki, K., Tsukiyama, S., Imani, S., Imagawa, T., Stegeman, J.J., Peterson, R.E., and Hiraga, T. (2002) 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in the zebrafish embryo: local circulation failure in the dorsal midbrain is associated with increased apoptosis. Toxicological sciences : an official journal of the Society of Toxicology. 69(1):191-201
Yamazaki, K., Teraoka, H., Dong, W., Stegeman, J.J., and Hiraga, T. (2002) cDNA cloning and expressions of cytochrome P450 1A in zebrafish embryos. The Journal of veterinary medical science. 64(9):829-833
Teraoka, H., Dong, W., Ogawa, S., Tsukiyama, S., Okuhara, Y., Niiyama, M., Ueno, N., Peterson, R.E., and Hiraga, T. (2002) 2,3,7,8-Tetrachlorodibenzo-p-dioxin toxicity in the zebrafish embryo: altered regional blood flow and impaired lower jaw development. Toxicological sciences : an official journal of the Society of Toxicology. 65(2):192-199
Dong, W., Teraoka, H., Tsukiyama, S., Yamazaki, K., Imani, S., Imagawa, T.,Kondo, S. and Hiraga, T. (2002) 2,3,7,8-tetrachlorodibenzo-p-dioxin induces apoptosis in central nervous system- Correlation between local circulation failure and apoptosis in the dorsal midbrain of zebrafish embryos. Rakuno Gakuen Univ.. 26:301-314
Dong, W., Teraoka, H., Kondo, S., and Hiraga, T. (2001) 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin induces apoptosis in the dorsal midbrain of zebrafish embryos by activation of arylhydrocarbon receptor. Neuroscience letters. 303(3):169-172
Guo, S., Brush, J., Teraoka, H., Goddard, A., Wilson, S.W., Mullins, M.C., and Rosenthal, A. (1999) Development of noradrenergic neurons in the zebrafish hindbrain requires BMP, FGF8, and the homeodomain protein Soulless/Phox2a. Neuron. 24:555