ZFIN ID: ZDB-PERS-970313-18
Heideman, Warren
Email: wheidema@wisc.edu
URL:
Affiliation: Heideman Lab
Address: School of Pharmacy University of Wisconsin 5109 Rennebohm Hall 777 Highland Avenue Madison, WI 53705-2222 USA
Country: United States
Phone: (608) 262-1795
Fax: (608) 262-5345
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS
Using zebrafish as a model for studying the effects of dioxin on the processes of development. This research uses a toxic chemical as a probe to study basic developmental processes, and zebrafish in applied research to study an important environmental problem.

The other main focus in the lab is studying signal transduction pathways that regulate the expression of cyclins in yeast.


PUBLICATIONS
Gawdzik, J.C., Yue, M.S., Martin, N.R., Elemans, L.M.H., Lanham, K.A., Heideman, W., Rezendes, R., Baker, T.R., Taylor, M.R., Plavicki, J.S. (2018) sox9b is required in cardiomyocytes for cardiac morphogenesis and function. Scientific Reports. 8:13906
Burns, F.R., Lanham, K.A., Xiong, K.M., Gooding, A.J., Peterson, R.E., Heideman, W. (2016) Analysis of the Zebrafish sox9b Promoter: Identification of Elements that Recapitulate Organ-Specific Expression of sox9b. Gene. 578(2):281-9
Yue, M.S., Plavicki, J.S., Li, X.Y., Peterson, R.E., Heideman, W. (2015) A co-culture assay of embryonic zebrafish hearts to assess migration of epicardial cells in vitro. BMC Developmental Biology. 15:50
Burns, F.R., Peterson, R.E., Heideman, W. (2015) Dioxin disrupts cranial cartilage and dermal bone development in zebrafish larvae. Aquatic toxicology (Amsterdam, Netherlands). 164:52-60
Yue, M.S., Peterson, R.E., Heideman, W. (2015) Dioxin inhibition of swim bladder development in zebrafish: Is it secondary to heart failure?. Aquatic toxicology (Amsterdam, Netherlands). 162:10-17
Baker, T.R., King-Heiden, T.C., Peterson, R.E., Heideman, W. (2014) Dioxin induction of transgenerational inheritance of disease in zebrafish. Molecular and Cellular Endocrinology. 398(1-2):36-41
Lanham, K.A., Plavicki, J., Peterson, R.E., Heideman, W. (2014) Cardiac Myocyte-Specific AHR Activation Phenocopies TCDD-Induced Toxicity in Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 141(1):141-54
Plavicki, J.S., Hofsteen, P., Yue, M.S., Lanham, K.A., Peterson, R.E., Heideman, W. (2014) Multiple modes of proepicardial cell migration require heartbeat. BMC Developmental Biology. 14:18
Baker, T.R., Peterson, R.E., and Heideman, W. (2014) Using zebrafish as a model system for studying the transgenerational effects of dioxin. Toxicological sciences : an official journal of the Society of Toxicology. 138(2):403-411
Kim, M.S., Louis, K.M., Pedersen, J.A., Hamers, R.J., Peterson, R.E., and Heideman, W. (2014) Using citrate-functionalized TiO2 nanoparticles to study the effect of particle size on zebrafish embryo toxicity. The Analyst. 139(5):964-972
Plavicki, J.S., Baker, T.R., Burns, F.R., Xiong, K.M., Gooding, A.J., Hofsteen, P., Peterson, R.E., Heideman, W. (2014) Construction and characterization of a sox9b transgenic reporter line.. The International journal of developmental biology. 58(9):693-9
Baker, T.R., Peterson, R.E., and Heideman, W. (2013) Early dioxin exposure causes toxic effects in adult zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 135(1):241-50
Hofsteen, P., Plavicki, J., Johnson, S.D., Peterson, R.E., and Heideman, W. (2013) Sox9b is Required for Epicardium Formation and Plays a Role in TCDD-induced Heart Malformation in Zebrafish. Molecular pharmacology. 84(3):353-60
Hofsteen, P., Plavicki, J., Peterson, R.E., Heideman, W. (2013) Epicardium Formation as a Sensor in Toxicology. Journal of developmental biology. 1:112-125
Zhang, J., Lanham, K.A., Heideman, W., Peterson, R.E., and Li, L. (2013) Statistically Enhanced Spectral Counting Approach to TCDD Cardiac Toxicity in the Adult Zebrafish Heart. Journal of Proteome Research. 12(7):3093-103
Yang, S., Bar-Ilan, O., Peterson, R.E., Heideman, W., Hamers, R.J., and Pedersen, J.A. (2013) Influence of Humic Acid on Titanium Dioxide Nanoparticle Toxicity to Developing Zebrafish. Environmental science & technology. 47(9):4718-4725
Bar-Ilan, O., Chuang, C.C., Schwahn, D.J., Yang, S., Joshi, S., Pedersen, J.A., Hamers, R.J., Peterson, R.E., and Heideman, W. (2013) TiO2 nanoparticle exposure and illumination during zebrafish development: Mortality at parts per billion concentrations. Environmental science & technology. 47(9):4726-33
Hofsteen, P., Mehta, V., Kim, M.S., Peterson, R.E., and Heideman, W. (2013) TCDD Inhibits Heart Regeneration in Adult Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 132(1):211-221
Plavicki, J., Hofsteen, P., Peterson, R.E., and Heideman, W. (2013) Dioxin inhibits zebrafish epicardium and proepicardium development. Toxicological sciences : an official journal of the Society of Toxicology. 131(2):558-567
Zhang, J., Lanham, K.A., Heideman, W., Peterson, R.E., and Li, L. (2013) Characterization of Zebrafish Cardiac Proteome Using Online pH Gradient SCX-RP HPLC-MS/MS Platform. Methods in molecular biology (Clifton, N.J.). 1005:119-127
Bar-Ilan, O., Louis, K.M., Yang, S.P., Pedersen, J.A., Hamers, R.J., Peterson, R.E., and Heideman, W. (2012) Titanium dioxide nanoparticles produce phototoxicity in the developing zebrafish. Nanotoxicology. 6:670-679
Lanham, K.A., Peterson, R.E., and Heideman, W. (2012) Sensitivity to Dioxin Decreases as Zebrafish Mature. Toxicological sciences : an official journal of the Society of Toxicology. 127(2):360-370
King-Heiden, T.C., Mehta, V., Xiong, K.M., Lanham, K.A., Antkiewicz, D.S., Ganser, A., Heideman, W., and Peterson, R.E. (2012) Reproductive and developmental toxicity of dioxin in fish. Molecular and Cellular Endocrinology. 354(1-2):121-138
Zhou, Y., Cashman, T.J., Nevis, K.R., Obregon, P., Carney, S.A., Liu, Y., Gu, A., Mosimann, C., Sondalle, S., Peterson, R.E., Heideman, W., Burns, C.E., and Burns, C.G. (2011) Latent TGF-β binding protein 3 identifies a second heart field in zebrafish. Nature. 474(7353):645-8
Lanham, K.A., Prasch, A.L., Weina, K.M., Peterson, R.E., and Heideman, W. (2011) A dominant negative zebrafish ahr2 partially protects developing zebrafish from dioxin toxicity. PLoS One. 6(12):e28020
Zhang, J., Lanham, K.A., Peterson, R.E., Heideman, W., and Li, L. (2010) Characterization of the adult zebrafish cardiac proteome using online pH gradient strong cation exchange-RP 2D LC coupled with ESI MS/MS. Journal of separation science. 33(10):1462-1471
King Heiden, T.C., Spitsbergen, J., Heideman, W., and Peterson, R.E. (2009) Persistent Adverse Effects on Health and Reproduction Caused by Exposure of Zebrafish to 2,3,7,8-Tetrachlorodibenzo-p-dioxin During Early Development and Gonad Differentiation. Toxicological sciences : an official journal of the Society of Toxicology. 109(1):75-87
King-Heiden, T.C., Wiecinski, P.N., Mangham, A.N., Metz, K.M., Nesbit, D., Pedersen, J.A., Hamers, R.J., Heideman, W., and Peterson, R.E. (2009) Quantum dot nanotoxicity assessment using the zebrafish embryo. Environmental science & technology. 43(5):1605-1611
Hill, A.J., Heiden, T.C., Heideman, W., and Peterson, R.E. (2009) Potential roles of arnt2 in zebrafish larval development. Zebrafish. 6(1):79-91
Xiong, K.M., Peterson, R.E., and Heideman, W. (2008) Aryl hydrocarbon receptor-mediated down-regulation of sox9b causes jaw malformation in zebrafish embryos. Molecular pharmacology. 74(6):1544-1553
Mehta, V., Peterson, R.E., and Heideman, W. (2008) 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure Prevents Cardiac Valve Formation in Developing Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 104(2):303-311
Chen, J., Carney, S.A., Peterson, R.E., and Heideman, W. (2008) Comparative Genomics Identifies Genes Mediating Cardiotoxicity in the Embryonic Zebrafish Heart. Physiological Genomics. 33(2):148-158
King Heiden, T.C., Dengler, E., Kao, W.J., Heideman, W., and Peterson, R.E. (2007) Developmental toxicity of low generation PAMAM dendrimers in zebrafish. Toxicology and applied pharmacology. 225(1):70-79
Kim, K.H., Antkiewicz, D.S., Yan, L., Eliceir, K.W., Heideman, W., Peterson, R.E., and Lee, Y. (2007) Lrrc10 is required for early heart development and function in zebrafish. Developmental Biology. 308(2):494-506
Antkiewicz, D.S., Peterson, R.E., and Heideman, W. (2006) Blocking Expression of AHR2 and ARNT1 in Zebrafish Larvae Protects Against Cardiac Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Toxicological sciences : an official journal of the Society of Toxicology. 94(1):175-182
Carney, S.A., Chen, J., Burns, C.G., Xiong, K.M., Peterson, R.E., and Heideman, W. (2006) Aryl hydrocarbon receptor activation produces heart-specific transcriptional and toxic responses in developing zebrafish. Molecular pharmacology. 70(2):549-561
Prasch, A.L., Tanguay, R.L., Mehta, V., Heideman, W., and Peterson, R.E. (2006) Identification of Zebrafish ARNT1 Homologs: 2,3,7,8-Tetrachlorodibenzo-p-dioxin Toxicity in the Developing Zebrafish Requires ARNT1. Molecular pharmacology. 69(3):776-787
Carney, S.A., Prasch, A.L., Heideman, W., and Peterson, R.E. (2006) Understanding dioxin developmental toxicity using the zebrafish model. Birth defects research. Part A, Clinical and molecular teratology. 76(1):7-18
Hill, A.J., Teraoka, H., Heideman, W., and Peterson, R.E. (2005) Zebrafish as a Model Vertebrate for Investigating Chemical Toxicity. Toxicological sciences : an official journal of the Society of Toxicology. 86(1):6-19
Antkiewicz, D.S., Burns, C.G., Carney, S.A., Peterson, R.E., and Heideman, W. (2005) Heart Malformation is an Early Response to TCDD in Embryonic Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 84(2):368-377
Heideman, W., Antkiewicz, D.S., Carney, S.A., and Peterson, R.E. (2005) Zebrafish and cardiac toxicology. Cardiovascular Toxicology. 5(2):203-214
Prasch, A.L., Heideman, W., and Peterson, R.E. (2004) ARNT2 Is Not Required for TCDD Developmental Toxicity in Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 82(1):250-258
Carney, S.A., Peterson, R.E., and Heideman, W. (2004) 2,3,7,8-Tetrachlorodibenzo-p-dioxin Activation of the Aryl Hydrocarbon Receptor/Aryl Hydrocarbon Receptor Nuclear Translocator Pathway Causes Developmental Toxicity through a CYP1A-Independent Mechanism in Zebrafish. Molecular pharmacology. 66(3):512-521
Hill, A.J., Bello, S.M., Prasch, A.L., Peterson, R.E., and Heideman, W. (2004) Water permeability and TCDD-induced edema in zebrafish early-life stages. Toxicological sciences : an official journal of the Society of Toxicology. 78(1):78-87
Prasch, A.L., Andreasen, E.A., Peterson, R.E., and Heideman, W. (2004) Interactions between TCDD and hypoxia signalling pathways in zebrafish: hypoxia decreases responses to TCDD in zebrafish embryos. Toxicological sciences : an official journal of the Society of Toxicology. 78(1):68-77
Prasch, A.L., Teraoka, H., Carney, S.A., Dong, W., Hiraga, T., Stegeman, J.J., Heideman, W., and Peterson, R.E. (2003) Aryl hydrocarbon receptor 2 mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin developmental toxicity in zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 76(1):138-150
Andreasen, E.A., Spitsbergen, J.M., Tanguay, R.L., Stegeman, J.J., Heideman, W., and Peterson, R.E. (2002) Tissue-specific expression of AHR2, ARNT2, and CYP1A in zebrafish embryos and larvae: effects of developmental stage and 2,3,7,8-Tetrachlorodibenzo-p-dioxin exposure. Toxicological sciences : an official journal of the Society of Toxicology. 68(2):403-419
Andreasen, E.A., Hahn, M.E., Heideman, W., Peterson, R.E., and Tanguay, R.L. (2002) The Zebrafish (Danio rerio) Aryl Hydrocarbon Receptor Type 1 Is a Novel Vertebrate Receptor. Molecular pharmacology. 62(2):234-249
Andreasen, E.A., Tanguay, R.L., Peterson, R.E., and Heideman, W. (2002) Identification of a critical amino acid in the Aryl hydrocarbon receptor. The Journal of biological chemistry. 277(15):13210-13218
Belair, C.D., Peterson, R.E., and Heideman, W. (2001) Disruption of erythropoiesis by dioxin in the zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 222(4):581-594
Henry, T.R., Nesbit, D.J., Heideman, W., and Peterson, R.E. (2001) Relative potencies of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners to induce cytochrome P4501A mRNA in a zebrafish liver cell line. Environmental toxicology and chemistry. 20(5):1053-1058
Tanguay, R.L., Andreasen, E., Heideman, W., and Peterson, R.E. (2000) Identification and expression of alternatively spliced aryl hydrocarbon nuclear translocator 2 (ARNT2) cDNAs from zebrafish with distinct functions. Biochim. Biophys. Acta Gene Struct. Exp.. 1494(1-2):117-128
Abnet, C.C., Tanguay, R.L., Heideman, W., and Peterson, R.E. (1999) Transactivation Activity of Human, Zebrafish, and Rainbow Trout Aryl Hydrocarbon Receptors Expressed in COS-7 Cells: Greater Insight into Species Differences in Toxic Potency of Polychlorinated Dibenzo-p-dioxin, Dibenzofuran, and Biphenyl Congeners. Toxicology and applied pharmacology. 159(1):41-51
Tanguay, R.L., Abnet, C.C., Heideman, W., and Peterson, R.E. (1999) Cloning and characterization of the zebrafish (Danio rerio) aryl hydrocarbon receptor. Biochim. Biophys. Acta Gene Struct. Exp.. 1444:35-48

NON-ZEBRAFISH PUBLICATIONS
TL Laabs, DD Markwardt, LL Newcomb, D Stillman, and W Heideman. ACE2 is required for daughter cell-specific G1 delay in Saccharomyces cerevisiae. PNAS 100(18):10275-80 (2003).

LL Newcomb, JA Diderich, MG Slattery, and W Heideman. Glucose regulation of S. cerevisiae cell cycle genes. Eukaryotic Cell 2:143-149 (2003).

LL Newcomb, DD Hall, and W Heideman. AZF1 is a glucose dependent positive regulator of CLN3 transcription in Saccharomyces cerevisiae. Mol Cell Biol 22:1607-1614 (2002).

M Wu, L Newcomb, and W Heideman. Regulation of gene expression by glucose in S. cerevisiae: A role for ADA2 and ADA3/NGG1. J Bact 181:4755-4760 (1999).

F Parviz, DD Hall, DD Markwardt, and W Heideman. Transcriptional regulation of CLN3 expression by glucose in Saccharomyces cerevisiae. J Bact 180:4508-4515 (1998).

DD Hall, DD Markwardt, F Parviz, and W Heideman. Regulation of the Cln3/Cdc28 kinase by cAMP. Saccharomyces cerevisiae. EMBO Journal 17:4370-4378 (1998).

F Parviz and W Heideman. Regulation of CLN3 mRNA levels by nutrients in Saccharomyces cerevisiae. J Bact 180:225-230 (1998).