ZFIN ID: ZDB-PUB-020402-7
Expression of the helix-loop-helix gene id3 in the zebrafish embryo
Dickmeis, T., Rastegar, S., Lam, C.S., Aanstad, P., Clark, M., Fischer, N., Rosa, F., Korzh, V., and Strähle, U.
Date: 2002
Source: Mechanisms of Development 113(1): 99-109 (Journal)
Registered Authors: Aanstad, Pia, Clark, Matthew D., Dickmeis, Thomas, Fischer, Nadine, Korzh, Vladimir, Lam, Eric (C.S.), Rastegar, Sepand, Rosa, Frederic, Strähle, Uwe
Keywords: helix-loop-helix; extramacrochaetae; id3; germ ring; embryonic shield; retina
MeSH Terms: Amino Acid Sequence; Animals; Blotting, Northern; DNA, Complementary/metabolism; DNA-Binding Proteins/biosynthesis* (all 22) expand
PubMed: 11900982 Full text @ Mech. Dev.
ABSTRACT
Proteins of the Extramacrochaetae and Id subfamily of Helix-Loop-Helix (HLH) proteins are negative regulators of bHLH transcription factors. We cloned a cDNA from zebrafish which encodes a member of the id3 subfamily. High levels of transcripts accumulated in the germ ring and in the embryonic shield. Towards the end of gastrulation, Id3 was highly expressed in the anterior prechordal plate and hypoblast. At later stages, id3 expression was turned on and off in a large variety of tissues within short periods of time. These include the lateral mesoderm, the cornea, the lens, the brain, the neural crest, the retina and the fins.
ADDITIONAL INFORMATION