ZFIN ID: ZDB-PERS-010827-8
Dickmeis, Thomas
Email: thomas.dickmeis@kit.edu
URL: https://bip.ibcs.kit.edu/dickmeis.php
Affiliation: Dickmeis Lab
Address: Institute of Biological and Chemical Systems - Biological Information Processing (IBCS-BIP) Karlsruhe Institute of Technology (KIT) Hermann-von-Helmholtz-Platz 1 76344 Eggenstein-Leopoldshafen
Phone: +49 -721-6082-6564
Fax: +49-721-6082-3354
ORCID ID: 0000-0002-9819-1962

Research interest: Zebrafish endocrinology and metabolism

PhD in the laboratory of Uwe Strähle, Strasbourg, on identification of target genes of the Nodal signalling pathway and analysis of differential gene expression in the midline of the zebrafish embryo. Postdoc on regulation and function of peripheral circadian clocks in the zebrafish in the laboratory of Nicholas Foulkes, Tübingen. Current research interest: zebrafish endocrinology and metabolism.

Hayot, G., Marcato, D., Cramer von Clausbruch, C.A., Pace, G., Strähle, U., Colbourne, J.K., Pylatiuk, C., Peravali, R., Weiss, C., Scholz, S., Dickmeis, T. (2024) Evaluating Toxicity of Chemicals using a Zebrafish Vibration Startle Response Screening System. Journal of visualized experiments : JoVE. (203):
Breus, O., Dickmeis, T. (2020) Genetically encoded thiol redox-sensors in the zebrafish model: lessons for embryonic development and regeneration. Biological chemistry. 402(3):363-378
Weger, M., Weger, B.D., Schink, A., Takamiya, M., Stegmaier, J., Gobet, C., Parisi, A., Kobitski, A.Y., Mertes, J., Krone, N., Strähle, U., Nienhaus, G.U., Mikut, R., Gachon, F., Gut, P., Dickmeis, T. (2020) MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly. eLIFE. 9:
Takamiya, M., Stegmaier, J., Kobitski, A.Y., Schott, B., Weger, B.D., Margariti, D., Cereceda Delgado, A.R., Gourain, V., Scherr, T., Yang, L., Sorge, S., Otte, J.C., Hartmann, V., van Wezel, J., Stotzka, R., Reinhard, T., Schlunck, G., Dickmeis, T., Rastegar, S., Mikut, R., Nienhaus, G.U., Strähle, U. (2020) Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves. PLoS Genetics. 16:e1008774
Adhikari, S.S., Zhao, L., Dickmeis, T., Korvink, J.G., Badilita, V. (2019) Inductively coupled magic angle spinning microresonators benchmarked for high-resolution single embryo metabolomic profiling. The Analyst. 144(24):7192-7199
Neukum, A., Bartschat, A., Breitwieser, H., Strähle, U., Dickmeis, T., Pylatiuk, C. (2019) Automated Classification of Fertilized Zebrafish Embryos. Zebrafish. 16(3):326-328
Dickmeis, T., Feng, Y., Mione, M.C., Ninov, N., Santoro, M., Spaink, H.P., Gut, P. (2019) Nano-Sampling and Reporter Tools to Study Metabolic Regulation in Zebrafish. Frontiers in cell and developmental biology. 7:15
Leidner, A., Bauer, J., Ebrahimi Khonachah, M., Takamiya, M., Strähle, U., Dickmeis, T., Rabe, K.S., Niemeyer, C.M. (2019) Oriented immobilization of a delicate glucose-sensing protein on silica nanoparticles. Biomaterials. 190-191:76-85
Weger, M., Weger, B.D., Görling, B., Poschet, G., Yildiz, M., Hell, R., Luy, B., Akcay, T., Güran, T., Dickmeis, T., Müller, F., Krone, N. (2018) Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism. EBioMedicine. 36:376-389
Breitwieser, H., Dickmeis, T., Vogt, M., Ferg, M., Pylatiuk, C. (2017) Fully Automated Pipetting Sorting System for Different Morphological Phenotypes of Zebrafish Embryos. SLAS technology. 23(2):128-133
Tsachaki, M., Meyer, A., Weger, B., Kratschmar, D.V., Tokarz, J., Adamski, J., Belting, H.G., Affolter, M., Dickmeis, T., Odermatt, A. (2017) Absence of 11-keto reduction of cortisone and 11-ketotestosterone in the model organism zebrafish. The Journal of endocrinology. 232(2):323-335
Geisler, R., Köhler, A., Dickmeis, T., Strähle, U. (2017) Archiving of zebrafish lines can reduce animal experiments in biomedical research. EMBO reports. 18(1):1-2
Weger, B.D., Weger, M., Görling, B., Schink, A., Gobet, C., Keime, C., Poschet, G., Jost, B., Krone, N., Hell, R., Gachon, F., Luy, B., Dickmeis, T. (2016) Extensive Regulation of Diurnal Transcription and Metabolism by Glucocorticoids. PLoS Genetics. 12:e1006512
Schutera, M., Dickmeis, T., Mione, M., Peravali, R., Marcato, D., Reischl, M., Mikut, R., Pylatiuk, C. (2016) Automated Phenotype Pattern Recognition of Zebrafish for High-throughput Screening. Bioengineered. 7(4):261-5
Shahid, M., Takamiya, M., Stegmaier, J., Middel, V., Gradl, M., Klüver, N., Mikut, R., Dickmeis, T., Scholz, S., Rastegar, S., Yang, L., Strähle, U. (2016) Zebrafish biosensor for toxicant induced muscle hyperactivity. Scientific Reports. 6:23768
Takamiya, M., Weger, B.D., Schindler, S., Beil, T., Yang, L., Armant, O., Ferg, M., Schlunck, G., Reinhard, T., Dickmeis, T., Rastegar, S., Strähle, U. (2015) Molecular Description of Eye Defects in the Zebrafish Pax6b Mutant, sunrise, Reveals a Pax6b-Dependent Genetic Network in the Developing Anterior Chamber. PLoS One. 10:e0117645
Ferg, M., Armant, O., Yang, L., Dickmeis, T., Rastegar, S., and Strähle, U. (2014) Gene transcription in the zebrafish embryo: regulators and networks. Briefings in Functional Genomics. 13(2):131-43
Tixier, V., Bataillé, L., Etard, C., Jagla, T., Weger, M., Daponte, J.P., Strähle, U., Dickmeis, T., and Jagla, K. (2013) Glycolysis supports embryonic muscle growth by promoting myoblast fusion. Proceedings of the National Academy of Sciences of the United States of America. 110(47):18982-7
Weger, B.D., Weger, M., Jung, N., Lederer, C., Bräse, S., and Dickmeis, T. (2013) A chemical screening procedure for glucocorticoid signaling with a zebrafish larva luciferase reporter system. Journal of visualized experiments : JoVE. (79)
Mikut, R., Dickmeis, T., Driever, W., Geurts, P., Hamprecht, F.A., Kausler, B.X., Ledesma-Carbayo, M.J., Marée, R., Mikula, K., Pantazis, P., Ronneberger, O., Santos, A., Stotzka, R., Strähle, U., and Peyriéras, N. (2013) Automated Processing of Zebrafish Imaging Data: A Survey. Zebrafish. 10(3):401-21
Weger, M., Weger, B.D., Diotel, N., Rastegar, S., Hirota, T., Kay, S.A., Strähle, U., and Dickmeis, T. (2013) Real-time in vivo monitoring of circadian E-box enhancer activity: A robust and sensitive zebrafish reporter line for developmental, chemical and neural biology of the circadian clock. Developmental Biology. 380(2):259-73
Weger, B.D., Weger, M., Nusser, M., Brenner-Weiss, G., and Dickmeis, T. (2012) A Chemical Screening System for Glucocorticoid Stress Hormone Signaling in an Intact Vertebrate. ACS Chemical Biology. 7(7):1178-1183
Weger, B.D., Sahinbas, M., Otto, G.W., Mracek, P., Armant, O., Dolle, D., Lahiri, K., Vallone, D., Ettwiller, L., Geisler, R., Foulkes, N.S., and Dickmeis, T. (2011) The light responsive transcriptome of the zebrafish: function and regulation. PLoS One. 6(2):e17080
Rastegar, S., Hess, I., Dickmeis, T., Nicod, J.C., Ertzer, R., Hadzhiev, Y., Thies, W.G., Scherer, G., and Strähle, U. (2008) The words of the regulatory code are arranged in a variable manner in highly conserved enhancers. Developmental Biology. 318(2):366-377
Pézeron, G., Lambert, G., Dickmeis, T., Strähle, U., Rosa, F.M., and Mourrain, P. (2008) Rasl11b knock down in zebrafish suppresses one-eyed-pinhead mutant phenotype. PLoS One. 3(1):e1434
Dickmeis, T., Lahiri, K., Nica, G., Vallone, D., Santoriello, C., Neumann, C.J., Hammerschmidt, M., and Foulkes, N.S. (2007) Glucocorticoids Play a Key Role in Circadian Cell Cycle Rhythms. PLoS Biology. 5(4):e78
Lahiri, K., Vallone, D., Gondi, S.B., Santoriello, C., Dickmeis, T., and Foulkes, N.S. (2005) Temperature Regulates Transcription in the Zebrafish Circadian Clock. PLoS Genetics. 3(11):e351
Plessy, C., Dickmeis, T., Chalmel, F., and Strähle, U. (2005) Enhancer sequence conservation between vertebrates is favoured in developmental regulator genes. Trends in genetics : TIG. 21(4):207-210
Vallone, D., Lahiri, K., Dickmeis, T., and Foulkes, N.S. (2005) Zebrafish Cell Clocks Feel the Heat and See the Light!. Zebrafish. 2(3):171-187
Dickmeis, T., Plessy, C., Rastegar, S., Aanstad, P., Herwig, R., Chalmel, F., Fischer, N., and Strähle, U. (2004) Expression profiling and comparative genomics identify a conserved regulatory region controlling midline expression in the zebrafish embryo. Genome research. 14(2):228-238
Mathieu, J., Griffin, K., Herbomel, P., Dickmeis, T., Strähle, U., Kimelman, D., Rosa, F.M., and Peyriéras, N. (2004) Nodal and Fgf pathways interact through a positive regulatory loop and synergize to maintain mesodermal cell populations. Development (Cambridge, England). 131(3):629-641
Dickmeis, T., Rastegar, S., Lam, C.S., Aanstad, P., Clark, M., Fischer, N., Rosa, F., Korzh, V., and Strähle, U. (2002) Expression of the helix-loop-helix gene id3 in the zebrafish embryo. Mechanisms of Development. 113(1):99-109
Aoki T.O., David, N.B., Minchiotti, G., Saint-Etienne, L., Dickmeis, T., Persico, G.M., Strähle, U., Mourrain, P., and Rosa, F.M. (2002) Molecular integration of casanova in the Nodal signalling pathway controlling endoderm formation. Development (Cambridge, England). 129(2):275-286
Dickmeis, T., Rastegar, S., Aanstad, P., Clark, M., Fischer, N., Plessy, C., Rosa, F., Korzh, V., Strähle, U. (2001) Expression of brain subtype creatine kinase in the zebrafish embryo. Mechanisms of Development. 109(2):409-412
Dickmeis, T., Rastegar, S., Aanstad, P., Clark, M., Fischer, N., Korzh, V., and Strähle, U. (2001) Expression of the anti-dorsalizing morphogenetic protein gene in the zebrafish embryo. Development genes and evolution. 211(11):568-572
Dickmeis, T., Aanstad, P., Clark, M., Fischer, N., Herwig, R., Mourrain, P., Blader, P., Rosa, F., Lehrach, H., and Strähle, U. (2001) Identification of nodal signaling targets by array analysis of induced complex probes. Developmental Dynamics : an official publication of the American Association of Anatomists. 222(4):571-580
Dickmeis, T., Mourrain, P., Saint-Etienne, L., Fischer, N., Aanstad, P., Clark, M., Strähle, U., and Rosa, F. (2001) A crucial component of the endoderm formation pathway, CASANOVA, is encoded by a novel sox-related gene. Genes & Development. 15(12):1487-1492

Stem cells and the circadian clock.
Weger M, Diotel N, Dorsemans AC, Dickmeis T, Weger BD. Dev Biol. 2017 Nov 15;431(2):111-123. doi: 10.1016/j.ydbio.2017.09.012. Epub 2017 Sep 9. PMID: 28899666

The circadian clock and glucocorticoids--interactions across many time scales.
Dickmeis T, Weger BD, Weger M. Mol Cell Endocrinol. 2013 Nov 5;380(1-2):2-15. doi: 10.1016/j.mce.2013.05.012. Epub 2013 May 21. PMID: 23707790

Glucocorticoids and circadian clock control of cell proliferation: at the interface between three dynamic systems.
Dickmeis T, Foulkes NS. Mol Cell Endocrinol. 2011 Jan 1;331(1):11-22. doi: 10.1016/j.mce.2010.09.001. Epub 2010 Sep 15. PMID: 20833224

Glucocorticoids and the circadian clock.
Dickmeis T.
J Endocrinol. 2009 Jan;200(1):3-22. Epub 2008 Oct 29.
PMID: 18971218 [PubMed - in process]

The identification and functional characterisation of conserved regulatory elements in developmental genes.
Dickmeis T, Müller F.
Brief Funct Genomic Proteomic. 2005 Feb;3(4):332-50. Review.
PMID: 15814024 [PubMed - indexed for MEDLINE]