|ZFIN ID: ZDB-PUB-011214-12|
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Expression of brain subtype creatine kinase in the zebrafish embryo
Dickmeis, T., Rastegar, S., Aanstad, P., Clark, M., Fischer, N., Plessy, C., Rosa, F., Korzh, V., Strähle, U.
|Source:||Mechanisms of Development 109(2): 409-412 (Journal)|
|Registered Authors:||Aanstad, Pia, Clark, Matthew D., Dickmeis, Thomas, Fischer, Nadine, Korzh, Vladimir, Plessy, Charles, Rastegar, Sepand, Rosa, Frederic, Strähle, Uwe|
|Keywords:||gastrulation, neuronal differentiation, maternal transcript, energy shuttle, primary neurons, zebrafish, embryogenesis, limb, somite, energy shuttle, rat brain, metabolism|
|PubMed:||11731259 Full text @ Mech. Dev.|
Dickmeis, T., Rastegar, S., Aanstad, P., Clark, M., Fischer, N., Plessy, C., Rosa, F., Korzh, V., Strähle, U. (2001) Expression of brain subtype creatine kinase in the zebrafish embryo. Mechanisms of Development. 109(2):409-412.
ABSTRACTCreatine kinases (CK) play crucial roles in intracellular energy transfer. We have isolated a cDNA from zebrafish embryos, which encodes a CK highly related to the mammalian brain subtype creatine kinase (BCK). The bck mRNA is expressed maternally in the zebrafish embryo and transcripts are distributed uniformly in blastula and gastrula stages. Expression becomes restricted to the prechordal plate and the nervous system during subsequent somitogenesis stages. bck transcripts are abundant in primary neurons in the developing central nervous system of the 1-day-old embryo. While some bck expression persists in the hindbrain, expression vanishes in the spinal cord of the 2-day-old embryo. In summary, the expression pattern of bck is highly dynamic and suggests a role for bck during gastrulation and neuronal differentiation.