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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-980220-9
Ghysen, Alain
Email: alain.ghysen@univ-montp2.fr
URL: http://www.univ-montp2.fr/~neurodvpmt/
Affiliation: Genetics of Neural Development
Address: INSERM U432 CC103 Universite Montpellier II Place Eugène Bataillon Cedex 05 Montpellier, 34095 France
Country: France
Phone: 33-4-67-14-48-02
Fax: 33-4-67-14-39-28
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS
Research interest: How neuronal connectivity is encoded in the genome.

I study this question in the case of the lateral line because this sensory system is simpler and more accessible than the central nervous system. The lateral line is also an adequate system to study questions of general interest in developmental biology such as the control of cell migration, of cell proliferation, of cell determination, and of pattern formation.


PUBLICATIONS
Nasri, A., Valverde, A.J., Roche, D.B., Desrumaux, C., Clair, P., Beyrem, H., Chaloin, L., Ghysen, A., Perrier, V. (2016) Neurotoxicity of a Biopesticide Analog on Zebrafish Larvae at Nanomolar Concentrations. International Journal of Molecular Sciences. 17(12)
Ghysen, A., Dambly-Chaudière, C. (2016) Development vs. behavior: a role for neural adaptation in evolution?. The International journal of developmental biology. 60:77-84
Graciarena, M., Dambly-Chaudière, C., and Ghysen, A. (2014) Dynamics of axonal regeneration in adult and aging zebrafish reveal the promoting effect of a first lesion. Proc. Natl. Acad. Sci. USA. 111(4):1610-1615
Schuster, K., and Ghysen, A. (2013) Labeling second-order sensory neurons in the posterior lateral-line system of zebrafish. Cold Spring Harbor protocols. 2013(12):pdb.prot079475
Schuster, K., and Ghysen, A. (2013) Making mosaic fish primordia by focal electroporation. Cold Spring Harbor protocols. 2013(12):pdb.prot079442
Schuster, K., and Ghysen, A. (2013) Labeling hair cells and afferent neurons in the posterior lateral-line system of zebrafish. Cold Spring Harbor protocols. 2013(12):pdb.prot079467
Schuster, K., and Ghysen, A. (2013) Labeling defined cells or subsets of cells in zebrafish by kaede photoconversion. Cold Spring Harbor protocols. 2013(11):13440-8
Wada, H., Ghysen, A., Asakawa, K., Abe, G., Ishitani, T., and Kawakami, K. (2013) Wnt/Dkk Negative Feedback Regulates Sensory Organ Size in Zebrafish. Current biology : CB. 23(16):1559-65
Wada, H., Dambly-Chaudière, C., Kawakami, K., and Ghysen, A. (2013) Innervation is required for sense organ development in the lateral line system of adult zebrafish. Proc. Natl. Acad. Sci. USA. 110(14):5659-5664
Ghysen, A., Dambly-Chaudière, C., Coves, D., de la Gandara, F., and Ortega, A. (2012) Developmental origin of a major difference in sensory patterning between zebrafish and bluefin tuna. Evolution & development. 14(2):204-211
Gamba, L., Cubedo, N., Lutfalla, G., Ghysen, A., and Dambly-Chaudiere, C. (2010) Lef1 controls patterning and proliferation in the posterior lateral line system of zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 239(12):3163-3171
Schuster, K., Dambly-Chaudière, C., and Ghysen, A. (2010) Glial cell line-derived neurotrophic factor defines the path of developing and regenerating axons in the lateral line system of zebrafish. Proc. Natl. Acad. Sci. USA. 107(45):19531-19536
Sarrazin, A.F., Nuñez, V.A., Sapède, D., Tassin, V., Dambly-Chaudière, C., and Ghysen, A. (2010) Origin and early development of the posterior lateral line system of zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(24):8234-8244
Wada, H., Ghysen, A., Satou, C., Higashijima, S.I., Kawakami, K., Hamaguchi, S., and Sakaizumi, M. (2010) Dermal morphogenesis controls lateral line patterning during postembryonic development of teleost fish. Developmental Biology. 340(2):583-594
Gamba, L., Cubedo, N., Ghysen, A., Lutfalla, G., and Dambly-Chaudière, C. (2010) Estrogen receptor ESR1 controls cell migration by repressing chemokine receptor CXCR4 in the zebrafish posterior lateral line system. Proc. Natl. Acad. Sci. USA. 107(14):6358-6363
Ghysen, A., Schuster, K., Coves, D., de la Gandara, F., Papandroulakis, N., and Ortega, A. (2010) Development of the posterior lateral line system in Thunnus thynnus, the atlantic blue-fin tuna, and in its close relative Sarda sarda. The International journal of developmental biology. 54(8-9):1317-1322
Nuñez, V.A., Sarrazin, A.F., Cubedo, N., Allende, M.L., Dambly-Chaudière, C., and Ghysen, A. (2009) Postembryonic development of the posterior lateral line in the zebrafish. Evolution & development. 11(4):391-404
Laguerre, L., Ghysen, A., and Dambly-Chaudière, C. (2009) Mitotic patterns in the migrating lateral line cells of zebrafish embryos. Developmental dynamics : an official publication of the American Association of Anatomists. 238(5):1042-1051
Ghysen, A., and Dambly-Chaudière, C. (2007) The lateral line microcosmos. Genes & Development. 21(17):2118-2130
Ghysen, A., Dambly-Chaudiere, C., and Raible, D. (2007) Making sense of zebrafish neural development in the Minervois. Neural Development. 2(1):15
Dambly-Chaudière, C., Cubedo, N., and Ghysen, A. (2007) Control of cell migration in the development of the posterior lateral line: antagonistic interactions between the chemokine receptors CXCR4 and CXCR7/RDC1. BMC Developmental Biology. 7:23
Fame, R.M., Brajon, C., and Ghysen, A. (2006) Second-order projection from the posterior lateral line in the early zebrafish brain. Neural Development. 1:4
Villablanca, E.J., Renucci, A., Sapede, D., Lec, V., Soubiran, F., Sandoval, P.C., Dambly-Chaudiere, C., Ghysen, A., and Allende, M.L. (2006) Control of cell migration in the zebrafish lateral line: Implication of the gene "Tumour-Associated Calcium Signal Transducer," tacstd. Developmental dynamics : an official publication of the American Association of Anatomists. 235(6):1578-1588
Laguerre, L., Soubiran, F., Ghysen, A., Konig, N., and Dambly-Chaudiere, C. (2005) Cell proliferation in the developing lateral line system of zebrafish embryos. Developmental dynamics : an official publication of the American Association of Anatomists. 233(2):466-472
Sapede, D., Rossel, M., Dambly-Chaudiere, C., and Ghysen, A. (2005) Role of SDF1 chemokine in the development of lateral line efferent and facial motor neurons. Proc. Natl. Acad. Sci. USA. 102(5):1714-1718
Pichon, F., and Ghysen, A. (2004) Evolution of posterior lateral line development in fish and amphibians. Evolution & development. 6(3):187-193
Ghysen, A., and Dambly-Chaudiere, C. (2004) Development of the zebrafish lateral line. Current opinion in neurobiology. 14(1):67-73
Ghysen, A. and Dambly-Chaudiere, C. (2003) The development of the nervous system: from fly to fish, from fish to man. Med. Sci.. 19(5):575-581
David, N.B., Sapede, D., Saint-Etienne, L., Thisse, C., Thisse, B., Dambly-Chaudiere, C., Rosa, F.M., and Ghysen, A. (2002) Molecular basis of cell migration in the fish lateral line: role of the chemokine receptor CXCR4 and of its ligand, SDF1. Proc. Natl. Acad. Sci. USA. 99(25):16297-16302
Sapède, D., Gompel, N., Dambly-Chaudière, C., and Ghysen, A. (2002) Cell migration in the postembryonic development of the fish lateral line. Development (Cambridge, England). 129:605-615
Gompel, N., Cubedo, N., Thisse, C., Thisse, B., Dambly-Chaudiere, C., and Ghysen, A. (2001) Pattern formation in the lateral line of zebrafish. Mechanisms of Development. 105(1-2):69-77
Bricaud, O., Chaar, V., Dambly-Chaudiere, C., and Ghysen, A. (2001) Early efferent innervation of the zebrafish lateral line. The Journal of comparative neurology. 434(3):253-261
Gompel, N., Dambly-Chaudière, C., and Ghysen, A. (2001) Neuronal differences prefigure somatotopy in the zebrafish lateral line. Development (Cambridge, England). 128(3):387-393
Alexandre, D. and Ghysen, A. (1999) Somatotopy of the lateral line projection in larval zebrafish. Proc. Natl. Acad. Sci. USA. 96(13):7558-7562

NON-ZEBRAFISH PUBLICATIONS
Alain Ghysen & Christine Dambly-Chaudière (2000)
A genetic programme for neuronal connectivity.
TIG 16: 221-226

Jean-François Brunet & Alain Ghysen (1999)
Deconstructing cell determination: proneural genes and neuronal identity.
BioEssays 21:313-318