ZFIN ID: ZDB-PERS-990223-19
Sun, Zhaoxia
Email: zhaoxia.sun@yale.edu
URL: https://www.sun-lab-yale.org/
Address: Associate Professor Department of Genetics Yale University School of Medicine P.O. Box 208005 333 Cedar Street New Haven, CT 06520-8005 USA
Country: United States
Phone: (203) 785-3589
Fax: (203) 785-7227

Associate Professor, co-director of Graduate Studeis, Department of Genetics, Yale School of Medicine

Li, Y., Xu, W., Jerman, S., Sun, Z. (2019) In vivo analysis of renal epithelial cells in zebrafish. Methods in cell biology. 154:163-181
Merrick, D., Mistry, K., Wu, J., Gresko, N., Baggs, J.E., Hogenesch, J.B., Sun, Z., Caplan, M.J. (2018) Polycystin-1 regulates bone development through an interaction with the transcriptional co-activator taz. Human molecular genetics. 28(1):16-30
Li, Y., Zhao, L., Yuan, S., Zhang, J., Sun, Z. (2017) Axonemal dynein assembly requires the R2TP complex component Pontin. Development (Cambridge, England). 144(24):4684-4693
Jerman, S., Sun, Z. (2017) Using Zebrafish to Study Kidney Development and Disease. Current topics in developmental biology. 124:41-79
Li, Y., Tian, X., Ma, M., Jerman, S., Kong, S., Somlo, S., Sun, Z. (2016) Deletion of ADP Ribosylation Factor-Like GTPase 13B Leads to Kidney Cysts. Journal of the American Society of Nephrology : JASN. 27(12):3628-3638
Soens, Z.T., Li, Y., Zhao, L., Eblimit, A., Dharmat, R., Li, Y., Chen, Y., Naqeeb, M., Fajardo, N., Lopez, I., Sun, Z., Koenekoop, R.K., Chen, R. (2016) Hypomorphic mutations identified in the candidate Leber congenital amaurosis gene CLUAP1. Genetics in medicine : official journal of the American College of Medical Genetics. 18(10):1044-51
Kallakuri, S., Yu, J.A., Li, J., Li, Y., Weinstein, B.M., Nicoli, S., Sun, Z. (2015) Endothelial Cilia Are Essential for Developmental Vascular Integrity in Zebrafish. Journal of the American Society of Nephrology : JASN. 26(4):864-75
Yuan, S., Zhao, L., Brueckner, M., Sun, Z. (2015) Intraciliary Calcium Oscillations Initiate Vertebrate Left-Right Asymmetry. Current biology : CB. 25(5):556-67
Aldahmesh, M.A., Li, Y., Alhashem, A., Anazi, S., Alkuraya, H., Hashem, M., Awaji, A.A., Sogaty, S., Alkharashi, A., Alzahrani, S., Al Hazzaa, S.A., Xiong, Y., Kong, S., Sun, Z., and Alkuraya, F.S. (2014) IFT27, encoding a small GTPase component of IFT particles, is mutated in a consanguineous family with Bardet-Biedl syndrome. Human molecular genetics. 23(12):3307-15
Zariwala, M.A., Gee, H.Y., Kurkowiak, M., Al-Mutairi, D.A., Leigh, M.W., Hurd, T.W., Hjeij, R., Dell, S.D., Chaki, M., Dougherty, G.W., Adan, M., Spear, P.C., Esteve-Rudd, J., Loges, N.T., Rosenfeld, M., Diaz, K.A., Olbrich, H., Wolf, W.E., Sheridan, E., Batten, T.F., Halbritter, J., Porath, J.D., Kohl, S., Lovric, S., Hwang, D.Y., Pittman, J.E., Burns, K.A., Ferkol, T.W., Sagel, S.D., Olivier, K.N., Morgan, L.C., Werner, C., Raidt, J., Pennekamp, P., Sun, Z., Zhou, W., Airik, R., Natarajan, S., Allen, S.J., Amirav, I., Wieczorek, D., Landwehr, K., Nielsen, K., Schwerk, N., Sertic, J., Köhler, G., Washburn, J., Levy, S., Fan, S., Koerner-Rettberg, C., Amselem, S., Williams, D.S., Mitchell, B.J., Drummond, I.A., Otto, E.A., Omran, H., Knowles, M.R., and Hildebrandt, F. (2013) ZMYND10 Is Mutated in Primary Ciliary Dyskinesia and Interacts with LRRC6. American journal of human genetics. 93(2):336-345
Zhao, L., Yuan, S., Cao, Y., Kallakuri, S., Li, Y., Kishimoto, N., Dibella, L., and Sun, Z. (2013) Reptin/Ruvbl2 is a Lrrc6/Seahorse interactor essential for cilia motility. Proceedings of the National Academy of Sciences of the United States of America. 110(31):12697-702
Paavola, J., Schliffke, S., Rossetti, S., Kuo, I.Y., Yuan, S., Sun, Z., Harris, P.C., Torres, V.E., and Ehrlich, B.E. (2013) Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy. Journal of Molecular and Cellular Cardiology. 58:199-208
Yuan, S., Zhao, L., and Sun, Z. (2013) Dissecting the Functional Interplay Between the TOR Pathway and the Cilium in Zebrafish. Methods in enzymology. 525:159-189
Yuan, S., Li, J., Diener, D.R., Choma, M.A., Rosenbaum, J.L., and Sun, Z. (2012) Target-of-rapamycin complex 1 (Torc1) signaling modulates cilia size and function through protein synthesis regulation. Proceedings of the National Academy of Sciences of the United States of America. 109(6):2021-2026
Merrick, D., Chapin, H., Baggs, J.E., Yu, Z., Somlo, S., Sun, Z., Hogenesch, J.B., and Caplan, M.J. (2012) The γ-Secretase Cleavage Product of Polycystin-1 Regulates TCF and CHOP-Mediated Transcriptional Activation through a p300-Dependent Mechanism. Developmental Cell. 22(1):197-210
Li, J., and Sun, Z. (2011) Qilin is essential for cilia assembly and normal kidney development in zebrafish. PLoS One. 6(11):e27365
Malicki, J., Avanesov, A., Li, J., Yuan, S., and Sun, Z. (2011) Analysis of cilia structure and function in zebrafish. Methods (San Diego, Calif.). 101:39-74
Hellman, N.E., Liu, Y., Merkel, E., Austin, C., Le Corre, S., Beier, D.R., Sun, Z., Sharma, N., Yoder, B.K., and Drummond, I.A. (2010) The zebrafish foxj1a transcription factor regulates cilia function in response to injury and epithelial stretch. Proceedings of the National Academy of Sciences of the United States of America. 107(43):18499-18504
Cao, Y., Park, A., and Sun, Z. (2010) Intraflagellar Transport Proteins Are Essential for Cilia Formation and for Planar Cell Polarity. Journal of the American Society of Nephrology : JASN. 21(8):1326-1333
Cao, Y., Semanchik, N., Lee, S.H., Somlo, S., Barbano, P.E., Coifman, R., and Sun, Z. (2009) Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models. Proceedings of the National Academy of Sciences of the United States of America. 106(51):21819-21824
Duldulao, N.A., Lee, S., and Sun, Z. (2009) Cilia localization is essential for in vivo functions of the Joubert syndrome protein Arl13b/Scorpion. Development (Cambridge, England). 136(23):4033-4042
Yuan, S., and Sun, Z. (2009) Microinjection of mRNA and morpholino antisense oligonucleotides in zebrafish embryos. Journal of visualized experiments : JoVE. (27)
Dibella, L.M., Park, A., and Sun, Z. (2009) Zebrafish Tsc1 Reveals Functional Interactions Between the Cilium and the TOR Pathway. Human molecular genetics. 18(4):595-606
Kishimoto, N., Cao, Y., Park, A., and Sun, Z. (2008) Cystic kidney gene seahorse regulates cilia-mediated processes and Wnt pathways. Developmental Cell. 14(6):954-961
Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2005) Submission and curation of data from an insertional mutagenesis screen. ZFIN Direct Data Submission.
Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 101(35):12792-12797
Sun, Z., Amsterdam, A., Pazour, G.J., Cole, D.G., Miller, M.S. and Hopkins, N. (2004) A Genetic Screen in Zebrafish Identifies Cilia Genes as a Principal Cause of Cystic Kidney Development. Development (Cambridge, England). 131(16):4085-4093
Golling, G., Amsterdam, A., Sun, Z., Antonelli, M., Maldonado, E., Chen, W., Burgess, S., Haldi, M., Artzt, K., Farrington, S., Lin, S.Y., Nissen, R.M., and Hopkins, N. (2002) Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development. Nature Genetics. 31(2):135-140
Sun, Z. and Hopkins, N. (2001) vhnf1, the MODY5 and familial GCKD-associated gene, regulates regional specification of the zebrafish gut, pronephros, and hindbrain. Genes & Development. 15(23):3217-3229
Amsterdam, A., Burgess, S., Golling, G., Chen, W., Sun, Z., Townsend, K., Farrington, S., Haldi, M., and Hopkins, N. (1999) A large-scale insertional mutagenesis screen in zebrafish. Genes & Development. 13(20):2713-2724