ZFIN ID: ZDB-PERS-970923-15
Patient, Roger K.
Email: roger.patient@imm.ox.ac.uk
URL: http://www.imm.ox.ac.uk/pages/research/molecular_haematology/roger.htm
Affiliation: Patient Lab
Address: MRC Molecular Haematology Unit Weatherall Institute of Molecular Medicine John Radcliffe Hospital Headington Oxford, OX3 9DS United Kingdom
Country: United Kingdom
Phone: +44 1865 222 613
Fax: 44 1865 222 424


Tamaoki, J., Maeda, H., Kobayashi, I., Takeuchi, M., Ohashi, K., Gore, A., Bonkhofer, F., Patient, R., Weinstein, B.M., Kobayashi, M. (2023) LSD1 promotes the egress of hematopoietic stem and progenitor cells into the bloodstream during the endothelial-to-hematopoietic transition. Developmental Biology. 501:92-103
Koth, J., Wang, X., Killen, A.C., Stockdale, W.T., Potts, H.G., Jefferson, A., Bonkhofer, F., Riley, P.R., Patient, R.K., Göttgens, B., Mommersteeg, M.T.M. (2020) Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration. Development (Cambridge, England). 147(8)
Dobrzycki, T., Mahony, C.B., Krecsmarik, M., Koyunlar, C., Rispoli, R., Peulen-Zink, J., Gussinklo, K., Fedlaoui, B., de Pater, E., Patient, R., Monteiro, R. (2020) Deletion of a conserved Gata2 enhancer impairs haemogenic endothelium programming and adult Zebrafish haematopoiesis. Communications biology. 3:71
Weinberger, M., Simões, F.C., Patient, R., Sauka-Spengler, T., Riley, P.R. (2020) Functional Heterogeneity within the Developing Zebrafish Epicardium. Developmental Cell. 52(5):574-590.e6
Dobrzycki, T., Lalwani, M., Telfer, C., Monteiro, R., Patient, R. (2019) The roles and controls of GATA factors in blood and cardiac development. IUBMB life. 72(1):39-44
Bonkhofer, F., Rispoli, R., Pinheiro, P., Krecsmarik, M., Schneider-Swales, J., Tsang, I.H.C., de Bruijn, M., Monteiro, R., Peterkin, T., Patient, R. (2019) Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium. Nature communications. 10:3577
Dobrzycki, T., Krecsmarik, M., Bonkhofer, F., Patient, R., Monteiro, R. (2018) An optimised pipeline for parallel image-based quantification of gene expression and genotyping after in situ hybridisation.. Biology Open. 7(4)
Koth, J., Maguire, M.L., McClymont, D., Diffley, L., Thornton, V.L., Beech, J., Patient, R.K., Riley, P.R., Schneider, J.E. (2017) High-Resolution Magnetic Resonance Imaging of the Regenerating Adult Zebrafish Heart. Scientific Reports. 7:2917
Ciau-Uitz, A., Patient, R. (2016) The embryonic origins and genetic programming of emerging haematopoietic stem cells. FEBS letters. 590(22):4002-4015
Monteiro, R., Pinheiro, P., Joseph, N., Peterkin, T., Koth, J., Repapi, E., Bonkhofer, F., Kirmizitas, A., Patient, R. (2016) Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells. Developmental Cell. 38(4):358-70
Long, H.K., King, H.W., Patient, R.K., Odom, D.T., Klose, R.J. (2016) Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved. Nucleic acids research. 44(14):6693-706
Gu, W., Monteiro, R., Zuo, J., Simões, F.C., Martella, A., Andrieu-Soler, C., Grosveld, F., Sauka-Spengler, T., Patient, R. (2015) A Novel TGFβ Modulator that Uncouples R-Smad/I-Smad-Mediated Negative Feedback from R-Smad/Ligand-Driven Positive Feedback. PLoS Biology. 13:e1002051
Pouget, C., Peterkin, T., Simões, F.C., Lee, Y., Traver, D., Patient, R. (2014) FGF signalling restricts haematopoietic stem cell specification via modulation of the BMP pathway. Nature communications. 5:5588
Ciau-Uitz, A., Monteiro, R., Kirmizitas, A., Patient, R. (2014) Developmental hematopoiesis: ontogeny, genetic programming and conservation. Experimental hematology. 42(8):669-683
Chatfield, J., O'Reilly, M.A., Bachvarova, R.F., Ferjentsik, Z., Redwood, C., Walmsley, M., Patient, R., Loose, M., Johnson, A.D. (2014) Stochastic specification of primordial germ cells from mesoderm precursors in axolotl embryos. Development (Cambridge, England). 141:2429-40
Gorsi, B., Liu, F., Ma, X., Chico, T.J., Shrinivasan, A., Kramer, K.L., Bridges, E., Monteiro, R., Harris, A.L., Patient, R., and Stringer, S.E. (2014) The heparan sulfate editing enzyme Sulf1 plays a novel role in zebrafish VegfA mediated arterial venous identity. Angiogenesis. 17(1):77-91
Wang, L., Liu, T., Xu, L., Gao, Y., Wei, Y., Duan, C., Chen, G.Q., Lin, S., Patient, R., Zhang, B., Hong, D., and Liu, F. (2013) Fev regulates hematopoietic stem cell development via ERK signaling. Blood. 122(3):367-75
Sacilotto, N., Monteiro, R., Fritzsche, M., Becker, P.W., Sanchez-Del-Campo, L., Liu, K., Pinheiro, P., Ratnayaka, I., Davies, B., Goding, C.R., Patient, R., Bou-Gharios, G., and De Val, S. (2013) Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development. Proceedings of the National Academy of Sciences of the United States of America. 110(29):11893-8
Long, H.K., Sims, D., Heger, A., Blackledge, N.P., Kutter, C., Wright, M.L., Grützner, F., Odom, D.T., Patient, R., Ponting, C.P., and Klose, R.J. (2013) Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates. eLIFE. 2:e00348
Zhang, C., Patient, R., and Liu, F. (2013) Hematopoietic stem cell development and regulatory signaling in zebrafish. Biochimica et biophysica acta. General subjects. 1830(2):2370-2374
Bridge, G., Monteiro, R., Henderson, S., Emuss, V., Lagos, D., Georgopoulou, D., Patient, R., and Boshoff, C. (2012) The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis. Blood. 120(25):5063-5072
van Riel, B., Pakozdi, T., Brouwer, R., Monteiro, R., Tuladhar, K., Franke, V., Bryne, J.C., Jorna, R., Rijkers, E.J., van Ijcken, W., Andrieu-Soler, C., Demmers, J., Patient, R., Soler, E., Lenhard, B., and Grosveld, F. (2012) A Novel Complex, RUNX1-MYEF2, Represses Hematopoietic Genes in Erythroid Cells. Molecular and cellular biology. 32(19):3814-3822
Wilkinson, R.N., Koudijs, M.J., Patient, R.K., Ingham, P.W., Schulte-Merker, S., and van Eeden, F.J. (2012) Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish. Blood. 120(2):477-488
Wang, L., Zhang, P., Wei, Y., Gao, Y., Patient, R., and Liu, F. (2011) A blood flow-dependent klf2a-NO signalling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos. Blood. 118(15):4102-10
Simões, F.C., Peterkin, T., and Patient, R. (2011) Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators. Development (Cambridge, England). 138(15):3235-3245
Monteiro, R., Pouget, C., and Patient, R. (2011) The gata1/pu.1 lineage fate paradigm varies between blood populations and is modulated by tif1γ. The EMBO journal. 30(6):1093-1103
Miller, L.C., Freter, S., Liu, F., Taylor, J.S., Patient, R., and Begbie, J. (2010) Separating early sensory neuron and blood vessel patterning. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(12):3297-3302
Ciau-Uitz, A., Liu, F., and Patient, R. (2010) Genetic control of hematopoietic development in Xenopus and zebrafish. The International journal of developmental biology. 54(6-7):1139-1143
Wilkinson, R.N., Pouget, C., Gering, M., Russell, A.J., Davies, S.G., Kimelman, D., and Patient, R. (2009) Hedgehog and Bmp polarize hematopoietic stem cell emergence in the zebrafish dorsal aorta. Developmental Cell. 16(6):909-916
Peterkin, T., Gibson, A., and Patient, R. (2009) Common genetic control of haemangioblast and cardiac development in zebrafish. Development (Cambridge, England). 136(9):1465-1474
Liu, F., and Patient, R. (2008) Genome-Wide Analysis of the Zebrafish ETS Family Identifies Three Genes Required for Hemangioblast Differentiation or Angiogenesis. Circulation research. 103(10):1147-1154
Liu, F., Walmsley, M., Rodaway, A., and Patient, R. (2008) Fli1 Acts at the Top of the Transcriptional Network Driving Blood and Endothelial Development. Current biology : CB. 18(16):1234-1240
Dee, C.T., Hirst, C.S., Shih, Y.H., Tripathi, V.B., Patient, R.K., and Scotting, P.J. (2008) Sox3 regulates both neural fate and differentiation in the zebrafish ectoderm. Developmental Biology. 320(1):289-301
Monteiro, R., van Dinther, M., Bakkers, J., Wilkinson, R., Patient, R., Ten Dijke, P., and Mummery, C. (2008) Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish. Developmental Biology. 315(1):55-71
Peterkin, T., Gibson, A., and Patient, R. (2007) Redundancy and evolution of GATA factor requirements in development of the myocardium. Developmental Biology. 311(2):623-635
Patterson, L.J., Gering, M., Eckfeldt, C.E., Green, A.R., Verfaillie, C.M., Ekker, S.C., and Patient, R. (2007) The transcription factors, Scl and Lmo2, act together during development of the hemangioblast in zebrafish. Blood. 109(6):2389-2398
Dee, C.T., Gibson, A., Rengifo, A., Sun, S.K., Patient, R.K., and Scotting, P.J. (2007) A change in response to Bmp signalling precedes ectodermal fate choice. The International journal of developmental biology. 51(1):79-84
Meier, N., Krpic, S., Rodriguez, P., Strouboulis, J., Monti, M., Krijgsveld, J., Gering, M., Patient, R., Hostert, A., and Grosveld, F. (2006) Novel binding partners of Ldb1 are required for haematopoietic development. Development (Cambridge, England). 133(24):4913-4923
Patterson, L.J., and Patient, R. (2006) The "Ets" factor: vessel formation in zebrafish--the missing link?. PLoS Biology. 4(1):e24
Patterson, L.J., Gering, M., and Patient, R. (2005) Scl is required for dorsal aorta as well as blood formation in zebrafish embryos. Blood. 105(9):3502-3511
Gering, M., and Patient, R. (2005) Hedgehog Signaling Is Required for Adult Blood Stem Cell Formation in Zebrafish Embryos. Developmental Cell. 8(3):389-400
Pinheiro, P., Gering, M., and Patient, R. (2004) The basic helix-loop-helix transcription factor, Tal2, marks the lateral floor plate of the spinal cord in zebrafish. Gene expression patterns : GEP. 4(1):85-92
Gering, M., Yamada, Y., Rabbitts, T.H., and Patient, R.K. (2003) Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1. Development (Cambridge, England). 130:6287-6199
Peterkin, T., Gibson, A., and Patient, R. (2003) GATA-6 maintains BMP-4 and Nkx2 expression during cardiomyocyte precursor maturation. The EMBO journal. 22(16):4260-4273
Barton, L.M., Gottgens, B., Gering, M., Gilbert, J.G., Grafham, D., Rogers, J., Bentley, D., Patient, R., and Green, A.R. (2001) Regulation of the stem cell leukemia (SCL) gene: a tale of two fishes. Proceedings of the National Academy of Sciences of the United States of America. 98(12):6747-6752
Rodaway, A. and Patient, R. (2001) Mesendoderm: An Ancient Germ Layer?. Cell. 105(2):169-172
Brown, L.A., Rodaway, A.R.F., Schilling, T.F., Jowett, T., Ingham, P.W., Patient, R.K., and Sharrocks, A.D. (2000) Insights into early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in wild-type and mutant zebrafish embryos. Mechanisms of Development. 90(2):237-252
Reiter, J.F., Alexander, J., Rodaway, A., Yelon, D., Patient, R., Holder, N., and Stainier, D.Y. (1999) Gata5 is required for the development of the heart and endoderm in zebrafish. Genes & Development. 13(22):2983-2995
Rodaway, A., Takeda, H., Koshida, S., Broadbent, J., Price, B., Smith, J.C., Patient, R., and Holder, N. (1999) Induction of the mesendoderm in the zebrafish germ ring by yolk cell-derived TGF-ß; family signals and discrimination of mesoderm and endoderm by FGF. Development (Cambridge, England). 126(14):3067-3078
Read, E.M., Rodaway, A.R., Neave, B., Brandon, N., Holder, N., Patient, R.K., and Walmsley, M.E. (1998) Evidence for non-axial A/P patterning in the nonneural ectoderm of Xenopus and zebrafish pregastrula embryos. The International journal of developmental biology. 42:763-774
Gering, M., Rodaway, A.R.F., Göttgens, B., Patient, R.K., and Green, A.R. (1998) The SCL gene specifies haemangioblast development from early mesoderm. The EMBO journal. 17:4029-4045
Neave, B., Holder, N., and Patient, R. (1997) A graded response to BMP-4 spatially coordinates patterning of the mesoderm and ectoderm in the zebrafish. Mechanisms of Development. 62(2):183-195
Griffin, K., Patient, R., and Holder, N. (1995) Analysis of FGF function in normal and no tail zebrafish embryos reveals separate mechanisms for formation of the trunk and the tail. Development (Cambridge, England). 121:2983-2994
Neave, B., Rodaway, A., Wilson, S.W., Patient, R., and Holder, N. (1995) Expression of zebrafish GATA 3 (gta3) during gastrulation and neurulation suggests a role in the specification of cell fate. Mechanisms of Development. 51:169-182
Xu, Q., Holder, N., Patient, R., and Wilson, S.W. (1994) Spatially regulated expression of three receptor tyrosine kinase genes during gastrulation in the zebrafish. Development (Cambridge, England). 120:287-299