ZFIN ID: ZDB-PERS-970429-2
Hans, Stefan
Email: stefan.hans@biotec.tu-dresden.de
Affiliation: Brand Lab
Address: Technische Universitaet Dresden BIOTEChnologisches Zentrum/ CRTD (Centre for Regenerative Therapies) Tatzberg 47/49 Dresden, 01307 Germany
Country: Germany
Phone: +49 (0)351 463 40153
Fax: +49 (0)351 463 40348


Metzkes-Ng, J., Brack, F.E., Kroll, F., Bernert, C., Bock, S., Bodenstein, E., Brand, M., Cowan, T.E., Gebhardt, R., Hans, S., Helbig, U., Horst, F., Jansen, J., Kraft, S.D., Krause, M., Leßmann, E., Löck, S., Pawelke, J., Püschel, T., Reimold, M., Rehwald, M., Richter, C., Schlenvoigt, H.P., Schramm, U., Schürer, M., Seco, J., Szabó, E.R., Umlandt, M.E.P., Zeil, K., Ziegler, T., Beyreuther, E. (2023) The DRESDEN PLATFORM is a research hub for ultra-high dose rate radiobiology. Scientific Reports. 13:2061120611
Celotto, L., Rost, F., Machate, A., Bläsche, J., Dahl, A., Weber, A., Hans, S., Brand, M. (2023) Single-cell RNA sequencing unravels the transcriptional network underlying zebrafish retina regeneration. eLIFE. 12:
Harish, R.K., Gupta, M., Zöller, D., Hartmann, H., Gheisari, A., Machate, A., Hans, S., Brand, M. (2023) Real-time monitoring of endogenous Fgf8a gradient attests to its role as a morphogen during zebrafish gastrulation. Development (Cambridge, England). 150(19):
Ezhkova, D., Schwarzer, S., Spieß, S., Geffarth, M., Machate, A., Zöller, D., Stucke, J., Alexopoulou, D., Lesche, M., Dahl, A., Hans, S. (2023) Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish. Biology Open. 12(6):
Mattonet, K., Riemslagh, F.W., Guenther, S., Prummel, K.D., Kesavan, G., Hans, S., Ebersberger, I., Brand, M., Burger, A., Reischauer, S., Mosimann, C., Stainier, D.Y.R. (2022) Endothelial versus pronephron fate decision is modulated by the transcription factors Cloche/Npas4l, Tal1, and Lmo2. Science advances. 8:eabn2082
Indrischek, H., Hammer, J., Machate, A., Hecker, N., Kirilenko, B., Roscito, J., Hans, S., Norden, C., Brand, M., Hiller, M. (2022) Vision-related convergent gene losses reveal SERPINE3's unknown role in the eye. eLIFE. 11:
Karsch, L., Pawelke, J., Brand, M., Hans, S., Hideghéty, K., Jansen, J., Lessmann, E., Löck, S., Schürer, M., Schurig, R., Seco, J., Szabó, E.R., Beyreuther, E. (2022) Beam pulse structure and dose rate as determinants for the flash effect observed in zebrafish embryo. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 173:49-54
Schwarzer, S., Rekhade, D.R., Machate, A., Spieß, S., Geffarth, M., Ezhkova, D., Hans, S. (2022) Reactivation of the Neurogenic Niche in the Adult Zebrafish Statoacoustic Ganglion Following a Mechanical Lesion. Frontiers in cell and developmental biology. 10:850624
Hammer, J., Röppenack, P., Yousuf, S., Schnabel, C., Weber, A., Zöller, D., Koch, E., Hans, S., Brand, M. (2022) Visual Function is Gradually Restored During Retina Regeneration in Adult Zebrafish. Frontiers in cell and developmental biology. 9:831322
Bertozzi, A., Wu, C.C., Hans, S., Brand, M., Weidinger, G. (2021) Wnt/β-catenin signaling acts cell-autonomously to promote cardiomyocyte regeneration in the zebrafish heart. Developmental Biology. 481:226-237
Suzzi, S., Ahrendt, R., Hans, S., Semenova, S.A., Chekuru, A., Wirsching, P., Kroehne, V., Bilican, S., Sayed, S., Winkler, S., Spieß, S., Machate, A., Kaslin, J., Panula, P., Brand, M. (2021) Deletion of lrrk2 causes early developmental abnormalities and age-dependent increase of monoamine catabolism in the zebrafish brain. PLoS Genetics. 17:e1009794
Hans, S., Zöller, D., Hammer, J., Stucke, J., Spieß, S., Kesavan, G., Kroehne, V., Eguiguren, J.S., Ezhkova, D., Petzold, A., Dahl, A., Brand, M. (2021) Cre-Controlled CRISPR mutagenesis provides fast and easy conditional gene inactivation in zebrafish. Nature communications. 12:1125
Pawelke, J., Brand, M., Hans, S., Hideghéty, K., Karsch, L., Lessmann, E., Löck, S., Schürer, M., Rita Szabó, E., Beyreuther, E. (2021) Electron dose rate and oxygen depletion protect zebrafish embryos from radiation damage. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 158:7-12
Brunner, S., TŐkÉs, T., SzabÓ, E.R., Polanek, R., SzabÓ, I.Z., Reisz, Z., GubÁn, B.K., SzijÁrtÓ, A.L., Brand, M., Hans, S., Karsch, L., Lessmann, E., Pawelke, J., SchÜrer, M., Beyreuther, E., HideghÉty, K. (2020) Dose-dependent Changes After Proton and Photon Irradiation in a Zebrafish Model. Anticancer research. 40:6123-6135
Kesavan, G., Machate, A., Hans, S., Brand, M. (2020) Cell-fate plasticity, adhesion and cell sorting complementarily establish a sharp midbrain-hindbrain boundary. Development (Cambridge, England). 147(11):
Schwarzer, S., Asokan, N., Bludau, O., Kuscha, V., Kaslin, J., Hans, S. (2020) Neurogenesis in the inner ear: the zebrafish statoacoustic ganglion provides new neurons from a Neurod/Nestin-positive progenitor pool well into adulthood. Development (Cambridge, England). 147(7):
Beyreuther, E., Brand, M., Hans, S., Hideghéty, K., Karsch, L., Leßmann, E., Schürer, M., Szabó, E.R., Pawelke, J. (2019) Feasibility of proton FLASH effect tested by zebrafish embryo irradiation. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 139:46-50
Szabó, E.R., Brand, M., Hans, S., Hideghéty, K., Karsch, L., Lessmann, E., Pawelke, J., Schürer, M., Beyreuther, E. (2018) Radiobiological effects and proton RBE determined by wildtype zebrafish embryos. PLoS One. 13:e0206879
Kesavan, G., Hammer, J., Hans, S., Brand, M. (2018) Targeted knock-in of CreER T2 in zebrafish using CRISPR/Cas9.. Cell and tissue research. 372(1):41-50
Ando, K., Shibata, E., Hans, S., Brand, M., Kawakami, A. (2017) Osteoblast Production by Reserved Progenitor Cells in Zebrafish Bone Regeneration and Maintenance. Developmental Cell. 43(5):643-650.e3
Schwarzer, S., Spieß, S., Brand, M., Hans, S. (2017) Dlx3b/4b is required for early-born but not later-forming sensory hair cells during zebrafish inner ear development. Biology Open. 6(9):1270-1278
Kaslin, J., Kroehne, V., Ganz, J., Hans, S., Brand, M. (2017) Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration. Development (Cambridge, England). 144(8):1462-1471
Chekuru, A., Kuscha, V., Hans, S., Brand, M. (2017) Ligand-Controlled Site-Specific Recombination in Zebrafish. Methods in molecular biology (Clifton, N.J.). 1642:87-97
Henninger, J., Santoso, B., Hans, S., Durand, E., Moore, J., Mosimann, C., Brand, M., Traver, D., Zon, L. (2017) Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development. Nature cell biology. 19(1):17-27
Pinzon-Olejua, A., Welte, C., Chekuru, A., Bosak, V., Brand, M., Hans, S., Stuermer, C.A. (2017) Cre inducible site-specific recombination in zebrafish oligodendrocytes. Developmental Dynamics : an official publication of the American Association of Anatomists. 246(1):41-49
Jungke, P., Hans, S., Gupta, M., Machate, A., Zöller, D., Brand, M. (2016) Generation of a conditional lima1a allele in zebrafish using the FLEx switch technology. Genesis (New York, N.Y. : 2000). 54(1):19-28
Jungke, P., Hammer, J., Hans, S., Brand, M. (2015) Isolation of Novel CreERT2-Driver Lines in Zebrafish Using an Unbiased Gene Trap Approach. PLoS One. 10:e0129072
Weber, A., Hochmann, S., Cimalla, P., Gärtner, M., Kuscha, V., Hans, S., Geffarth, M., Kaslin, J., Koch, E., and Brand, M. (2013) Characterization of light lesion paradigms and optical coherence tomography as tools to study adult retina regeneration in zebrafish. PLoS One. 8(11):e80483
de Oliveira-Carlos, V., Ganz, J., Hans, S., Kaslin, J., and Brand, M. (2013) Notch receptor expression in neurogenic regions of the adult zebrafish brain. PLoS One. 8(9):e73384
Jungke, P., Hans, S., and Brand, M. (2013) The Zebrafish CreZoo: An Easy-to-Handle Database for Novel CreERT2-Driver Lines. Zebrafish. 10(3):259-63
Hans, S., Irmscher, A., and Brand, M. (2013) Zebrafish Foxi1 provides a neuronal ground state during inner ear induction preceding the Dlx3b/4b-regulated sensory lineage. Development (Cambridge, England). 140(9):1936-1945
Hochmann, S., Kaslin, J., Hans, S., Weber, A., Machate, A., Geffarth, M., Funk, R.H., and Brand, M. (2012) Fgf Signaling is Required for Photoreceptor Maintenance in the Adult Zebrafish Retina. PLoS One. 7(1):e30365
Kroehne, V., Freudenreich, D., Hans, S., Kaslin, J., and Brand, M. (2011) Regeneration of the adult zebrafish brain from neurogenic radial glia-type progenitors. Development (Cambridge, England). 138(22):4831-4841
Knopf, F., Hammond, C., Chekuru, A., Kurth, T., Hans, S., Weber, C.W., Mahatma, G., Fisher, S., Brand, M., Schulte-Merker, S., and Weidinger, G. (2011) Bone Regenerates via Dedifferentiation of Osteoblasts in the Zebrafish Fin. Developmental Cell. 20(5):713-724
Hans, S., Freudenreich, D., Geffarth, M., Kaslin, J., Machate, A., and Brand, M. (2011) Generation of a non-leaky heat shock-inducible Cre line for conditional Cre/lox strategies in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(1):108-115
Picker, A., Cavodeassi, F., Machate, A., Bernauer, S., Hans, S., Abe, G., Kawakami, K., Wilson, S.W., and Brand, M. (2009) Dynamic coupling of pattern formation and morphogenesis in the developing vertebrate retina. PLoS Biology. 7(10):e1000214
Kaslin, J., Ganz, J., Geffarth, M., Grandel, H., Hans, S., and Brand, M. (2009) Stem cells in the adult zebrafish cerebellum: initiation and maintenance of a novel stem cell niche. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(19):6142-6153
Hans, S., Kaslin, J., Freudenreich, D., and Brand, M. (2009) Temporally-controlled site-specific recombination in zebrafish. PLoS One. 4(2):e4640
Ochi, H., Hans, S., and Westerfield, M. (2008) Smarcd3 regulates the timing of zebrafish myogenesis onset. The Journal of biological chemistry. 283(6):3529-3536
Hans, S., and Westerfield, M. (2007) Changes in retinoic acid signaling alter otic patterning. Development (Cambridge, England). 134(13):2449-2458
Hans, S., Christison, J., Liu, D., and Westerfield, M. (2007) Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b. BMC Developmental Biology. 7(1):5
Hans, S., Liu, D., and Westerfield, M. (2004) Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors. Development (Cambridge, England). 131(20):5091-5102
Hans, S., Scheer, N., Riedl, I., Von Weizsacker, E., Blader, P., and Campos-Ortega, J.A. (2004) her3, a zebrafish member of the hairy-E(spl) family, is repressed by Notch signalling. Development (Cambridge, England). 131(12):2957-2969
Gajewski, M., Sieger, D., Alt, B., Leve, C., Hans, S., Wolff, C., Rohr, K.B., and Tautz, D. (2003) Anterior and posterior waves of cyclic her1 gene expression are differentially regulated in the presomitic mesoderm of zebrafish. Development (Cambridge, England). 130(18):4269-4278
Hans, S. and Campos-Ortega, J.A. (2002) On the organisation of the regulatory region of the zebrafish deltaD gene. Development (Cambridge, England). 129(20):4773-4784
Scheer, N., Groth, A., Hans, S., and Campos-Ortega, J.A. (2001) An instructive function for Notch in promoting gliogenesis in the zebrafish retina. Development (Cambridge, England). 128(7):1099-1107

Beckers, J., Caron, A., Hrabé de Angelis, M., Hans, S., Campos-Ortega, J.A. and Gossler, A. (2000) 'Distinct regulatory elements direct Delta1 expression in the nervous system and paraxial mesoderm of transgenic mice' Mechanisms of Development 95, 23-34