ZFIN ID: ZDB-PERS-970217-4
Cornell, Robert
Email: robert-cornell@uiowa.edu
URL: http://www.anatomy.uiowa.edu/pages/directory/faculty/cornell.asp
Affiliation: Cornell Lab
Address: Department of Anatomy and Cell Biology Roy J. and Lucille A. Carver College of Medicine University of Iowa 1-532 Bowen Science Building 51 Newton Road Iowa City, IA 52242-1109 USA
Country: United States
Phone: (319) 335-8908
Fax: (319) 335-7198

Genetic regulation of neural crest specification and patterning.

Lansdon, L.A., Dickinson, A., Arlis, S., Liu, H., Hlas, A., Hahn, A., Bonde, G., Long, A., Standley, J., Tyryshkina, A., Wehby, G., Lee, N.R., Daack-Hirsch, S., Mohlke, K., Girirajan, S., Darbro, B.W., Cornell, R.A., Houston, D.W., Murray, J.C., Manak, J.R. (2022) Genome-wide analysis of copy number variation in humans with cleft lip and/or cleft palate identifies COBLL1, RIC1, and ARHGEF38 as clefting genes. American journal of human genetics. 110(1):71-91
Kent, M.E., Hu, B., Eggleston, T.M., Squires, R.S., Zimmerman, K.A., Weiss, R.M., Roghair, R.D., Lin, F., Cornell, R.A., Haskell, S.E. (2022) Hypersensitivity of zebrafish htr2b mutant embryos to sertraline indicates a role for serotonin signaling in cardiac development. Journal of Cardiovascular Pharmacology. 80(2):261-269
Kenny, C., Dilshat, R., Seberg, H.E., Van Otterloo, E., Bonde, G., Helverson, A., Franke, C.M., Steingrímsson, E., Cornell, R.A. (2022) TFAP2 paralogs facilitate chromatin access for MITF at pigmentation and cell proliferation genes. PLoS Genetics. 18:e1010207
Sveinsdóttir, H.S., Decker, A., Christensen, C., Lucena, P.B., Þorsteinsson, H., Richert, E., Maier, V.H., Cornell, R., Karlsson, K.Æ. (2022) Motility phenotype in a zebrafish vmat2 mutant. PLoS One. 17:e0259753
Campbell, N.R., Rao, A., Hunter, M.V., Sznurkowska, M.K., Briker, L., Zhang, M., Baron, M., Heilmann, S., Deforet, M., Kenny, C., Ferretti, L.P., Huang, T.H., Perlee, S., Garg, M., Nsengimana, J., Saini, M., Montal, E., Tagore, M., Newton-Bishop, J., Middleton, M.R., Corrie, P., Adams, D.J., Rabbie, R., Aceto, N., Levesque, M.P., Cornell, R.A., Yanai, I., Xavier, J.B., White, R.M. (2021) Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation. Developmental Cell. 56(20):2808-2825.e10
Sturgeon, M.L., Langton, R., Sharma, S., Cornell, R.A., Glykys, J., Bassuk, A.G. (2021) The opioid antagonist naltrexone decreases seizure-like activity in genetic and chemically induced epilepsy models. Epilepsia open. 6:528-538
Baronio, D., Chen, Y.C., Decker, A.R., Enckell, L., Fernández-López, B., Semenova, S., Puttonen, H.A.J., Cornell, R.A., Panula, P. (2021) Vesicular monoamine transporter 2 (SLC18A2) regulates monoamine turnover and brain development in zebrafish. Acta physiologica (Oxford, England). 234(1):e13725
Dilshat, R., Fock, V., Kenny, C., Gerritsen, I., Lasseur, R.M.J., Travnickova, J., Eichhoff, O.M., Cerny, P., Möller, K., Sigurbjörnsdóttir, S., Kirty, K., Einarsdottir, B.Ó., Cheng, P.F., Levesque, M., Cornell, R.A., Patton, E.E., Larue, L., de Tayrac, M., Magnúsdóttir, E., Helga Ögmundsdóttir, M., Steingrimsson, E. (2021) MITF reprograms the extracellular matrix and focal adhesion in melanoma. eLIFE. 10:
Zhang, M., Zhang, J., Zhao, H., Ievlev, V., Zhong, W., Huang, W., Cornell, R.A., Lin, J., Chen, F. (2020) Functional Characterization of a Novel IRF6 Frameshift Mutation From a Van Der Woude Syndrome Family. Frontiers in genetics. 11:562
Liu, H., Duncan, K., Helverson, A., Kumari, P., Mumm, C., Xiao, Y., Carlson, J.C., Darbellay, F., Visel, A., Leslie, E., Breheny, P., Erives, A.J., Cornell, R.A. (2020) Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near human KRT8/18. eLIFE. 9:
Brueggeman, L., Sturgeon, M.L., Martin, R.M., Grossbach, A.J., Nagahama, Y., Zhang, A., Howard, M.A., Kawasaki, H., Wu, S., Cornell, R.A., Michaelson, J.J., Bassuk, A.G. (2018) Drug repositioning in epilepsy reveals novel antiseizure candidates. Annals of clinical and translational neurology. 6:295-309
Weinberg, S.M., Cornell, R., Leslie, E.J. (2018) Craniofacial genetics: Where have we been and where are we going?. PLoS Genetics. 14:e1007438
Duncan, K., Mukherjee, K., Cornell, R.A., Liao, E.C. (2017) Zebrafish models of orofacial clefts. Developmental Dynamics : an official publication of the American Association of Anatomists. 246(11):897-914
Cornell, R., Dorsky, R.I. (2017) Zebrafish as models for developmental disease & repair. Developmental Dynamics : an official publication of the American Association of Anatomists. 246:867
Brophy, P.D., Rasmussen, M., Parida, M., Bonde, G., Darbro, B.W., Hong, X., Clarke, J.C., Peterson, K.A., Denegre, J., Schneider, M., Sussman, C.R., Sunde, L., Lildballe, D.L., Hertz, J.M., Cornell, R.A., Murray, S.A., Manak, J.R. (2017) A Gene Implicated in Activation of Retinoic Acid Receptor Targets is a Novel Renal Agenesis Gene in Humans. Genetics. 207(1):215-228
Eshete, M.A., Liu, H., Li, M., Adeyemo, W.L., Gowans, L.J.J., Mossey, P.A., Busch, T., Deressa, W., Donkor, P., Olaitan, P.B., Aregbesola, B.S., Braimah, R.O., Oseni, G.O., Oginni, F., Audu, R., Onwuamah, C., James, O., Augustine-Akpan, E., Rahman, L.A., Ogunlewe, M.O., Arthur, F.K.N., Bello, S.A., Agbenorku, P., Twumasi, P., Abate, F., Hailu, T., Demissie, Y., Hailu, A., Plange-Rhule, G., Obiri-Yeboah, S., Dunnwald, M.M., Gravem, P.E., Marazita, M.L., Adeyemo, A.A., Murray, J.C., Cornell, R.A., Butali, A. (2017) Loss-of-Function GRHL3 Variants Detected in African Patients with Isolated Cleft Palate. Journal of dental research. 97(1):41-48
Liu, H., Leslie, E.J., Carlson, J.C., Beaty, T.H., Marazita, M.L., Lidral, A.C., Cornell, R.A. (2017) Identification of common non-coding variants at 1p22 that are functional for non-syndromic orofacial clefting. Nature communications. 8:14759
Seberg, H.E., Van Otterloo, E., Loftus, S.K., Liu, H., Bonde, G., Sompallae, R., Gildea, D.E., Santana, J.F., Manak, J.R., Pavan, W.J., Williams, T., Cornell, R.A. (2017) TFAP2 paralogs regulate melanocyte differentiation in parallel with MITF. PLoS Genetics. 13:e1006636
Liu, H., Busch, T., Eliason, S., Anand, D., Bullard, S., Gowans, L.J., Nidey, N., Petrin, A., Augustine-Akpan, E.A., Saadi, I., Dunnwald, M., Lachke, S.A., Zhu, Y., Adeyemo, A., Amendt, B., Roscioli, T., Cornell, R., Murray, J., Butali, A. (2017) Exome sequencing provides additional evidence for the involvement of ARHGAP29 in Mendelian orofacial clefting and extends the phenotypic spectrum to isolated cleft palate. Birth defects research. Part A, Clinical and molecular teratology. 109(1):27-37
Leslie, E.J., Liu, H., Carlson, J.C., Shaffer, J.R., Feingold, E., Wehby, G., Laurie, C.A., Jain, D., Laurie, C.C., Doheny, K.F., McHenry, T., Resick, J., Sanchez, C., Jacobs, J., Emanuele, B., Vieira, A.R., Neiswanger, K., Standley, J., Czeizel, A.E., Deleyiannis, F., Christensen, K., Munger, R.G., Lie, R.T., Wilcox, A., Romitti, P.A., Field, L.L., Padilla, C.D., Cutiongco-de la Paz, E.M., Lidral, A.C., Valencia-Ramirez, L.C., Lopez-Palacio, A.M., Valencia, D.R., Arcos-Burgos, M., Castilla, E.E., Mereb, J.C., Poletta, F.A., Orioli, I.M., Carvalho, F.M., Hecht, J.T., Blanton, S.H., Buxó, C.J., Butali, A., Mossey, P.A., Adeyemo, W.L., James, O., Braimah, R.O., Aregbesola, B.S., Eshete, M.A., Deribew, M., Koruyucu, M., Seymen, F., Ma, L., de Salamanca, J.E., Weinberg, S.M., Moreno, L., Cornell, R.A., Murray, J.C., Marazita, M.L. (2016) A Genome-wide Association Study of Nonsyndromic Cleft Palate Identifies an Etiologic Missense Variant in GRHL3. American journal of human genetics. 98(4):744-54
Liu, H., Leslie, E.J., Jia, Z., Smith, T., Eshete, M., Butali, A., Dunnwald, M., Murray, J., Cornell, R.A. (2016) Irf6 directly regulates Klf17 in zebrafish periderm and Klf4 in murine oral epithelium, and dominant-negative KLF4 variants are present in patients with cleft lip and palate. Human molecular genetics. 25(4):766-76
Lidral, A.C., Liu, H., Bullard, S.A., Bonde, G., Machida, J., Visel, A., Moreno Uribe, L.M., Li, X., Amendt, B., Cornell, R.A. (2015) A Single Nucleotide Polymorphism Associated with Isolated Cleft Lip and Palate, Thyroid Cancer and Hypothyroidism Alters the Activity of an Oral Epithelium and Thyroid Enhancer Near FOXE1. Human molecular genetics. 24(14):3895-907
Azaiez, H., Decker, A.R., Booth, K.T., Simpson, A.C., Shearer, A.E., Huygen, P.L., Bu, F., Hildebrand, M.S., Ranum, P.T., Shibata, S.B., Turner, A., Zhang, Y., Kimberling, W.J., Cornell, R.A., Smith, R.J. (2015) HOMER2, a Stereociliary Scaffolding Protein, Is Essential for Normal Hearing in Humans and Mice. PLoS Genetics. 11:e1005137
Decker, A.R., McNeill, M.S., Lambert, A.M., Overton, J.D., Chen, Y.C., Lorca, R.A., Johnson, N.A., Brockerhoff, S.E., Mohapatra, D.P., Macarthur, H., Panula, P., Masino, M.A., Runnels, L.W., and Cornell, R.A. (2014) Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern. Developmental Biology. 386(2):428-39
Peyrard-Janvid, M., Leslie, E.J., Kousa, Y.A., Smith, T.L., Dunnwald, M., Magnusson, M., Lentz, B.A., Unneberg, P., Fransson, I., Koillinen, H.K., Rautio, J., Pegelow, M., Karsten, A., Basel-Vanagaite, L., Gordon, W., Andersen, B., Svensson, T., Murray, J.C., Cornell, R.A., Kere, J., and Schutte, B.C. (2014) Dominant mutations in GRHL3 cause Van der Woude Syndrome and disrupt oral periderm development. American journal of human genetics. 94(1):23-32
Praetorius, C., Grill, C., Stacey, S.N., Metcalf, A.M., Gorkin, D.U., Robinson, K.C., Van Otterloo, E., Kim, R.S., Bergsteinsdottir, K., Ogmundsdottir, M.H., Magnusdottir, E., Mishra, P.J., Davis, S.R., Guo, T., Zaidi, M.R., Helgason, A.S., Sigurdsson, M.I., Meltzer, P.S., Merlino, G., Petit, V., Larue, L., Loftus, S.K., Adams, D.R., Sobhiafshar, U., Emre, N.C., Pavan, W.J., Cornell, R., Smith, A.G., McCallion, A.S., Fisher, D.E., Stefansson, K., Sturm, R.A., and Steingrimsson, E. (2013) A Polymorphism in IRF4 Affects Human Pigmentation through a Tyrosinase-Dependent MITF/TFAP2A Pathway. Cell. 155(5):1022-1033
Dougherty, M., Kamel, G., Grimaldi, M., Gfrerer, L., Shubinets, V., Ethier, R., Hickey, G., Cornell, R.A., and Liao, E.C. (2013) Distinct requirements for wnt9a and irf6 in extension and integration mechanisms during zebrafish palate morphogenesis. Development (Cambridge, England). 140(1):76-81
de la Garza, G., Schleiffarth, J.R., Dunnwald, M., Mankad, A., Weirather, J.L., Bonde, G., Butcher, S., Mansour, T.A., Kousa, Y.A., Fukazawa, C.F., Houston, D.W., Manak, J.R., Schutte, B.C., Wagner, D.S., and Cornell, R.A. (2013) Interferon Regulatory Factor 6 Promotes Differentiation of the Periderm by Activating Expression of Grainyhead-Like 3. The Journal of investigative dermatology. 133(1):68-77
Van Otterloo, E., Li, W., Garnett, A., Cattell, M., Medeiros, D.M., and Cornell, R.A. (2012) Novel Tfap2-mediated control of soxE expression facilitated the evolutionary emergence of the neural crest. Development (Cambridge, England). 139(4):720-730
Cornell, R.A. (2011) Investigations of the in vivo requirements of transient receptor potential ion channels using frog and zebrafish model systems. Advances in experimental medicine and biology. 704:341-357
Kwon, H.J., Bhat, N., Sweet, E.M., Cornell, R.A., and Riley, B.B. (2010) Identification of early requirements for preplacodal ectoderm and sensory organ development. PLoS Genetics. 6(9):pii: e1001133
Van Otterloo, E., Li, W., Bonde, G., Day, K.M., Hsu, M.Y., and Cornell, R.A. (2010) Differentiation of zebrafish melanophores depends on transcription factors AP2 alpha and AP2 epsilon. PLoS Genetics. 6(9):pii: e1001122
Sabel, J.L., d'Alençon, C., O'Brien, E.K., Otterloo, E.V., Lutz, K., Cuykendall, T.N., Schutte, B.C., Houston, D.W., and Cornell, R.A. (2009) Maternal Interferon Regulatory Factor 6 is required for the differentiation of primary superficial epithelia in Danio and Xenopus embryos. Developmental Biology. 325(1):249-262
McNeill, M.S., Paulsen, J., Bonde, G., Burnight, E., Hsu, M.Y., and Cornell, R.A. (2007) Cell Death of Melanophores in Zebrafish trpm7 Mutant Embryos Depends on Melanin Synthesis. The Journal of investigative dermatology. 127(8):2020-30
Li, W., and Cornell, R.A. (2007) Redundant activities of Tfap2a and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos. Developmental Biology. 304(1):338-354
Nair, S., Li, W., Cornell, R., and Schilling, T.F. (2007) Requirements for Endothelin type-A receptors and Endothelin-1 signaling in the facial ectoderm for the patterning of skeletogenic neural crest cells in zebrafish. Development (Cambridge, England). 134(2):335-345
Lee, L.M., Seftor, E.A., Bonde, G., Cornell, R.A., and Hendrix, M.J. (2005) The fate of human malignant melanoma cells transplanted into zebrafish embryos: Assessment of migration and cell division in the absence of tumor formation. Developmental Dynamics : an official publication of the American Association of Anatomists. 233(4):1560-1570
Elizondo, M.R., Arduini, B.L., Paulsen, J., MacDonald, E.L., Sabel, J.L., Henion, P.D., Cornell, R.A., Parichy, D.M. (2005) Defective Skeletogenesis with Kidney Stone Formation in Dwarf Zebrafish Mutant for trpm7. Current biology : CB. 15(7):667-671
Bateman, M.J., Cornell, R., d'Alencon, C., and Sandra, A. (2004) Expression of the zebrafish Staufen gene in the embryo and adult. Gene expression patterns : GEP. 5(2):273-278
Cornell, R.A., Yemm, E., Bonde, G., Li, W., d'Alencon, C., Wegman, L., Eisen, J., and Zahs, A. (2004) Touchtone promotes survival of embryonic melanophores in zebrafish. Mechanisms of Development. 121(11):1365-1376
O'Brien, E.K., d'Alencon, C., Bonde, G., Li, W., Schoenebeck, J., Allende, M.L., Gelb, B.D., Yelon, D., Eisen, J.S., and Cornell, R.A. (2004) Transcription factor Ap-2alpha is necessary for development of embryonic melanophores, autonomic neurons and pharyngeal skeleton in zebrafish. Developmental Biology. 265(1):246-261
Cornell, R.A. and Eisen, J.S. (2002) Delta/Notch signaling promotes formation of zebrafish neural crest by repressing Neurogenin 1 function. Development (Cambridge, England). 129(11):2639-2648
Cornell, R.A. and Eisen, J.S. (2000) Delta signaling mediates segregation of neural crest and spinal sensory neurons from zebrafish lateral neural plate. Development (Cambridge, England). 127(13):2873-2882
Cornell, R.A. and Ohlen, T.V. (2000) Vnd/nkx, ind/gsh, and msh/msx: conserved regulators of dorsoventral neural patterning?. Current opinion in neurobiology. 10(1):63-71

Cornell, R. A. and Ohlen, T. V. (2000) Vnd/nkx, ind/gsh, and msh/msx: conserved regulators of dorsoventral neural patterning?. Current Opinion in Neurobiology 10: 63-71.

Cornell, R.A., Musci, T.J., and Kimelman, D.K. (1995) FGF is a prospective competence factor for early activin-type signals during Xenopus mesoderm induction. Development 121: 2429-2437.

Cornell, R.A. and Kimelman, D. K. (1994) Activin-mediated mesoderm induction requires FGF. Development 120: 453-462.

Cornell, R.A. and Kimelman, D.K. (1994) Combinatorial signaling in development. Bioessays 16: 577-581.