ZFIN ID: ZDB-PERS-960805-442
Piotrowski, Tatjana
Email: pio@stowers.org
Affiliation: Piotrowski Lab
Address: The Stowers Institute for Medical Research 1000 E. 50th St. Kansas City, MO 64110 USA
Country: United States
Phone: (816) 926-4527

During embryonic development, cells organize themselves into distinct and often complex three-dimensional organs or tissues. In order for proper morphogenesis to occur, a variety of cellular behaviors have to be tightly coordinated (e.g., cell migration, cell-cell adhesion, cell proliferation, cell death, interactions with the environment, changes in cell morphology). Because of this complexity, the molecular and cell biological mechanisms that regulate embryonic morphogenesis remain poorly understood. The central goal of my research is to identify the regulatory mechanisms that orchestrate morphogenetic processes during development and regeneration, and determine how their misregulation can lead to disease.
To dissect complex morphogenetic processes during development and regeneration we identified the zebrafish lateral line as a powerful experimental model. We have been performing genetic screens for mutants with defects in the development of the lateral line and hair cell regeneration and have already isolated approximately 20 mutations. The analysis of some of these mutations has already yielded fundamental insights into mechanisms underlying cell migration and stem cell regulation.

Denans, N., Tran, N.T.T., Swall, M.E., Diaz, D.C., Blanck, J., Piotrowski, T. (2022) An anti-inflammatory activation sequence governs macrophage transcriptional dynamics during tissue injury in zebrafish. Nature communications. 13:5356
Baek, S., Tran, N.T.T., Diaz, D.C., Tsai, Y.Y., Acedo, J.N., Lush, M.E., Piotrowski, T. (2022) Single-cell transcriptome analysis reveals three sequential phases of gene expression during zebrafish sensory hair cell regeneration. Developmental Cell. 57(6):799-819.e6
Peloggia, J., Münch, D., Meneses-Giles, P., Romero-Carvajal, A., Lush, M.E., Lawson, N.D., McClain, M., Pan, Y.A., Piotrowski, T. (2021) Adaptive cell invasion maintains lateral line organ homeostasis in response to environmental changes. Developmental Cell. 56(9):1296-1312.e7
Denans, N., Baek, S., Piotrowski, T. (2019) Comparing Sensory Organs to Define the Path for Hair Cell Regeneration. Annual Review of Cell and Developmental Biology. 35:567-589
Navajas Acedo, J., Voas, M.G., Alexander, R., Woolley, T., Unruh, J.R., Li, H., Moens, C., Piotrowski, T. (2019) PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation. Nature communications. 10:3993
Postlethwait, J.H., Navajas Acedo, J., Piotrowski, T. (2019) Evolutionary Origin and Nomenclature of Vertebrate Wnt11-Family Genes. Zebrafish. 16(5):469-476
Nikaido, M., Acedo, J.N., Hatta, K., Piotrowski, T. (2017) Retinoic acid is required and Fgf, Wnt, and Bmp signaling inhibit posterior lateral line placode induction in zebrafish. Developmental Biology. 431(2):215-225
Nogare, D.D., Nikaido, M., Somers, K., Head, J., Piotrowski, T., Chitnis, A. (2017) In toto imaging of the migrating Zebrafish lateral line primordium at single cell resolution. Developmental Biology. 422(1):14-23
Kozlovskaja-Gumbrienė, A., Yi, R., Alexander, R., Aman, A., Jiskra, R., Nagelberg, D., Knaut, H., McClain, M., Piotrowski, T. (2017) Proliferation-independent regulation of organ size by Fgf/Notch signaling. eLIFE. 6
Venero Galanternik, M., Nikaido, M., Yu, Z., McKinney, S.A., Piotrowski, T. (2016) Localized Gene Induction by Infrared-Mediated Heat Shock. Zebrafish. 13(6):537-540
Venero Galanternik M., Lush, M.E., Piotrowski, T. (2016) Glypican4 Modulates Lateral Line Collective Cell Migration Non Cell-Autonomously. Developmental Biology. 419(2):321-335
Kniss, J.S., Jiang, L., Piotrowski, T. (2016) Insights into sensory hair cell regeneration from the zebrafish lateral line. Current opinion in genetics & development. 40:32-40
Venero Galanternik, M., Navajas Acedo, J., Romero-Carvajal, A., Piotrowski, T. (2016) Imaging collective cell migration and hair cell regeneration in the sensory lateral line. Methods in cell biology. 134:211-56
Duncan, R.N., Panahi, S., Piotrowski, T., Dorsky, R.I. (2015) Identification of Wnt Genes Expressed in Neural Progenitor Zones during Zebrafish Brain Development. PLoS One. 10:e0145810
Jiang, L., Romero-Carvajal, A., Haug, J.S., Seidel, C.W., Piotrowski, T. (2015) Correction to Supporting Information for Jiang et al., Gene-expression analysis of hair cell regeneration in the zebrafish lateral line. Proceedings of the National Academy of Sciences of the United States of America. 112:E6080
Romero-Carvajal, A., Navajas Acedo, J., Jiang, L., Kozlovskaja-Gumbrienė, A., Alexander, R., Li, H., Piotrowski, T. (2015) Regeneration of Sensory Hair Cells Requires Localized Interactions between the Notch and Wnt Pathways. Developmental Cell. 34(3):267-82
Venero Galanternik, M., Kramer, K.L., Piotrowski, T. (2015) Heparan Sulfate Proteoglycans Regulate Fgf Signaling and Cell Polarity during Collective Cell Migration. Cell Reports. 10(30):414-428
Lush, M.E., Piotrowski, T. (2014) Sensory hair cell regeneration in the zebrafish lateral line. Developmental Dynamics : an official publication of the American Association of Anatomists. 243(10):1187-202
Piotrowski, T., Baker, C.V. (2014) The development of lateral line placodes: taking a broader view. Developmental Biology. 389:68-81
Jiang, L., Romero-Carvajal, A., Haug, J.S., Seidel, C.W., Piotrowski, T. (2014) Gene-expression analysis of hair cell regeneration in the zebrafish lateral line. Proceedings of the National Academy of Sciences of the United States of America. 111:E1383-92
Lush, M.E., Piotrowski, T. (2014) ErbB expressing Schwann cells control lateral line progenitor cells via non-cell-autonomous regulation of Wnt/beta-catenin. eLIFE. 3:e01832
Stevenson, T.J., Trinh, T., Kogelschatz, C., Fujimoto, E., Lush, M.E., Piotrowski, T., Brimley, C.J., and Bonkowsky, J.L. (2012) Hypoxia Disruption of Vertebrate CNS Pathfinding through EphrinB2 Is Rescued by Magnesium. PLoS Genetics. 8(4):e1002638
Perlin, J.R., Lush, M.E., Stephens, W.Z., Piotrowski, T., and Talbot, W.S. (2011) Neuronal Neuregulin 1 type III directs Schwann cell migration. Development (Cambridge, England). 138(21):4639-4648
Aman, A., and Piotrowski, T. (2011) Cell-cell signaling interactions coordinate multiple cell behaviors that drive morphogenesis of the lateral line. Cell adhesion & migration. 5(6):499-508
Aman, A., Nguyen, M., and Piotrowski, T. (2011) Wnt/β-catenin dependent cell proliferation underlies segmented lateral line morphogenesis. Developmental Biology. 349(2):470-482
Stephens, W.Z., Senecal, M., Nguyen, M., and Piotrowski, T. (2010) Loss of adenomatous polyposis coli (apc) results in an expanded ciliary marginal zone in the zebrafish eye. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(7):2066-2077
Aman, A., and Piotrowski, T. (2010) Cell migration during morphogenesis. Developmental Biology. 341(1):20-33
Aman, A., and Piotrowski, T. (2009) Multiple signaling interactions coordinate collective cell migration of the posterior lateral line primordium. Cell adhesion & migration. 3(4):365-368
Piotrowski, T. (2009) Cell Signaling during Lateral Line Development. Handbook of Cell Signaling.
Aman, A., and Piotrowski, T. (2008) Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression. Developmental Cell. 15(5):749-761
Kopinke, D., Sasine, J., Swift, J., Stephens, W.Z., and Piotrowski, T. (2006) Retinoic acid is required for endodermal pouch morphogenesis and not for pharyngeal endoderm specification. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(10):2695-2709
Grant, K.A., Raible, D.W., and Piotrowski, T. (2005) Regulation of latent sensory hair cell precursors by glia in the zebrafish lateral line. Neuron. 45(1):69-80
Piotrowski, T., Ahn, D.-G., Schilling, T.F., Nair, S., Ruvinsky, I., Geisler, R., Rauch, G.-J., Haffter, P., Zon, L.I., Zhou, Y., Foott, H., Dawid, I.B., and Ho, R.K. (2003) The zebrafish van gogh mutation disrupts tbx1, which is involved in the DiGeorge deletion syndrome in humans. Development (Cambridge, England). 130(20):5043-5052
Chien, C.-B. and Piotrowski, T. (2002) How the lateral line gets its glia. Trends in neurosciences. 25(11):544-546
Grandel, H., Lun, K., Rauch, G.J., Rhinn, M., Piotrowski, T., Houart, C., Sordino, P., Küchler, A.M., Schulte-Merker, S., Geisler, R., Holder, N., Wilson, S.W., and Brand, M. (2002) Retinoic acid signalling in the zebrafish embryo is necessary during pre-segmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud. Development (Cambridge, England). 129(12):2851-2865
Piotrowski, T. and Nüsslein-Volhard, C. (2000) The endoderm plays an important role in patterning the segmented pharyngeal region in zebrafish (Danio rerio). Developmental Biology. 225(2):339-356
Schilling, T.F., Piotrowski, T., Grandel, H., Brand, M., Heisenberg, C.P., Jiang, Y.J., Beuchle, D., Hammerschmidt, M., Kane, D.A., Mullins, M.C., van Eeden, F.J., Kelsh, R.N., Furutani-Seiki, M., Granato, M., Haffter, P., Odenthal, J., Warga, R.M., Trowe, T., and Nüsslein-Volhard, C. (1996) Jaw and branchial arch mutants in zebrafish. I. Branchial arches. Development (Cambridge, England). 123:329-344
Piotrowski, T., Schilling, T.F., Brand, M., Jiang, Y.J., Heisenberg, C.P., Beuchle, D., Grandel, H., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) Jaw and branchial arch mutants in zebrafish. II. Anterior arches and cartilage differentiation. Development (Cambridge, England). 123:345-356