ZFIN ID: ZDB-PERS-960805-254
Hopkins, Nancy
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Address: The Hopkins lab is no longer in operation. Please see the Lees lab record for current information: ZDB-LAB-141110-4
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BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Zhang, G., Hoersch, S., Amsterdam, A., Whittaker, C.A., Beert, E., Catchen, J.M., Farrington, S., Postlethwait, J.H., Legius, E., Hopkins, N., and Lees, J.A. (2013) Comparative oncogenomic analysis of copy number alterations in human and zebrafish tumors enables cancer driver discovery. PLoS Genetics. 9(8):e1003734
Barresi, M.J., Burton, S., Dipietrantonio, K., Amsterdam, A., Hopkins, N., and Karlstrom, R.O. (2010) Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 239(10):2603-2618
Zhang, G., Hoersch, S., Amsterdam, A., Whittaker, C.A., Lees, J.A., and Hopkins, N. (2010) Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers. Proc. Natl. Acad. Sci. USA. 107(39):16940-16945
Sansam, C.L., Cruz, N.M., Danielian, P.S., Amsterdam, A., Lau, M.L., Hopkins, N., and Lees, J.A. (2010) A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. Genes and Development. 24(2):183-194
Amsterdam, A., Lai, K., Komisarczuk, A.Z., Becker, T.S., Bronson, R.T., Hopkins, N., and Lees, J.A. (2009) Zebrafish Hagoromo Mutants Up-Regulate fgf8 Postembryonically and Develop Neuroblastoma. Molecular cancer research : MCR. 7(6):841-850
Lai, K., Amsterdam, A., Farrington, S., Bronson, R.T., Hopkins, N., and Lees, J.A. (2009) Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 238(1):76-85
MacInnes, A.W., Amsterdam, A., Whittaker, C.A., Hopkins, N., and Lees, J.A. (2008) Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations. Proc. Natl. Acad. Sci. USA. 105(30):10408-10413
Carney, T.J., von der Hardt, S., Sonntag, C., Amsterdam, A., Topczewski, J., Hopkins, N., and Hammerschmidt, M. (2007) Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis. Development (Cambridge, England). 134(19):3461-3471
Sansam, C.L., Shepard, J.L., Lai, K., Ianari, A., Danielian, P.S., Amsterdam, A., Hopkins, N., and Lees, J.A. (2006) DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. Genes and Development. 20(22):3117-3129
Amsterdam, A., and Hopkins, N. (2006) Mutagenesis strategies in zebrafish for identifying genes involved in development and disease. Trends in genetics : TIG. 22(9):473-478
Nissen, R.M., Amsterdam, A., and Hopkins, N. (2006) A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for Endothelin-1 expression. BMC Developmental Biology. 6:28
Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2005) Submission and curation of data from an insertional mutagenesis screen. ZFIN Direct Data Submission.
Hong, J.H., Hwang, E.S., McManus, M.T., Amsterdam, A., Tian, Y., Kalmukova, R., Mueller, E., Benjamin, T., Spiegelman, B.M., Sharp, P.A., Hopkins, N., and Yaffe, M.B. (2005) TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (New York, N.Y.). 309(5737):1074-1078
Sadler, K.C., Amsterdam, A., Soroka, C., Boyer, J., and Hopkins, N. (2005) A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease. Development (Cambridge, England). 132(15):3561-3572
Gross, J.M., Perkins, B.D., Amsterdam, A., Egana, A., Darland, T., Matsui, J.I., Sciascia, S., Hopkins, N., and Dowling, J.E. (2005) Identification of Zebrafish Insertional Mutants with Defects in Visual System Development and Function. Genetics. 170(1):245-261
Amsterdam, A., Nissen, R.M., Sun, Z., Swindell, E., Farrington, S., and Hopkins, N. (2004) Identification of 315 genes essential for early zebrafish development. Proc. Natl. Acad. Sci. USA. 101(35):12792-12797
Sun, Z., Amsterdam, A., Pazour, G.J., Cole, D.G., Miller, M.S. and Hopkins, N. (2004) A Genetic Screen in Zebrafish Identifies Cilia Genes as a Principal Cause of Cystic Kidney Development. Development (Cambridge, England). 131(16):4085-4093
Amsterdam, A., Sadler, K.C., Lai, K., Farrington, S., Bronson, R.T., Lees, J.A., and Hopkins, N. (2004) Many ribosomal protein genes are cancer genes in zebrafish. PLoS Biology. 2(5):E139
Amsterdam, A., and Hopkins, N. (2004) Retroviral-mediated insertional mutagenesis in zebrafish. The Zebrafish: Genetics, Genomics and Informatics, 2nd ed., Methods Cell Biol.. 77:3-20
Nissen, R.M., Yan, J., Amsterdam, A., Hopkins, N., and Burgess, S.M. (2003) Zebrafish foxi one modulates cellular responses to Fgf signaling required for the integrity of ear and jaw patterning. Development (Cambridge, England). 130(11):2543-2554
Yan, Y.-L., Miller, C.T., Nissen, R.M., Singer, A., Liu, D., Kirn, A., Draper, B., Willoughby, J., Morcos, P.A., Amsterdam, A., Chung, B.-C., Westerfield, M., Haffter, P., Hopkins, N., Kimmel, C., and Postlethwait, J.H. (2002) A zebrafish sox9 gene required for cartilage morphogenesis. Development (Cambridge, England). 129(21):5065-5079
Golling, G., Amsterdam, A., Sun, Z., Antonelli, M., Maldonado, E., Chen, W., Burgess, S., Haldi, M., Artzt, K., Farrington, S., Lin, S.Y., Nissen, R.M., and Hopkins, N. (2002) Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development. Nature Genetics. 31(2):135-140
Chen, W.B., Burgess, S., Golling, G., Amsterdam, A., and Hopkins, N. (2002) High-throughput selection of retrovirus producer cell lines leads to markedly improved efficiency of germ line-transmissible insertions in zebra fish. Journal of virology. 76(5):2192-2198
Burgess, S., Reim, G., Chen, W., Hopkins, N., and Brand, M. (2002) The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and for pre-gastrula morphogenesis. Development (Cambridge, England). 129(4):905-916
Raz, E. and Hopkins, N. (2002) Primordial germ-cell development in zebrafish. Results Probl. Cell Diff.. 40:166-179
Sun, Z. and Hopkins, N. (2001) vhnf1, the MODY5 and familial GCKD-associated gene, regulates regional specification of the zebrafish gut, pronephros, and hindbrain. Genes and Development. 15(23):3217-3229
Chen, W., Burgess, S., and Hopkins, N. (2001) Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity. Development (Cambridge, England). 128(12):2385-2396
Wiellette, E., Grinblat, Y., Austen, M., Hopkins, N., and Sive, H. (2001) An insertional screen for identification of genes required for neural induction and patterning in the zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(5):A1071
Kawakami, K., Amsterdam, A., Shimoda, N., Becker, T., Mugg, J., Shima, A., and Hopkins, N. (2000) Proviral insertions in the zebrafish hagoromo gene, encoding an F-box/WD40-repeat protein, cause stripe pattern anomalies. Current biology : CB. 10(8):463-466
Talbot, W.S. and Hopkins, N. (2000) Zebrafish mutations and functional analysis of the vertebrate genome. Genes and Development. 14(7):755-762
Burgess, S. and Hopkins, N. (2000) Use of pseudotyped retroviruses in zebrafish as genetic tags. Methods Enzymol.. 327:145-161
Amsterdam, A., Burgess, S., Golling, G., Chen, W., Sun, Z., Townsend, K., Farrington, S., Haldi, M., and Hopkins, N. (1999) A large-scale insertional mutagenesis screen in zebrafish. Genes and Development. 13(20):2713-2724
Amsterdam, A. and Hopkins, N. (1999) Retrovirus-mediated insertional mutagenesis in zebrafish. In The Zebrafish: Genetics and Genomics, H.W. Detrich, III, M. Westerfield, and L.I. Zon, eds., San Diego, CA: Academic Press, Methods Cell Biol.. 60:87-98
Becker, T.S., Burgess, S.M., Amsterdam, A.H., Allende, M.L., and Hopkins, N. (1998) not really finished is crucial for development of the zebrafish outer retina and encodes a transcription factor highly homologous to human Nuclear Respiratory Factor-1 and avian Initiation Binding Repressor. Development (Cambridge, England). 125:4369-4378
Hopkins, N. (1998) A large scale insertional mutagenesis screen in zebrafish - a progress report. Proceedings of the EMBO Workshop on Reproduction & Early Development Conference. :62
Yoon, C., Kawakami, K., and N. Hopkins (1997) Zebrafish vasa homologue RNA is localized to the cleavage planes of 2- and 4-cell-stage embryos and is expressed in the primordial germ cells. Development (Cambridge, England). 124(16):3157-3165
Sakai, N., Burgess, S., and Hopkins, N. (1997) Delayed in vitro fertilization of zebrafish eggs in Hank's saline containing bovine serum albumin. Molecular marine biology and biotechnology. 6(2):84-87
Willett, C.E., Zapata, A.G., Hopkins, N.A., and Steiner, L.A. (1997) Expression of zebrafish rag genes during early development identifies the thymus. Developmental Biology. 182(2):331-341
Amsterdam, A., Yoon, C., Allende, M., Becker, T., Kawakami, K., Burgess, S., Gaiano, N., and Hopkins, N. (1997) Retrovirus-mediated insertional mutagenesis in zebrafish and identification of a molecular marker for embryonic germ cells. Cold Spring Harbor symposia on quantitative biology. 62:437-450
Allende, M.L., Amsterdam, A., Becker, T., Kawakami, K., Gaiano, N., and Hopkins, N. (1996) Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development. Genes and Development. 10(24):3141-3155
Haffter, P., Odenthal, J., Mullins, M.C., Lin, S., Farrell, M.J., Vogelsang, E., Haas, F., Brand, M., van Eeden, F.J.M., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Hopkins, N., and Nüsslein-Volhard, C. (1996) Mutations affecting pigmentation and shape of the adult zebrafish. Development genes and evolution. 206(4):260-276
Gaiano, N., Amsterdam, A., Kawakami, K., Allende, M., Becker, T., and Hopkins, N. (1996) Insertional mutagenesis and rapid cloning of essential genes in zebrafish. Nature. 383(6603):829-832
Gaiano, N. and Hopkins, N. (1996) Introducing genes into zebrafish. Biochim. Biophys. Acta. Rev. Cancer. 1288(1):011-014
Gaiano, N., Allende, M., Amsterdam, A., Kawakami, K., and Hopkins, N. (1996) Highly efficient germ-line transmission of proviral insertions in zebrafish. Proc. Natl. Acad. Sci. USA. 93(15):7777-7782
Kawakami, K. and Hopkins, N. (1996) Rapid identification of transgenic zebrafish. Trends in genetics : TIG. 12:9-10
Amsterdam, A., Lin, S., Moss, L.G., and Hopkins, N. (1996) Requirements for green fluorescent protein detection in transgenic zebrafish embryos. Gene. 173(1 Spec No):99-103
Amsterdam, A., Lin, S., and Hopkins, N. (1995) The Aequorea victoria green fluorescent protein can be used as a reporter in live zebrafish embryos. Developmental Biology. 171:123-129
Lin, S., Gaiano, N., Culp, P., Burns, J.C., Friedmann, T., Yee, J.K., and Hopkins, N. (1994) Integration and germ-line transmission of a pseudotyped retroviral vector in zebrafish. Science (New York, N.Y.). 265(5172):666-669
Lin, S., Yang, S., and Hopkins, N. (1994) lacZ expression in germline transgenic zebrafish can be detected in living embryos. Developmental Biology. 161:77-83
Lin, S., Long, W., Chen, J., and Hopkins, N. (1992) Production of germ-line chimeras in zebrafish by cell transplants from genetically pigmented to albino embryos. Proc. Natl. Acad. Sci. USA. 89:4519-4523
Rossant, J. and Hopkins, N. (1992) Of fin and fur: mutational analysis of vertebrate embryonic development. Genes and Development. 6:1-13
Culp, P., Nüsslein-Volhard, C., and Hopkins, N. (1991) High-frequency germ-line transmission of plasmid DNA sequences injected into fertilized zebrafish eggs. Proc. Natl. Acad. Sci. USA. 88:7953-7957

NON-ZEBRAFISH PUBLICATIONS