ZFIN ID: ZDB-PERS-120625-1
Otis, Jessica P.
Email: otis@ciwemb.edu
URL: http://emb.carnegiescience.edu/labs/farber/index.php
Affiliation: Farber Lab
Address: Carnegie Institution 3520 San Martin Dr. Baltimore MD 21218 USA
Country: United States
Phone: 410 246 3028
Fax: 410 243 6311

I am interested in elucidating the role of intestinal caveolae in nutrient processing and systemic metabolism. Additionally, I investigate apolipoprotein metabolism.

I earned my Ph.D. from the University of Wisconsin-Madison in 2011 and am currently a postdoc in the Farber lab at the Carnegie Institution.

Otis, J.P., Shen, M.C., Caldwell, B.A., Reyes Gaido, O.E., Farber, S.A. (2019) Dietary cholesterol and apolipoprotein A-I are trafficked in endosomes and lysosomes in the live zebrafish intestine. American journal of physiology. Gastrointestinal and liver physiology. 316(3):G350-G365
Otis, J.P., Shen, M.C., Quinlivan, V., Anderson, J.L., Farber, S.A. (2017) Intestinal epithelial cell Caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels. Disease models & mechanisms. 10(3):283-295
Otis, J.P., Farber, S.A. (2016) High-fat Feeding Paradigm for Larval Zebrafish: Feeding, Live Imaging, and Quantification of Food Intake. Journal of visualized experiments : JoVE. (116)
Otis, J.P., Zeituni, E.M., Thierer, J.H., Anderson, J.L., Brown, A.C., Boehm, E.D., Cerchione, D.M., Ceasrine, A.M., Avraham-Davidi, I., Tempelhof, H., Yaniv, K., Farber, S.A. (2015) Zebrafish as a model for apolipoprotein biology: Comprehensive expression analysis and a role for ApoA-IV in regulating food intake. Disease models & mechanisms. 8(3):295-309
Otis, J.P., and Farber, S.A. (2013) Imaging vertebrate digestive function and lipid metabolism in vivo.. Drug Discovery Today: Disease Models. 10(1):e11-e16

Cholesterol and lipoprotein dynamics in a hibernating mammal. Otis JP, Sahoo D, Drover VA, Yen CL, Carey HV. PLoS One. 2011;6(12):e29111. Epub 2011 Dec 15.

Induction of torpor: mimicking natural metabolic suppression for biomedical applications. Bouma HR, Verhaag EM, Otis JP, Heldmaier G, Swoap SJ, Strijkstra AM, Henning RH, Carey HV. J Cell Physiol. 2012 Apr;227(4):1285-90. doi: 10.1002/jcp.22850. Review.

Cholecystokinin activation of central satiety centers changes seasonally in a mammalian hibernator. Otis JP, Raybould HE, Carey HV. Gen Comp Endocrinol. 2011 May 1;171(3):269-74. Epub 2011 Mar 21.

Global analysis of circulating metabolites in hibernating ground squirrels. Nelson CJ, Otis JP, Carey HV. Comp Biochem Physiol Part D Genomics Proteomics. 2010 Dec;5(4):265-73. Epub 2010 Jul 30.

Identification of qRT-PCR reference genes for analysis of opioid gene expression in a hibernator. Otis JP, Ackermann LW, Denning GM, Carey HV. J Comp Physiol B. 2010 Apr;180(4):619-29. Epub 2009 Dec 23.

A role for nuclear receptors in mammalian hibernation. Nelson CJ, Otis JP, Carey HV. J Physiol. 2009 May 1;587(Pt 9):1863-70. Epub 2009 Mar 16. Review.

Analysis of the hibernation cycle using LC-MS-based metabolomics in ground squirrel liver. Nelson CJ, Otis JP, Martin SL, Carey HV. Physiol Genomics. 2009 Mar 3;37(1):43-51. Epub 2008 Dec 23.

Intergenerational transmission of glucose intolerance and obesity by in utero undernutrition in mice. Jimenez-Chillaron JC, Isganaitis E, Charalambous M, Gesta S, Pentinat-Pelegrin T, Faucette RR, Otis JP, Chow A, Diaz R, Ferguson-Smith A, Patti ME. Diabetes. 2009 Feb;58(2):460-8. Epub 2008 Nov 18.

Hypoxic ventilatory responses in rats after hypercapnic hyperoxia and intermittent hyperoxia. Bavis RW, Russell KE, Simons JC, Otis JP. Respir Physiol Neurobiol. 2007 Mar 15;155(3):193-202. Epub 2006 Jun 23.

Reductions in caloric intake and early postnatal growth prevent glucose intolerance and obesity associated with low birthweight. Jimenez-Chillaron JC, Hernandez-Valencia M, Lightner A, Faucette RR, Reamer C, Przybyla R, Ruest S, Barry K, Otis JP, Patti ME. Diabetologia. 2006 Aug;49(8):1974-84. Epub 2006 Jun 8.

Respiratory plasticity after perinatal hypercapnia in rats. Bavis RW, Johnson RA, Ording KM, Otis JP, Mitchell GS. Respir Physiol Neurobiol. 2006 Aug;153(1):78-91. Epub 2005 Dec 9.