ZFIN ID: ZDB-PERS-070129-1
Huttenlocher, Anna
Email: huttenlocher@wisc.edu
URL: http://www.medmicro.wisc.edu/department/faculty/huttenlocher.html
Affiliation: Huttenlocher Lab
Address: Madison, WI USA
Country: United States
Phone: 608-265-4669
Fax: 608-262-1257


Samimi, K., Desa, D.E., Lin, W., Weiss, K., Li, J., Huisken, J., Miskolci, V., Huttenlocher, A., Chacko, J.V., Velten, A., Rogers, J.D., Eliceiri, K.W., Skala, M.C. (2023) Light-sheet autofluorescence lifetime imaging with a single-photon avalanche diode array. Journal of Biomedical Optics. 28:066502066502
Robertson, T.F., Hou, Y., Schrope, J., Shen, S., Rindy, J., Sauer, J.D., Dinh, H.Q., Huttenlocher, A. (2023) A tessellated lymphoid network provides whole-body T cell surveillance in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 120:e2301137120e2301137120
Schoen, T.J., Calise, D.G., Bok, J.W., Giese, M.A., Nwagwu, C.D., Zarnowski, R., Andes, D., Huttenlocher, A., Keller, N.P. (2023) Aspergillus fumigatus transcription factor ZfpA regulates hyphal development and alters susceptibility to antifungals and neutrophil killing during infection. PLoS pathogens. 19:e1011152e1011152
Dieterich, P., Lindemann, O., Moskopp, M.L., Tauzin, S., Huttenlocher, A., Klages, R., Chechkin, A., Schwab, A. (2022) Anomalous diffusion and asymmetric tempering memory in neutrophil chemotaxis. PLoS Computational Biology. 18:e1010089
Miskolci, V., Tweed, K.E., Lasarev, M.R., Britt, E.C., Walsh, A.J., Zimmerman, L.J., McDougal, C.E., Cronan, M.R., Fan, J., Sauer, J.D., Skala, M.C., Huttenlocher, A. (2022) In vivo fluorescence lifetime imaging of macrophage intracellular metabolism during wound responses in zebrafish. eLIFE. 11:
Korte, B.G., Giese, M.A., Ramakrishnan, G., Ma, S., Bennin, D., Rindy, J., Dewey, C.N., Huttenlocher, A. (2022) Cell Type-Specific Transcriptome Profiling Reveals a Role for Thioredoxin During Tumor Initiation. Frontiers in immunology. 13:818893
Houseright, R.A., Miskolci, V., Mulvaney, O., Bortnov, V., Mosher, D.F., Rindy, J., Bennin, D.A., Huttenlocher, A. (2021) Myeloid-derived growth factor regulates neutrophil motility in interstitial tissue damage. The Journal of cell biology. 220(8):
Horton, M.V., Johnson, C.J., Zarnowski, R., Andes, B.D., Schoen, T.J., Kernien, J.F., Lowman, D., Kruppa, M.D., Ma, Z., Williams, D.L., Huttenlocher, A., Nett, J.E. (2021) Candida auris Cell Wall Mannosylation Contributes to Neutrophil Evasion through Pathways Divergent from Candida albicans and Candida glabrata. mSphere. 6(3):e0040621
Barros-Becker, F., Squirrell, J.M., Burke, R., Chini, J., Rindy, J., Karim, A., Eliceiri, K.W., Gibson, A., Huttenlocher, A. (2020) Distinct Tissue Damage and Microbial Cues Drive Neutrophil and Macrophage Recruitment to Thermal Injury. iScience. 23:101699
Houseright, R.A., Rosowski, E.E., Lam, P.Y., Tauzin, S.J.M., Mulvaney, O., Dewey, C.N., Huttenlocher, A. (2020) Cell type specific gene expression profiling reveals a role for complement component C3 in neutrophil responses to tissue damage. Scientific Reports. 10:15716
Bastos, R.W., Valero, C., Silva, L.P., Schoen, T., Drott, M., Brauer, V., Silva-Rocha, R., Lind, A., Steenwyk, J.L., Rokas, A., Rodrigues, F., Resendiz-Sharpe, A., Lagrou, K., Marcet-Houben, M., Gabaldón, T., McDonnell, E., Reid, I., Tsang, A., Oakley, B.R., Loures, F.V., Almeida, F., Huttenlocher, A., Keller, N.P., Ries, L.N.A., Goldman, G.H. (2020) Functional Characterization of Clinical Isolates of the Opportunistic Fungal Pathogen Aspergillus nidulans. mSphere. 5(2):
Golenberg, N., Squirrell, J.M., Bennin, D.A., Rindy, J., Pistono, P.E., Eliceiri, K.W., Shelef, M.A., Kang, J., Huttenlocher, A. (2020) Citrullination regulates wound responses and tissue regeneration in zebrafish. The Journal of cell biology. 219(4):
de Oliveira, S., Houseright, R.A., Korte, B.G., Huttenlocher, A. (2020) DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of Fibrolamellar Carcinoma. Disease models & mechanisms. 13(4):
Blachowicz, A., Raffa, N., Bok, J.W., Choera, T., Knox, B., Lim, F.Y., Huttenlocher, A., Wang, C.C.C., Venkateswaran, K., Keller, N.P. (2020) Contributions of Spore Secondary Metabolites to UV-C Protection and Virulence Vary in Different Aspergillus fumigatus Strains. mBio. 11(1):
Rosowski, E.E., He, J., Huisken, J., Keller, N.P., Huttenlocher, A. (2019) Efficacy of voriconazole against A. fumigatus infection depends on host immune function. Antimicrobial Agents and Chemotherapy. 64(2):
Schoen, T.J., Rosowski, E.E., Knox, B.P., Bennin, D., Keller, N.P., Huttenlocher, A. (2019) Neutrophil phagocyte oxidase activity controls invasive fungal growth and inflammation in zebrafish. Journal of Cell Science. 133(5):
Hsu, A.Y., Wang, D., Liu, S., Lu, J., Syahirah, R., Bennin, D.A., Huttenlocher, A., Umulis, D.M., Wan, J., Deng, Q. (2019) Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration. Proceedings of the National Academy of Sciences of the United States of America. 116(37):18561-18570
Miskolci, V., Squirrell, J., Rindy, J., Vincent, W., Sauer, J.D., Gibson, A., Eliceiri, K.W., Huttenlocher, A. (2019) Distinct inflammatory and wound healing responses to complex caudal fin injuries of larval zebrafish. eLIFE. 8:
Tsai, T.Y., Collins, S.R., Chan, C.K., Hadjitheodorou, A., Lam, P.Y., Lou, S.S., Yang, H.W., Jorgensen, J., Ellett, F., Irimia, D., Davidson, M.W., Fischer, R.S., Huttenlocher, A., Meyer, T., Ferrell, J.E., Theriot, J.A. (2019) Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization. Developmental Cell. 49:189-205.e6
de Oliveira, S., Houseright, R.A., Graves, A.L., Golenberg, N., Korte, B.G., Miskolci, V., Huttenlocher, A. (2018) Metformin modulates innate immune-mediated inflammation and early progression of NAFLD-associated hepatocellular carcinoma in zebrafish. Journal of hepatology. 70(4):710-721
Rosowski, E.E., Knox, B.P., Archambault, L.S., Huttenlocher, A., Keller, N.P., Wheeler, R.T., Davis, J.M. (2018) The Zebrafish as a Model Host for Invasive Fungal Infections. Journal of fungi (Basel, Switzerland). 4(4)
Powell, D., Lou, M., Barros Becker, F., Huttenlocher, A. (2018) Cxcr1 mediates recruitment of neutrophils and supports proliferation of tumor-initiating astrocytes in vivo. Scientific Reports. 8:13285
Fischer, R.S., Lam, P.Y., Huttenlocher, A., Waterman, C.M. (2018) Filopodia and focal adhesions: An integrated system driving branching morphogenesis in neuronal pathfinding and angiogenesis. Developmental Biology. 451(1):86-95
Johnson, C.J., Davis, J.M., Huttenlocher, A., Kernien, J.F., Nett, J.E. (2018) Emerging Fungal Pathogen Candida auris Evades Neutrophil Attack. mBio. 9(4)
Rosowski, E.E., Raffa, N., Knox, B.P., Golenberg, N., Keller, N.P., Huttenlocher, A. (2018) Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing. PLoS pathogens. 14:e1007229
Jain, S., Sekonyela, R., Knox, B., Palmer, J.M., Huttenlocher, A., Kabbage, M., Keller, N.P. (2018) Selenate sensitivity of a laeA mutant is restored by overexpression of the bZIP protein MetR in Aspergillus fumigatus. Fungal genetics and biology : FG & B. 117:1-10
LeBert, D., Squirrell, J.M., Freisinger, C., Rindy, J., Golenberg, N., Frecentes, G., Gibson, A., Eliceiri, K.W., Huttenlocher, A. (2018) Damage-induced reactive oxygen species regulate vimentin and dynamic collagen-based projections to mediate wound repair.. eLIFE. 7:e30703
Huemer, K., Squirrell, J.M., Swader, R., Pelkey, K., LeBert, D.C., Huttenlocher, A., Eliceiri, K.W. (2017) Long-term Live Imaging Device for Improved Experimental Manipulation of Zebrafish Larvae. Journal of visualized experiments : JoVE. (128)
Barros-Becker, F., Lam, P.Y., Fisher, R., Huttenlocher, A. (2017) Live imaging reveals distinct modes of neutrophil and macrophage migration within interstitial tissues. Journal of Cell Science. 130(22):3801-3808
Knox, B.P., Huttenlocher, A., Keller, N.P. (2017) Real-time visualization of immune cell clearance of Aspergillus fumigatus spores and hyphae. Fungal genetics and biology : FG & B. 105:52-54
Vincent, W.J.B., Harvie, E.A., Sauer, J.D., Huttenlocher, A. (2017) Neutrophil derived LTB4 induces macrophage aggregation in response to encapsulated Streptococcus iniae infection. PLoS One. 12:e0179574
Powell, D., Tauzin, S., Hind, L.E., Deng, Q., Beebe, D.J., Huttenlocher, A. (2017) Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues. Cell Reports. 19:1572-1585
Huemer, K., Squirrell, J.M., Swader, R., LeBert, D.C., Huttenlocher, A., Eliceiri, K.W. (2017) zWEDGI: Wounding and Entrapment Device for Imaging Live Zebrafish Larvae. Zebrafish. 14(1):42-50
Rosowski, E.E., Deng, Q., Keller, N.P., Huttenlocher, A. (2016) Rac2 Functions in Both Neutrophils and Macrophages To Mediate Motility and Host Defense in Larval Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 197(12):4780-4790
Knox, B.P., Blachowicz, A., Palmer, J.M., Romsdahl, J., Huttenlocher, A., Wang, C.C., Keller, N.P., Venkateswaran, K. (2016) Characterization of Aspergillus fumigatus Isolates from Air and Surfaces of the International Space Station.. mSphere. 1(5)
Davis, J.M., Huang, M., Botts, M.R., Hull, C.M., Huttenlocher, A. (2016) A Zebrafish Model of Cryptococcal Infection Reveals Roles for Macrophages, Endothelial Cells and Neutrophils in the Establishment and Control of Sustained Fungemia. Infection and Immunity. 84(10):3047-62
Vincent, W.J., Freisinger, C.M., Lam, P.Y., Huttenlocher, A., Sauer, J.D. (2016) Macrophages mediate flagellin induced inflammasome activation and host defense in zebrafish. Cellular Microbiology. 18(4):591-604
LeBert, D.C., Squirrell, J.M., Huttenlocher, A., Eliceiri, K.W. (2016) Second harmonic generation microscopy in zebrafish. Methods in cell biology. 133:55-68
Harvie, E.A., Huttenlocher, A. (2015) Neutrophils in host defense: new insights from zebrafish. Journal of Leukocyte Biology. 98(4):523-37
Rosowski, E.E., Huttenlocher, A. (2015) Neutrophils, wounds, and cancer progression. Developmental Cell. 34:134-6
LeBert, D.C., Squirrell, J.M., Rindy, J., Broadbridge, E., Lui, Y., Zakrzewska, A., Eliceiri, K.W., Meijer, A.H., Huttenlocher, A. (2015) Matrix metalloproteinase 9 modulates collagen matrices and wound repair. Development (Cambridge, England). 142(12):2136-46
Jing, L., Tamplin, O.J., Chen, M.J., Deng, Q., Patterson, S., Kim, P.G., Durand, E.M., McNeil, A., Green, J.M., Matsuura, S., Ablain, J., Brandt, M.K., Schlaeger, T.M., Huttenlocher, A., Daley, G.Q., Ravid, K., Zon, L.I. (2015) Adenosine signaling promotes hematopoietic stem and progenitor cell emergence. The Journal of experimental medicine. 212(5):649-63
Harvie, E.A., Huttenlocher, A. (2015) Non-invasive Imaging of the Innate Immune Response in a Zebrafish Larval Model of Streptococcus iniae Infection. Journal of visualized experiments : JoVE. (98)
Lam, P.Y., Mangos, S., Green, J.M., Reiser, J., Huttenlocher, A. (2015) In vivo imaging and characterization of actin microridges. PLoS One. 10:e0115639
Tauzin, S., Starnes, T.W., Becker, F.B., Lam, P.Y., Huttenlocher, A. (2014) Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration. The Journal of cell biology. 207:589-98
Freisinger, C.M., Huttenlocher, A. (2014) Live Imaging and Gene Expression Analysis in Zebrafish Identifies a Link between Neutrophils and Epithelial to Mesenchymal Transition. PLoS One. 9:e112183
Knox, B.P., Deng, Q., Rood, M., Eickhoff, J.C., Keller, N.P., Huttenlocher, A. (2014) Distinct Innate Immune Phagocyte Responses to Aspergillus fumigatus Conidia and Hyphae in Zebrafish Larvae. Eukaryotic Cell. 13(10):1266-77
LeBert, D.C., Huttenlocher, A. (2014) Inflammation and wound repair. Seminars in immunology. 26(4):315-320
Lam, P.Y., Fischer, R.S., Shin, W.D., Waterman, C.M., and Huttenlocher, A. (2014) Spinning disk confocal imaging of neutrophil migration in zebrafish. Methods in molecular biology (Clifton, N.J.). 1124:219-233
Lam, P.Y., Harvie, E.A., and Huttenlocher, A. (2013) Heat shock modulates neutrophil motility in zebrafish. PLoS One. 8(12):e84436
Shelef, M.A., Tauzin, S., and Huttenlocher, A. (2013) Neutrophil migration: moving from zebrafish models to human autoimmunity. Immunological reviews. 256(1):269-281
Bischel, L.L., Mader, B.R., Green, J.M., Huttenlocher, A., and Beebe, D.J. (2013) Zebrafish Entrapment By Restriction Array (ZEBRA) device: a low-cost, agarose-free zebrafish mounting technique for automated imaging. Lab on a Chip. 13(9):1732-1736
Deng, Q., Sarris, M., Bennin, D.A., Green, J.M., Herbomel, P., and Huttenlocher, A. (2013) Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish. Journal of Leukocyte Biology. 93(5):761-9
Dagliyan, O., Shirvanyants, D., Karginov, A.V., Ding, F., Fee, L., Chandrasekaran, S.N., Freisinger, C.M., Smolen, G.A., Huttenlocher, A., Hahn, K.M., and Dokholyan, N.V. (2013) Rational design of a ligand-controlled protein conformational switch. Proceedings of the National Academy of Sciences of the United States of America. 110(17):6800-4
Harvie, E.A., Green, J.M., Neely, M.N., and Huttenlocher, A. (2013) Innate Immune Response to Streptococcus iniae Infection in Zebrafish Larvae. Infection and Immunity. 81(1):110-121
Berthier, E., Lim, F.Y., Deng, Q., Guo, C.J., Kontoyiannis, D.P., Wang, C.C., Rindy, J., Beebe, D.J., Huttenlocher, A., and Keller, N.P. (2013) Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites. PLoS pathogens. 9(4):e1003289
Yoo, S.K., Lam, P.Y., Eichelberg, M.R., Zasadil, L., Bement, W.M., and Huttenlocher, A. (2012) The role of microtubules in neutrophil polarity and migration in live zebrafish. Journal of Cell Science. 125(23):5702-5710
Lam, P.Y., Yoo, S.K., Green, J.M., and Huttenlocher, A. (2012) The SH2-domain-containing inositol 5-phosphatase (SHIP) limits neutrophil motility and wound recruitment in zebrafish. Journal of Cell Science. 125(21):4973-4978
Yoo, S.K., Freisinger, C.M., Lebert, D.C., and Huttenlocher, A. (2012) Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish. The Journal of cell biology. 199(2):225-234
Deng, Q., and Huttenlocher, A. (2012) Leukocyte migration from a fish eye's view. Journal of Cell Science. 125(17):3949-3956
Starnes, T.W., and Huttenlocher, A. (2012) Neutrophil Reverse Migration Becomes Transparent with Zebrafish. Advances in hematology. 2012:398640
Yoo, S.K., Starnes, T.W., Deng, Q., and Huttenlocher, A. (2011) Lyn is a redox sensor that mediates leukocyte wound attraction in vivo. Nature. 480(7375):109-12
Deng, Q., Yoo, S.K., Cavnar, P.J., Green, J.M., and Huttenlocher, A. (2011) Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue. Developmental Cell. 21(4):735-745
Yoo, S.K., and Huttenlocher, A. (2011) Spatiotemporal photolabeling of neutrophil trafficking during inflammation in live zebrafish. Journal of Leukocyte Biology. 89(5):661-667
Walters, K.B., Green, J.M., Surfus, J.C., Yoo, S.K., and Huttenlocher, A. (2010) Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome. Blood. 116(15):2803-2811
Yoo, S.K., Deng, Q., Cavnar, P.J., Wu, Y.I., Hahn, K.M., and Huttenlocher, A. (2010) Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish. Developmental Cell. 18(2):226-236
Mathias, J.R., Dodd, M.E., Walters, K.B., Yoo, S.K., Ranheim, E.A., and Huttenlocher, A. (2009) Characterization of Zebrafish Larval Inflammatory Macrophages. Developmental and comparative immunology. 33(11):1212-1217
Dodd, M.E., Hatzold, J., Mathias, J.R., Walters, K.B., Bennin, D.A., Rhodes, J., Kanki, J.P., Look, A.T., Hammerschmidt, M., and Huttenlocher, A. (2009) The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish. Development (Cambridge, England). 136(15):2591-2600
Yoo, S.K., and Huttenlocher, A. (2009) Innate immunity: wounds burst H2O2 signals to leukocytes. Current biology : CB. 19(14):R553-R555
Brannon, M.K., Davis, J.M., Mathias, J.R., Hall, C.J., Emerson, J.C., Crosier, P.S., Huttenlocher, A., Ramakrishnan, L., and Moskowitz, S.M. (2009) Pseudomonas aeruginosa Type III secretion system interacts with phagocytes to modulate systemic infection of zebrafish embryos. Cellular Microbiology. 11(5):755-768
Szabady, R.L., Lokuta, M.A., Walters, K.B., Huttenlocher, A., and Welch, R.A. (2009) Modulation of Neutrophil Function by a Secreted Mucinase of Escherichia coli O157:H7. PLoS pathogens. 5(2):e1000320
Walters, K.B., Dodd, M.E., Mathias, J.R., Gallagher, A.J., Bennin, D.A., Rhodes, J., Kanki, J.P., Look, A.T., Grinblat, Y., and Huttenlocher, A. (2009) Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish fad24. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(1):86-99
Mathias, J.R., Walters, K.B., and Huttenlocher, A. (2009) Neutrophil motility in vivo using zebrafish. Methods in molecular biology (Clifton, N.J.). 571:151-166
Aleström, P., Begemann, G., Carvan, M.J. 3rd, Cheng, K.C., Crosier, K., Crosier, P., Ekker, S., Huttenlocher, A., Kawakami, K., Kelly, G., Korzh, V., Lieschke, G., Mione, M., Neely, M.N., Neuhauss, S., and Trede, N.S. (2008) Views on four key questions about zebrafish research. Zebrafish. 5(1):9-24
Mathias, J.R., Dodd, M.E., Walters, K.B., Rhodes, J., Kanki, J.P., Look, A.T., and Huttenlocher, A. (2007) Live imaging of chronic inflammation caused by mutation of zebrafish Hai1. Journal of Cell Science. 120(19):3372-3383
Clay, H., Davis, J.M., Beery, D., Huttenlocher, A., Lyons, S.E., and Ramakrishnan, L. (2007) Dichotomous role of the macrophage in early Mycobacterium marinum infection of the zebrafish. Cell Host & Microbe. 2(1):29-39
Mathias, J.R., Perrin, B.J., Liu, T.X., Kanki, J., Look, A.T., and Huttenlocher, A. (2006) Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish. Journal of Leukocyte Biology. 80(6):1281-1288