ZFIN ID: ZDB-PERS-050519-15
Berman, Jason
Email: jberman@cheo.on.ca
URL: http://bermanzebrafishlab.com/
Affiliation: Berman Lab
Address: Chief Executive Officer and Scientific Director, CHEO Research Institute Vice President Research, CHEO Professor of Pediatrics, University of Ottawa Attending Staff, Division of Hematology/Oncology CHEO 401 Smyth Road, Ottawa, ONK1H 8L1
Country: Canada
Phone: 613-737-7600 x 2957


Prykhozhij, S.V., Berman, J.N. (2024) Mutation Knock-in Methods Using Single-Stranded DNA and Gene Editing Tools in Zebrafish. Methods in molecular biology (Clifton, N.J.). 2707:279303279-303
Pietrobon, A., Yockell-Lelièvre, J., Melong, N., Smith, L.J., Delaney, S.P., Azzam, N., Xue, C., Merwin, N., Lian, E., Camacho-Magallanes, A., Doré, C., Musso, G., Julian, L.M., Kristof, A.S., Tam, R.Y., Berman, J.N., Shoichet, M.S., Stanford, W.L. (2023) Tissue-Engineered Disease Modeling of Lymphangioleiomyomatosis Exposes a Therapeutic Vulnerability to HDAC Inhibition. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 10(26):e2302611
MacLean, J.E., Wertman, J.N., Prykhozhij, S.V., Chedrawe, E., Langley, S., Steele, S.L., Ban, K., Blake, K., Berman, J.N. (2023) phox2ba: The Potential Genetic Link behind the Overlap in the Symptomatology between CHARGE and Central Congenital Hypoventilation Syndromes. Genes. 14(5):
Laroche, F.J.F., Li, S., Shen, N., Hwang, S.K., Nguyen, G., Yu, W., Wong, C.K., Quinton, R.J., Berman, J.N., Liu, C.T., Singh, A., Ganem, N.J., Thiagalingam, S., Feng, H. (2023) S1P1 Threonine 236 Phosphorylation Mediates the Invasiveness of Triple-Negative Breast Cancer and Sensitivity to FTY720. Cells. 12(7):
Prykhozhij, S.V., Caceres, L., Ban, K., Cordeiro-Santanach, A., Nagaraju, K., Hoffman, E.P., Berman, J.N. (2023) Loss of calpain3b in Zebrafish, a Model of Limb-Girdle Muscular Dystrophy, Increases Susceptibility to Muscle Defects Due to Elevated Muscle Activity. Genes. 14(2):
Biggs, C.M., Cordeiro-Santanach, A., Prykhozhij, S.V., Deveau, A.P., Lin, Y., Del Bel, K.L., Orben, F., Ragotte, R.J., Saferali, A., Mostafavi, S., Dinh, L., Dai, D., Weinacht, K.G., Dobbs, K., Ott de Bruin, L., Sharma, M., Tsai, K., Priatel, J.J., Schreiber, R.A., Rozmus, J., Hosking, M.C., Shopsowitz, K.E., McKinnon, M.L., Vercauteren, S., Seear, M., Notarangelo, L.D., Lynn, F.C., Berman, J.N., Turvey, S.E. (2022) Human JAK1 gain of function causes dysregulated myelopoeisis and severe allergic inflammation. JCI insight. 7(24):
McKeown, B.T., Relja, N.J., Hall, S.R., Gebremeskel, S., MacLeod, J.M., Veinotte, C., Bennett, L.G., Ohlund, L.B., Sleno, L., Jakeman, D.L., Berman, J.N., Johnston, B., Goralski, K.B. (2022) Pilot Study of Jadomycin B Pharmacokinetics and Anti-Tumoral Effects in Zebrafish Larvae and Mouse Breast Cancer Xenograft Models. Canadian journal of physiology and pharmacology. 100(11):1065-1076
Piccolo, O., Lincoln, J.D., Melong, N., Orr, B.C., Fernandez, N.R., Borsavage, J., Berman, J.N., Robar, J., Ha, M.N. (2022) Radiation dose enhancement using gold nanoparticles with a diamond linear accelerator target: a multiple cell type analysis. Scientific Reports. 12:1559
Rajan, V., Collett, K., Woodside, R., Prykhozhij, S.V., Moksa, M., Carles, A., Wong, M., Liebman, M., Hirst, M., Berman, J.N. (2021) Stress hematopoiesis induces a proliferative advantage in TET2 deficiency. Leukemia. 36(3):809-820
Adane, B., Alexe, G., Seong, B.K.A., Lu, D., Hwang, E.E., Hnisz, D., Lareau, C.A., Ross, L., Lin, S., Dela Cruz, F.S., Richardson, M., Weintraub, A.S., Wang, S., Iniguez, A.B., Dharia, N.V., Conway, A.S., Robichaud, A.L., Tanenbaum, B., Krill-Burger, J.M., Vazquez, F., Schenone, M., Berman, J.N., Kung, A.L., Carr, S.A., Aryee, M.J., Young, R.A., Crompton, B.D., Stegmaier, K. (2021) STAG2 loss rewires oncogenic and developmental programs to promote metastasis in Ewing sarcoma. Cancer Cell. 39:827-844.e10
Kobar, K., Collett, K., Prykhozhij, S.V., Berman, J.N. (2021) Zebrafish Cancer Predisposition Models. Frontiers in cell and developmental biology. 9:660069
Wertman, J.N., Melong, N., Stoyek, M.R., Piccolo, O., Langley, S., Orr, B., Steele, S.L., Razaghi, B., Berman, J.N. (2020) The identification of dual protective agents against cisplatin-induced oto-and nephrotoxicity using the zebrafish model. eLIFE. 9:
Prykhozhij, S.V., Cordeiro-Santanach, A., Caceres, L., Berman, J.N. (2020) Genome Editing in Zebrafish Using High-Fidelity Cas9 Nucleases: Choosing the Right Nuclease for the Task. Methods in molecular biology (Clifton, N.J.). 2115:385-405
Pringle, E.S., Wertman, J., Melong, N., Coombs, A.J., Young, A.L., O'Leary, D., Veinotte, C., Robinson, C.A., Ha, M.N., Dellaire, G., Druley, T.E., McCormick, C., Berman, J.N. (2019) The Zebrafish Xenograft Platform-A Novel Tool for Modeling KSHV-Associated Diseases. Viruses. 12(1):
Rajan, V., Melong, N., Wong, W.H., King, B., Tong, R.S., Mahajan, N., Gaston, D., Lund, T., Rittenberg, D., Dellaire, G., Campbell, C.J.V., Druley, T., Berman, J.N. (2019) Humanized zebrafish enhance human hematopoietic stem cell survival and promote acute myeloid leukemia clonal diversity. Haematologica. 105(10):2391-2399
Caceres, L., Prykhozhij, S.V., Cairns, E., Gjerde, H., Duff, N.M., Collett, K., Ngo, M., Nasrallah, G.K., McMaster, C.R., Litvak, M., Robitaille, J.M., Berman, J.N. (2019) Frizzled 4 regulates ventral blood vessel remodeling in the zebrafish retina. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(12):1243-1256
Prykhozhij, S.V., Berman, J.N. (2018) Zebrafish knock-ins swim into the mainstream. Disease models & mechanisms. 11(10)
Prykhozhij, S.V., Fuller, C., Steele, S.L., Veinotte, C.J., Razaghi, B., Robitaille, J.M., McMaster, C.R., Shlien, A., Malkin, D., Berman, J.N. (2018) Optimized knock-in of point mutations in zebrafish using CRISPR/Cas9. Nucleic acids research.
Prykhozhij, S.V., Fuller, C., Steele, S.L., Veinotte, C.J., Razaghi, B., Robitaille, J.M., McMaster, C.R., Shlien, A., Malkin, D., Berman, J.N. (2018) Optimized knock-in of point mutations in zebrafish using CRISPR/Cas9. Nucleic acids research. 46(17):e102
Cloney, K., Steele, S.L., Stoyek, M.R., Croll, R.P., Smith, F.M., Prykhozhij, S.V., Brown, M.M., Midgen, C., Blake, K., Berman, J.N. (2018) Etiology and functional validation of gastrointestinal motility dysfunction in a zebrafish model of CHARGE syndrome. The FEBS journal. 285(11):2125-2140
Strynatka, K.A., Gurrola-Gal, M.C., Berman, J.N., McMaster, C.R. (2018) How Surrogate and Chemical Genetics in Model Organisms Can Suggest Therapies for Human Genetic Diseases. Genetics. 208:833-851
Arumuggam, N., Melong, N., Too, C.K., Berman, J.N., Rupasinghe, H.V. (2017) Phloridzin docosahexaenoate, a novel flavonoid derivative, suppresses growth and induces apoptosis in T-cell acute lymphoblastic leukemia cells. American journal of cancer research. 7:2452-2464
Prykhozhij, S.V., Caceres, L., Berman, J.N. (2017) New Developments in CRISPR/Cas-based Functional Genomics and their Implications for Research using Zebrafish. Current gene therapy. 17(4):286-300
Leung, A.W.Y., Veinotte, C.J., Melong, N., Oh, M.H., Chen, K.T.J., Enfield, K., Backstrom, I., Warburton, C., Yapp, D.T., Berman, J.N., Bally, M.B., Lockwood, W.W. (2017) In Vivo Validation of PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) as a Cisplatin-sensitizing Therapeutic Target.. Clinical cancer research : an official journal of the American Association for Cancer Research. 23(21):6555-6566
Melong, N., Steele, S., MacDonald, M., Holly, A., Collins, C.C., Zoubeidi, A., Berman, J.N., Dellaire, G. (2017) Enzalutamide inhibits testosterone-induced growth of human prostate cancer xenografts in zebrafish and can induce bradycardia. Scientific Reports. 7(1):14698
Razaghi, B., Steele, S.L., Prykhozhij, S.V., Stoyek, M.R., Hill, J.A., Cooper, M.D., McDonald, L., Lin, W., Daugaard, M., Crapoulet, N., Chacko, S., Lewis, S., Scott, I.C., Sorensen, P.H.B., Berman, J.N. (2017) hace1 influences zebrafish cardiac development via ROS-dependent mechanisms. Developmental Dynamics : an official publication of the American Association of Anatomists. 247(2):289-303
Corkery, D.P., Clarke, L.E., Gebremeskel, S., Salsman, J., Pinder, J., Le Page, C., Meunier, L., Xu, Z., Mes-Masson, A.M., Berman, J.N., Johnston, B., Dellaire, G. (2017) Loss of PRP4K drives anoikis resistance in part by dysregulation of epidermal growth factor receptor endosomal trafficking. Oncogene. 37(2):174-184
Prykhozhij, S.V., Steele, S.L., Razaghi, B., Berman, J.N. (2017) A rapid and effective method for screening, sequencing and reporter verification of engineered frameshift mutations in zebrafish. Disease models & mechanisms. 10(6):811-822
Deveau, A.P., Bentley, V.L., Berman, J.N. (2017) Using zebrafish models of leukemia to streamline drug screening and discovery. Experimental hematology. 45:1-9
Couturier, A.M., Fleury, H., Patenaude, A.M., Bentley, V.L., Rodrigue, A., Coulombe, Y., Niraj, J., Pauty, J., Berman, J.N., Dellaire, G., Di Noia, J.M., Mes-Masson, A.M., Masson, J.Y. (2016) Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction. Nucleic acids research. 44(22):10879-10897
Moore, J.C., Mulligan, T.S., Torres Yordán, N., Castranova, D., Pham, V.N., Tang, Q., Lobbardi, R., Anselmo, A., Liwski, R.S., Berman, J.N., Sadreyev, R.I., Weinstein, B.M., Langenau, D.M. (2016) T cell immune deficiency in zap70 mutant zebrafish. Molecular and cellular biology. 36(23):2868-2876
LeBlanc, M.A., Bettle, A., Berman, J.N., Price, V.E., Pambrun, C., Yu, Z., Tiller, M., McMaster, C.R., Fernandez, C.V. (2016) Study of Glycine and Folic Acid Supplementation to Ameliorate Transfusion Dependence in Congenital SLC25A38 Mutated Sideroblastic Anemia. Pediatric blood & cancer. 63(7):1307-9
Sultana, S., Truong, N.Y., Vieira, D.B., Wigger, J.G., Forrester, A.M., Veinotte, C.J., Berman, J.N., van der Spoel, A.C. (2016) Characterization of the Zebrafish Homolog of β-Glucosidase 2: A Target of the Drug Miglustat. Zebrafish. 13(3):177-87
Fernández-Murray, J.P., Prykhozhij, S.V., Dufay, J.N., Steele, S.L., Gaston, D., Nasrallah, G.K., Coombs, A.J., Liwski, R.S., Fernandez, C.V., Berman, J.N., McMaster, C.R. (2016) Glycine and Folate Ameliorate Models of Congenital Sideroblastic Anemia. PLoS Genetics. 12:e1005783
Rajan, V., Dellaire, G., Berman, J.N. (2016) Modeling Leukemogenesis in the Zebrafish Using Genetic and Xenograft Models. Methods in molecular biology (Clifton, N.J.). 1451:171-89
Wertman, J., Veinotte, C.J., Dellaire, G., Berman, J.N. (2016) The Zebrafish Xenograft Platform: Evolution of a Novel Cancer Model and Preclinical Screening Tool. Advances in experimental medicine and biology. 916:289-314
Dhanraj, S., Gunja, S.M., Deveau, A.P., Nissbeck, M., Boonyawat, B., Coombs, A.J., Renieri, A., Mucciolo, M., Marozza, A., Buoni, S., Turner, L., Li, H., Jarrar, A., Sabanayagam, M., Kirby, M., Shago, M., Pinto, D., Berman, J.N., Scherer, S.W., Virtanen, A., Dror, Y. (2015) Bone marrow failure and developmental delay caused by mutations in poly(A)-specific ribonuclease (PARN). Journal of Medical Genetics. 52(11):738-48
Deveau, A.P., Forrester, A.M., Coombs, A.J., Wagner, G.S., Grabher, C., Chute, I.C., Léger, D., Mingay, M., Alexe, G., Rajan, V., Liwski, R., Hirst, M., Steigmaier, K., Lewis, S.M., Look, A.T., Berman, J.N. (2015) Epigenetic therapy restores normal hematopoiesis in a zebrafish model of NUP98-HOXA9-induced myeloid disease. Leukemia. 29(10):2086-97
Prykhozhij, S.V., Rajan, V., Gaston, D., Berman, J.N. (2015) CRISPR MultiTargeter: A Web Tool to Find Common and Unique CRISPR Single Guide RNA Targets in a Set of Similar Sequences. PLoS One. 10:e0119372
Da'as, S.I., Balci, T.B., Berman, J.N. (2015) Mast cell development and function in the zebrafish. Methods in molecular biology (Clifton, N.J.). 1220:29-57
Bentley, V.L., Veinotte, C.J., Corkery, D.P., Pinder, J.B., LeBlanc, M.A., Bedard, K., Weng, A.P., Berman, J.N., Dellaire, G. (2015) Focused Chemical Genomics Using Zebrafish Xenotransplantation As A Pre-Clinical Therapeutic Platform For T-Cell Acute Lymphoblastic Leukemia. Haematologica. 100(1):70-6
Liu, Y., Asnani, A., Zou, L., Bentley, V.L., Yu, M., Wang, Y., Dellaire, G., Sarkar, K.S., Dai, M., Chen, H.H., Sosnovik, D.E., Shin, J.T., Haber, D.A., Berman, J.N., Chao, W., Peterson, R.T. (2014) Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase. Science Translational Medicine. 6:266ra170
Balci, T.B., Prykhozhij, S.V., Teh, E.M., Da'as, S.I., McBride, E., Liwski, R., Chute, I.C., Leger, D., Lewis, S.M., Berman, J.N. (2014) A transgenic zebrafish model expressing KIT-D816V recapitulates features of aggressive systemic mastocytosis. British journal of haematology. 167(1):48-61
Prykhozhij, S.V., and Berman, J.N. (2014) The progress and promise of zebrafish as a model to study mast cells. Developmental and comparative immunology. 46(1):74-83
Tang, Q., Abdelfattah, N.S., Blackburn, J.S., Moore, J.C., Martinez, S.A., Moore, F.E., Lobbardi, R., Tenente, I.M., Ignatius, M.S., Berman, J.N., Liwski, R.S., Houvras, Y., Langenau, D.M. (2014) Optimized cell transplantation using adult rag2 mutant zebrafish. Nature Methods. 11(8):821-4
Veinotte, C.J., Dellaire, G., Berman, J.N. (2014) Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era. Disease models & mechanisms. 7:745-754
Steele, S.L., Prykhozhij, S.V., and Berman, J.N. (2014) Zebrafish as a model system for mitochondrial biology and diseases: a review. Translational research : the journal of laboratory and clinical medicine. 163(2):79-98
Smithen, D.A., Forrester, A.M., Corkery, D.P., Dellaire, G., Colpitts, J., McFarland, S.A., Berman, J.N., and Thompson, A. (2013) Investigations regarding the utility of prodigiosenes to treat leukemia. Organic & biomolecular chemistry. 11(1):62-68
Daugaard, M., Nitsch, R., Razaghi, B., McDonald, L., Jarrar, A., Torrino, S., Castillo-Lluva, S., Rotblat, B., Li, L., Malliri, A., Lemichez, E., Mettouchi, A., Berman, J.N., Penninger, J.M., and Sorensen, P.H. (2013) Hace1 controls ROS generation of vertebrate Rac1-dependent NADPH oxidase complexes. Nature communications. 4:2180
Konantz, M., Balci, T.B., Hartwig, U.F., Dellaire, G., André, M.C., Berman, J.N., and Lengerke, C. (2012) Zebrafish xenografts as a tool for in vivo studies on human cancer. Annals of the New York Academy of Sciences. 1266(1):124-137
Da'as, S.I., Coombs, A.J., Balci, T.B., Grondin, C.A., Ferrando, A.A., and Berman, J.N. (2012) The zebrafish reveals dependence of the mast cell lineage on Notch signaling in vivo. Blood. 119(15):3585-3594
Berman, J., Payne, E., and Hall, C. (2012) The zebrafish as a tool to study hematopoiesis, human blood diseases, and immune function. Advances in hematology. 2012:425345
Forrester, A.M., Berman, J.N., and Payne, E.M. (2012) Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish. Advances in hematology. 2012:358518
Forrester, A.M., Grabher, C., McBride, E.R., Boyd, E.R., Vigerstad, M.H., Edgar, A., Kai, F.B., Da'as, S.I., Payne, E., Look, A.T., and Berman, J.N. (2011) NUP98-HOXA9-transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis. British journal of haematology. 155(2):167-81
Corkery, D.P., Dellaire, G., and Berman, J.N. (2011) Leukaemia xenotransplantation in zebrafish - chemotherapy response assay in vivo. British journal of haematology. 153(6):786-789
Da'as, S., Teh, E.M., Dobson, J.T., Nasrallah, G.K., McBride, E.R., Wang, H., Neuberg, D.S., Marshall, J.S., Lin, T.J., and Berman, J.N. (2011) Zebrafish mast cells possess an FcepsilonRI-like receptor and participate in innate and adaptive immune responses. Developmental and comparative immunology. 35(1):125-134
Pillay, L.M., Forrester, A.M., Erickson, T., Berman, J.N., and Waskiewicz, A.J. (2010) The Hox cofactors Meis1 and Pbx act upstream of gata1 to regulate primitive hematopoiesis. Developmental Biology. 340(2):306-317
Klein, L.C., Yeung, P.K., and Berman, J.N. (2009) Cladribine inhibits a diltiazem-induced increase in red blood cell purine nucleotide concentrations in a zebrafish model. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 14(8):554-559
Dobson, J.T., Da'as, S., McBride, E.R., and Berman, J.N. (2009) Fluorescence-activated cell sorting (FACS) of whole mount in situ hybridization (WISH) labelled haematopoietic cell populations in the zebrafish. British journal of haematology. 144(5):732-735
Dobson, J.T., Seibert, J., Teh, E.M., Daas, S., Fraser, R.B., Paw, B.H., Lin, T.J., and Berman, J.N. (2008) Carboxypeptidase A5 identifies a novel mast cell lineage in the zebrafish providing new insight into mast cell fate determination. Blood. 112(7):2969-2972
Berman, J.N., Kanki, J.P., and Look, A.T. (2005) Zebrafish as a model for myelopoiesis during embryogenesis. Experimental hematology. 33(9):997-1006
Hsu, K., Traver, D., Kutok, J.L., Hagen, A., Liu, T.X., Paw, B.H., Rhodes, J., Berman, J., Zon, L.I., Kanki, J.P., and Look, A.T. (2004) The pu.1 promoter drives myeloid gene expression in zebrafish. Blood. 104(5):1291-1297
Berman, J., Hsu, K., and Look, A.T. (2003) Zebrafish as a model organism for blood diseases. British journal of haematology. 123(4):568-576