PUBLICATION
Using zebrafish models of leukemia to streamline drug screening and discovery
- Authors
- Deveau, A.P., Bentley, V.L., Berman, J.N.
- ID
- ZDB-PUB-161011-7
- Date
- 2017
- Source
- Experimental hematology 45: 1-9 (Review)
- Registered Authors
- Bentley, Victoria, Berman, Jason, Deveau, Adam
- Keywords
- none
- MeSH Terms
-
- Disease Models, Animal
- Drug Evaluation, Preclinical*
- Animals
- Humans
- Antineoplastic Agents/pharmacology*
- Antineoplastic Agents/therapeutic use
- Drug Discovery*
- Leukemia/drug therapy
- Xenograft Model Antitumor Assays
- Zebrafish*
- High-Throughput Screening Assays*
- Animals, Genetically Modified
- Genomics/methods
- Phenotype
- PubMed
- 27720937 Full text @ Exp. Hematol.
Citation
Deveau, A.P., Bentley, V.L., Berman, J.N. (2017) Using zebrafish models of leukemia to streamline drug screening and discovery. Experimental hematology. 45:1-9.
Abstract
Current treatment strategies for acute leukemias largely rely on nonspecific cytotoxic drugs that result in high therapy-related morbidity and mortality. Cost effective, pertinent animal models are needed to link in vitro studies with the development of new therapeutic agents in clinical trials on a high-throughput scale. However, targeted therapies have had limited success moving from bench-to-clinic, often due to unexpected off-target effects. The zebrafish has emerged as a reliable in vivo tool for modeling human leukemia. Zebrafish genetic and xenograft models of acute leukemia provide an unprecedented opportunity to conduct rapid phenotype-based screens. This prospect allows for the identification of relevant therapies, while simultaneously evaluating drug toxicity, circumventing the limitations of target-centric approaches.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping