ZFIN Person: Sun, Yonghua

ZFIN ID: ZDB-PERS-021126-3

ZFIN ID: ZDB-PERS-021126-3

Sun, Yonghua

Email:	yhsun@ihb.ac.cn
URL:	http://sourcedb.ihb.cas.cn/cn/expert/xkdtr/201111/t20111116_3397228.html
Affiliation:	China Zebrafish Resource Center (CZRC) and also: Yonghua Sun Lab
Address:	State Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology, Chinese Academy of Sciences Wuhan, 430072 China
Country:	China
Phone:	+8618986132720
Fax:	+862768780123
ORCID ID:	0000-0001-9368-6969

BIOGRAPHY AND RESEARCH INTERESTS

Fish developmental biotechnology.
Zebrafish resource center of China.

PUBLICATIONS

Ye, D., Sun, Y. (2021) Manipulating and Visualizing the Germline with Transgenic Lines. Methods in molecular biology (Clifton, N.J.). 2218:265-276

Li, X., Zhang, F., Wu, N., Ye, D., Wang, Y., Zhang, X., Sun, Y., Zhang, Y.A. (2020) A critical role of foxp3a-positive regulatory T cells in maintaining immune homeostasis in zebrafish testis development. Journal of genetics and genomics = Yi chuan xue bao. 47(9):547-561

Liu, C., Ye, D., Wang, H., He, M., Sun, Y. (2020) Elovl2 But Not Elovl5 Is Essential for the Biosynthesis of Docosahexaenoic Acid (DHA) in Zebrafish: Insight from a Comparative Gene Knockout Study. Marine biotechnology (New York, N.Y.). 22(5):613-619

He, M., Zhang, R., Jiao, S., Zhang, F., Ye, D., Wang, H., Sun, Y. (2020) Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors. PLoS Biology. 18:e3000561

Zhang, Q., Ye, D., Wang, H., Wang, Y., Sun, Y. (2020) Zebrafish cyp11c1 knockout reveals the roles of 11-ketotestosterone and cortisol in sexual development and reproduction. Endocrinology. 161(6):

Zhang, F., Li, X., He, M., Ye, D., Xiong, F., Amin, G., Zhu, Z., Sun, Y. (2020) Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted primordial germ cells. Journal of genetics and genomics = Yi chuan xue bao. 47(1):37-47

Feng, K., Cui, X., Song, Y., Tao, B., Chen, J., Wang, J., Liu, S., Sun, Y., Zhu, Z., Trudeau, V.L., Hu, W. (2019) Gnrh3 regulates PGC proliferation and sex differentiation in developing zebrafish. Endocrinology. 161(1):

Ye, D., Wang, X., Wei, C., He, M., Wang, H., Wang, Y., Zhu, Z., Sun, Y. (2019) Marcksb plays a key role in the secretory pathway of zebrafish Bmp2b. PLoS Genetics. 15:e1008306

Yang, X., Li, Y., Li, Y., Ye, D., Yuan, L., Sun, Y., Han, D., Hu, Q. (2019) Solid Matrix-Supported Supercritical CO₂ Enhances Extraction of γ-Linolenic Acid from the Cyanobacterium Arthrospira (Spirulina) platensis and Bioactivity Evaluation of the Molecule in Zebrafish. Marine drugs. 17(4):

Ye, D., Zhu, L., Zhang, Q., Xiong, F., Wang, H., Wang, X., He, M., Zhu, Z., Sun, Y. (2019) Abundance of Early Embryonic Primordial Germ Cells Promotes Zebrafish Female Differentiation as Revealed by Lifetime Labeling of Germline. Marine biotechnology (New York, N.Y.). 21(2):217-228

Tian, J., Shao, J., Liu, C., Hou, H.Y., Chou, C.W., Shboul, M., Li, G.Q., El-Khateeb, M., Samarah, O.Q., Kou, Y., Chen, Y.H., Chen, M.J., Lyu, Z., Chen, W.L., Chen, Y.F., Sun, Y.H., Liu, Y.W. (2018) Deficiency of lrp4 in zebrafish and human LRP4 mutation induce aberrant activation of Jagged-Notch signaling in fin and limb development. Cellular and molecular life sciences : CMLS. 76(1):163-178

Khaliq, M., Ko, S., Liu, Y., Wang, H., Sun, Y., Solnica-Krezel, L., Shin, D. (2018) Stat3 regulates liver progenitor cell-driven liver regeneration in zebrafish. Gene Expression. 18(3):157-170

Chen, M., Zhang, J., Pang, S., Wang, C., Wang, L., Sun, Y., Song, M., Liang, Y. (2017) Evaluating estrogenic and anti-estrogenic effect of endocrine disrupting chemicals (EDCs) by zebrafish (Danio rerio) embryo-based vitellogenin 1 (vtg1) mRNA expression. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 204:45-50

Ma, D., Xue, Y., Zhang, Y., Sun, Y., Meng, A., Liu, F. (2016) The rising zebrafish research in China: Meeting report of the 3rd Chinese Zebrafish Principal Investigator Meeting & the Inaugural Meeting of China Zebrafish Society. Journal of genetics and genomics = Yi chuan xue bao. 43(10):617-620

Liu, L., Pan, L., Li, K., Zhang, Y., Zhu, Z., Sun, Y. (2016) Zebrafish Health Conditions in the China Zebrafish Resource Center and 20 Major Chinese Zebrafish Laboratories. Zebrafish. 13 Suppl 1:S8-S18

He, M.D., Zhang, F.H., Wang, H.L., Wang, H.P., Zhu, Z.Y., Sun, Y.H. (2015) Efficient ligase 3-dependent microhomology-mediated end joining repair of DNA double-strand breaks in zebrafish embryos. Mutation research. 780:86-96

Pang, S.C., Wang, H.P., Zhu, Z.Y., Sun, Y.H. (2015) Transcriptional Activity and DNA Methylation Dynamics of the Gal4/UAS System in Zebrafish. Marine biotechnology (New York, N.Y.). 17(5):593-603

Dai, Z., Wang, H., Jin, X., Wang, H., He, J., Liu, M., Yin, Z., Sun, Y., Lou, Q. (2015) Depletion of suppressor of cytokine signaling-1a causes hepatic steatosis and insulin resistance in zebrafish. American journal of physiology. Endocrinology and metabolism. 308(10):E849-59

Xie, X., Pan, L., Sun, Y. (2015) Growing with the world: rapid development of the zebrafish research in China and the China Zebrafish Resource Center. Science China. Life sciences. 58:396-9

Lu, F.I., Sun, Y.H., Wei, C.Y., Thisse, C., Thisse, B. (2014) Tissue-specific derepression of TCF/LEF controls the activity of the Wnt/β-catenin pathway. Nature communications. 5:5368

Pang, S.C., Wang, H.P., Li, K.Y., Zhu, Z.Y., Kang, J.X., Sun, Y.H. (2014) Double Transgenesis of Humanized fat1 and fat2 Genes Promotes Omega-3 Polyunsaturated Fatty Acids Synthesis in a Zebrafish Model. Marine biotechnology (New York, N.Y.). 16(5):580-93

Wei, C.Y., Wang, H.P., Zhu, Z.Y., and Sun, Y.H. (2014) Transcriptional factors Smad1 and Smad9 act redundantly to mediate zebrafish ventral specification downstream of Smad5. The Journal of biological chemistry. 289(10):6604-18

Xiong, F., Wei, Z.Q., Zhu, Z.Y., and Sun, Y.H. (2013) Targeted Expression in Zebrafish Primordial Germ Cells by Cre/loxP and Gal4/UAS Systems. Marine biotechnology (New York, N.Y.). 15(5):526-39

Wang, Y.W., Wei, C.Y., Dai, H.P., Zhu, Z.Y., and Sun, Y.H. (2013) Subtractive phage display technology identifies zebrafish marcksb that is required for gastrulation. Gene. 521(1):69-77

Liu, J.X., Zhang, D., Xie, X., Ouyang, G., Liu, X., Sun, Y., and Xiao, W. (2013) Eaf1 and Eaf2 negatively regulate canonical Wnt/β-catenin signaling. Development (Cambridge, England). 140(5):1067-1078

Liu, C.W., Xiong, F., Jia, H.Z., Wang, X., Cheng, H., Sun, Y., Zhang, X.Z., Zhuo, R.X., and Feng, J. (2013) Graphene-based Anticancer Nanosystem and Its Biosafety Evaluation Using a Zebrafish Model. Biomacromolecules. 14(2):358-366

Ishtiaq Ahmed, A.S., Xiong, F., Pang, S.C., He, M.D., Waters, M.J., Zhu, Z.Y., and Sun, Y.H. (2011) Activation of GH signaling and GH-independent stimulation of growth in zebrafish by introduction of a constitutively activated GHR construct. Transgenic Research. 20(3):557-567

Chen, C.H., Sun, Y.H., Pei, D.S., and Zhu, Z.Y. (2009) Comparative expression of zebrafish lats1 and lats2 and their implication in gastrulation movements. Developmental dynamics : an official publication of the American Association of Anatomists. 238(11):2850-2859

Pei, D.S., Sun, Y.H., and Zhu, Z.Y. (2009) Identification of a novel gene K23 over-expressed in fish cross-subfamily cloned embryos. Molecular biology reports. 36(6):1375-1380

Liu, J., Sun, Y.H., Wang, Y.W., Wang, N., Pei, D.S., Wang, Y.P., Hu, W., and Zhu, Z.Y. (2008) Identification of differential transcript profiles between mutual crossbred embryos of zebrafish (Danio rerio) and Chinese rare minnow (Gobiocypris rarus) by cDNA-AFLP. Theriogenology. 70(9):1525-1535

Pei, D.S., Sun, Y.H., Long, Y., and Zhu, Z.Y. (2008) Inhibition of no tail (ntl) gene expression in zebrafish by external guide sequence (EGS) technique. Molecular biology reports. 35(2):139-143

Pei, D.S., Sun, Y.H., Chen, C.H., Chen, S.P., Wang, Y.P., Hu, W., and Zhu, Z.Y. (2008) Identification and characterization of a novel gene differentially expressed in zebrafish cross-subfamily cloned embryos. BMC Developmental Biology. 8:29

Pei, D.S., Sun, Y.H., and Zhu, Z.Y. (2008) Construction of cytoplasmic molecular markers distinguishing Danio rerio from Gobiocypris rarus at high identity domains based on MP-PCR strategy and Sybr Green I detection. Molecular biology reports. 35(1):45-50

Pei, D.S., Sun, Y.H., Chen, S.P., Wang, Y.P., Hu, W., and Zhu, Z.Y. (2007) Identification of differentially expressed genes from the cross-subfamily cloned embryos derived from zebrafish nuclei and rare minnow enucleated eggs. Theriogenology. 68(9):1282-1291

Wang, N., Sun, Y.H., Liu, J., Wu, G., Su, J.G., Wang, Y.P., and Zhu, Z.Y. (2007) Knock down of gfp and no tail expression in zebrafish embryo by in vivo-transcribed short hairpin RNA with T7 plasmid system. Journal of Biomedical Science. 14(6):767-776

Wang, W., Liu, X., Gelinas, D., Ciruna, B., and Sun, Y. (2007) A fully automated robotic system for microinjection of zebrafish embryos. PLoS One. 2(9):e862

Pei, D.S., Sun, Y.H., Chen, S.P., Wang, Y.P., Hu, W., and Zhu, Z.Y. (2007) Zebrafish GAPDH can be used as a reference gene for expression analysis in cross-subfamily cloned embryos. Analytical biochemistry. 363(2):291-293

Wang, N., Sun, Y.H., Liu, J., Wang, Y.P., and Zhu, Z.Y. (2007) Molecular characterization of common carp (Cyprinus carpio) Sonic Hedgehog and discovery of its maternal expression. Development genes and evolution. 217(4):299-305

Pei, D.S., Sun, Y.H., Chen, S.P., Wang, Y.P., and Zhu, Z.Y. (2007) Cloning and characterization of cytochrome c oxidase subunit I (COXI) in Gobiocypris rarus. DNA sequence : the journal of DNA sequencing and mapping. 18(1):1-8

Liu, J., Sun, Y.H., Wang, N., Wang, Y.P., and Zhu, Z.Y. (2006) Upstream Regulatory Region of Zebrafish lunatic fringe: Isolation and Promoter Analysis. Marine biotechnology (New York, N.Y.). 8(4):357-365

Liu, W.Y., Wang, Y., Sun, Y.H., Wang, Y., Wang, Y.P., Chen, S.P., and Zhu, Z.Y. (2005) Efficient RNA interference in zebrafish embryos using siRNA synthesized with SP6 RNA polymerase. Development, growth & differentiation. 47(5):323-331

NON-ZEBRAFISH PUBLICATIONS
1. Sun YH, Chen SP, Wang YP, Hu W, Zhu ZY. Cytoplasmic impact on cross-genus cloned fish derived from transgenic common carp (Cyprinus carpio) nuclei and goldfish (Carassius auratus) enucleated eggs. Biology of Reproduction 2005; 72: 510-515 (Highlight in this issue of BOR; Reported by Science News and The Scientists in US.)
2. Zhi H, Wang W, Li L, Chai B, Sun Y, Liang A. Cloning and analysis of 16 Rab genes from macronuclear DNA of Euplotes octocarinatus. DNA Seq. 2005; 16:260-5.
3. Wu B*, Sun YH*, Wang YW, Wang YP, Zhu ZY. Characterization of transgene integration pattern in transgenic F4 common carp (Cyprinus carpio L.). Cell Research 2005; 15: 447-454 (*Equal contribution)
4. Li SF, Hu W, Wang YP, Sun YH, Chen SP, Zhu ZY. Cloning and expression analysis in mature individuals of salmon gonadotropin-releasing hormone (sGnRH) gene in common carp. Acta Genetica Sinica 2004; 31: 1072-1081
5. Wu B*, Sun YH*, Wang YP, Wang YW, Zhu ZY. Sequences of transgene insertion sites in transgenic F4 common carp. Transgenic Research 2004; 13: 95-96. (*Equal contribution).
6. Mao WF, Sun YH, Wang YP, Wu G, Chen SP, Zhu ZY. Cloning of rainbow trout (Oncorhynchus mykiss) histone H3 promoter and the activity analysis in rare minnow (Gobiocypris rarus). Progress in Natural Science 2004; 14: 322-326.
7. Sun YH, Zhu ZY, 2004. Producing transgenic fish for aquaculture. In: Lee CS editor, Aquaculture: Retrospective and Outlook �C An Aquaculture Summit. Asian Fisheries Society, Manila, Philippines and World Aquaculture Society, Baton Rouge, Louisiana, USA. p. 245-262 (peer reviewed chapter in a book).
8. Wu G*, Sun YH*, Zhu ZY. Gene transfer in common carp. Aquatic Living Resources 2003; 16: 416-420 (*Equal contribution).
9. Wang W, Sun YH, Wang YP, Zhu ZY. Expression of grass carp growth hormone in the yeast Pichia pastoris. Acta Genetica Sinica 2003; 30: 301-306.
10. Zhang YA, Nie P, Luo HY, Wang YP, Sun YH, Zhu ZY. Characterization of cDNA encoding immunoglobulin light chain of the mandarin fish (Siniperca chuatsi). Veterinary Immunology and Immunopathology 2003; 95: 81�C90.
11. Wang YP, Hu W, Wu G, Sun YH, Chen SP, Zhang FY, Zhu ZY, Feng JX, Zhang XR. Genetic analysis of ��all-fish�� growth hormone gene transferred carp (Cyprinus carpio L.) and its F1 generation. Chinese Science Bulletin 2001; 46: 1174-1177.
12. Wang W, Wang YP, Sun YH, Zhu ZY. Growth acceleration of Yellow river carp following oral administration of recombinant grass carp growth hormone expressed in yeast. High technology letters 2000; 10: 5-8.
13. Sun YH, Chen SP, Wang YP, Zhu ZY. The onset of foreign gene transcription in nuclear-transferred embryos of fish. Science in China (Series C) 2000; 43: 597-605.
14. Zhu ZY, Sun YH. Embryonic and genetic manipulation in fish. Cell Research 2000; 10: 17-27.
15. Zhao HB, Chen SP, Sun YH, Wang YP, Zhu ZY. The time course of foreign gene integration and expression in transgenic fish embryos. Chinese Science Bulletin 2000; 45: 734-739.
16. Chen SP, Zhao HB, Sun YH, Zhang FY, Zhu ZY. Nuclear transplantation with early-embryonic cells of transgenic fish. Progress in Natural Science 2000; 10: 925-930.