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Figure 6
Illustration of the mechanisms underlying the activation of SpaC to intestinal pyroptosis. The SpaC pilin of LGG induces intestinal epithelium injury through a species‐specific activation of TLR4ba, which initiates Caspase‐3−GSDMEa pyroptosis and secondarily activates Gaspy2−GSDMEb pyroptosis via gut microbiota dysbiosis.
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