ZFIN Image: Xing et al., 2022, Figure 5

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Figure 5

Lineage and transcription factor analysis for motor neuron and OPC lineages.A, monocle showing the putative developmental processes of progenitors or precursors in the pMN domain. Each dot represents an individual cell. Bifurcation of pMN progenitors into motor neuron (2) and OPC (11) lineages is shown. B, cells in (A) are shown in pseudotime. C, the temporal distribution of progenitors or precursors in the pMN domain. D, expression of known markers along the motor neuron or OPC lineage ordered in pseudotime. Note that isl1, mnx1, and neurod1 are enriched in the motor neuron branch, but nkx2.2a, olig1, sox10 are enriched in the OPC branch. E, heatmaps of the most differentially expressed transcription factors prebranching, in the motor neuron and OPC lineages. The color red denotes upregulation; blue denotes downregulation of genes. OPC, oligodendrocyte progenitor cell.

Acknowledgments

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