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Fig. S6 Validation of the selective expression of some genes in zebrafish delta cells. cdx1b, cdx4, lamc2, and map3k15 are specifically expressed in delta cells at 24 hpf (A, C, E, G, arrows show colocalization with delta cell-specific markers, somatostatin 2; n > 10). No expression was detected for none of the genes in beta cells (B, D, F, H). ins: insulin, sst2: somatostatin 2, ZHM: Gene expression conserved in zebrafish, human and mouse, ZM: Gene expression conserved in zebrafish and mouse, Z: Endocrine gene with no conserved expression, N-orth: Endocrine-enriched zebrafish gene with no described ortholog in human and/or mouse.

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