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Figure Caption
Fig. 6 Ezetimibe inhibits lipid metabolism in zebrafish larvae.
(A) Bright field image of a 6 day post-fertilization wild type (wt) zebrafish larva, lateral view. Red asterisk - intestine. (B–I) Gallbladder (red arrow) and intestinal (red asterisk) fluorescence in live 6 day post-fertilization wt and ezetimibe (50 μM) treated larvae following ingestion of fluorescent lipid reporters. (B, C) NBD-cholesterol; (D, G) PED6, (E, H) C16 bodipy (BdpC16), and (F, I) C5 bodipy (BdpC5). (J) Mean reduction in lipid reporter metabolism in ezetimibe vs wild type larvae. Error bars – standard deviation.
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