ZFIN ID: ZDB-GENE-991213-3
Gene Name: draculin
Gene Symbol: drl    Nomenclature History

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Attributions

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Previous Names: cb253 (1), dra, zgc:109857, zgc:136538

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and zinc ion binding activity. Involved in gastrulation with mouth forming second. Predicted to localize to nucleus. Is expressed in several structures, including forerunner cell group; hematopoietic cell; hematopoietic system; hypoblast; and mesoderm. Orthologous to several human genes including ZNF226 (zinc finger protein 226); ZNF235 (zinc finger protein 235); and ZNF429 (zinc finger protein 429).
Genome Resources: Alliance (1),  Gene:30167 (1),  Ensembl(GRCz11):ENSDARG00000078004 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
kz2 Small Deletion Unknown Unknown CRISPR
la010687Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-drl 1
    CRISPR2-drl
    1
    CRISPR3-drl,drll.2
    1
    MO1-drl N/A 1
    MO2-drl,drll.1,drll.2 N/A 2
    MO3-drl,drll.2 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH drl HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH drl VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process gastrulation with mouth forming second (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA drl-201 (1)    Ensembl 1862
    Browsers: UCSCEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM drl
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(+2.0drl:Cre-ERT2) drl CreERT2 Danio rerio 0 1
    Tg(+2.0drl:EGFP) drl EGFP Danio rerio 0 1
    Tg(+2.5drl:EGFP) drl EGFP Danio rerio 0 1
    Tg(-0.4drl:EGFP) drl EGFP Danio rerio 0 1
    Tg(-0.9drl:EGFP) drl EGFP Danio rerio 0 1
    Tg(-6.3drl:mCherry) drl mCherry Danio rerio 1 5
    Tg(-6.35drl:Cre-ERT2,cryaa:Venus) cryaadrl CreERT2Venus Danio rerio 1 8
    Tg(-6.35drl:Cre-ERT2,myl7:EGFP) drlmyl7 CreEGFPERT2 Danio rerio 1 1
    Tg(-6.35drl:EGFP) drl EGFP Danio rerio 1 8
    Tg(drl:Cre-ERT2) drl CreERT2 Danio rerio 1 1
    tg(drl:mcherry-2a-cre) drl 2ACremCherry Danio rerio 1 1
    MARKER RELATIONSHIPS
    drl Contained in: [BAC] DKEY-261J4 (1) (order this)
    drl Encodes: [EST] cb253 (1) (order this)
    [cDNA] MGC:109857 (1), MGC:136538 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_130977 (1) 1848 nt
    Genomic GenBank:AL935280 (1) 221563 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q1JPV8 (1) 411 aa
    Sequence Information (all 16)
    ORTHOLOGY for drl ( Chr: 5 )
    CITATIONS (71)