Gene

tcf7l2

ID
ZDB-GENE-991110-8
Name
transcription factor 7 like 2
Symbol
tcf7l2 Nomenclature History
Previous Names
  • tcf4
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including diencephalon development; exocrine pancreas development; and intestinal epithelial structure maintenance. Localizes to nucleus. Is expressed in several structures, including anterior neural keel; brain; digestive system; lateral line system; and optic vesicle. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2).
Genome Resources
Note
None
Expression
All Expression Data
31 figures from 15 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tcf7l2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
type 2 diabetes mellitus Alliance {Diabetes mellitus, type 2, susceptibility to} 125853
Associated With tcf7l2 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR009071 High mobility group box domain
Domain IPR013558 CTNNB1 binding, N-teminal
Family IPR024940 Transcription factor TCF/LEF
Family IPR028778 Transcription factor 7-like 1
Homologous_superfamily IPR027397 Catenin binding domain superfamily
Homologous_superfamily IPR036910 High mobility group box domain superfamily
Domain Details Per Protein
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-tcf7l2 monoclonal IgG1 Mouse
  • IHC
Biomol GmbH
2
Ab2-tcf7l2 monoclonal IgG Rabbit
  • IHC
Millipore
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations