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ZIRC
ZFIN ID: ZDB-GENE-991110-8
Gene Name: transcription factor 7 like 2
Gene Symbol: tcf7l2
Sequence Ontology ID : SO:0000704

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Previous Name: tcf4

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(Including Attributions)
Location: Chr: 12 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have beta-catenin binding activity; sequence-specific DNA binding activity; and transcription regulatory region DNA binding activity. Involved in several processes, including  ...
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb316 Small Deletion Exon 1 Unknown CRISPR
la012186Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018208Tg Transgenic Insertion Unknown Unknown DNA
    la018209Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa103 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2624 Point Mutation Unknown Splice Site ENU
    sa22132 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35327 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35328 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • u754 Point Mutation Acceptor Splice Site of Exon 6 Splice Site ENU
    u763 Point Mutation Donor Splice Site of Exon 2 Splice Site ENU
    zf55 Point Mutation Donor Splice Site of Intron 1 Unknown ENU
    Targeting reagents:
    DISEASE ASSOCIATED WITH tcf7l2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    type 2 diabetes mellitus {Diabetes mellitus, type 2, susceptibility to} 125853
    DISEASE ASSOCIATED WITH tcf7l2 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    type 2 diabetes mellitus tcf7l2zf55/zf55 standard conditions Facchinello et al., 2017
    tcf7l2zf55/+ standard conditions Facchinello et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process digestive system development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 18)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA tcf7l2-003 (1) 631
    mRNA tcf7l2-201 (1) 2139
    tcf7l2-202 (1) 2022
    tcf7l2-203 (1) 2078
    tcf7l2-205 (1) 1986
    tcf7l2-206 (1) 2063
    tcf7l2-208 (1) 477
    tcf7l2-209 (1) 680
    tcf7l2-210 (1) 4203
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM tcf7l2 No data available
    MARKER RELATIONSHIPS
    tcf7l2Contained in: [BAC] CH73-13L15 (1) (order this), DKEY-41E15 (1) (order this), DKEY-46I8 (1) (order this)
    tcf7l2Encodes: [EST] cegs350 (1) (order this)
    [cDNA] MGC:195358 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131259 (1) 2164bp
    Genomic GenBank:CR456684 (1) 262809bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8Q786 (1) 630aa
    Sequence Clusters UniGene:67692 (1)
    Sequence Information (all 47)
    ORTHOLOGY for tcf7l2 (Chr: 12)
    CITATIONS (65)