ZFIN ID: ZDB-GENE-991110-8
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Gene Name: transcription factor 7 like 2
Gene Symbol: tcf7l2
Sequence Ontology ID : SO:0000704

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Previous Name: tcf4

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(Including Attributions)
Location: Chr: 12 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 30 figures from 14 publications
Directly Submitted Expression Data: 12 figures (4 images) from Rauch et al., 2003 [cegs350]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la012186Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la018208Tg Transgenic Insertion Unknown Unknown DNA
    la018209Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa103 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa2624 Point Mutation Unknown Splice Site ENU
    sa22132 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa35327 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa35328 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • u754 Point Mutation Acceptor Splice Site of Exon 6 Splice Site ENU
    u763 Point Mutation Donor Splice Site of Exon 2 Splice Site ENU
    zf55 Point Mutation Donor Splice Site of Intron 1 Unknown ENU
    Targeting reagents:
    PHENOTYPE
    Data: 14 figures from 6 publications
    Observed in:
    DISEASE ASSOCIATED WITH tcf7l2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    type 2 diabetes mellitus {Diabetes mellitus, type 2, susceptibility to} 125853
    DISEASE ASSOCIATED WITH tcf7l2 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    type 2 diabetes mellitus tcf7l2zf55/+ standard conditions Facchinello et al., 2017
    tcf7l2zf55/zf55 standard conditions Facchinello et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process digestive system development (more)
    Cellular Component nucleus (more)
    Molecular Function beta-catenin binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR009071 (1)
  • InterPro:IPR013558 (1)
  • InterPro:IPR024940 (1)
  • InterPro:IPR027397 (1)
  • InterPro:IPR028773 (1)
  • InterPro:IPR036910 (1)
    		•
  • PROSITE:PS50118 (1)
    		•
  • Pfam:PF00505 (1)
  • Pfam:PF08347 (1)
    		•
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tcf7l2-001 (1) 4203
    Select Tool
    tcf7l2-002 (1) 2022
    Select Tool
    ncRNA tcf7l2-003 (1) 631
    Select Tool
    mRNA tcf7l2-004 (1) 680
    Select Tool
    tcf7l2-005 (1) 477
    Select Tool
    tcf7l2-006 (1) 1986
    Select Tool
    tcf7l2-007 (1) 2139
    Select Tool
    tcf7l2-008 (1) 2063
    Select Tool
    tcf7l2-009 (1) 2078
    Select Tool
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM tcf7l2 No data available
    MARKER RELATIONSHIPS
    tcf7l2Contained in: [BAC] CH73-13L15 (1) (order this), DKEY-41E15 (1) (order this), DKEY-46I8 (1) (order this)
    tcf7l2Encodes: [EST] cegs350 (1) (order this)
    [cDNA] MGC:195358 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131259 (1) 2164bp
    Select Tool
    Genomic GenBank:CR456684 (1) 262809bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8Q786 (1) 630aa
    Select Tool
    Sequence Clusters UniGene:67692 (1)
    Sequence Information (all 46)
    OTHER tcf7l2 GENE PAGES
  • Alliance (1)
  • Gene:30510 (1)
  • VEGA:OTTDARG00000020611 (1)
    • ORTHOLOGY for tcf7l2 (Chr: 12)
    CITATIONS (60)