ZFIN ID: ZDB-GENE-991110-8
Gene Name: transcription factor 7 like 2
Gene Symbol: tcf7l2
Sequence Ontology ID : SO:0000704

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Previous Name: tcf4

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Location: Chr: 12 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 28 figures from 13 publications
Directly Submitted Expression Data: 12 figures (4 images) from Rauch et al., 2003 [cegs350]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  anatomical structure, anterior neural keel, brain, diencephalon (all 29) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la012186Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018208Tg Transgenic Insertion Unknown Unknown DNA
    la018209Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa103 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2624 Point Mutation Unknown Splice Site ENU
    sa22132 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35327 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35328 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • u754 Point Mutation Acceptor Splice Site of Exon 6 Splice Site ENU
    u763 Point Mutation Donor Splice Site of Exon 2 Splice Site ENU
    zf55 Point Mutation Unknown Unknown ENU
    Targeting reagents: CRISPR1-tcf7l2 (1), MO1-tcf7l2 (1), MO2-tcf7l2 (1), MO3-tcf7l2 (1), MO4-tcf7l2 (1) (all 6) expand
    PHENOTYPE
    Data: 10 figures from 5 publications
    Observed in: canonical Wnt signaling pathway, epithelial cell, habenula determination of left/right asymmetry in diencephalon, habenula neuron projection (all 13) expand
    DISEASE ASSOCIATED WITH tcf7l2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    type 2 diabetes mellitus {Diabetes mellitus, type 2, susceptibility to} 125853
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process Wnt signaling pathway involved in digestive tract morphogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR009071 (1)
  • InterPro:IPR013558 (1)
  • InterPro:IPR024940 (1)
  • InterPro:IPR027397 (1)
  • InterPro:IPR028773 (1)
  • InterPro:IPR036910 (1)
  • PROSITE:PS50118 (1)
  • Pfam:PF00505 (1)
  • Pfam:PF08347 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tcf7l2-001 (1) 4203
    tcf7l2-002 (1) 2022
    ncRNA tcf7l2-003 (1) 631
    mRNA tcf7l2-004 (1) 680
    tcf7l2-005 (1) 477
    tcf7l2-006 (1) 1986
    tcf7l2-007 (1) 2139
    tcf7l2-008 (1) 2063
    tcf7l2-009 (1) 2078
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Ab1-tcf7l2 (1), Ab2-tcf7l2 (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM tcf7l2 No data available
    MARKER RELATIONSHIPS
    tcf7l2Contained in: [BAC] CH73-13L15 (1) (order this), DKEY-41E15 (1) (order this), DKEY-46I8 (1) (order this)
    tcf7l2Encodes: [EST] cegs350 (1) (order this)
    [cDNA] MGC:195358 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131259 (1) 2164bp
    Genomic GenBank:CR456684 (1) 262809bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1QC44 (1) 613aa
    Sequence Clusters UniGene:67692 (1)
    Sequence Information (all 43)
    OTHER tcf7l2 GENE PAGES
  • Alliance (1)
  • Gene:30510 (1)
  • VEGA:OTTDARG00000020611 (1)
  • Ensembl(GRCz10):ENSDARG00000004415 (1)
  • ORTHOLOGY for tcf7l2 (Chr: 12)
    CITATIONS (58)