ZFIN Gene: tcf7l2

ZFIN ID: ZDB-GENE-991110-8

ZFIN ID: ZDB-GENE-991110-8

Gene Name:

transcription factor 7 like 2

Gene Symbol:

tcf7l2

Sequence Ontology ID :

SO:0000704

Previous Name:

tcf4

Location:

Chr: 12 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have beta-catenin binding activity; sequence-specific DNA binding activity; and transcription regulatory region DNA binding activity. Involved in several processes, including ...

GENE EXPRESSION
All Expression Data:	30 figures from 14 publications
Directly Submitted Expression Data:	12 figures (4 images) from Rauch et al., 2003 [cegs350]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
	anterior neural keel brain diencephalon dorsal region diencephalon dorsal thalamus exocrine pancreas fin forebrain gut hindbrain intestinal bulb intestinal epithelium intestinal villus intestine midbrain anterior region midbrain neuromast optic tectum optic vesicle pancreas pharynx posterior lateral line primordium pretectum primary islet rhombomere rhombomere 4 rhombomere 5 thalamus neuron thalamus nucleus unspecified whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
ihb316	Small Deletion	Exon 1	Unknown	CRISPR
la012186Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la018208Tg	Transgenic Insertion	Unknown	Unknown	DNA
la018209Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
sa103	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa2624	Point Mutation	Unknown	Splice Site	ENU
sa22132	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa35327	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa35328	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
u754	Point Mutation	Acceptor Splice Site of Exon 6	Splice Site	ENU
u763	Point Mutation	Donor Splice Site of Exon 2	Splice Site	ENU
zf55	Point Mutation	Donor Splice Site of Intron 1	Unknown	ENU

Targeting reagents:

PHENOTYPE

Data:

14 figures from 6 publications

Observed in:

DISEASE ASSOCIATED WITH tcf7l2 HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
type 2 diabetes mellitus	{Diabetes mellitus, type 2, susceptibility to}	125853

DISEASE ASSOCIATED WITH tcf7l2 VIA EXPERIMENTAL MODELS

Human Disease	Fish	Conditions	Citations
type 2 diabetes mellitus	tcf7l2^zf55/zf55	standard conditions	Facchinello et al., 2017
	tcf7l2^zf55/+	standard conditions	Facchinello et al., 2017

GENE ONTOLOGY

Ontology	GO Term
Biological Process	digestive system development (more)
Cellular Component	nucleus (more)
Molecular Function	DNA binding (more)

GO Terms (all 18)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR009071 (1) InterPro:IPR013558 (1) InterPro:IPR024940 (1) InterPro:IPR027397 (1) InterPro:IPR028778 (1) InterPro:IPR036910 (1)	PROSITE:PS50118 (1)	Pfam:PF00505 (1) Pfam:PF08347 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
ncRNA	tcf7l2-003 (1)	631	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tcf7l2-201 (1)	2139	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	tcf7l2-202 (1)	2022	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	tcf7l2-203 (1)	2078	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	tcf7l2-205 (1)	1986	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	tcf7l2-206 (1)	2063	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	tcf7l2-208 (1)	477	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	tcf7l2-209 (1)	680	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	tcf7l2-210 (1)	4203	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION No description available

INTERACTIONS AND PATHWAYS

ANTIBODIES

Ab1-tcf7l2 (1)
Ab2-tcf7l2 (1)

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM tcf7l2 No data available

MARKER RELATIONSHIPS

tcf7l2Contained in:	[BAC] CH73-13L15 (1) (order this), DKEY-41E15 (1) (order this), DKEY-46I8 (1) (order this)
tcf7l2Encodes:	[EST] cegs350 (1) (order this) [cDNA] MGC:195358 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131259 (1)	2164bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR456684 (1)	262809bp	Blast at MegaBLAST
Polypeptide	UniProtKB:A0A2R8Q786 (1)	630aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:67692 (1)

Sequence Information (all 47)

OTHER tcf7l2 GENE PAGES

Alliance (1)

Gene:30510 (1)

VEGA:OTTDARG00000020611 (1)

Ensembl(GRCz11):ENSDARG00000004415 (1)

ORTHOLOGY for tcf7l2 (Chr: 12)

CITATIONS (65)

{{control.fieldName}} Edit

Attributions

Add new Alias

Attributions for Alias: {{control.newAlias}}

Delete Alias: