Gene
tcf7l2
- ID
- ZDB-GENE-991110-8
- Name
- transcription factor 7 like 2
- Symbol
- tcf7l2 Nomenclature History
- Previous Names
-
- tcf4
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in digestive system development. Acts upstream of or within several processes, including diencephalon development; exocrine pancreas development; and intestinal epithelial structure maintenance. Located in nucleus. Predicted to be part of beta-catenin-TCF complex and catenin-TCF7L2 complex. Is expressed in several structures, including anterior neural plate; brain; digestive system; gonad; and sensory system. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 35 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
type 2 diabetes mellitus | Alliance | {Diabetes mellitus, type 2, susceptibility to} | 125853 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
type 2 diabetes mellitus | tcf7l2zf55/zf55 | standard conditions | Facchinello et al., 2017 |
type 2 diabetes mellitus | tcf7l2zf55/+ | standard conditions | Facchinello et al., 2017 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR009071 | High mobility group box domain |
Domain | IPR013558 | CTNNB1 binding, N-teminal |
Family | IPR024940 | Transcription factor TCF/LEF |
Homologous_superfamily | IPR027397 | Catenin binding domain superfamily |
Homologous_superfamily | IPR036910 | High mobility group box domain superfamily |
Domain Details Per Protein
Protein | Length | Catenin binding domain superfamily | CTNNB1 binding, N-teminal | High mobility group box domain | High mobility group box domain superfamily | Transcription factor TCF/LEF |
---|---|---|---|---|---|---|
UniProtKB:Q71G54
|
477 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
tcf7l2-201
(1)
|
2139 nt | |
mRNA |
tcf7l2-202
(1)
|
2022 nt | |
mRNA |
tcf7l2-203
(1)
|
2078 nt | |
mRNA |
tcf7l2-205
(1)
|
1986 nt | |
mRNA |
tcf7l2-206
(1)
|
2063 nt | |
mRNA |
tcf7l2-208
(1)
|
477 nt | |
mRNA |
tcf7l2-209
(1)
|
680 nt | |
mRNA |
tcf7l2-210
(1)
|
4203 nt | |
ncRNA |
tcf7l2-003
(1)
|
631 nt |
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab1-tcf7l2 | monoclonal | IgG1 | Mouse |
|
Biomol GmbH
|
2 | |
Ab2-tcf7l2 | monoclonal | IgG | Rabbit |
|
Millipore
|
2 |
Plasmids
No data available