ZFIN ID: ZDB-GENE-991110-8
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Gene Name: transcription factor 7 like 2
Gene Symbol: tcf7l2    Nomenclature History

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Previous Name: tcf4

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have beta-catenin binding activity; sequence-specific DNA binding activity; and transcription regulatory region DNA binding activity. Involved in several processes, including diencephalon development; exocrine pancreas development; and intestinal epithelial structure maintenance. Localizes to the nucleus. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Is expressed in several structures, including anterior neural keel; brain; digestive system; lateral line system; and optic vesicle. Orthologous to human TCF7L2 (transcription factor 7 like 2).
Genome Resources: Alliance (1),  Gene:30510 (1),  Ensembl(GRCz11):ENSDARG00000004415 (1)
GENE EXPRESSION
All Expression Data: 31 figures from 15 publications
Directly Submitted Expression Data: 12 figures (4 images) from Rauch et al., 2003 [cegs350]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb316 Small Deletion Exon 1 Unknown CRISPR
la012186Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la018208Tg Transgenic Insertion Unknown Unknown DNA
    la018209Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa103 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa2624 Point Mutation Unknown Splice Site ENU
    sa22132 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa35327 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa35328 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • u754 Point Mutation Acceptor Splice Site of Exon 6 Splice Site ENU
    u763 Point Mutation Donor Splice Site of Exon 2 Splice Site ENU
    zf55 Point Mutation Donor Splice Site of Intron 1 Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tcf7l2
    		1
    CRISPR2-tcf7l2 1
    MO1-tcf7l2 N/A 2
    MO2-tcf7l2 N/A 4
    MO3-tcf7l2 N/A 1
    MO4-tcf7l2 N/A 2
    MO5-tcf7l2 N/A 1
    PHENOTYPE
    Data: 14 figures from 6 publications
    Observed in:
    DISEASE ASSOCIATED WITH tcf7l2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    type 2 diabetes mellitus Alliance {Diabetes mellitus, type 2, susceptibility to} 125853
    DISEASE ASSOCIATED WITH tcf7l2 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    type 2 diabetes mellitus tcf7l2zf55/zf55 standard conditions Facchinello et al., 2017
    tcf7l2zf55/+ standard conditions Facchinello et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process digestive system development (more)
    Cellular Component nucleus (more)
    Molecular Function beta-catenin binding (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR009071 High mobility group box domain
    Domain IPR013558 CTNNB1 binding, N-teminal
    Family IPR024940 Transcription factor TCF/LEF
    Family IPR028778 Transcription factor 7-like 1
    Homologous_superfamily IPR027397 Catenin binding domain superfamily
    Homologous_superfamily IPR036910 High mobility group box domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tcf7l2-201 (1)    Ensembl 2139
    Select Tool
    tcf7l2-202 (1)    Ensembl 2022
    Select Tool
    tcf7l2-203 (1)    Ensembl 2078
    Select Tool
    tcf7l2-205 (1)    Ensembl 1986
    Select Tool
    tcf7l2-206 (1)    Ensembl 2063
    Select Tool
    tcf7l2-208 (1)    Ensembl 477
    Select Tool
    tcf7l2-209 (1)    Ensembl 680
    Select Tool
    tcf7l2-210 (1)    Ensembl 4203
    Select Tool
    ncRNA tcf7l2-003 (1) 631
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-tcf7l2 monoclonal IgG1 Mouse IHC Biomol GmbH
    		2
    Ab2-tcf7l2 monoclonal IgG Rabbit IHC Millipore
    		2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tcf7l2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(tetre:hsa.ctnnb1-2a-tcf7l2) TETRE 2A,  tcf7l2 Danio rerio,  Homo sapiens 1 1
    MARKER RELATIONSHIPS
    tcf7l2 Contained in: [BAC] CH73-13L15 (1), DKEY-41E15 (1) (order this), DKEY-46I8 (1) (order this)
    tcf7l2 Encodes: [EST] cegs350 (1) (order this)
    [cDNA] MGC:195358 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131259 (1) 2164 nt
    Select Tool
    Genomic GenBank:CR456684 (1) 262809 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8Q786 (1) 630 aa
    Select Tool
    Sequence Information (all 46)
    ORTHOLOGY for tcf7l2 ( Chr: 12 )
    CITATIONS (69)