Gene

tcf7l2

ID

ZDB-GENE-991110-8

Name

transcription factor 7 like 2

Symbol

tcf7l2 Nomenclature History

Previous Names

tcf4

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in several processes, including diencephalon development; exocrine pancreas development; and intestinal epithelial structure maintenance. Localizes to nucleus. Is expressed in several structures, including anterior neural keel; brain; digestive system; lateral line system; and optic vesicle. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

34 figures from 17 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 16 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tcf7l2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
type 2 diabetes mellitus	Alliance	{Diabetes mellitus, type 2, susceptibility to}	125853

Associated With tcf7l2 Via Experimental Models

Human Disease	Fish	Conditions	Citations
type 2 diabetes mellitus	tcf7l2^zf55/zf55	standard conditions	Facchinello et al., 2017
type 2 diabetes mellitus	tcf7l2^zf55/+	standard conditions	Facchinello et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR009071	High mobility group box domain
Domain	IPR013558	CTNNB1 binding, N-teminal
Family	IPR024940	Transcription factor TCF/LEF
Homologous_superfamily	IPR027397	Catenin binding domain superfamily
Homologous_superfamily	IPR036910	High mobility group box domain superfamily

Domain Details Per Protein

Protein	Length	Catenin binding domain superfamily	CTNNB1 binding, N-teminal	High mobility group box domain	High mobility group box domain superfamily	Transcription factor TCF/LEF
UniProtKB:F1QC44 InterPro	613
UniProtKB:F1QLQ0 InterPro	159
UniProtKB:Q9W7B9 InterPro	102
UniProtKB:A0A2R8RT79 InterPro	199
UniProtKB:Q8JIY2 InterPro	438
UniProtKB:E9QC17 InterPro	426
UniProtKB:Q6DEL9 InterPro	411
UniProtKB:Q71G52 InterPro	610
UniProtKB:F1RC81 InterPro	438
UniProtKB:Q71G53 InterPro	605
UniProtKB:F1Q7T6 InterPro	610
UniProtKB:Q8JIY3 InterPro	426
UniProtKB:A0A2R8QTB4 InterPro	630
UniProtKB:U3JAK3 InterPro	109
UniProtKB:E9QFQ3 InterPro	605
UniProtKB:B3DKP7 InterPro	477
UniProtKB:Q71G54 InterPro	477
UniProtKB:U3JA54 InterPro	472
UniProtKB:A0A2R8Q786 InterPro	630
UniProtKB:A0A2R8RU78 InterPro	593

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	tcf7l2-201 (1) Ensembl	2139 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tcf7l2-202 (1) Ensembl	2022 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tcf7l2-203 (1) Ensembl	2078 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tcf7l2-205 (1) Ensembl	1986 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tcf7l2-206 (1) Ensembl	2063 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tcf7l2-208 (1) Ensembl	477 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tcf7l2-209 (1) Ensembl	680 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tcf7l2-210 (1) Ensembl	4203 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	tcf7l2-003 (1) Ensembl	631 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tcf7l2	monoclonal	tcf7l2	IgG1	Mouse	IHC	Biomol GmbH	2
Ab2-tcf7l2	monoclonal	tcf7l2	IgG	Rabbit	IHC	Millipore	2

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations