ZFIN ID: ZDB-GENE-991110-23
Gene Name: keratin 5
Gene Symbol: krt5    Nomenclature History

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Previous Names: ckii (1), wu:fb02h09 (1), wu:fj02d02, wu:fk78b12 (1), zfCKII

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Involved in fin regeneration. Predicted to localize to keratin filament. Is expressed in EVL; epidermal cell; eye; integument; and periderm. Human ortholog(s) of this gene implicated in several diseases, including Dowling-Degos disease; epidermolysis bullosa simplex (multiple); epidermolytic hyperkeratosis; ichthyosis (multiple); and palmoplantar keratosis (multiple). Orthologous to several human genes including KRT5 (keratin 5).
Genome Resources: Alliance (1),  Gene:797351 (1),  Ensembl(GRCz11):ENSDARG00000058371 (1)
GENE EXPRESSION
All Expression Data: 16 figures from 9 publications
Directly Submitted Expression Data: 6 figures (7 images) from Thisse et al., 2004 [MGC:77647]
Wild-type Stages, Structures: Blastula:30%-epiboly (4.66h-5.25h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa29880 Point Mutation Unknown Missense, Splice Site ENU
sa31083 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37628 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43920 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-krt5
    2
    CRISPR2-krt5
    2
    MO1-krt5 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH krt5 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Dowling-Degos disease Alliance Dowling-Degos disease 1 179850
    epidermolysis bullosa simplex Alliance Epidermolysis bullosa simplex, recessive 1 601001
    epidermolysis bullosa simplex Dowling-Meara type Alliance Epidermolysis bullosa simplex, Dowling-Meara type 131760
    epidermolysis bullosa simplex generalized type Alliance Epidermolysis bullosa simplex, Koebner type 131900
    epidermolysis bullosa simplex localized type Alliance Epidermolysis bullosa simplex, Weber-Cockayne type 131800
    epidermolysis bullosa simplex with mottled pigmentation Alliance Epidermolysis bullosa simplex-MP 131960
    Epidermolysis bullosa simplex-MCR 609352
    DISEASE ASSOCIATED WITH krt5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fin regeneration (more)
    Cellular Component intermediate filament (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA krt5-201 (1)    Ensembl 2397
    krt5-202 (1)    Ensembl 693
    krt5-203 (1)    Ensembl 841
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-krt5 polyclonal IgG Rabbit WB Thermo Scientific Pierce Protein Research Products
    2
    PLASMIDS
    Addgene:82585
    CONSTRUCTS WITH SEQUENCES FROM krt5
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-2.3krt5:RFP) krt5 RFP Danio rerio 1 3
    Tg(krt5:cdx1b-EGFP) krt5 cdx1bEGFP Danio rerio 1 3
    Tg(krt5:EGFP) krt5 EGFP Danio rerio 1 4
    Tg(krt5:GAL4-ERT2-VP16,myl7:ECFP) krt5myl7 ECFPERT2GAL4VP16 Danio rerio 1 3
    Tg(krt5:GAL4-VP16,14xUAS:smo-EGFP) krt5UAS EGFPGAL4smoVP16 Danio rerio 1 3
    Tg(krt5:GAL4FF) krt5 GAL4FF Danio rerio 1 4
    Tg(krt5:h2az2a-mCherry) krt5 h2az2amCherry Danio rerio 1 2
    tg(krt5:lifeact-gfp) krt5 GFPLIFEACT Danio rerio 1 1
    tg(krt5:lifeact-mruby) krt5 LIFEACTmRuby Danio rerio 1 1
    tg(krt5:myl12.1-egfp) krt5 EGFPmyl12.1 Danio rerio 1 1
    Tg(krt5:RTTA-VP16) krt5 RTTAVP16 Danio rerio 1 1
    Tg2(krt5:EGFP) krt5 EGFP Danio rerio 2 4
    MARKER RELATIONSHIPS
    krt5 Contained in: [BAC] CH211-188C24 (1)
    krt5 Encodes: [EST] fb02h09 (1), fj02d02, fk78b12 (1)
    [cDNA] MGC:77647 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131156 (1) 2382 nt
    Genomic GenBank:CR352294 (1) 146924 nt
    Select Tool
    Polypeptide UniProtKB:F1QV31 (1) 566 aa
    Sequence Information (all 31)
    ORTHOLOGY for krt5 ( Chr: 23 )
    CITATIONS (58)