Gene

krt5

ID
ZDB-GENE-991110-23
Name
keratin 5
Symbol
krt5 Nomenclature History
Previous Names
  • ckii (1)
  • wu:fb02h09 (1)
  • wu:fj02d02
  • wu:fk78b12 (1)
  • zfCKII
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Involved in fin regeneration. Predicted to localize to keratin filament. Human ortholog(s) of this gene implicated in several diseases, including Dowling-Degos disease; epidermolysis bullosa simplex (multiple); epidermolytic hyperkeratosis; ichthyosis (multiple); and palmoplantar keratosis (multiple). Is expressed in EVL; epidermal cell; eye; integument; and periderm. Orthologous to several human genes including KRT5 (keratin 5).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
21 figures from 12 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With krt5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Dowling-Degos disease Alliance Dowling-Degos disease 1 179850
epidermolysis bullosa simplex with mottled pigmentation Alliance Epidermolysis bullosa simplex 2F, with mottled pigmentation 131960
Epidermolysis bullosa simplex 2A, generalized severe 619555
Epidermolysis bullosa simplex 2B, generalized intermediate 619588
Epidermolysis bullosa simplex 2C, localized 619594
Epidermolysis bullosa simplex 2D, generalized, intermediate or severe, autosomal recessive 619599
Epidermolysis bullosa simplex 2E, with migratory circinate erythema 609352
Associated With krt5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018039 Intermediate filament protein, conserved site
Domain IPR032444 Keratin type II head
Domain IPR039008 Intermediate filament, rod domain
Family IPR003054 Keratin, type II
Domain Details Per Protein
Protein Length Intermediate filament protein, conserved site Intermediate filament, rod domain Keratin, type II Keratin type II head
UniProtKB:Q6P3K5 553
UniProtKB:Q9PUB5 558
UniProtKB:F1QV31 566
UniProtKB:E9QBD7 226
UniProtKB:E9QFT4 201
UniProtKB:F1R5A5 560
UniProtKB:Q9YH66 111
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-krt5 polyclonal IgG Rabbit
  • WB
Thermo Scientific Pierce Protein Research Products
2
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations