ZFIN ID: ZDB-GENE-990708-8
Gene Name: uncoupling protein 2
Gene Symbol: ucp2    Nomenclature History

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Previous Names: zUCP2 (1), cb74 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have oxidative phosphorylation uncoupler activity. Predicted to be involved in adaptive thermogenesis; mitochondrial transmembrane transport; and response to cold. Predicted to localize to integral component of membrane and mitochondrial inner membrane. Is expressed in several structures, including blood; brain; cardiovascular system; pleuroperitoneal region; and ventral mesoderm. Human ortholog(s) of this gene implicated in artery disease (multiple); diabetic neuropathy; end stage renal disease; non-alcoholic fatty liver disease; and obesity. Orthologous to human UCP2 (uncoupling protein 2).
Genome Resources: Alliance (1),  Gene:555812 (1),  Ensembl(GRCz11):ENSDARG00000043154 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb233 Indel Exon 3 Unknown CRISPR
ihb234 Small Deletion Exon 3 Unknown CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-ucp2 1
MO1-ucp2 N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ucp2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Obesity, susceptibility to, BMIQ4} 607447
DISEASE ASSOCIATED WITH ucp2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process mitochondrial transport (more)
Cellular Component integral component of membrane (more)
Molecular Function oxidative phosphorylation uncoupler activity (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ucp2-201 (1)    Ensembl 1518
ncRNA ucp2-002 (1)    Ensembl 789
ucp2-003 (1)    Ensembl 779
ucp2-004 (1)    Ensembl 757
ucp2-005 (1)    Ensembl 807
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ucp2 No data available
MARKER RELATIONSHIPS
ucp2 Contained in: [BAC] CH211-176G13 (1)
ucp2 Encodes: [EST] cb74 (1) (order this)
[cDNA] MGC:65762 (1), MGC:76853 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131176 (1) 1501 nt
Genomic GenBank:AL845435 (1) 141424 nt
Select Tool
Polypeptide UniProtKB:Q6P0I3 (1) 310 aa
Sequence Information (all 21)
ORTHOLOGY for ucp2 ( Chr: 10 )
CITATIONS (66)