ZFIN ID: ZDB-GENE-990708-7
Gene Name: orthopedia homeobox b
Gene Symbol: otpb    Nomenclature History

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Previous Names: otp1 (1), otp, otpa, cb977 (1), otp a

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have sequence-specific DNA binding activity. Involved in forebrain neuron development; hypothalamus development; and mammillary body development. Predicted to localize to nucleus. Is expressed in several structures, including brain; gonad; neural keel; neural plate; and neurons. Orthologous to human OTP (orthopedia homeobox).
Genome Resources: Alliance (1),  Gene:30316 (1),  Ensembl(GRCz11):ENSDARG00000058379 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
az9 Small Deletion Unknown Unknown CRISPR
az10 Small Deletion Unknown Unknown CRISPR
sa115 Small Deletion Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa8966 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12381 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45228 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-otpb 1
    MO1-otpb N/A 2
    MO2-otpb N/A 2
    MO3-otpb N/A 5
    MO4-otpb N/A 1
    MO5-otpb N/A 1
    DISEASE ASSOCIATED WITH otpb HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH otpb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process forebrain neuron development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA otpb-201 (1)    Ensembl 1845
    otpb-202 (1)    Ensembl 1825
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM otpb
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(otpb:Eco.NsfB-EGFP) otpb EGFP Danio rerioEscherichia coli 1 3
    Tg(otpb:EGFP) otpb EGFP Danio rerio 1 1
    Tg(otpb:GAL4,myl7:EGFP) myl7otpb EGFPGAL4 Danio rerio 1 3
    Tg(otpb:GAL4-VP16,myl7:GFP) myl7otpb GAL4GFPVP16 Danio rerio 1 15
    Tg1(otpb:EGFP) otpb EGFP Danio rerio 1 6
    Tg2(otpb:EGFP) otpb EGFP Danio rerio 1 9
    Tg2(otpb:GAL4-VP16,myl7:TagRFP) myl7otpb GAL4TagRFPVP16 Danio rerio 1 3
    MARKER RELATIONSHIPS
    otpb Contained in: [BAC] CH211-194B21 (1)
    otpb Encodes: [EST] cb977 (1) (order this)
    [cDNA] MGC:92914 (1), MGC:191282 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131100 (1) 1880 nt
    Genomic GenBank:BX470070 (1) 228177 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B0S6A5 (1) 315 aa
    Sequence Information (all 20)
    ORTHOLOGY for otpb ( Chr: 5 )
    CITATIONS (67)