ZFIN ID: ZDB-GENE-990630-14
Gene Name: clock circadian regulator a
Gene Symbol: clocka    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: clk1 (1), Clock1a (1), clock, zCLOCK1 (1), zfCLOCK1 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific. Contributes to DNA binding activity. Involved in several processes, including photoperiodism; primitive hemopoiesis; and regulation of gene expression. Localizes to the nuclear chromatin and transcription factor complex. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is expressed in brain; head; ovary; red sensitive photoreceptor cell; and retinal cone cell. Orthologous to human CLOCK (clock circadian regulator).
Genome Resources: Alliance (1),  Gene:30140 (1),  Ensembl(GRCz11):ENSDARG00000011703 (2)
GENE EXPRESSION
All Expression Data: 18 figures from 13 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
dg3 Point Mutation Unknown Missense ENU
sa14713 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17257 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23683 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37017 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39276 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-clocka N/A 5
    MO2-clocka N/A 1
    DISEASE ASSOCIATED WITH clocka HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH clocka VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process photoperiodism (more)
    Cellular Component nuclear chromatin (more)
    Molecular Function CONTRIBUTES_TO   DNA binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000014 PAS domain
    Family IPR001067 Nuclear translocator
    Repeat IPR001610 PAC motif
    Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Domain IPR013767 PAS fold
    Homologous_superfamily IPR035965 PAS domain superfamily
    Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    antisense ottdart00000059169 (1) 1935
    mRNA clocka-202 (1)    Ensembl 6535
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-clock polyclonal IgG Goat IHC, WB Santa Cruz Biotechnology, Inc.
    3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM clocka
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(aanat2:EGFP-2A-Dclocka-5xMYC) aanat2 2AclockaEGFPMYC Danio rerio 1 3
    MARKER RELATIONSHIPS
    clocka Contained in: [BAC] CH211-278F21 (1)
    clocka Encodes: [cDNA] MGC:194542 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130957 (1) 2682 bp
    Genomic GenBank:BX088688 (1) 179801 bp
    Select Tool
    Polypeptide UniProtKB:Q9W6J4 (1) 893 aa
    Sequence Information (all 17)
    ORTHOLOGY for clocka ( Chr: 20 )
    CITATIONS (92)