ZFIN ID: ZDB-GENE-990621-1
Gene Name: midkine a
Gene Symbol: mdka    Nomenclature History

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Previous Names: fb05b02, fc32h11, plei1, wu:fb05b02 (1), wu:fc32h11 (1), zgc:86655

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have growth factor activity. Involved in neural tube formation; regulation of cell cycle; and sensory epithelium regeneration. Localizes to Golgi apparatus. Is expressed in several structures, including brain; eye; neural tube; neuroectoderm; and paraxial mesoderm. Human ortholog(s) of this gene implicated in brain ischemia. Orthologous to human MDK (midkine).
Genome Resources: Alliance (1),  Gene:30277 (1),  Ensembl(GRCz11):ENSDARG00000036036 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a299 Complex Unknown Unknown CRISPR
mi5001 Small Deletion Exon 3 Unknown CRISPR
sa34130 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-mdka 1
    CRISPR2-mdka
    1
    CRISPR3-mdka 1
    CRISPR4-mdka 1
    CRISPR5-mdka 1
    CRISPR6-mdka 1
    MO1-mdka N/A 3
    MO2-mdka N/A 1
    DISEASE ASSOCIATED WITH mdka HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mdka VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neural tube formation (more)
    Cellular Component Golgi apparatus (more)
    Molecular Function growth factor activity (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mdka-201 (1)    Ensembl 2516
    mdka-202 (1)    Ensembl 767
    mdka-203 (1)    Ensembl 802
    mdka-204 (1)    Ensembl 434
    mdka-205 (1)    Ensembl 579
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-mdka polyclonal Rabbit IHC, WB 3
    CONSTRUCTS WITH SEQUENCES FROM mdka No data available
    MARKER RELATIONSHIPS
    mdka Contained in: [BAC] DKEY-210E9 (1) (order this)
    mdka Encodes: [EST] fb05b02 (1), fc32h11
    [cDNA] MGC:86655 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131070 (1) 1975 nt
    Genomic GenBank:CR356225 (1) 201825 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A1D5NS41 (1) 154 aa
    Sequence Information (all 23)
    ORTHOLOGY for mdka ( Chr: 7 )
    CITATIONS (46)