ZFIN Gene: etv4

ZFIN ID: ZDB-GENE-990415-71

ZFIN ID: ZDB-GENE-990415-71

Gene Name:

ETS variant transcription factor 4

Gene Symbol:

etv4

Sequence Ontology ID :

SO:0000704

Previous Names:

etID309954.12 (1), pea3 (1)

Location:

Chr: 12 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Exhibits sequence-specific DNA binding activity. Involved in limb morphogenesis; positive regulation of transcription, DNA-templated; and pronephric nephron tubule epithelial cell differentiation. ...

GENE EXPRESSION
All Expression Data:	105 figures from 75 publications
Directly Submitted Expression Data:	6 figures (18 images) from Thisse et al., 2004 [MGC:76984]
Wild-type Stages, Structures:	Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
	axial mesoderm axis caudal fin cell corneal epithelium ectoderm epibranchial placode eye forebrain forebrain neural rod forerunner cell group gonad primordium somatic cell head hindbrain hindbrain neural keel hindbrain neural plate hindbrain neural rod hindbrain neural tube hypothalamus lateral line system lens lens placode margin maxillary barbel mesenchyme pectoral fin mesoderm mesonephric nephron midbrain hindbrain boundary midbrain hindbrain boundary neural keel midbrain hindbrain boundary neural plate midbrain hindbrain boundary neural rod midbrain neural rod neural crest cell neural keel neural tube neuromast neuron notochord optic stalk oral epithelium otic vesicle anterior crista otic vesicle pancreatic bud paraxial mesoderm pectoral fin ectoderm pectoral fin pectoral fin bud ectoderm pectoral fin bud mesenchyme pectoral fin bud pharyngeal arch epithelium pharyngeal arch pharyngeal arch 2 cranial neural crest pharyngeal arch 3 cranial neural crest pharyngeal arch 3-7 pharyngeal arch 4 cranial neural crest pharyngeal pouch pharynx epithelium posterior lateral line primordium posterior lateral plate mesoderm presumptive paraxial mesoderm pronephric glomerulus retina retinal ganglion cell layer rhombomere 1 rhombomere 2 rhombomere 3 rhombomere 4 Rohon-Beard neuron secondary posterior lateral line primordium segmental plate shield solid lens vesicle somite antero-dorsal region somite spinal cord tail bud telencephalon trunk unspecified ventricular zone whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
hu3536	Point Mutation	Unknown	Premature Stop	ENU
la010075Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la011544Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la018185Tg	Transgenic Insertion	Unknown	Unknown	DNA
la018186Tg	Transgenic Insertion	Unknown	Unknown	DNA
sa45463	Point Mutation	Unknown	Splice Site	ENU	Zebrafish International Resource Center (ZIRC) (order this)

Targeting reagents:

PHENOTYPE

Data:	Fig. 4 from Marra et al., 2016
Observed in:	pronephric nephron tubule epithelial cell differentiation pronephros multi-ciliated epithelial cell pronephros multi-ciliated epithelial cell differentiation pronephros

DISEASE ASSOCIATED WITH etv4 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH etv4 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	positive regulation of transcription, DNA-templated (more)
Cellular Component	nucleus (more)
Molecular Function	sequence-specific DNA binding (more)

GO Terms (all 11)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000418 (1) InterPro:IPR006715 (1) InterPro:IPR036388 (1) InterPro:IPR036390 (1)	PROSITE:PS00345 (1) PROSITE:PS00346 (1) PROSITE:PS50061 (1)	Pfam:PF00178 (1) Pfam:PF04621 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	etv4-201 (1)	1957	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	etv4-202 (1)	757	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	etv4-203 (1)	789	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDS

Addgene

CONSTRUCTS WITH SEQUENCES FROM etv4 No data available

MARKER RELATIONSHIPS

etv4Contained in:	[BAC] DKEY-69O7 (1) (order this)
etv4Encodes:	[EST] fc19f01 (1) [cDNA] MGC:76984 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131425 (1)	1813bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:AL833789 (1)	175664bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F1RD02 (1)	494aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:75840 (1)

Sequence Information (all 27)

OTHER etv4 GENE PAGES

Alliance (1)

Gene:30700 (1)

VEGA:OTTDARG00000020582 (1)

Ensembl(GRCz11):ENSDARG00000018303 (1)

ORTHOLOGY for etv4 (Chr: 12)

CITATIONS (175)

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