Gene

ddx4

ID
ZDB-GENE-990415-272
Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Symbol
ddx4 Nomenclature History
Previous Names
  • vas
  • vasa
  • vlg
  • wu:fi24g05
  • zgc:109812
  • zgc:158535
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have RNA binding activity and RNA helicase activity. Involved in germ cell development; gonad development; and regulation of meiotic cell cycle. Localizes to P granule. Is expressed in several structures, including blastodisc; germ line cell; reproductive system; shield; and unfertilized egg. Orthologous to human DDX4 (DEAD-box helicase 4).
Genome Resources
Note
None
Expression
All Expression Data
144 figures from 78 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from Hartung et al., 2014
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ddx4 Human Ortholog
No data available
Associated With ddx4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
Domain IPR001650 Helicase, C-terminal
Domain IPR011545 DEAD/DEAH box helicase domain
Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
Domain IPR014014 RNA helicase, DEAD-box type, Q motif
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length ATP-dependent RNA helicase DEAD-box, conserved site DEAD/DEAH box helicase domain Helicase, C-terminal Helicase superfamily 1/2, ATP-binding domain P-loop containing nucleoside triphosphate hydrolase RNA helicase, DEAD-box type, Q motif
UniProtKB:O42378 700
UniProtKB:E7EZA2 716
UniProtKB:F1R6M3 700
UniProtKB:A1L1Z2 688
UniProtKB:Q8QFU0 715
UniProtKB:F8W3U8 699
UniProtKB:Q504J0 306
UniProtKB:Q8QGG8 715
UniProtKB:F8W4P0 687
UniProtKB:F1QSP5 688
UniProtKB:O42107 716
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ddx4 Rabbit
  • IHC
18
Ab2-ddx4 polyclonal Rabbit
  • IHC
  • WB
5
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations