ZFIN ID: ZDB-GENE-990415-272
Gene Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
Gene Symbol: ddx4    Nomenclature History

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Previous Names: vas, vasa, vlg, wu:fi24g05, zgc:109812, zgc:158535

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have RNA binding activity and RNA helicase activity. Involved in germ cell development; gonad development; and regulation of meiotic cell cycle. Localizes to the P granule. Is expressed in several structures, including blastodisc; germ line cell; reproductive system; shield; and unfertilized egg. Orthologous to human DDX4 (DEAD-box helicase 4).
Genome Resources: Alliance (1),  Gene:30263 (1),  Ensembl(GRCz11):ENSDARG00000014373 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6158 Point Mutation Unknown Premature Stop ENU
sa9472 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15900 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18973 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ddx4 N/A 2
    DISEASE ASSOCIATED WITH ddx4 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ddx4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process germ cell development (more)
    Cellular Component P granule (more)
    Molecular Function ATP binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
    Domain IPR001650 Helicase, C-terminal
    Domain IPR011545 DEAD/DEAH box helicase domain
    Domain IPR014001 Helicase superfamily 1/2, ATP-binding domain
    Domain IPR014014 RNA helicase, DEAD-box type, Q motif
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ddx4-204 (1)    Ensembl 2787
    ddx4-205 (1)    Ensembl 2519
    ddx4-206 (1)    Ensembl 2856
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-ddx4 Rabbit IHC 17
    Ab2-ddx4 polyclonal Rabbit IHC, WB 5
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ddx4
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(ddx4:ddx4-EGFP) ddx4 ddx4EGFP Danio rerio 1 43
    tg(ddx4:dendra2-ntr-utr) ddx4 Dendra2NTRUTR Danio rerio 1 1
    Tg(ddx4:DsRed2-ddx4) ddx4 ddx4DsRed2 Danio rerio 1 5
    tg(ddx4:gfp) ddx4 GFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    ddx4 Contained in: [BAC] CH73-194F17 (1), DKEY-117I20 (1) (order this)
    ddx4 Encodes: [EST] fi24g05
    [cDNA] MGC:109812 (1), MGC:158535 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131057 (1) 2865 nt
    Genomic GenBank:BX571726 (1) 106819 nt
    Select Tool
    Polypeptide UniProtKB:E7EZA2 (1) 716 aa
    Sequence Information (all 48)
    ORTHOLOGY for ddx4 ( Chr: 10 )
    CITATIONS (215)