ZFIN ID: ZDB-GENE-990415-268
Gene Name: thyroid hormone receptor beta
Gene Symbol: thrb    Nomenclature History

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Previous Names: thr2 (1), trb, fj24f03, NR1A2 (1), nr1a2 (1), TR[b]1 (1), wu:fj24f03 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Exhibits nuclear receptor activity. Involved in regulation of transcription, DNA-templated; sensory organ development; and thyroid hormone mediated signaling pathway. Predicted to localize to RNA polymerase II transcription regulator complex. Is expressed in several structures, including brain; eye; heart; liver; and optic vesicle. Used to study thyroid hormone resistance syndrome. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); cervix uteri carcinoma in situ; renal cell carcinoma; selective pituitary thyroid hormone resistance; and thyroid hormone resistance syndrome. Orthologous to human THRB (thyroid hormone receptor beta).
Genome Resources: Alliance (1),  Gene:30607 (1),  Ensembl(GRCz11):ENSDARG00000021163 (2)
GENE EXPRESSION
All Expression Data: 17 figures from 11 publications
Directly Submitted Expression Data: 7 figures (16 images) from Thisse et al., 2008 [af109732]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020642Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la020643Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa749 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • vp34rc1 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-thrb
    1
    CRISPR2-thrb
    1
    CRISPR3-thrb 1
    MO1-thrb N/A 1
    MO2-thrb N/A 3
    MO3-thrb N/A 1
    MO4-thrb N/A 1
    MO5-thrb N/A 1
    DISEASE ASSOCIATED WITH thrb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    selective pituitary thyroid hormone resistance Alliance Thyroid hormone resistance, selective pituitary 145650
    thyroid hormone resistance syndrome Alliance Thyroid hormone resistance 188570
    Thyroid hormone resistance, autosomal recessive 274300
    DISEASE ASSOCIATED WITH thrb VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    thyroid hormone resistance syndrome AB + MO4-thrb standard conditions Marelli et al., 2016
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component host cell nucleus (more)
    Molecular Function nuclear receptor activity (more)
    GO Terms (all 25)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript thrb-201 (1)    Ensembl 1992
    mRNA thrb-203 (1)    Ensembl 3136
    ncRNA thrb-002 (1)    Ensembl 1234
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM thrb
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(crx:MA-YFP-2A-thrb) crx thrbYFP Danio rerio 0 3
    Tg(crx:MA-YFP-2A-thrb,myl7:EGFP) crxmyl7 2AEGFPMAthrbYFP Danio rerio 1 4
    Tg(gnat2:MA-YFP-2A-thrb) gnat2 thrbYFP Danio rerio 1 3
    tg(hsp70l:dnthrb-2a-nls-egfp) hsp70l 2AEGFPNLSthrb Danio rerio 1 1
    Tg(thrb:GAL4,myl7:EGFP) myl7thrb EGFPGAL4 Danio rerio 1 2
    Tg(thrb:MA-YFP) thrb YFP Danio rerio 1 5
    Tg(thrb:Tomato) thrb Tomato Danio rerio 1 10
    Tg2(thrb:Tomato) thrb Tomato Danio rerio 1 2
    MARKER RELATIONSHIPS
    thrb Contained in: [BAC] CH211-264A6 (1), DKEY-126A1 (1) (order this)
    [Fosmid] CH1073-16E3 (1)
    thrb Encodes: [EST] af109732 (2), fj24f03 (1)
    [cDNA] MGC:194860 (1), MGC:194900 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131340 (1) 2198 nt
    Genomic GenBank:BX927163 (1) 157282 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QK91 (1) 508 aa
    Sequence Information (all 57)
    ORTHOLOGY for thrb ( Chr: 19 )
    CITATIONS (162)