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ZIRC
ZFIN ID: ZDB-GENE-990415-224
Gene Name: frizzled class receptor 2
Gene Symbol: fzd2    Nomenclature History

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Previous Names: fz-2 (1), fz2 (1), fz8, cb383 (1), wu:fb70g09, zg08

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have Wnt-activated receptor activity and Wnt-protein binding activity. Involved in several processes, including Wnt signaling pathway, calcium modulating pathway; heart development; and sensory epithelium regeneration. Localizes to the plasma membrane. Human ortholog(s) of this gene implicated in omodysplasia. Is expressed in several structures, including cardiovascular system; fin; head; head mesenchyme; and mesoderm. Orthologous to human FZD2 (frizzled class receptor 2).
Genome Resources: Alliance (1),  Gene:30370 (1),  Ensembl(GRCz11):ENSDARG00000054438 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028896Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sdu2 Small Deletion Exon 1 Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fzd2 N/A 1
    MO2-fzd2 N/A 4
    MO3-fzd2 N/A 4
    TALEN1-fzd2 1
    DISEASE ASSOCIATED WITH fzd2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    omodysplasia Alliance Omodysplasia 2 164745
    DISEASE ASSOCIATED WITH fzd2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of left/right symmetry (more)
    Cellular Component plasma membrane (more)
    Molecular Function transmembrane signaling receptor activity (more)
    GO Terms (all 20)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fzd2-201 (1)    Ensembl 2440
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fzd2 No data available
    MARKER RELATIONSHIPS
    fzd2 Contained in: [BAC] DKEY-194J22 (1) (order this)
    fzd2 Encodes: [EST] cb383 (1) (order this), fb70g09 (1)
    [cDNA] MGC:65755 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131140 (1) 2360 bp
    Genomic GenBank:CU062431 (1) 183293 bp
    Select Tool
    Polypeptide UniProtKB:F1QBI2 (1) 550 aa
    Sequence Clusters UniGene:12607 (1)
    Sequence Information (all 17)
    ORTHOLOGY for fzd2 ( Chr: 3 )
    CITATIONS (49)